SPDL1 overexpression was associated with poor prognosis and immune status in HCC through in vitro experiment and bioinformatics analysis.

Background: Numerous studies have established a strong link between the overexpression of spindle apparatus coiled-coil protein 1 (SPDL1) and cancer progression. However, the role of SPDL1 in hepatocellular carcinoma (HCC) remains unconfirmed.

Methods: The level of SPDL1 in HCC and its potential associations with prognosis and clinicopathological features were analyzed using TCGA and XENA databases.

Waste catkins-mediated synthesis of in situ graphitic carbon-modified ZnO tubes rich in oxygen vacancy for boosting sensitive NO gas at near room temperature.

Boosting the low-temperature response of ZnO-based sensors still remains a key factor in precise detection of harmful NO gas in complex environments. Herein, two in situ graphitic carbon (GC)-modified ZnO biomorphic tubes were controllably synthesized by separately annealing zinc salt-immersed catkins in air and H/N atmospheres. Among them, 3.

[Remediation Effect of Iron-manganese Composite-modified Biochar from Different Biomasses on Cd-contaminated Alkaline Soil].

To investigate the remediation effect of iron-manganese-modified biochar from different biomasses （FM-BC） on Cd-contaminated alkaline soil, FM-BC was prepared using branches of , durian shells, and corn stalks. The characteristics of FM-BC, the adsorption of Cd（Ⅱ） in water, and the available, fraction of Cd in alkaline soil were studied using bath adsorption and soil culture experiments. The results showed that the specific surface area, total pore volume, and oxygen content of FM-BC were significantly improved.

Two-dimensional viologen-based lanthanide coordination polymers as multi-stimuli responsive materials to light and amines with a fluorescence response.

Integrating multi-stimuli response properties in one molecule is challenging. This study presents two 2D polymers, [(Bpydp)Ln(HO)(BDC)]·NO·2HO (Ln = Eu(1), Tb(2)), exhibiting rapid photo-responsiveness and the ability to detect specific small-molecule amines. In particular, complex 1 combines the functions of inkless printing, amine detection, anti-counterfeiting, and fluorescence recognition.

[Effects of Nano-copper Oxide on Physiobiochemical Properties of L. and Its Heavy Metal Accumulation Under Cadmium Stress].

To investigate the effects of nano-copper oxide (CuO NPs) on plant growth, physio-biochemical characteristics, and heavy metal content under cadmium stress, a hydroponics experiment was conducted on the effects of single and combined treatments of CuO NPs (0, 10, 20, and 50 mg·L) and Cd (0, 1, and 5 μmol·L) on the fresh weight, photosynthetic pigment content, MDA content, antioxidant enzyme activity (CAT, POD, SOD, and GR), and Cu and Cd contents in L. The results showed that under the single addition of CuO NPs, the fresh weight and activities of CAT, POD, and GR were inhibited as a whole. Photosynthetic pigment content and SOD activity increased first and then decreased with the increase in CuO NPs concentration, whereas MDA content in leaves and roots, and Cu content in subcells of L.

CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia.

T cell acute lymphoblastic leukemia (T-ALL) is invasive and heterogeneous, and existing therapies are sometimes unsuccessful. Chimeric antigen receptor (CAR) T cell therapy is a breakthrough tumor treatment method, particularly for B cell acute lymphoblastic leukemia. We found that CD147 was highly expressed in tumor T cells of T-ALL patients and T cell lymphoma.

Porous CrO Architecture Assembled by Nano-Sized Cylinders/Ellipsoids for Enhanced Sensing to Trace HS Gas.

How to achieve high sensing of CrO-based sensors for harmful inorganic gases is still a challenge. To this end, CrO nanomaterials assembled from different building blocks were simply prepared by chromium salt immersion and air calcination with waste scallion roots as the biomass template. The hierarchical architecture calcined at 600 °C is constructed from nanocylinders and nanoellipsoids (named as CrO-600), and also possesses multistage pore distribution for target gas accessibility.

[Variations in Cadmium Accumulation and Transport and Ionomic Traits Among Different Winter Wheat Varieties].

