Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification.

Introduction: Diabetic nephropathy (DN) is a serious complication of diabetes with limited therapeutic options. Although Huangkui capsule (HKC) and finerenone individually show potential in DN management, their combined mechanism remains unclear. This study aimed to explore the therapeutic effects and underlying mechanisms of HKC and finerenone combination for DN.

The impact of agricultural trade on green technological innovation in China's agricultural sector.

As environmental awareness grows, the agricultural sector must balance rising product demands with sustainable development. This study investigates the relationship between agricultural trade and green technological innovation, emphasizing how trade-induced efficiency improvements promote input-saving practices. Using panel data from 31 Chinese provinces between 2011 and 2021, our analysis reveals that agricultural trade significantly enhances resource use efficiency, particularly in rural areas where agriculture is concentrated.

Evolution and maintenance of a large multidrug-resistant plasmid in a Typhimurium host under differing antibiotic selection pressures.

The dissemination of antibiotic resistance genes (ARGs) through plasmids is a major mechanism for the development of bacterial antimicrobial resistance. The adaptation and evolution mechanisms of multidrug-resistant (MDR) plasmids with their hosts are not fully understood. Herein, we conducted experimental evolution of a 244 kb MDR plasmid (pJXP9) under various conditions including no antibiotics and mono- or combinational drug treatments of colistin (CS), cefotaxime (CTX), and ciprofloxacin (CIP).

Applications of nanomaterials with enzyme-like activity for the detection of phytochemicals and hazardous substances in plant samples.

Plants such as herbs, vegetables, fruits, and cereals are closely related to human life. Developing effective testing methods to ensure their safety and quantify their active components are of significant importance. Recently, nanomaterials with enzyme-like activity (known as nanozymes) have been widely developed in various assays, including colorimetric, fluorescence, chemiluminescence, and electrochemical analysis.

Limiting heterogeneity in cross-border data flow: Impact on domestic value chains stability and the role of innovation.

Amidst growing skepticism towards globalization and rising digital trade, this study investigates the impact of Restrictions on Cross-Border Data Flows (RCDF) on Domestic Value Chains (DVCs) stability. As global value chains participation declines, the stability of DVCs-integral to internal economic dynamics-becomes crucial. This study situates within a framework exploring the role of innovation and RCDF in the increasingly interconnected global trade.

Applications of Nanozymes in Chiral-Molecule Recognition through Electrochemical and Ultraviolet-Visible Analysis.

Chiral molecules have similar physicochemical properties, which are different in terms of physiological activities and toxicities, rendering their differentiation and recognition highly significant. Nanozymes, which are nanomaterials with inherent enzyme-like activities, have garnered significant interest owing to their high cost-effectiveness, enhanced stability, and straightforward synthesis. However, constructing nanozymes with high activity and enantioselectivity remains a significant challenge.

Antimicrobial resistance and population genomics of emerging multidrug-resistant 4,[5],12:i:- in Guangdong, China.

4,[5],12:i:-, a monophasic variant of Typhimurium, has emerged as a global cause of multidrug-resistant salmonellosis and has become endemic in many developing and developed countries, especially in China. Here, we have sequenced 352 clinical isolates in Guangdong, China, during 2009-2019 and performed a large-scale collection of 4,[5],12:i:- with whole genome sequencing (WGS) data across the globe, to better understand the population structure, antimicrobial resistance (AMR) genomic characterization, and transmission routes of 4,[5],12:i:- across Guangdong. 4,[5],12:i:- strains showed broad genetic diversity; Guangdong isolates were found to be widely distributed among the global lineages.

Confining Co-Based Nanocatalysts by Ultrathin Nanotubes for Efficient Transfer Hydrogenation of Biomass Derivatives.

Catalytic transfer hydrogenation (CTH) based on non-noble-metal catalysts has emerged as an environmentally friendly way for the utilization of biomass resources. However, the development of efficient and stable non-noble-metal catalysts is crucially challenging due to their inherent inactivity. Herein, a metal-organic framework (MOF)-transformed CoAl nanotube catalyst (CoAl NT) with unique confinement effect was developed via a "MOF transformation and reduction" strategy, which exhibited excellent catalytic activity for the CTH reaction of levulinic acid (LA) to γ-valerolactone (GVL) with isopropanol (2-PrOH) as the H donor.

Hybrid MOF Template-Directed Construction of Hollow-Structured In O @ZrO Heterostructure for Enhancing Hydrogenation of CO to Methanol.

