Solute carrier family 16 member 3 is a target of nodakenetin in breast cancer.

Nodakenetin is a plant-derived coumarin with anti-tumor activities. However, the roles of nodakenetin in treating breast cancer are unknown. This study aimed to investigate the effects of nodakenetin on breast cancer cell viability, apoptosis, and glycolysis, and to explore its action mechanisms.

Nitrogen addition substantially affects plant phenology in terrestrial ecosystems: a meta-analysis.

Introduction: Phenology is a sensitive biological indicator of climate change. Increasing nitrogen (N) deposition has amplified phenological shifts, making their study across terrestrial ecosystems crucial for understanding global change responses. While existing research focuses on single ecosystems, comparative analyses are lacking.

Investigating the Impact of Aspartame on Ulcerative Colitis Through Network Toxicology and Molecular Docking.

The aim of this study is to elucidate the impact of aspartame on ulcerative colitis (UC). The research methodology involved extracting aspartame-associated targets from the ChEMBL and STITCH databases, while potential UC-related targets were obtained from the OMIM and GeneCards databases. The STRING platform and Cytoscape software were utilized to identify key targets through which aspartame may exert its influence on UC.

The impact of marital status on hypertension: SEM analysis of a Chinese general population cohort.

Background: Hypertension, a chronic non-communicable disease, has multifaceted and complex etiologies influenced by various risk factors. This study examines the role of marital status among the factors influencing blood pressure levels and assesses its potential indirect effects through other variables.

Methods: This study involved 1852 individuals from the Baoding area in the Beijing-Tianjin-Hebei region, China.

Systemic Inflammatory Burden Causes Liver Injury in H1N1-Infected Mice.

Clinical evidence has associated H1N1 influenza with liver impairment, yet the underlying mechanisms remain poorly understood. Here, we investigated H1N1-induced liver damage and its potential mechanisms using a BALB/c mouse infection model. Pathological examination and serum aspartate transaminase (AST) and alanine transaminase (ALT) were assessed.

Community Structure, Growth-Promoting Potential, and Genomic Analysis of Seed-Endophytic Bacteria in .

is an important plant in desert ecosystems. Its seed-endophytic bacteria may play a critical role in plant growth and environmental adaptation processes. This study systematically analyzed the community composition and potential plant growth-promoting (PGP) functions of seed-endophytic bacteria associated with .

Molecular characterization and genetic diversity of Blastocystis sp. in animals from four zoos in China.

Aims: Blastocystis sp. is a widespread unicellular protozoan that is a gastrointestinal eukaryotic parasite of humans and animals. At present, Blastocystis sp.

Underappreciated role of canopy nitrogen deposition for forest productivity.

Atmospheric nitrogen (N) deposition is generally expected to stimulate plant carbon (C) sequestration and promote tree growth, thereby mitigating atmospheric CO accumulation. Yet, the magnitude of N deposition contribution to forest productivity remains contentious. While correlative studies suggest substantial plant growth enhancement, controlled fertilization experiments typically demonstrate a limited impact.

Renal prognostic value of serum monoclonal immunoglobulin in cryoglobulinemic glomerulonephritis.

Aims: To explore the clinicopathological features and renal outcome in patients with cryoglobulinemic glomerulonephritis (Cryo-GN) without confirmed systemic autoimmune diseases.

Methods: Sixty-nine patients with Cryo-GN from a single center were recruited in this retrospective study. Their clinical, pathologic, and follow-up data were collected and analyzed.

Mol-SGGI: an attention-guided comprehensive molecular multi-representation learning and adaptive fusion framework for molecular property prediction.

Molecular property prediction is pivotal for drug discovery, offering significant potential to accelerate development and reduce costs. With the rapid development of artificial intelligence, molecular representation methods have become increasingly diversified. However, existing methods still have obvious deficiencies in the comprehensiveness of molecular representation and the effectiveness of feature fusion: single representation methods often can only capture part of a molecule's features, while multi-representation methods focus on limited combinations and use simple fusion strategies.

Genetic Characteristics of Enterocytozoon bieneusi in Cattle from Hebei Province, China.

Purpose: Enterocytozoon bieneusi (E. bieneusi) is a microsporidium that causes intestinal disease in animals and humans, and transmits person to person and/or animals to people. A survey was conducted to determine the prevalence and genetic diversity E.

Elucidation of the Hemostatic and Anti-Inflammatory Effects of Walnut Shell Ethanol Extract by Network Pharmacology and Experimental Verification.

Effective hemostatic and anti-inflammatory measures are essential for wound healing. In this study, Ultra-performance liquid chromatography (UPLC) combined with network pharmacology was used to analyze the composition of walnut shell ethanol extract (WSEE), and in vivo and in vitro experiments elucidated its potential mechanisms of hemostatic and anti-inflammatory effects. The results showed that 45 components were identified from WSEE, and the NF-κB signaling pathway, IL-17 signaling pathway, etc.

Inspiration from apomictic species of Rutaceae: AGL11-FIE module induces autonomous development of maize embryo and endosperm without fertilization.

Apomixis is a form of asexual reproduction that produces offspring with the same genetic material as the female parent. Introducing apomixis into major food crops would revolutionize agricultural breeding by allowing the self-propagation of superior hybrids. We found that the MADS-box transcription factor D-class member AGAMOUS-like 11 (AGL11) plays a key role in the apomictic species Zanthoxylum bungeanum during somatic embryogenesis.

Fecal microbiota transplantation: A promising treatment strategy for chronic liver disease.

