Latent profile analysis of healthcare-related regret coping among Master of Nursing specialist students during clinical internships: A multi-center cross-sectional study.

Background: Healthcare-related regret (HRR) is frequently encountered by healthcare professionals, even in the early clinical stages. Effective coping strategies are essential for mental well-being, professional performance, and career satisfaction. However, the specific coping mechanisms used by Master of Nursing specialist (MNS) students during clinical internships are not well understood.

SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging.

Ferroptosis has been implicated in skeletal muscle aging. Nevertheless, specific ferroptosis-related genes (FRGs) governing skeletal muscle aging remain unclear. The aim of this study was to identify ferroptosis-related marker genes associated with skeletal muscle aging, uncovering potential therapeutic targets for skeletal muscle aging.

Effect of Esketamine and Etomidate on Postoperative Cognitive Function in Elderly Patients Undergoing Painless retain-->Bronchoscopy: A Randomized Controlled Trial.

Purpose: This study aimed to evaluate the effects of different doses of esketamine with etomidate on anesthesia and postoperative cognitive function of elderly patients undergoing painless tracheoscopy.

Design: This was a double-blind, randomized controlled trial.

Methods: In this study, 150 patients over 65 were divided into group A (low-dose: 0.

Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey.

Objective: This study evaluated trends in population immunity against measles, rubella, mumps, and varicella in Suqian City (2005-2024) using serological surveys (2019-2024) and incidence data, incorporating participants with known/unknown vaccination statuses to explore immunity dynamics amid evolving policies, and inform public health planning.

Methods: Serum samples from 541 (2019) and 506 (2024) healthy participants were analyzed for virus-specific IgG antibodies using ELISA. Disease incidence data were obtained from China's National Notifiable Disease Reporting System.

Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy?

Background: Type 2 diabetes mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) are mutually causal, which can jointly promote the development of the disease. As an important means to evaluate the steatosis of MAFLD, Controlled Attenuation Parameter (CAP) can also evaluate the metabolism related fat parameters. Whether Traditional Chinese Medicine preparation (TCM-preparation) can improve CAP has not been reported yet, so the purpose of this meta-analysis is to evaluate the effect of TCM-preparation on CAP in T2DM patients with MAFLD.

Alkali Metalation Enables Natural Anthraquinone Derivatives as Sustainable Cathode Materials for Lithium-Ion Batteries.

Organic electrode materials (OEMs) derived from natural quinones can enable sustainable lithium-ion batteries (LIBs) if their dissolution-induced capacity fading in organic electrolytes and their conductivity issues are addressed. It is demonstrated that converting natural anthraquinones (AQs) into organic alkali-metalated salts effectively inhibits their dissolution in aprotic electrolytes. For this purpose, a solubility indicator (ΔMPI) is developed, which reliably guides the selection of compatible OEMs and electrolytes.

Varicella-Zoster Virus Infection and Varicella-Zoster Virus Vaccine-Related Ocular Complications.

The varicella-zoster virus is a human herpesvirus that causes varicella as the primary infection and HZ as the reactivation of a latent infection. Ten to twenty percent of cases of herpes zoster ophthalmicus (HZO) involve the ophthalmic branch of the fifth cranial nerve. Any area of the eye may be affected by the condition.

Electrolyte engineering regulating the interfacial water structure of CuO catalysts to promote electrochemical C-C coupling reactions.

Here we engineer the solvated structure of metal cations by introducing dimethyl sulfoxide as an electrolyte additive to modulate the interfacial water environment. This tailored solvation facilitates faster proton-coupled electron transfer on Cu-based catalysts during CO activation and increases *CO intermediate absorption, thereby promoting C-C coupling toward CH formation in the electrochemical CO reduction.

The impact of pt-NGS technology on antimicrobial use and outcomes in patients with lower respiratory tract infections: a hospital-based real-world study.

Objective: This study aimed to evaluate the impact of pathogen-targeted next-generation sequencing (pt-NGS) technology on antimicrobial use and clinical outcomes in hospitalized adults with lower respiratory tract infections (LRTIs).

Methods: In this retrospective cohort study, 340 adult LRTI patients were stratified into two groups: a pt-NGS-guided group ( = 140) and a conventional microbiological testing-guided group ( = 200). Outcomes included pathogen detection rates, antimicrobial therapy adjustments, clinical outcomes (mortality, length of stay LOS, ICU admission), and healthcare costs.

Clinical features and genetic analysis of A20 haploinsufficiency.