Direct hydrogenation of CO  to methanol using green hydrogen has emerged as a promising method for carbon neutrality, but qualifying catalysts represent a grand challenge. In O /ZrO  catalyst has been extensively applied in methanol synthesis due to its superior activity; however, the electronic effect by strong oxides-support interactions between In O  and ZrO  at the In O /ZrO  interface is poorly understood. In this work, abundant In O /ZrO  heterointerfaces are engineered in a hollow-structured In O @ZrO  heterostructure through a facile pyrolysis of a hybrid metal-organic framework precursor MIL-68@UiO-66.

Lam. Peptide Remodels Intestinal Mucosal Barrier by Inhibiting JAK-STAT Activation and Modulating Gut Microbiota in Colitis.

Ulcerative colitis is a chronic inflammatory bowel disease (IBD), but progress in exploring its pathogenesis and finding effective drugs for its prevention and treatment has stalled in recent years. The seeds of Lam. are rich in proteins known to have multiple physiological activities.

[Value of autism screening checklists in the early identification of autism spectrum disorder].

Objective: To evaluate the value of autism screening checklists in the early identification of autism spectrum disorder (ASD).

Methods: A total of 2 571 children who attended the Children's Hospital of Chongqing Medical University and completed autism screening and diagnostic test were enrolled as subjects, among whom 2 074 were diagnosed with ASD, 261 were diagnosed with global developmental delay (GDD), 206 were diagnosed with developmental language disorder (DLD), and 30 had normal development. The sensitivity, specificity, and optimal threshold value of the Modified Checklist for Autism in Toddlers (M-CHAT) and the Autism Behavior Checklist (ABC) for the early identification of ASD were evaluated by the receiver operating characteristic (ROC) curve.

Identification of crucial genes associated with lung adenocarcinoma by bioinformatic analysis.

Lung cancer is the world's most common malignancies and ranks first among all cancer-related deaths. Lung adenocarcinoma (LUAD) is the most frequent histological type in lung cancer. Its pathogenesis has not yet been fully elucidated, so it is of great significance to explore related genes for elucidating the molecular mechanism involved in occurrence and development of LUAD.

[Effect of Foliar Zinc Application on Bioaccessibility of Cadmium and Zinc in Pakchoi].

Two cultivars of pakchoi with different cadmium (Cd) accumulation were grown in nutrient solutions containing low and sufficient zinc (Zn) levels. ZnSO and ZnNa EDTA were applied as foliar fertilizers. The bioaccessibilities of Cd and Zn in pakchoi were assessed by the digestion method, and the bioaccessible established daily intakes (BEDI) of Cd and Zn from pakchoi were calculated.

Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida.

Chemical investigation of the Jatropha multifida has led to the isolation of nine diterpenoids (1-9), including a new jatromulone A, four podocarpane diterpenoids (2-5), two lathyrane-type diterpenoids (6 and 7) and two dinorditerpenoids (8 and 9). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1 were determined by CD analysis. All of the diterpenoids were screened for inhibitory activity against thioredoxin reductase (TrxR), which is a potential target for cancer chemotherapy with redox balance and antioxidant functions.

[Isolation, identification and inhibition activity of endophytes in Fengdan].

Endophytes were isolated and purified from the roots of medicinal plant Fengdan also known as Paeonia suffruticosa from Tongling region, Anhui province, China. Morphology and molecular biology methods were applied to indentify the endophyte strains. And methods of growth rate and filtering paper were also used for studying antibacterial/antifungal effects of the strains.

[Reflectance characteristics of rare earth solution with different concentrations].

In the present paper, ten aqueous samples which contain-different concentrations of REE were collected in south Jiangxi province, and the reflectance spectra and the concentrations of REE were measured by analytical spectral devices (ASD) FieldSpec-3 reflectance spectroscopy and inductively coupled plasma mass spectrometry (ICP-MS), respectively. The results show that the spectra presented mix characteristics of pure water and rare earth oxide. In addition, six diagnostic absorption features caused by REE in visible and near-infrared wavelengths were detected.

[Three-dimensional fluorescence properties of sodium butyl naphthalene sulfonate in aqueous solution].

Three-dimensional fluorescence spectroscopy is a new and effective chemical analysis method and is employed in water environment more and more widely. But the utilization is limited by the bottleneck, i. e.

Aluminium content of some processed foods, raw materials and food additives in China by inductively coupled plasma-mass spectrometry.

The level of aluminium in 178 processed food samples from Shenzhen city in China was evaluated using inductively coupled plasma-mass spectrometry. Some processed foods contained a concentration of up to 1226 mg/kg, which is about 12 times the Chinese food standard. To establish the main source in these foods, Al levels in the raw materials were determined.