Polyphenol from walnut septum alleviates DSS-induced colonic injury by regulating the PI3K-AKT pathway signaling and gut microbiota in mice.

Background: Walnut septum, a Juglans regia L. by-product with culinary-medicinal value, is a rich source of bioactive polyphenols. The chemical complexity and anti-colitis activities of these polyphenols remain uncharacterized.

Exploring flavor differences and microbial community characteristics of raw Pu-erh tea from different vintages based on flavoromics and high-throughput sequencing.

To better understand how storage time affects raw Pu-erh tea (RAPT) quality. Eight RAPT samples with varying storage durations (2009, 2011, 2013, 2015, 2017, 2021, and 2023) were selected for analysis to evaluate how storage time influences flavor quality and microbial composition, using sensory evaluation, gas chromatography-ion mobility spectrometry(GC-IMS), high-throughput sequencing, and chemometric methods. The results showed that as storage time increased, the color of tea leaves gradually shifted from dark green to brownish yellow, the infusion color transitioned from yellow-green to deep orange-yellow and eventually to brownish red, and the aroma evolved from fresh to aged.

Protective effects of hydrolysates against renal injury: Val-Lys as a potent renoprotective peptide.

Elevated serum uric acid (UA), a hallmark of diet-induced metabolic dysregulation, induces renal inflammation and oxidative stress, progressively leading to irreversible kidney injury (KI). Although hydrolysates (KPHs) exhibit UA-lowering activity, their potential renoprotective effects remain unknown. In this work, KPHs ameliorating UA-induced HK-2 cell injury were first obtained by controlled enzymatic hydrolysis.

Walnut Protein Peptides Ameliorate DSS-Induced Ulcerative Colitis Damage in Mice: An Analysis and Investigation.

Walnut ( L.) is a food with food-medicine homology, whose derived protein peptides have been shown to have anti-inflammatory activity . However, the effects and mechanisms of walnut protein peptides on ulcerative colitis (UC) have not been systematically and thoroughly investigated.

Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review.

As human life expectancy increases, the incidence of neurodegenerative diseases in older adults has increased in parallel. Walnuts contain bioactive peptides with demonstrated neuroprotective effects, making them a valuable addition to the diet. We here present a comprehensive review of the various methods used to prepare, isolate, purify, and identify the neuroprotective peptides found in walnuts.

Lam. Isothiocyanate Quinazolinone Derivatives Inhibit U251 Glioma Cell Proliferation through Cell Cycle Regulation and Apoptosis Induction.

A major active constituent of Lam. is 4-[(α-L-rhamnose oxy) benzyl] isothiocyanate (MITC). To broaden MITC's application and improve its biological activity, we synthesized a series of MITC quinazolinone derivatives and evaluated their anticancer activity.

Lam. Peptide Remodels Intestinal Mucosal Barrier by Inhibiting JAK-STAT Activation and Modulating Gut Microbiota in Colitis.

Ulcerative colitis is a chronic inflammatory bowel disease (IBD), but progress in exploring its pathogenesis and finding effective drugs for its prevention and treatment has stalled in recent years. The seeds of Lam. are rich in proteins known to have multiple physiological activities.