Effects of aerobic and resistance exercise on patients with hypertension: a systematic review and meta-analysis focusing on the sympathetic nervous system.

Background: Treatment and control of hypertension are important for the prevention of cardiovascular diseases. The autonomic nervous system plays a major role in the development and progression of hypertension and has become a new research hotspot in cardiovascular disease. Exercise as a non-pharmacologic intervention has likewise received much attention in the field of cardiovascular disease.

Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5-year update of the CinClare trial.

Background: The optimal regimen and chemotherapy intensity are still under investigation for neoadjuvant treatment of locally advanced rectal cancer (LARC). The CinClare trial has demonstrated improved pathologic complete response (pCR) with the addition of irinotecan to neoadjuvant chemoradiotherapy (CRT) guided by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype in LARC. Here, we report the 5-year follow-up outcomes of the CinClare study.

Photochemical Generation of Peroxynitrite: Concurrent Inhibition of Glycolysis and Glutamine Metabolism for Enhanced Metabolic Therapy.

Disrupting homeostasis within tumor cells by interfering with their diverse metabolic pathways is an attractive tumor treatment method. However, current methods generally focus on one pathway within tumor cells, such as glycolysis or the glutamine (Gln) metabolic pathway, overlooking potential strong correlations between different cellular pathways and preventing a comprehensive blockade of the tumor energy supply, thereby compromising therapeutic efficacy. Herein, a photochemistry-activated peroxynitrite (ONOO) nanogenerator, capable of simultaneously inhibiting glycolysis and Gln metabolism in tumor cells, is proposed to achieve enhanced metabolic therapy.

Contact-dominated localized electric-displacement-field-enhanced pressure sensing.

Pressure sensors, especially the typical capacitive sensors that feature low power consumption, have drawn considerable interest in emerging and rapidly growing fields such as flexible electronics and humanoid robots, but often suffer from limited performance. Here, we report a contact-dominated design for capacitive pressure sensors to dramatically improve the sensing response and linearity over a broad pressure range. This design is implemented by utilizing hierarchical microstructured electrodes made of robust conductive composites with metallic coverage and layered dielectrics with high unit-area capacitance to realize localized electric-displacement-field-enhanced capacitance change.

Dual-functional DNA nanoribbon-templated copper nanoclusters synergistically activate NRF2/HO-1 pathway for synergistic oxidative stress mitigation.

Employing antioxidant nanozymes to eliminate reactive oxygen species (ROS) is a promising strategy for alleviating oxidative stress. However, most current nanozymes struggle to balance catalytic efficacy with biosafety, limiting their clinical applicability. In this study, we introduce a novel platform: DNA nanoribbon-templated copper nanoclusters (DNR/Cu NCs), which harness dual antioxidative mechanisms (direct ROS scavenging and activation of nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway) to synergistically mitigate oxidative stress.

Exploring the Roles of Superwetting in Atmospheric Water Harvesting.

Atmospheric water harvesting (AWH) is an emerging technology to extract water from the atmosphere, aiming to alleviate the worldwide water crisis. Water capture and transportation are two primary processes in AWH systems that are closely linked to surface superwetting. It is important to understand the roles of superwetting in advanced AWH technologies.

Substrate recycling amplification enabled by hierarchically mesoporous MOFs for the specific screening of pheochromocytoma and paraganglioma.

The sensitive and specific diagnosis of pheochromocytoma and paraganglioma (PPGL) remains challenging due to the low abundance of their detectable biomarker of catecholamines (CAs) in serum. Herein, we established an enzyme-assisted substrate recycling amplification model based on a hierarchically mesoporous UiO-66-NH (HMAUiO) to address these difficulties. Such porous platform was constructed by the Hofmeister ion-assisted nanoemulsion method with mesoporous size beyond 20 nm, in which Pt (II) meso-tetra(4-carboxyphenyl)porphyrin (TCPP-Pt) was incorporated within the microporous framework to form an HMAUiO-Pt sensing probe.

Ultra-sensitive solid-state nanochannel electrochemical biosensor based on interfacial charge density modulation and signal synergistic amplification for microRNA-155 detection.

Solid-state nanochannel sensors have emerged as a promising platform for next-generation disease marker detection. However, significant challenges remain in detecting low-abundance miRNAs in biological systems. This study presents an ultra-sensitive electrochemical sensing system based on interfacial charge density modulation and signal synergistic amplification within nanochannel for precise detection of microRNA-155 (miR-155).

