A Trailblazing Quenching Strategy for Simultaneous LiF Formation at Surface and Intergranular Interfaces for Enhanced Stability of High-Ni NCM Cathodes.

Water-washing effectively removes surface residual lithium from high-Ni LiNiCoMnO (NCM) cathodes; however, it inevitably degrades the electrochemical performance. To address this issue, integrated strategies targeting the conversion of surface residual lithium into artificial coating layers on high-Ni NCM cathodes have been proposed; however, these require further processing, thus hindering their industrial application. This study proposes a trailblazing strategy for directly converting residual lithium into a LiF layer simultaneously formed on both the surface of secondary particles and the interfaces between the primary particles of high-Ni NCM, without requiring further processing.

New Insights into the Formation of PBDD/Fs in the Incineration Flue Gas: The Activity of Typical Metal and Metalloid Species.

The catalytic mechanisms underlying the formation of polybrominated dibenzo--dioxins and dibenzofurans (PBDD/Fs) have emerged as a critical environmental concern, particularly regarding the roles of metal- and metalloid-based catalysts. Although these catalysts are recognized as crucial agents for the formation of PBDD/Fs, there is still significant knowledge gaps in identifying the active species and quantifying their catalytic activities. This study systematically investigates four key reaction pathways governing PBDD/Fs formation: aromatic bromination, the Deacon reaction, the precursor, and the de novo synthesis process.

First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer: a phase 2 trial.

Sacituzumab tirumotecan (sac-TMT, also known as MK-2870 or SKB264) is an antibody-drug conjugate targeting trophoblast cell surface antigen 2. We report the initial findings from the ongoing phase 2 OptiTROP-Lung01 study, evaluating the combination of sac-TMT and tagitanlimab (KL-A167), an anti-PD-L1 antibody, as first-line therapy in patients with advanced or metastatic non-small-cell lung cancer who lack actionable genomic alterations (cohorts 1A and 1B). Cohort 1A received sac-TMT (5 mg kg, every 3 weeks) plus tagitanlimab (1,200 mg, every 3 weeks) in each 3-week cycle, whereas cohort 1B was treated with sac-TMT (5 mg kg, every 2 weeks) plus tagitanlimab (900 mg, every 2 weeks) in each 4-week cycle, in a nonrandomized manner until disease progression or unacceptable toxicity.

Renal prognostic value of serum monoclonal immunoglobulin in cryoglobulinemic glomerulonephritis.

Aims: To explore the clinicopathological features and renal outcome in patients with cryoglobulinemic glomerulonephritis (Cryo-GN) without confirmed systemic autoimmune diseases.

Methods: Sixty-nine patients with Cryo-GN from a single center were recruited in this retrospective study. Their clinical, pathologic, and follow-up data were collected and analyzed.

Insights into the disinfection byproduct bromochloroacetamide-induced cardiotoxicity of zebrafish embryo-larvae: A multiomics approach and comparison of biomarker responsiveness.

Bromochloroacetamide (BCAcAm), an inevitable byproduct of the water treatment disinfection process, is widely detected in drinking water. Previous toxicological and in silico results suggested that developmental effects are associated with analogous chemical exposure; however, the key molecular events and underlying mechanisms remain unclear, especially in the early stages of aquatic organisms. In the present study, a zebrafish larval model was used to comprehensively assess the developmental toxicity of BCAcAm via transcriptional, metabolic, biochemical and morphological tests.

Electrochemical coupling of carbon monoxide and amine on iodide coordination stabilized Cu site.

The use of renewable electricity to drive the electrocatalytic coupling of CO with nitrogen-containing organics offers a promising strategy for producing high-value chemicals. In this work, we conduct a systematic investigation of the coordination effect between iodide and copper oxide to generate Cu active sites. These Cu sites enable the electrosynthesis of dimethylacetamide from CO and dimethylamine.

Efficacy and safety of first-line PD-1/PD-L1 inhibitors combined with or without anti-angiogenesis therapy for extensive-stage small-cell lung cancer: a network meta-analysis.

Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy, with or without angiogenesis inhibitors, have been investigated as the first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC). However, it remains unclear which treatment modalities are the most effective and safest, as comparative studies evaluating these treatment options are limited.

