In-depth comparative immunotoxicity assessment of pristine and aged PLA microplastics in zebrafish larvae: Bioaccumulation and NF-κB signaling insights.

Polylactic acid (PLA) plastics are widely utilized as biodegradable alternatives, yet their fragmentation into microplastics (MPs) poses ecological risks. Comprehensive assessments and mechanistic insights into their immunotoxicity are currently lacking. This study systematically evaluated immunotoxic effects and underlying mechanism of pristine and aged PLA (APLA) MPs in larval zebrafish.

Efficacy and safety of tazemetostat, an EZH2 inhibitor, in Chinese patients with relapsed/refractory follicular lymphoma: a multicentre, single-arm, phase 2 study.

Background: Tazemetostat, the first enhancer of zeste homolog 2 (EZH2) inhibitor approved by the U.S. Food and Drug Administration, has shown efficacy in a global population with relapsed or refractory (R/R) follicular lymphoma (FL).

Dataset of personal protective equipment.

Personal Protective Equipment (PPE) is critical to the safety and health of workers, especially in high-risk environments such as construction sites and manufacturing facilities. PPE such as helmets and reflective vests play an important role in protecting workers from potential hazards. To protect workers, we have developed a dataset specifically for PPE target detection.

The Advance of Single-Cell RNA Sequencing Applications in Ocular Physiology and Disease Research.

The eye, a complex organ essential for visual perception, is composed of diverse cell populations with specialized functions; however, the complex interplay between these cellular components and their underlying molecular mechanisms remains largely elusive. Traditional biotechnologies, such as bulk RNA sequencing and in vitro models, are limited in capturing cellular heterogeneity or accurately mimicking the complexity of human ophthalmic diseases. The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized ocular research by enabling high-resolution analysis at the single-cell level, uncovering cellular heterogeneity, and identifying disease-specific gene profiles.

Genetically predicted interleukin 7 levels and neuroblastoma risk combined with analysis of radiation therapy timing effects.

Background: The causal relationship between interleukin-7 levels and neuroblastoma risk remains unclear, and optimal radiation therapy timing lacks definitive evidence. This study investigated causal associations using Mendelian randomization while examining radiation therapy timing effects.

Methods: We conducted two-sample Mendelian randomization analysis using GWAS summary statistics for interleukin-7 levels and neuroblastoma with three SNPs as instrumental variables.

Advances in biomimetic nano delivery systems for pulmonary hypertension therapy.

Pulmonary hypertension (PH), a condition triggered by various pathogenic factors, is characterized by a progressive increase in intra-pulmonary artery pressure and pulmonary resistance and progressive right ventricular hypertrophy, eventually culminating in right heart failure. Despite the fact that the conventional treatments can alleviate symptoms, they are limited by sub-optimal drug accumulation in the pulmonary vasculature and low bioavailability. Currently, as an emerging technology, the Nano Drug Delivery System (NDDS) has played a decisive role in enhancing drug targeting and precision and concomitantly minimizing side effects.

First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer: a phase 2 trial.

Sacituzumab tirumotecan (sac-TMT, also known as MK-2870 or SKB264) is an antibody-drug conjugate targeting trophoblast cell surface antigen 2. We report the initial findings from the ongoing phase 2 OptiTROP-Lung01 study, evaluating the combination of sac-TMT and tagitanlimab (KL-A167), an anti-PD-L1 antibody, as first-line therapy in patients with advanced or metastatic non-small-cell lung cancer who lack actionable genomic alterations (cohorts 1A and 1B). Cohort 1A received sac-TMT (5 mg kg, every 3 weeks) plus tagitanlimab (1,200 mg, every 3 weeks) in each 3-week cycle, whereas cohort 1B was treated with sac-TMT (5 mg kg, every 2 weeks) plus tagitanlimab (900 mg, every 2 weeks) in each 4-week cycle, in a nonrandomized manner until disease progression or unacceptable toxicity.

Surfactant Interlayer-Tuned Positively Charged Nanofiltration Membranes via Kinetics-Enhanced Interfacial Polymerization for Ultrahigh Li/MgSelectivity in Salt-Lake Brines.

