Fxyd5 downregulation protects the heart from ischemia/reperfusion injury by suppressing myocardial inflammation.

Background: Myocardial ischemia/reperfusion (I/R) injury is a common cause of death. FXYD domain-containing ion transport regulator-5 (Fxyd5) is a type I membrane protein that plays a significant role in mediating cellular functions. However, the expression and function of Fxyd5 in myocardial I/R injury remain unclear.

Constructing a predictive model for acute mastitis in lactating women based on machine learning.

Acute lactational mastitis is a frequently occurring complication for lactating women, exerting a certain degree of influence on their physical condition, breastfeeding, mental health, and daily life. The etiology of this disease is complex, and the early symptoms lack typicality. Delayed diagnosis often occurs, which further progresses to abscess or more severe infections, adversely affecting the therapeutic effect and eventually leading to a prolonged recovery process and triggering other complications.

Segmenting Based on UNETR Network and 3D Reconstruction of Interventricular Septal-Free Wall Structure.

Percutaneous intramuscular septal radiofrequency ablation (PIMSRA) provi des an innovative alternative to septal myectomy (SM) and alcohol septal ablation (ASA). The precise segmentation of the interventricular septal is of paramount importance for the successful execution of the PIMSRA procedure. The study is based on the feasibility of applying the neural network-based method of UNETR model to the automatic segmentation of ventricular septal free wall structure in cardiac CT images of patients with HOCM and the three-dimensional reconstruction method based on visualization toolkit (VTK).

Molecular characterization and genetic diversity of Blastocystis sp. in animals from four zoos in China.

Aims: Blastocystis sp. is a widespread unicellular protozoan that is a gastrointestinal eukaryotic parasite of humans and animals. At present, Blastocystis sp.

NSUN2 promotes osteosarcoma metastasis via stabilizing UBE2S mRNA in an m5C-dependent manner.

5-methylcytosine (m5C) is a prevalent posttranscriptional RNA modification that participates in the initiation and progression of various cancers. NSUN2 is the primary RNA methyltransferase responsible for catalyzing the formation of m5C. However, its regulatory role and potential mechanism in osteosarcoma are still unclear.

Association Between Atherogenic Index of Plasma and Endometriosis: Evidence from NHANES 1999-2006.

Background And Aims: Due to its association with various diseases, atherogenic index of plasma (AIP) has garnered increasing attention. Exploration of the relationship between AIP and endometriosis risk has not been thorough. This nationwide study will attempt to explore this association.

Transcriptome Analysis Reveals the Role of Trehalose in Response to Polyethylene Terephthalate Nanoplastics Treatment in Foxtail Millet () Seedlings.

Foxtail millet (), a drought-tolerant C4 model plant, faces increasing threats from polyethylene terephthalate (PET) nanoplastics in agricultural ecosystems. While prior studies indicate that PET nanoplastics induce reactive oxygen species (ROS) accumulation and impair crop productivity, the physiological mechanisms underlying plant responses remain unclear. This study investigates the role of trehalose metabolism in mitigating PET nanoplastic stress in foxtail millet.

Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC.

Non-small cell lung cancer (NSCLC) with PIK3CA mutations demonstrates significant challenges in treatment due to enhanced bone metastasis and immune checkpoint resistance. This study investigates the efficacy of tumor-targeting peptide 1-modified cancer stem cell-derived extracellular vesicles (TMTP1-TSRP-EVs) in reshaping the tumor microenvironment and reversing immune checkpoint resistance in NSCLC. By integrating TMTP1-TSRP into EVs, we aim to specifically deliver therapeutic agents to NSCLC cells, focusing on inhibiting the PI3K/Akt/mTOR pathway, a crucial driver of oncogenic activity and immune evasion in PIK3CA-mutated cells.

Influential Factors on Crease Width Post Cosmetic Blepharoplasty Among Young Asian Women.

Background: Cosmetic blepharoplasty is the most common plastic surgery procedures in East Asian and also one of the procedures most prone to unsatisfactory outcomes. The crease width is a crucial aesthetic criterion for individuals seeking aesthetic enhancements, and due to the various influencing factors, the outcomes of blepharoplasty tend to be unpredictable.

Method: We assessed the apparent height of the double eyelid, incision width, levator muscle function, palpebral fissure height, skin-orbicularis oculi muscle thickness, upper eyelid tissue thickness, and age of Asian women aged 18-35 seeking aesthetic enhancements one-year post-blepharoplasty.

Causal effect of gut microbiota on the risk of cancer and potential mediation by inflammatory proteins.

Background: While growing evidence highlights the role of gut microbiota and inflammatory proteins in cancer, with cancer-related inflammation now considered the seventh hallmark of cancer, the direct causal relationships between specific microbiota, cancer, and the potential mediating effects of inflammatory proteins have not been fully established.

Methods: We employed Mendelian randomization (MR) to assess the causal relationships between gut microbiota, inflammatory proteins, and eighteen distinct cancers using data from extensive genome-wide association studies (GWAS). The primary statistical method utilized was inverse variance weighting (IVW).

Altered Lactylation Myocardial Tissue May Contribute to a More Severe Energy-Deprived State of the Tissue and Left Ventricular Outflow Tract Obstruction in HOCM.

Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiovascular disease. In general, obstructive hypertrophic cardiomyopathy (HOCM) is more closely related to severe clinical symptoms and adverse clinical outcomes. Therefore, it is necessary to explore the possible causes of HOCM, which may help physicians better understand the disease and effectively control and manage the progression of the disease.