Objectives: This article aims to compare the relative efficacy and safety of ICIs + Chemo + angiogenesis inhibitors versus ICIs + Chemo as the first-line treatment for ES-SCLC.

High-Dose Aumolertinib for Untreated EGFR-Variant Non-Small Cell Lung Cancer With Brain Metastases: The ACHIEVE Phase 2 Nonrandomized Clinical Trial.

Importance: Central nervous system (CNS) metastases remain a significant challenge in the management of EGFR-variant non-small cell lung cancer (NSCLC).

Objective: To evaluate the activity and safety of high-dose aumolertinib in patients with untreated EGFR-variant NSCLC and brain metastases.

Design, Setting, And Participants: This was a phase 2 nonrandomized clinical trial conducted at 10 centers in China.

Chinese Expert Consensus on Leptomeningeal Metastases of Lung Cancer.

Lung cancer patients with leptomeningeal metastases (LMs) suffer from severe clinical symptoms, poor quality of life, narrow diagnostic and therapeutic time windows, low response to standard treatments, short survival periods, and poor prognoses. At present, there is a lack of precise diagnosis and treatment pathways and relevant consensus for LMs of lung cancer. In order to better guide the clinical diagnosis and treatment of LMs of lung cancer in an early, reasonable, and safe way, the experts of the Neurological Tumor Specialist Committee of the Chinese Society of Clinical Oncology (CSCO) have formulated this consensus based on the actual diagnosis and treatment of LMs of lung cancer in China, with reference to the latest research data, relevant guidelines and consensus, and the experts' clinical experience, as well as the results of experts' polling on the pre-set issues of LMs.

Survival and prognostic factors of HER2-mutant advanced non-small cell lung cancer with brain metastases.

Background: Brain metastases (BM) represent a common complication in non-small-cell lung cancer (NSCLC) with human epidermal growth factor receptor 2 (HER2) mutations. We aimed to characterize the BM incidence and its association with genetic subtypes, and to analyze treatment outcomes and prognostic factors in this patient population.

Methods: Between July 2018 and July 2023, we retrospectively screened 6536 patients with advanced NSCLC.

Sacituzumab tirumotecan versus docetaxel for previously treated -mutated advanced non-small cell lung cancer: multicentre, open label, randomised controlled trial.

Objective: To compare the efficacy and safety of sacituzumab tirumotecan (sac-TMT) with docetaxel in patients with locally advanced or metastatic epidermal growth factor receptor (-mutated non-small cell lung cancer (NSCLC) after previous treatment failure with EGFR-tyrosine kinase inhibitors and platinum based chemotherapy.

Design: Multicentre, open label, randomised controlled trial.

Setting: 48 centres in China, 1 September 2023 to 31 December 2024.

Quantitative and Dynamic ctDNA as a Biomarker of Response and Survival in Patients With Advanced Lung Squamous Cell Carcinoma Receiving Immunochemotherapy or Chemotherapy Alone.

Introduction: Although circulating tumor DNA (ctDNA) dynamics have been widely explored for therapeutic response assessment, standardized methodologies remain elusive. Here, we developed MinerVa-Delta, a novel approach to quantify ctDNA dynamics by calculating weighted mutation changes in samples with multiple tracked variants.

Methods: MinerVa-Delta was developed and analytically validated using serially diluted reference samples.

Impact of prophylactic cranial irradiation on survival in extensive-stage small cell lung cancer receiving first-line chemoimmunotherapy: a propensity score-matched study.

Background: Chemoimmunotherapy has emerged as the standard first-line treatment for extensive-stage small cell lung cancer (ES-SCLC), improving survival outcomes. However, the role of prophylactic cranial irradiation (PCI) in the context of chemoimmunotherapy remains undefined.

Objectives: This study aimed to evaluate the impact of PCI on overall survival (OS) in patients with ES-SCLC after chemoimmunotherapy administration.

A four gene risk score model for prognosis and immune microenvironment insights in small cell lung cancer based on CAF functional-related genes.

Small cell lung cancer (SCLC) is still one of the most formidable challenges in oncology. In this study, we introduce an innovative risk scoring model rooted in cancer-associated fibroblast (CAF)-related functional genes, designed to predict patient prognosis and illuminate the microenvironment of SCLC. Through Kaplan-Meier survival analysis and receiver operating characteristic (ROC) curves, our model could effectively classify patients into high- and low-risk groups, with distinct survival outcomes and remarkable predictive accuracy, which has been evidenced by the AUC values.

Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria.

Objectives: In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria.

Design: Prospective, multicenter cohort study.

Setting: This study was conducted from September 2020 to December 2022 across 28 geriatric centers in China.

Investigation into the bromination of polybrominated dibenzo-p-dioxins and dibenzofurans.

The formation and emission of polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) are under consideration for inclusion in the Stockholm Convention due to their significant environmental and health hazards. This study systematically investigated the aromatic bromination mechanism in municipal solid waste incineration (MSWI) flue gas, with a focus on the catalytic roles of FeBr, CuBr, FeO, and CuO in PBDD/Fs formation. Iron-containing particles exhibited significantly higher activity than copper-based counterparts in promoting bromination, particularly in the synthesis of highly brominated PBDD/Fs.

Acupuncture attenuates experimental autoimmune thyroiditis by modulating intestinal microbiota and palmitic acid metabolism.

Introduction: Autoimmune thyroiditis (AIT) is a common and chronic autoimmune disease. Recent evidence indicates that serum metabolites and dysbiosis of the intestinal microbiota are associated with AIT, with the underlying mechanism involving the apoptosis of thyroid follicular epithelial cells. Acupuncture, a traditional Chinese therapy, has demonstrated potential regulatory effects on various immune-related diseases.

Emerging frontiers in chiral metal-organic framework membranes: diverse synthesis techniques and applications.

Chirality is a basic and universal property in nature, refering to the asymmetry of molecules, where they do not coincide with their mirror images. Chiral materials, in multiple forms, usually exhibit unique physical phenomena such as chiral luminescence and distinctive chemical properties. Metal-organic framework (MOF) membranes have high porosity and abundant active sites; thus, they are an excellent candidate for functionalization.

Genetic biomarker study of sunvozertinib for clinical prognosis and prediction in NSCLC with EGFR exon 20 insertion mutation.

This is a report of biomarker analysis for sunvozertinib, a leading epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting EGFR exon 20 insertion mutation (exon20ins) non-small cell lung cancer (NSCLC). There is a positive correlation between positive EGFR exon20ins in plasma circulating tumor DNA (ctDNA) and advanced disease. Shorter progression-free survival and lower objective response rate (45.

Identification and validation of biomarkers in Alzheimer's disease based on machine learning algorithms and single-cell sequencing analysis.

Objective: Alzheimer's disease (AD) is a complicated neurodegenerative disease with unknown pathogenesis. Identifying possible diagnostic markers of AD is essential to elucidate its mechanisms and facilitate diagnosis.

Methods: A total of 295 samples (153 AD and 142 normal) were analyzed from two datasets (GSE122063 and GSE132903) in the Gene Express Omnibus (GEO) database.

Effect of single and hybrid microplastic exposures on anaerobic sludge in microbial electrochemical technology (MET).

Microplastics (MPs) in wastewater treatment pose significant environmental risks. While microbial electrochemical technology (MET) is effective in removing refractory pollutants, most studies focus on single MP types, despite real-world wastewater often containing mixtures. This study examines the effects of single and hybrid MPs (HD-MPs) on wastewater treatment performance and microbial communities in MET systems.

Sacituzumab tirumotecan in advanced non-small-cell lung cancer with or without EGFR mutations: phase 1/2 and phase 2 trials.

Trophoblast cell-surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC) is a promising anticancer agent that has shown remarkable efficacy in several malignancies. However, in lung cancer, two phase 3 trials on TROP2-ADCs in unselected patients with advanced non-small-cell lung cancer (NSCLC) have both failed. Sacituzumab tirumotecan (sac-TMT) is a novel TROP2-directed ADC.

Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice.

Background: Bisphenol S (BPS) is a substitute for bisphenol A in various commercial products and is increasingly used globally due to restrictions on bisphenol A usage. Consequently, there are increasing public health concerns that substantial effects mediated by synthetic chemicals may impact human health. Recently, epidemiology studies reported associations between bisphenol exposure and nonalcoholic fatty liver disease [metabolic dysfunction-associated steatotic liver disease (MASLD)].