A field trial was conducted to identify the key factors affecting intraspecific variation in the cadmium (Cd) content in the grain of winter wheat. Three wheat cultivars with low Cd accumulation and two wheat cultivars with high Cd accumulation were planted. The Cd accumulation and transport and ionomic traits were examined in different organs of the tested wheat cultivars.

[Effects of Intercropping of L. and L. on the Growth and Cadmium Accumulation of Plants].

A pot experiment was conducted to reveal the effects of intercropping a low-cadmium (Cd) accumulating cultivar and a Cd hyperaccumulator on the safe utilization and phytoextraction of Cd-polluted soils. Two cultivars of L. (the low-Cd accumulating cultivar Huajun, and the common cultivar Hanlü), were intercropped with four cultivars of L.

[Effect of Mn-Modified Biochar on the Characteristics of Aggregate Structure and the Content of Cd in Weakly Alkaline Cd-Contaminated Soil].

Field experiments were conducted to investigate the effects of Mn-based modified rice husk biochar on soil organic carbon, aggregate structure, mass load, and the content of available Cd in aggregates. The results showed that the concentration of soil organic carbon increased gradually with additional modified biochar, resulting in a 3.2%-32% increase compared with the CK.

[Effect of Different Passivating Agents on the Stabilization of Heavy Metals in Chicken Manure Compost and Its Maturity Evaluating Indexes].

We explore the effects of different passivating agents on livestock manure treatment by using chicken manure and straw as raw materials and thermophilic rapid fermentation. We investigate the effects of sepiolite (SE), calcium magnesium phosphate fertilizer (NP), biochar (BI), compounds of sepiolite plus calcium magnesium phosphate fertilizer (S+N), sepiolite plus biochar (S+B), calcium magnesium phosphate fertilizer plus biochar (N+B), and sepiolite plus calcium magnesium phosphate fertilizer and biochar (SNB) on the physical and chemical characteristics, heavy metal fraction and distribution, and organic matter content in chicken manure compost. The results showed that the addition of different passivating agents significantly increased the pH in chicken manure organic fertilizer (<0.

[Substructure Characteristics of Combined Acid-Base Modified Sepiolite and Its Adsorption for Cd(Ⅱ)].

To enhance the adsorption capacity of sepiolite (Sep) on Cd in solution, an acid-base Sep (ABsep) was obtained using the method of combined acid-base modification. The structural properties of Sep and ABsep were analyzed by adsorption-desorption isotherms of N, scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRD). Static adsorption experiments were carried out to evaluate the effects of time, mass ratio of ABsep/Cd, temperature, adsorbent dose, pH, and co-existing ions on the adsorption of Cd by ABsep.

Large-Scale Synthesis of Hierarchically Porous ZnO Hollow Tubule for Fast Response to ppb-Level HS Gas.

Response and recovery time to toxic and inflammable hydrogen sulfide (HS) gas are important indexes for metal oxide sensors in real-time environmental monitoring. However, large-scale production of ZnO-based sensing materials for fast response to ppb-level HS has been rarely reported. In this work, hierarchically porous hexagonal ZnO hollow tubule was simply fabricated by zinc salt impregnation and subsequently calcination using absorbent cotton as the template.

Enhanced Sub-ppm NH Gas Sensing Performance of PANI/TiO Nanocomposites at Room Temperature.

PANI/TiO nanocomposites spheres were synthesized using a simple and efficient one-step hydrothermal process. The morphology and structure of PANI/TiO nanocomposites spheres were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques. The PANI/TiO nanocomposite sphere-based sensor exhibits good selectivity, sensitivity (5.

[Characteristics of Heavy Metals in Chicken Manure Organic Fertilizers in the Huang-Huai-Hai Region and related Environmental Risk Assessment].

One hundred and twenty types of chicken manure organic fertilizer samples were collected from five provinces and two cities in the Huang-Huai-Hai region, to investigate heavy metal content, fractionation, and environmental risk through toxicity characteristic leaching procedures. Results showed that content of heavy metals in chicken manure organic fertilizer varied greatly, in the order of Zn > Cu > Pb > As > Cd. When compared with the standard for organic manure, ratios of Cd, As, and Pb exceeded the standard by 6.

[Effect of Foliar Zinc Application on Bioaccessibility of Cadmium and Zinc in Pakchoi].