Tunable Detection of MicroRNA-21 in Cancer Cells Using a 3D DNA Walker Mediated by Remote Toehold Strand Displacement Reaction.

Finely tunable detection of microRNAs (miRNAs) is crucial for personalized medicine and cancer diagnosis, and it is a challenge to construct a tunable sensor for miRNA detection due to the diversity and complexity of cancer patient samples. This study introduces a three-dimensional (3D) DNA walker mediated by a remote toehold strand displacement reaction, which addresses the challenge of achieving tunable detection limits and sensitivities for microRNA-21 (miR-21) at a kinetic level, enabling specific recognition of cancer cells. By engineering a spacer domain within the DNA walker, the kinetics of the strand displacement reaction can be precisely modulated, thereby controlling the walking efficiency and achieving tunable detection with a detection limit range from 32 aM to 290 pM and a broad dynamic range from ∼1100-fold to ∼283,000-fold.

Global, regional, and national time trends in prevalence of metabolic dysfunction associated steatotic liver disease among women of reproductive age: an age-period-cohort analysis for the global Burden of Disease 2021 study.

Objective: This study aims to investigate the time trends in the prevalence of metabolic dysfunction associated steatotic liver disease (MASLD) among women of reproductive age (WRA) globally, regionally, and nationally from 1992 to 2021, and to explore associations with age, period, and birth cohort effects.

Methods: MASLD prevalence estimates were sourced from the Global Burden of Disease (GBD) 2021 study. We used an age-period-cohort model to analyze cohort and period effects, overall annual percentage changes (net drifts), annual percentage change in each age group, and longitudinal age-specific rates.

hijacks mitophagy and lysosomal function to persist in endothelial cells.

Introduction: The direct infection of endothelial cells by (), a keystone periodontal pathogen, has been implicated in the development of atherosclerosis. While non-selective autophagy facilitates its intracellular persistence in endothelial cells, the role of selective autophagy in this process remains unclear. This study investigated whether hijacks mitophagy and lysosomes to persist in endothelial cells.

Spatiotemporally Traceable Peptide Self-Assemblies for Mitochondrial-Specific Dysfunction.

Peptide self-assembly has emerged as a highly regarded strategy for developing functional agents to control cellular fate. However, due to the complexity of intracellular environments, achieving spatiotemporally traceable organelle localization and functional perturbation through peptide self-assembly remains a challenge. In this study, we developed T-FFVLK, a fluorescent peptide probe that integrates a red-emitting mitochondria-targeted molecule with a self-assembling peptide for visual tracking.

Solvent Polarity Triggered Rapidly Reversible Quadruple-Mode Luminescence Adjustment in 0D Hybrid Antimony Halides.

Zero-dimension (0D) organic-inorganic hybrid metal halides are highly attractive as smart responsive luminescent materials, but the multiple-mode luminescence switch is rarely achieved and intrinsic solvochromism mechanism is unclear. Herein, we report a yellowish-green-emitting (MeBzN)SbCl (MeBzN: trimethylbenzyl ammonium) single crystal, revealing quadruple/triple-mode luminescence switch with rapid response time (<1 s) and excellent recyclability (≥ 100 cycles) when triggered by moderately-polar and strongly-polar solvents. Significantly, the intrinsic solvochromism mechanism is systematically proposed, of which the reversibly multiple-mode luminescence tuning is closely related to solvent polarity, the moderate polarity can lead to luminescence redshift from 560 to 670 nm due to the increase of dipole moment for inorganic polyhedron.

Ultrasensitive Nanofluidic Detection of 17β-Estradiol in Natural Water by DNA Circuit-Mediated Hyperbranched DNA Nanowire Dual-Signal Amplification.

The pervasive detection of trace 17β-estradiol (E2) in aquatic ecosystems necessitates innovative analytical platforms capable of ultrahigh sensitivity and field applicability. Herein, we report a nanofluidic biosensor integrating polydopamine-functionalized graphene oxide (PDA/GO) membranes with an entropy-driven DNA circuit and hyperbranched DNA nanowires (HDW) for femtomolar-level E2 quantification. Leveraging E2-specific aptamer recognition, the system triggers an entropy-driven DNA circuit and subsequent hierarchical assembly of guanine quadruplex (G4)-enriched HDW nanostructures on nanochannel surfaces, amplifying interfacial electronegativity through phosphate backbone accumulation.

Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging.

