Network pharmacology prediction and experimental validation to explore the potential mechanism of Danggui Shaoyao San against Acute Kidney Injury.

Ethnopharmacological Relevance: Acute kidney injury (AKI) is a growing worldwide health concern. Danggui Shaoyao San (DGSYS) was an frequently-used representative prescription to "promote blood and water and harmonize the body" in traditional Chinese medicine, and its underlying mechanism against AKI remains to be elucidated.

Aim Of The Study: To investigate the protective effect and potential molecular mechanism of DGSYS in alleviating AKI by network pharmacology and experiment validation.

Exploring the Roles of Superwetting in Atmospheric Water Harvesting.

Atmospheric water harvesting (AWH) is an emerging technology to extract water from the atmosphere, aiming to alleviate the worldwide water crisis. Water capture and transportation are two primary processes in AWH systems that are closely linked to surface superwetting. It is important to understand the roles of superwetting in advanced AWH technologies.

Robotic versus open hepatectomy for large(≥ 5 cm) hepatocellular carcinoma: A large volume center, propensity score matched study.

Background: Robotic hepatectomy is widely used to treat liver tumors. However, there are limited studies comparing robotic hepatectomy with conventional open hepatectomy for large (≥ 5 cm) hepatocellular carcinoma. This study aims to evaluate the perioperative and long-term outcomes of patients with large and huge hepatocellular carcinoma undergoing robotic or open hepatectomy.

A bispecific antibody-drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial.

Research on patients with advanced esophageal squamous cell carcinoma (ESCC) who have progressed on immunotherapy remains limited. BL-B01D1 is a first-in-class antibody-drug conjugate consisting of an EGFR-HER3 bispecific antibody bound to a topoisomerase I inhibitor (Ed-04) payload via a cleavable linker. Here, we present safety and efficacy data from a phase 1 study of BL-B01D1, in 82 patients previously treated for ESCC.

Right Trisegmentectomy and Caudate Lobectomy with Portal Vein (PV) and Inferior Vena Cava (IVC) Reconstruction for Intrahepatic Cholangiocarcinoma (ICC): More Preoperation 3D-Simulated Details and More Safety.

Background: Extended hepatectomy combined with complex vascular reconstruction for huge intrahepatic cholangiocarcinoma (ICC) invading the first hilum, and even inferior vena cava (IVC), is an extreme surgical procedure. High-quality three-dimensional (3D) simulations can offer a clear understanding of intraoperative anatomical structures, allowing for increases in resectability rates and reductions in postoperative complications. In this video, we present a case of precise surgical resection based on 3D simulation: right trisegmentectomy and caudate lobectomy with portal vein (PV) and IVC reconstruction.

AGEN: Adaptive Error Control-Driven Cross-View Geo-Localization Under Extreme Weather Conditions.

Cross-view geo-localization is a task of matching the same geographic image from different views, e.g., drone and satellite.

Universal Anion-Interface-Confinement Strategy to Regulate Robust Solid-Electrolyte Interphase for Lithium Metal Batteries.

The inherent high reactivity of lithium metal and the nonuniform deposition/stripping behavior of Li during the cycle lead to the deterioration of performance and safety risks of lithium metal batteries. Herein, we designed and fabricated a multifunctional ferroelectric (β-PVDF) composite separator with dipole directional arrangement. Detailed characterization indicates that the directional arrangement of negative dipoles caused by spontaneous polarization of ferroelectric coatings induces anion interface confinement and promotes the complete reduction of lithium salts, thereby constructing a robust solid-electrolyte interphase (SEI) rich in inorganic species on the Li metal anode surface.

Differentiation of hESC-Derived Neural Crest Cells into Trabecular Meshwork Cells.

Primary open-angle glaucoma is a prevalent type of degenerative eye disease that results in lifelong blindness, and its critical pathogenic cause is trabecular meshwork (TM) dysfunction or decreased TM cellularity. Considering that TM develops from neural crest cells (NCCs), we investigate the potential of human embryonic stem cell (hESC)-derived NCCs transplantation for TM regeneration. We used a chemically defined method to induce the differentiation of NCCs and injected 1.

Mechanisms, diagnosis, and treatment of olfactory dysfunction in rhinosinusitis.

Background: Olfactory dysfunction is a common symptom of chronic rhinosinusitis (CRS), affecting approximately 60-80% of patients. This impairment significantly impacts patients' quality of life and increases the risk of hazardous events.