[Transesophageal echocardiography assessment of mitral valve for patients with atrial septal defects undergoing surgical repair].

Objectives: To investigate the application of transesophageal echocar-diography assessment for mitral valve in patients with atrial septal defects undergoing repair surgery.

Methods: The study group comprised of thirty-two adult patients with atrial septal defect who underwent thoracoscopic repair surgery at the First Affiliated Hospital of the Air Force Medical University from March to September 2022. Two-dimensional and real-time three-dimensional transesophageal ultrasonography of the mitral valve were performed after anesthesia.

[Efficacy of the transcatheter tricuspid valve replacement for patients with severe tricuspid regurgitation: Lux-Valve versus Lux-Valve Plus].

Objectives: To compare the efficacy of transcatheter tricuspid valve replacement (TTVR) using Lux-Valve and Lux-Valve Plus in patients with severe tricuspid regurgitation.

Methods: A total of 28 consecutive patients with severe tricuspid regurgitation who underwent TTVR with Lux-Valve (=14) or Lux-Valve Plus (=14) in the First Affiliated Hospital of the Air Force Medical University from August 2019 to November 2023 were enrolled. Transthoracic echocardiography was performed in all patients before and 6 months after the TTVR.

Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity.

Adriamycin (ADR), as an anti-cancer drug in routine clinical application, is utilized to treat various cancers such as ovarian cancer, hematological malignant tumor, and endometrial carcinoma. However, its serious dose-dependent cardiotoxicity extremely limits its clinical application. Currently, there remains a dearth of therapeutic agents to mitigate ADR-induced cardiotoxicity.

Impact of Combining Ultrasound Parameter and the Caprini Score on Predicting Lower Extremity Deep Venous Thrombosis After Orthopedic Surgery.

Aims: This study combined a new ultrasound venous filling degree (VFD) parameter with the Caprini score to assess the clinical value of the Caprini score in predicting deep venous thrombosis (DVT) of the lower extremities.

Methods: This retrospective study included 150 inpatients undergoing orthopedic lower extremity surgery at the First Affiliated Hospital of the Air Force Medical University between June 2023 and June 2024. They included 41 (27.

Semi-synthesis of functionalized cell-permeable ubiquitin probes SrtA-mediated ligation.

Cell-permeable ubiquitin (Ub) probes labeled with a fluorescent or biotin tag have become effective tools for studying the activity of deubiquitinating enzymes (DUBs) in living cells. However, such probes are usually obtained through total chemical synthesis. In this study, we develop a Sortase A (SrtA)-mediated semi-synthetic strategy for preparing cell-permeable Ub-propargylamide (Ub-PA) with a fluorescent or biotin tag.

A unique presentation of systolic anterior motion of the mitral valve in a patient with obstructive hypertrophic cardiomyopathy and recurrent syncope: a case report.

Background: Systolic anterior motion (SAM) of the mitral valve is a hallmark feature of hypertrophic obstructive cardiomyopathy (HOCM) and a primary cause of dynamic left ventricular outflow tract obstruction. This case report highlights an unusual presentation of SAM associated with acute haemodynamic collapse.

Case Summary: A 36-year-old male with HOCM presented with recurrent episodes of syncope.

Percutaneous intramyocardial septal radiofrequency ablation: a novel treatment for drug-refractory non-obstructive hypertrophic cardiomyopathy with severe septal hypertrophy.

Background: Patients with drug-refractory non-obstructive hypertrophic cardiomyopathy (NOHCM) lack effective invasive treatment options. This study aimed to evaluate the safety and effectiveness of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA, Liwen procedure) in patients with NOHCM and severe septal hypertrophy (≥28 mm).

Method: This single-arm, open-label, prospective study enrolled 20 adult patients with drug-refractory NOHCM between June 2017 and June 2023.

Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression.

Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. Oxidative damage and inflammation are critical factors in secondary pathological processes. Selenium nanoparticles have demonstrated significant antioxidative and anti-inflammatory properties via a non-immunosuppressive pathway; however, their clinical application has been limited by their inadequate stability and functionality to cross the blood-spinal cord barrier (BSCB).

Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis.

Background: Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death. However, currently, there are no therapeutic strategies available to prevent the onset of cardiac fibrosis.

Methods And Results: Here, biomimetic ATP-responsive nanozymes based on genetically engineered cell membranes are adapted to specifically recognize activated cardiac fibroblasts (CFs) for the treatment of cardiac fibrosis.

Echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation procedure for the treatment of Fabry disease: a case report.

Background: This is a case report of a patient with Fabry disease (FD). We successfully treated a patient with ventricular septal hypertrophy and left ventricular outflow tract (LVOT) obstruction caused by FD. We report our exclusive new surgery for patients with LVOT obstruction, percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) procedure™ (percutaneous intramyocardial septal radiofrequency ablation).

Polyethylene terephthalate nanoplastics affect potassium accumulation in foxtail millet (Setaria italica) seedlings.

Background: As modern industrial activities have advanced, the prevalence of microplastics and nanoplastics in the environment has increased, thereby impacting plant growth. Potassium is one of the most crucial nutrient cations for plant biology. Understanding how polyethylene terephthalate (PET) treatment affects potassium uptake will deepen our understanding of plant response mechanisms to plastic pollution.