Two cultivars of pakchoi with different cadmium (Cd) accumulation were grown in nutrient solutions containing low and sufficient zinc (Zn) levels. ZnSO and ZnNa EDTA were applied as foliar fertilizers. The bioaccessibilities of Cd and Zn in pakchoi were assessed by the digestion method, and the bioaccessible established daily intakes (BEDI) of Cd and Zn from pakchoi were calculated.

[Immobilization remediation of Cd and Pb contaminated soil: remediation potential and soil environmental quality].

A pot experiment was conducted to investigate the immobilization remediation effects of sepiolite on soils artificially combined contamination by Cd and Pb using a set of various pH and speciation of Cd and Pb in soil, heavy metal concentration in Oryza sativa L., and soil enzyme activity and microbial quantity. Results showed that the addition of sepiolite increased the soil pH, and the exchangeable fraction of heavy metals was converted into Fe-Mn oxide, organic and residual forms, the concentration of exchangeable form of Cd and Pb reduced by 1.

GABAergic inhibition regulated pain sensitization through STEP61 signaling in spinal dorsal horn of mice.

Background: The reduction of γ-aminobutyric acid (GABA) type A receptor-mediated inhibition has long been implicated in spinal sensitization of nociceptive responses. However, it is largely unknown which signaling cascades in spinal dorsal horn neurons are initiated by the reduced inhibition to trigger pain hypersensitivity.

Methods: GABAergic inhibition was manipulated by intrathecal application of GABA type A receptor antagonist bicuculline in intact mice or by GABA type A receptor agonist muscimol in complete Freund's adjuvant-injected mice.

α(2) noradrenergic receptor suppressed CaMKII signaling in spinal dorsal horn of mice with inflammatory pain.

Intrathecal application of α2 noradrenergic receptor agonists effectively alleviates the pathological pain induced by peripheral tissue injury. However, the spinal antinociceptive mechanisms of α2 noradrenergic receptors remain to be characterized. The present study performed immunohistochemistry and western blot to elucidate the signaling pathway initiated by α2 noradrenergic receptors in spinal dorsal horn of mice, and identified calcium/calmodulin-dependent protein kinase II (CaMKII) as an important target for noradrenergic suppression of inflammatory pain.

[Adsorption of Cd2+ on biochar from aqueous solution].

Biomass-based materials such as biochar have a good performance in heavy metal adsorption. The adsorption of Cd2+ on biochar converted from cotton straw was studied. Adsorption isotherm, kinetics and effect factors such as temperature, pH and ionic strength were investigated.

[Effect and mechanism of immobilization of cadmium and lead compound contaminated soil using new hybrid material].

The effect of new hybrid material and its compound treatments with phosphate on immobilization of cadmium and lead in contaminated soil was investigated using a pot-culture experiment, and the immobilization mechanism of hybrid material was clarified through analysis of heavy metal fractions, sorption equilibration experiment and X-ray photoelectron spectroscopy (XPS). The single treatments of hybrid material could not significantly promote growth of Brassica chinensis, while the compound treatments of hybrid material and phosphate markedly increased dry biomass of shoots and roots, with maximal increases of 75.53% and 151.

[Effects of acid and heating treatments on the structure of sepiolite and its adsorption of lead and cadmium].

The effects of acid and heating treatment on the structure of sepiolite and its adsorption capacities for Pb2+ and Cd2+ were investigated using X-ray powder diffraction, infrared spectroscopy, surface area analyses and batch sorption experiments in this paper. The results showed that the BET surface area of the sepiolite samples grew with increase concentrations of HCl and prolong treatment time and no obvious structural changes were observed. CaCO3 as the impurity in the natural sepiolite can not be removed completely in the treatment process with 0.

2,2'-[Ethyl-enebis(azanediyl-methyl-ene)]diphenol.

In the title compound, C(16)H(20)N(2)O(4), the mol-ecule features a zigzag -CH(2)-NH-CH(2)-CH(2)-NH-CH(2)- chain whose ends are connected to the hydroxy-phenyl rings. The mol-ecules lies about a center of inversion. The imino group is a hydrogen-bond donor for the hydr-oxy group, which is a hydrogen-bond donor for the imino group of an adjacent mol-ecule.