Objective: This study aims to summarize and analyze the epidemiology, risk factors, and pathogenesis of CRS-related olfactory dysfunction.

Development and external validation of a model for post-endoscopic retrograde cholangiopancreatography pancreatitis.

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a common complication in patients undergoing ERCP for choledocholithiasis, yet effective predictive models are lacking. This study included 2,247 patients who underwent ERCP for complete stone removal at the First Affiliated Hospital of USTC from January 2015 to January 2023. Six machine learning algorithms were utilized, incorporating 25 clinical parameters, to develop a predictive model for PEP risk.

Polaron-Polariton Bose-Einstein Condensation Lasing via Longitudinal Optical Phonon Scattering in GaN-Based Microcavity.

Exciton-polaritons, hybrid states composed of excitons and photons under strong coupling, play a crucial role in investigating Bose-Einstein condensation (BEC) and optoelectronics. However, the relaxation bottleneck in exciton-polaritons, arising from reduced scattering efficiency with acoustic phonons, hinders the achievement of thermal equilibrium Bose-Einstein condensation (BEC). Here, by invoking the polaronic effect of the exciton, we present the first observation of polaron-polariton BEC in a GaN-based microcavity.

Silencing FGL1 promotes prostate cancer cell apoptosis and inhibits EMT progression.

Emerging evidence from recent studies demonstrates that the FGL1/LAG-3 interaction axis plays a crucial role in mediating tumor immune evasion mechanisms, particularly through the suppression of T lymphocyte effector functions. However, the role of FGL1 in prostate cancer (PCa) remains unclear. Data was downloaded from The Cancer Genome Atlas (TCGA) database, and subjected to differential expression analysis.

A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway.

Tear secretion from the lacrimal gland is essential for maintaining ocular surface homeostasis, and its insufficiency causes aqueous-deficient dry eye. Unlike the well-established parasympathetic neuronal regulation, the role of sympathetic nervous system (SNS) in tear secretion remains controversial. Here, we demonstrate the intact sympathetic innervation in lacrimal gland and its activation under multiple dry eye stresses.

Unraveling the role of M2 TAMs in ovarian cancer dynamics: a systematic review.

Tumor-associated macrophages (TAMs) represent the dominant immune cell subset within the ovarian tumor microenvironment, which exhibits remarkable plasticity. They can readily undergo polarization toward an immunosuppressive M2-like phenotype in response to various factors secreted by tumor cells, playing a pivotal role in ovarian cancer advancement and the development of resistance to chemotherapy. M2 TAMs promote the invasiveness of ovarian cancer cells and their resistance to therapeutic agents through the secretion of numerous tumor-promoting factors, including cytokines, chemokines, enzymes, and exosomes.

LDPC Codes on Balanced Incomplete Block Designs: Construction, Girth, and Cycle Structure Analysis.

In this paper, we investigate the cycle structure inherent in the Tanner graphs of low-density parity-check (LDPC) codes constructed from balanced incomplete block designs (BIBDs). We begin by delineating the incidence structure of BIBDs and propose a methodology for constructing LDPC codes based on these designs. By analyzing the incidence relations between points and blocks within a BIBD, we prove that the resulting LDPC codes possess a girth of 6.

Halogen bond-enhanced spin dynamics: investigating co-crystallization effects on spin crossover in mononuclear Mn(III) Schiff-base complexes.

We present co-crystallization with 1,3,5-trifluoro-2,4,6-triiodobenzene (TFTIB) as an approach to tuning the spin crossover (SCO) properties of mononuclear Mn(III) Schiff-base complexes. The isostructural complexes [Mn(naphth-sal-N-1,5,8,12)]Y (Y = Br (1) and Y = I (2)) and (naphth-sal-N-1,5,8,12), which is a big conjugated hexadentate Schiff-base ligand, share similar magnetic behavior and between them complex 2 shows gradual SCO with transition temperature ∼ 380 K. These complexes [Mn(naphth-sal-N-1,5,8,12)]·TFTIB·Y (Y = Br (3) and Y = I (4)) are synthesized by the co-crystallization of their parent complexes 1 and 2 with TFTIB and they both exhibit more gradual SCO with rising to over 400 K.

Role and Mechanism of Olfactory Stem Cells in the Treatment of Olfactory Disorders.