Chronic liver disease has become a global health crisis, with increasing incidence and mortality rates placing a substantial burden on healthcare systems worldwide. A key factor in the progression of chronic liver disease is intestinal microbiota dysbiosis, which influences liver function the intricate liver-gut axis. This axis plays a central role in various physiological processes, and disruptions in microbial composition can exacerbate liver pathology.

Twist angle-dependent resonant tunneling electron transfer in WS/WSe/MoSe heterostructures.

Twisted van der Waals heterostructures formed by stacking monolayer materials offer a simple and exciting platform in condensed matter physics, where many novel physical effects have been observed. In the present work, a twist angle-dependent resonant tunneling electron transfer (RTET) effect, which was verified by giant quenching of WS photoluminescence (PL), is found in the WS/WSe/MoSe heterostructures (HS) by using PL measurements. Two types of interlayer excitons (IXs) are clearly observed, and the PL spectra measured under different excitations imply that charge transfer was a main contributor to the visibility of IXs.

The underlying mechanism of physical exercise on neurodegenerative diseases: the mediating role of psychological stress and resilience: a systematic review.

Theories and experiments have shown that physical exercise can improve mental resilience and resist the negative effects of psychological stress. Neurodegenerative diseases are a collection of diseases in which progressive changes in the structure and function of neurons result in progressive disorders of cognitive and motor function, greatly reducing the quality of life of the patient. The latest research suggests that psychological factors such as psychological stress and resilience also have an impact on the onset, symptoms, and course of Neurodegenerative diseases.

Analysis of the Network Pharmacology Mechanism and Clinical Efficacy of Qingre Jiedu Decoction (QJD) in the Treatment of Infectious Mononucleosis (IM) in Children.

Purpose: This study aimed to clarify the molecular mechanisms of Qingre Jiedu Decoction (QJD), a traditional Chinese medicine (TCM), in treating infectious mononucleosis (IM). By combining network pharmacology and clinical trial validation, the research sought to understand how QJD interacts with biological pathways to combat IM.

Methods: The research team identified active compounds and their targets in QJD using databases like TCMSP and STITCH.

Triple stem cell infusion alleviated graft-versus-host disease and improves outcomes in unmanipulated haploidentical hematopoietic stem cell transplantation.

Haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) provides cure opportunity for patients requiring prompt allogeneic HSCT but failing to identify well-matched donor, but its outcomes are potentially impaired by increased transplant-related mortality (TRM). We performed haplo-HSCT using granulocyte colony-stimulating factor (G-CSF)-primed peripheral blood stem cells (PBSCs), umbilical cord mesenchymal stem cells (UC-MSCs) and third-party unrelated umbilical cord blood (UCB) stem cells. Modified "Beijing protocol" were performed in this study.

Significant association between systemic immune-inflammation index and stroke.

The study aimed to investigate the relationship between the systematic immune-inflammation index (SII) and stroke among American adults using data from the National Health and Nutrition Examination Survey from 2011 to 2020. The SII was calculated as the platelet count multiplied by the neutrophil count divided by the lymphocyte count. Weighted multivariate logistic analysis was used to estimate the relationship between SII and stroke, with subgroup and sensitivity analyses conducted to explore potential moderators and ensure result stability.

DNA methylation, metabolome, and transcriptome analysis reveal epigenomic differences between diploid Chinese cabbage seeds and tetraploid Chinese cabbage seeds.

This study aimed to elucidate the epigenomic differences between diploid and tetraploid Chinese cabbage seeds and preliminarily explore the mechanisms underlying the reduced seed vigor in tetraploid seeds. We comprehensively analyzed the transcriptome, metabolome, and whole-genome bisulfite sequencing (WGBS) to investigate gene expression, metabolite profiles, and DNA methylation patterns in diploid and tetraploid Chinese cabbage seeds from different years. Results showed that tetraploid seeds exhibited lower DNA methylation levels and fewer methylated cytosines than diploid seeds across all sequence contexts (CG, CHG, and CHH).

The Mechanism of Micrografting With Salt-Tolerant Rootstock in Improving the Salt Tolerance of Scion in Vitis vinifera.

Grapevine (Vitis vinifera L.) is highly sensitive to soil salinization, which severely restricts its cultivation in salt-affected areas. In this study, "Pinot Noir" (V.

Elucidating the role of AfLPMO8 from Aspergillus fumigatus Z5 in cellulose oxidative degradation: mechanistic insights into a lytic polysaccharide monooxygenase.

The potential applications of lytic polysaccharide monooxygenases (LPMOs) in biomass degradation have garnered significant interest. In this study, we characterized AfLPMO8, a novel AA9 family protein derived from Aspergillus fumigatus Z5. AfLPMO8 demonstrated the ability to bind copper and enhanced its melting temperature (Tm) by 17.

Radiomics based on lumbar CT to identify high-risk patients for OVCF in postmenopausal women.

Objective: Osteoporosis vertebral compressive fracture (OVCF) is a severe complication in patients with osteoporosis. There were limitations in finding the risk factor of OVCF in previous evaluation techniques. In this study, we developed a radiomics model (R-model) based on a lumbar CT scan to identify vertebrae at high risk of OVCF in postmenopausal women.

A high-performance genetically encoded sensor for cellular imaging of PKC activity in vivo.

Neuromodulators impose powerful control over brain function via their regulation of intracellular signaling through G-protein coupled receptors. In contrast to those of Gs and Gi pathways, in vivo imaging of the signaling events downstream of Gq-coupled receptors remains challenging. Here, we introduce CKAR3, a genetically encoded fluorescence lifetime sensor that reports the activity of protein kinase C (PKC), a major downstream effector of the Gq pathway.