The burgeoning energy sector exhibits a demand for lithium resources. Notably, salt lakes, rich in lithium, challenge due to the high Mg/Li ratios encountered. Nanofiltration, characterized by its simplicity, environmental sustainability, holds promising prospects for Mg/Li separation in salt lakes.

IMforte: A new starting point and new challenges.

The IMforte study demonstrated that maintenance treatment with atezolizumab plus lurbinectedin significantly improved progression-free survival and overall survival in patients with extensive-stage small cell lung cancer (ES-SCLC). This phase 3 study is the first to report a positive result in first-line maintenance therapy for ES-SCLC, representing another milestone that is likely to establish a new standard of care for this condition.

Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial.

We aimed to assess the tolerability and efficacy of finotonlimab (an anti-programmed cell death protein-1 antibody) in combination with SCT510, a bevacizumab biosimilar, versus sorafenib in unresectable advanced HCC. This randomized phase 2 and 3 study (ClinicalTrials.gov, NCT04560894; Chinadrugtrials.

Experimental Observation of k-Dependent Bulk-Edge Correspondence in Sonic Semimetals with High Winding Numbers.

The bulk-edge correspondence plays a crucial role in topological physics bridging the gap between the bulk topology and the topological edge states, which recently was extended to topological metamaterials having a large number of topological boundary states. In this work, we experimentally observe the k-dependent bulk-edge correspondence in the framework of a manmade sonic semimetal, supporting the coexistence of multiple topological phases which are separated by boundaries formed by versatile types of Dirac points. The structure is composed of stacked one-dimensional (1D) extended Su-Schrieffer-Heeger chains through long-range couplings, in which the topological phases are characterized by k-dependent winding numbers.

Subcutaneous versus intravenous amivantamab, both in combination with lazertinib, in refractory EGFR-mutated non-small cell lung cancer: Patient satisfaction and resource utilization results from the PALOMA-3 study.

Introduction: Intravenous anticancer treatments present challenges for patients and healthcare professionals (HCPs), prompting the development of subcutaneous formulations. In the phase 3 PALOMA-3 study, subcutaneous amivantamab demonstrated noninferior pharmacokinetics and response rates versus intravenous amivantamab (both with lazertinib), with substantially faster administration, a 5-fold reduction in infusion-related reactions, reduced venous thromboembolism, and numerically prolonged survival.

Methods: Participants with EGFR-mutated NSCLC and progression on osimertinib and chemotherapy were randomized to subcutaneous (n = 206) or intravenous amivantamab (n = 212), plus lazertinib.

Artificial intelligence-augmented ultrasound diagnosis of follicular-patterned thyroid neoplasms: a multicenter retrospective study.

Background: Conventional diagnostic tools, including ultrasound, fine-needle aspiration cytology, and intraoperative frozen section pathology, may fail to reliably distinguish between benign and malignant FNs, leading to unnecessary or inadequate surgical interventions. We aimed to develop and validate a deep learning (DL) system for the preoperative diagnosis of follicular-patterned thyroid neoplasms (FNs) using routine ultrasound images, with the goal of improving diagnostic accuracy and reducing unnecessary procedures.

Methods: In this multicenter, retrospective study, we included 3817 patients (2877 [75.

Multiply doses of FDC of rosuvastatin and ezetimibe versus rosuvastatin monotherapy in Chinese patients with hypercholesterolemia (ROSE-CH): multicenter, randomized-controlled trial.

Objective: Rosuvastatin plus ezetimibe improves the lipid-lowering effect through different mechanisms of action. This study intended to compare the efficacy and safety of the fixed-dose combination (FDC) of rosuvastatin/ezetimibe vs. rosuvastatin alone in hypercholesterolemia patients.

Noninvasive Deep Learning System for Preoperative Diagnosis of Follicular-Like Thyroid Neoplasms Using Ultrasound Images: A Multicenter, Retrospective Study.

Objective: To propose a deep learning (DL) system for the preoperative diagnosis of follicular-like thyroid neoplasms (FNs) using routine ultrasound images.

Summary Background Data: Preoperative diagnosis of malignancy in nodules suspicious for an FN remains challenging. Ultrasound, fine-needle aspiration cytology, and intraoperative frozen section pathology cannot unambiguously distinguish between benign and malignant FNs, leading to unnecessary biopsies and operations in benign nodules.