Olfactory dysfunction is one of the most prevalent diseases in otorhinolaryngology, particularly since the coronavirus 2019 (COVID-19) pandemic, with a potential impact on daily life. Several etiological factors can contribute to olfactory dysfunction owing to the complexity and specificity of the olfactory transmission pathway. However, current treatments for olfactory dysfunction are limited and their efficacy is unsatisfactory.

Design and analysis of two degrees of freedom flexure hinges with remote center of motion.

This paper presents the design, analysis, fabrication, and testing of a series of two degrees of freedom (2-DOF) Remote Center of Motion (RCM) flexure hinges. These hinges are constructed using planner generalized cross-spring pivots according to the building block approach. Load-rotation relationships for the flexure hinge are established through the beam constraint method, with finite element analysis confirming theoretical predictions and elucidating parametric dependencies of critical dimensions.

Role of a New Walk Test in Pulmonary Arterial Hypertension: A Retrospective Cohort Study.

The 6-min walk test (6MWT) has significant prognostic value, but requires long walking distances and lacks evaluation of exercise speed. This study aimed to investigate the clinical utility of a new walk test, the 18-meter walk test (18MWT), in patients with pulmonary arterial hypertension (PAH) as a complement to the 6MWT. In summary, a total of 117 patients with PAH from January 2018 to December 2022 were included.

Izalontamab (SI-B001), a novel EGFRxHER3 bispecific antibody in patients with Locally Advanced or Metastatic Epithelial Tumor: Results from first-in-human phase I/Ib study.

Purpose: Izalontamab (SI-B001) is a novel EGFR×HER3 bispecific antibody. This first-in-human phase I study presents the safety and pharmacokinetics of izalontamab.

Patients And Methods: Previously treated patients with locally advanced or metastatic epithelial tumors were enrolled in the dose-escalation or dose-expansion phases.

Spleen volume after stage-I associated liver partition and portal vein ligation for staged hepatectomy predicts future liver remnant.

Background: The spleen has been reported to inhibit liver regeneration following hepatectomy; however, the underlying mechanisms remain poorly understood. In particular, its role in future liver remnant (FLR) regeneration after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) warrants investigation.

Aim: To evaluate the relationship between splenic volume changes and FLR regeneration following ALPPS-stage I in patients with massive hepatocellular carcinoma (HCC).

Multi-omics analysis identifies DLX4 as a novel biomarker for diagnosis, prognosis, and immune infiltration: from pan-cancer to renal cancer.

Background: DLX4 is involved in the regulation of embryonic development, but its function in cancer remains unclear. Here, we conducted a pan-cancer analysis to investigate the molecular mechanisms of DLX4, with a particular emphasis on its role in renal cancer.

Methods: A comprehensive analysis of DLX4 was performed, focusing on differences in expression, prognostic value, somatic mutations, methylation modifications, and immune landscapes across various cancer types using multiple databases.

Triboelectric charge-separable probes for potential single-droplet biochemical sensing.

Biochemical sensors have found widespread applications in the fields of health and environment. As the number of biochemical sensors continues to increase, their energy supply has emerged as a challenge. Self-powered biochemical sensors based on triboelectric generators (TENGs) offer a promising solution to this challenge.

Uteroplacental microvascular remodeling in health and disease.

The microvascular system is essential for delivering oxygen and nutrients to tissues while removing metabolic waste. During pregnancy, the uteroplacental microvascular system undergoes extensive remodeling to meet the increased demands of the fetus. Key adaptations include vessel dilation and increases in vascular volume, density, and permeability, all of which ensure adequate placental perfusion while maintaining stable maternal blood pressure.

Halogen-Driven Spin Dynamics: Exploring Correlation of Cooperativity and Spin Crossover in Solid-State Mononuclear Fe(III) Schiff-Base Complexes.

We report the synthesis, crystal structures, and magnetic properties of four new mononuclear iron(III) complexes, [Fe(5-X-saltrien)]ReO (X = F (); X= Cl (); X = Br (); X = I ()), where (5-X-saltrien) is a halogen-substituted hexadentate Schiff-base (NO) ligand. Magnetic susceptibility measurements demonstrated that complex maintains a high-spin (HS) state, while complexes and display a very gradual spin crossover (SCO) above 300 K. Complex exhibits a unique two-step thermo-induced spin-state switching at = 250 K (1) and 209 K (2) with symmetry breakings.