Senescent cardiac fibroblasts (CFs), which are activated and acquire a pro-fibrotic phenotype, exacerbate age-related interstitial fibrosis and cardiac dysfunction by unclear mechanisms. Traditionally regarded as a central organ involved in regulating aging, the small intestine (SI) communicates with remote organs. However, the mechanisms underlying its role in CFs senescence remain undefined.

Natural Cell-Inspired Nanoparticles: Preparation, Mechanisms, Applications, and Prospects for Clinical Translation.

Natural cell-inspired nanoparticles (NCINPs) represent a transformative innovation in nanomedicine, featuring a core-shell structure coated with isolated natural cell membranes (NCMs) that effectively mimic the functions of native cells. The development of NCINPs achieves molecular-level emulation of native cells by precisely reconstructing the hierarchical architecture of the bio-interface, including the structure of the phospholipid bilayer, lipid rafts, protein matrix, and polysaccharide interactions. This advanced biomimetic strategy not only retains the inherent biocompatibility and targeting precision of natural cells but also enables programmable functionalities that surpass those of natural systems, offering enhanced therapeutic potential.

The association of food insecurity with hepatic steatosis in women with and without HIV.

Objective: Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in the general population. However, little is known about the impact of food insecurity on hepatic steatosis among women with (WWH) and without HIV (WWOH).

Design: We assessed hepatic steatosis by controlled attenuated parameter (CAP) in decibels/meter (dB/m) and food security status using the U.

Ultrasensitive Mechanoluminescence of Pr-Doped Perovskite Oxide for 3D Strain Sensing and Visualization.

Owing to the unique mechano-optical response, mechanoluminescence (ML) materials possess dynamic, sensitive, visual, and recoverable strain sensing capabilities. However, the dilemma of lacking outstanding ML materials with high detection precision under micro deformations still exists, thereby hindering advanced applications in multi-angle and multidimensional scenarios. Herein, a novel Pr-doped perovskite oxide (NaTaO:Pr)-based composite elastic thin film is developed, which achieves ultrasensitive ML responses to both microscale compressive and tensile strains.

Adipose tissue-specific Yap knockout exacerbates diet-induced obesity through suppression of lipolysis.

Background And Aims: YAP regulates various cellular processes, including cell contact inhibition, mechanotransduction, cell differentiation and proliferation, apoptosis, and cancer progression. Although YAP suppresses adipogenesis in vitro, its role in obesity has not yet been completely elucidated.

Methods And Results: In this study, we generated an adipose tissue-specific Yap knockout mouse model (YapaKO), and found that male, but not female, YapaKO mice showed an enhanced high-fat diet-induced obesity phenotype compared to control mice.

Valorization of blueberry pomace and red mud to zero valent iron biochar for antibiotic degradation with diminishment of toxic reagents.

Application of zero valent iron biochar (ZVI-BC) activated persulfate (PS) oxidation in various antibiotics treatments has been universally confirmed. Full utilization of biomass waste characteristics to reduce usage of toxic reagents in the preparation of ZVI-BC is an environmental optimization strategy. Herein, tetracycline (TC) degradation based on PS-oxidation activated by a novel ZVI-BC (ZVI-FeO-BC) was assessed, in which blueberry pomace extraction substitutes part of sodium borohydride and red mud substitutes iron salt.

Cigarette smoke-free home adoption attempts among formerly homeless adults living in permanent supportive housing.

Introduction: Globally, tobacco use causes 8.7 million deaths annually. Approximately 50 % of formerly homeless adults in permanent supportive housing (PSH) in the United States smoke cigarettes.

Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis.

Based on the Caco-2 cell heat stress model, the study explored the heat stress preventive regulatory mechanisms of key polyphenol fractions in mung bean by metabolomics and transcriptomics association analysis. Results Mung bean polyphenol intervention before heat stress significantly reduced the elevated expression level of heat shock protein 70 (HSP70) caused by 39 °C temperature. At the metabolic level, mung bean polyphenols could play a role in heat stress regulation by alleviating oxidative stress damage.

Gaussian-to-Non-Gaussian Transition of a Quantum Spin Bath Revealed by Fourth-Order Correlation.

Non-Gaussian fluctuations are one of the essential properties of quantum systems. However, the direct detection of non-Gaussian fluctuations has not yet been achieved in experiments since the specific order of correlation has to be isolated from the complex dynamics of the whole system. In this Letter, we measure the second- and fourth-order correlations of ^{13}C nuclear spins around a nitrogen vacancy center in diamond, using the recently developed quantum nonlinear spectroscopy.