Facile preparation of alkali metal-modified hollow nanotubular manganese-based oxide catalysts and their excellent catalytic soot combustion performance.

The soot emitted during the operation of diesel engine exhaust seriously threatens the human health and environment, so treating diesel engine exhaust is critical. At present, the most effective method for eliminating soot particles is post-treatment technology. Preparation of economically viable and highly active soot combustion catalysts is a pivotal element of post-treatment technology.

Polymyxin B delivery systems: smart solutions for improved antibacterial activity and reduced toxicity.

Polymyxin B (PMB) serves as the last-line drug for treating multidrug-resistant Gram-negative bacterial infections. However, its clinical application is limited due to significant nephrotoxicity and neurotoxicity. In recent years, smart drug delivery systems have emerged as a research hotspot, aiming to optimise the functions and therapeutic effects of PMB.

Lazertinib Versus Osimertinib in Previously Untreated EGFR-Mutant Advanced NSCLC: A Randomized, Double-Blind, Exploratory Analysis From MARIPOSA.

Introduction: Lazertinib is a central nervous system-penetrant, third-generation EGFR tyrosine kinase inhibitor (TKI) that was selected for combination with amivantamab due to its relatively low rates of wild-type EGFR toxicities. In the phase 3 MARIPOSA study, amivantamab plus lazertinib (amivantamab-lazertinib) significantly improved progression-free survival (PFS; p < 0.001) versus osimertinib in participants with treatment-naive EGFR-mutant advanced NSCLC.

Effects of the Ecdysone Receptor on the Regulation of Reproduction in .

The effects of the gene encoding the ecdysone receptor () on the reproduction of the ladybug was evaluated. transcription was measured by quantitative real-time PCR in ladybug adults reared on artificial diets with and without 20-hydroxyecdysone (20E). expression levels in 5 d old male and female ladybugs supplied with the 20E-amended artificial diet were lower than expression levels in ladybugs reared on an artificial diet lacking 20E.

A Patient-Centric, Open-Label, Multicenter, Phase II Study of Lorlatinib Monotherapy in the First-Line Treatment of Patients With locally Advanced or Metastatic ALK-Positive Non-Small Cell Lung Cancer (CTONG2203).

Background: Lorlatinib is a potent third-generation ALK tyrosine kinase inhibitor (TKI). CROWN study demonstrated remarkable efficacy and manageable toxicity of first-line lorlatinib treatment for advanced non-small cell lung cancer (NSCLC) with ALK rearrangements. However, only 10 ALK-positive NSCLC patients were randomized to the lorlatinib group in China mainland.

Protective effects of hydrolysates against renal injury: Val-Lys as a potent renoprotective peptide.

Elevated serum uric acid (UA), a hallmark of diet-induced metabolic dysregulation, induces renal inflammation and oxidative stress, progressively leading to irreversible kidney injury (KI). Although hydrolysates (KPHs) exhibit UA-lowering activity, their potential renoprotective effects remain unknown. In this work, KPHs ameliorating UA-induced HK-2 cell injury were first obtained by controlled enzymatic hydrolysis.

Vascular Protection of Neferine on Attenuating Angiotensin II-Induced Blood Pressure Elevation by Integrated Network Pharmacology Analysis and RNA-Sequencing Approach.

Objective: To explore the functional roles and underlying mechanisms of neferine in the context of angiotensin II (Ang II)-induced hypertension and vascular dysfunction.

Methods: Male mice were infused with Ang II to induce hypertension and randomly divided into treatment groups receiving neferine or a control vehicle based on baseline blood pressure using a random number table method. The hypertensive mouse model was constructed by infusing Ang II via a micro-osmotic pump (500 ng/kg per minute), and neferine (0.

Genetically predicted immune cells mediates the association between hepatocellular carcinoma and inflammatory proteins: a Mendelian randomization study.

Background: Hepatocellular carcinoma (HCC) currently poses a formidable threat to human life and health, and an observable increase in the number of deaths is evident year by year. Currently, surgical resection stands as the foremost treatment modality; however, recurrence remains a persistent challenge, posing a significant barrier to the long-term prognosis for individuals diagnosed with HCC. Studies indicated that the risk of HCC may be influenced by inflammatory proteins and immune cells, but the associations between inflammatory proteins, immune cells, and HCC remained unclear.