Objective: To described clinical and genetic characteristics of 4 patients presenting A20 haploinsufficiency (HA20) treated at Children's hospital affiliated to Zhengzhou university from 2015 to 2024.

Methods: A retrospective analysis was conducted on the clinical data, genetic testing results, and treatment outcomes of four children with HA20 treated at the Children's hospital affiliated to Zhengzhou university from 2015 to 2024.

Results: All four patients developed symptoms before the age of 1 year, presenting with recurrent fever and abdominal pain with diarrhea.

Synergistic Dual-Pinning Engineering Enables Stable Mn-Based Layered Oxide Cathodes for High-Performance Sodium-Ion Batteries.

Mn-based oxide cathodes for sodium-ion batteries (SIBs) often suffer from structural degradation caused by Jahn-Teller distortion and irreversible phase transitions. Here, we propose a dual-site stabilization strategy by Mo/Mg codoping, which not only drives the transformation of the tunnel-type NaMnO into a P2-layered structure (NaMnMoMgO, denoted as MoMg-12) by modulating the total energy to enhance capacity but also employs Mo and Mg ions substituting Mn sites to implement synergistic dual-pinning engineering to stabilize the structure. This dual-pinning mechanism concurrently suppresses Jahn-Teller distortion by stabilizing Mn redox activity and improves air stability by reducing Na/H exchange while promoting a hydrophobic surface.

A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.

Sickle cell disease (SCD) is a common, life-threatening group of disorders caused by missense mutations in the b-globin gene (HBB). Mouse models have helped to elucidate the most common form of SCD (HbSS, homozygous p.Glu6Val) and develop new therapies.

Multiple roles of EML1 in microtubule stabilization and vesicle transport in the nervous system.

Microtubule-associated protein EML1 is an important member of the EML family and plays a key role in cytoskeleton regulation and neural development. During neural development, EML1 expression is spatiotemporally specific, and its functional abnormalities are closely associated with neural developmental disorders such as subcortical band heterotopia. This article systematically reviews the structural characteristics and biological functions of EML1.

PRAME immunohistochemistry distinguishes breast secondary angiosarcoma from benign and atypical vascular lesions of the breast.

Objective: We examined the utility of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry (IHC) in distinguishing breast angiosarcoma from benign or atypical vascular lesions (AVLs) of the breast.

Methods: There were 26 breast angiosarcomas (24 radiation related and 2 primary), 6 radiation-related AVLs of the breast, and 16 other benign vascular lesions of the breast retrieved from our institutional archive and stained with PRAME IHC.

Results: Twenty-four of 26 (92%) breast angiosarcomas were positive for PRAME with moderate to strong staining intensities (median HScore, 255 [range, 90-300]), while 0 of 22 benign or atypical vascular lesions of the breast were PRAME positive (sensitivity, 92.

Multifunctional Gallium Nanorods-Embedded Calcium Alginate/Silk Fibroin Microspheres for Tumor Therapy: Integrating Embolization, Photothermal Therapy, Chemotherapy, and Imaging.

Embolization is a crucial clinical technique in interventional therapy to control bleeding and treat tumors and vascular lesions. However, current embolization therapies still present challenges such as limited therapeutic efficacy, the inability to track embolization over time, inadequate drug release, and uncontrollable degradation effects of embolic materials. This study introduces a novel multifunctional embolic microspheres (CA/SF Ga@DOX MS) composed of biodegradable silk fibroin, calcium alginate, and gallium nanorods (Ga NRs) and loaded with doxorubicin(DOX), aiming to enhance the efficacy of tumor embolization through photothermal chemotherapy.

Bilayer Flexible Films with Controllable Porous/Dense Structure via Single-Step Fabrication for Advanced Piezoelectric Wearables.

Polyvinylidene fluoride (PVDF) and its copolymer poly(vinylidene fluoride--trifluoroethylene) (PVTF) have attracted significant attention in energy harvesters and piezoelectric sensing devices due to their inherent piezoelectric properties and exceptional flexibility. However, their limited piezoelectric performance restricts practical applications. Inspired by microstructural design principles and based on the traditional nonsolvent-induced phase separation (NIPS) method, we developed a low-pressure-assisted in situ nonsolvent-induced phase separation (LPA-NIPS) technique and successfully fabricated high-performance 3D porous PVTF-based flexible piezoelectric films with a bilayer sponge-like structure.

Pharmacokinetics and pharmacodynamics studies of Relugolix long-acting microcrystalline formulation in male Beagle dogs.

