hijacks mitophagy and lysosomal function to persist in endothelial cells.

Introduction: The direct infection of endothelial cells by (), a keystone periodontal pathogen, has been implicated in the development of atherosclerosis. While non-selective autophagy facilitates its intracellular persistence in endothelial cells, the role of selective autophagy in this process remains unclear. This study investigated whether hijacks mitophagy and lysosomes to persist in endothelial cells.

Porphyromonas gingivalis Induces Endothelial Dysfunction Through Sirt3-Dependent CypD Acetylation.

Aims: To investigate how Porphyromonas gingivalis induces endothelial dysfunction, focusing on the regulatory role of Sirtuin 3 (Sirt3) in mitochondrial function.

Methods: Differentially expressed Sirtuin family genes in P. gingivalis-infected human aortic endothelial cells (HAECs) were identified through RNA sequencing and validated by quantitative real-time PCR and Western blot.

The Association of Intake of Vitamin Mixtures With Periodontitis: A Machine Learning Approach on NHANES.

Aims: Previous studies have focused on the association of single vitamin intake with periodontitis. However, the consumption of vitamins is commonly in the form of mixtures. The relationship between the consumption of multiple vitamins and the prevalence of periodontitis needs to be investigated.

Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders.

Background: Depression and anxiety have been suggested to be associated with temporomandibular disorders (TMD) in observational studies. However, the causal association and the direction in the relationship between depression/anxiety and TMD remain unknown.

Objectives: This study investigated the potential causal relationship between depression/anxiety and TMD with two-sample bi-directional Mendelian randomization (MR).