Relugolix is the first oral GnRH receptor antagonist. However, its oral formulation requires daily administration, leading to poor patient adherence and suboptimal treatment outcomes for long-term users. To address these issues, we developed a long-acting microcrystalline formulation of relugolix administered once every 28 days.

A personalized prediction model for distinguishing between asymptomatic bacteriuria and symptomatic urinary tract infections in patients with type 2 diabetes mellitus using machine learning.

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased susceptibility to urinary tract infections (UTIs), caused by uropathogenic (UPEC). Asymptomatic bacteriuria (ASB) is a significant contributor, but lots of patients are difficult to distinguish. Distinguishing between ASB and symptomatic UTIs can greatly assist clinicians in rational use of antimicrobials.

SciToolAgent: a knowledge-graph-driven scientific agent for multitool integration.

Scientific research increasingly relies on specialized computational tools, yet effectively utilizing these tools requires substantial domain expertise. While large language models show promise in tool automation, they struggle to seamlessly integrate and orchestrate multiple tools for complex scientific workflows. Here we present SciToolAgent, a large language model-powered agent that automates hundreds of scientific tools across biology, chemistry and materials science.

Efficacy and Safety of Firsekibart Compared to Etoricoxib for Gout Flares: A Phase 2, Multicenter, Open-label, Active-controlled, Randomized Non-inferiority Trial.

Introduction: Firsekibart, an anti-interleukin (IL)-1β monoclonal antibody, has demonstrated more sustained control of gout flares compared with compound betamethasone in previous clinical studies. This study evaluated the efficacy and safety of firsekibart versus etoricoxib for the treatment of frequent gout flares.

Methods: In this phase 2, randomized, open-label, active-controlled, multicenter study (NCT05936268), adults with gout according to American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) 2015 criteria experiencing frequent flares (≥ 2 flares within 12 months pre-screening) were randomized (1:1) to receive either a single subcutaneous injection of firsekibart 200 mg, or once-daily oral etoricoxib 120 mg administered until pain remission or treatment intolerance for up to 8 days.

Contributions of lifestyle, education, and cardiovascular risk factors to the brain age gap.

The brain age gap is the difference between chronological age and the age predicted from Magnetic Resonance Imaging (MRI) brain scans. We investigated the influence of life habits and cardio-metabolic factors on this gap. A convolutional neural network (CNN) was trained on structural MRI scans from dementia-free participants in the Rotterdam Study.

Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging.

Senescent cardiac fibroblasts (CFs), which are activated and acquire a pro-fibrotic phenotype, exacerbate age-related interstitial fibrosis and cardiac dysfunction by unclear mechanisms. Traditionally regarded as a central organ involved in regulating aging, the small intestine (SI) communicates with remote organs. However, the mechanisms underlying its role in CFs senescence remain undefined.

Progress on nucleos(t)idyl lipid-based nanoparticles for nucleic acid drugs delivery.

Nucleic acid drugs can function at the gene level, and have the advantages of simple synthesis, easy modification and high specificity. However, there are many obstacles in transfection and delivery due to their negative charge, high molecular weight, and hydrophilicity. Lipid nanoparticles (LNPs) can encapsulate siRNA or mRNA through electrostatic interactions and five related drugs have been approved as of April 2025.

The functions of rice SSIIa alleles in starch biosynthesis modulated by the distinct genetic backgrounds.

Natural variations in rice starch synthase IIa (SSIIa) gene confer different enzyme activities, leading to biosynthesis of starch with altered structures. To investigate the interaction effects of SSIIa and other starch synthesis-related genes on starch structural and functional properties, indica rice genotypes with different allelic combinations of SSIIa, Waxy (Wx), and branching enzyme IIb (BEIIb) were analyzed. Although SSIIa alleles exerted minimal effects on starch structures in the background of Wx/BEIIb, SSIIa specifically reduced gelatinization enthalpy by enhancing amylose synthesis in the background of Wx/BEIIb.

Firsekibart versus compound betamethasone in acute gout patients unsuitable for standard therapy: A randomized phase 3 trial.

This phase 3 trial evaluated the efficacy and safety of Firsekibart, a novel, fully human anti-interleukin-1β monoclonal antibody, in patients with frequent acute gout flares unsuitable for standard therapy. Patients were randomized (1:1, stratified by baseline pain visual analog scale [VAS]) to the Firsekibart (200 mg) or compound betamethasone (CB; 7 mg) group. Co-primary endpoints included change in pain intensity in the target joint at 72 h (non-inferiority testing) and time to first new flare within 12 weeks (superiority testing).