Hepatotoxicity of 8:2 Polyfluoroalkyl Phosphate Diesters Exposure via JAK2/STAT3 Pathway Activation and M1 Macrophage Polarization in Mice.

Polyfluoroalkyl phosphate esters (PAPs) are widely used as substitutes for legacy perfluoroalkyl and polyfluoroalkyl substances (PFAS), contributing a non-negligible environmental burden. However, their in vivo hepatotoxicity and underlying mechanisms remain poorly understood. We developed a mouse model to assess the hepatotoxic effects and mechanisms of 8:2 polyfluoroalkyl phosphate diesters (8:2 diPAP).

Aspirin inhibits the heat stress-induced apoptosis of bull primary Sertoli cells by enhancing the extracellular transport of misfolded proteins.

The dairy breeding industry is facing increasing heat stress, which affects the reproductive systems and semen quality of bulls. Sertoli cells are important types of somatic cells that protect and regulate sperm production, and heat stress can damage these cells, impairing semen quality. Protein homeostasis is essential for the functional maintenance of cells.

Calcium Vacancy Generated Luminescence Improvement of the CaScSiO:Ce Phosphor for WLED.

Phosphors with high efficiency and excellent thermal stability for solid-state lighting have kept catching researchers' attention. Herein, a series of CaScSiO:Ce cyan-emitting phosphors are synthesized, and calcium vacancy is introduced into the lattice to improve emission and thermal stability. Detailed structure information is studied via X-ray diffraction and X-ray photoelectron spectroscopy to obtain the effect of Ca vacancy on the lattice structure.

Integrating Cortical Source Reconstruction and Adversarial Learning for EEG Classification.

Existing methods for diagnosing depression rely heavily on subjective evaluations, whereas electroencephalography (EEG) emerges as a promising approach for objective diagnosis due to its non-invasiveness, low cost, and high temporal resolution. However, current EEG analysis methods are constrained by volume conduction effect and class imbalance, both of which adversely affect classification performance. To address these issues, this paper proposes a multi-stage deep learning model for EEG-based depression classification, integrating a cortical feature extraction strategy (CFE), a feature attention module (FA), a graph convolutional network (GCN), and a focal adversarial domain adaptation module (FADA).

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review.

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory, hypoglycemic, and hypolipidemic effects, as well as skin-protective properties and gut microbiota modulation. Due to these multifunctional properties, TFP has garnered considerable attention in the food, pharmaceutical, and cosmetic industries.

Utilizing Octanoic Acid to Quantitatively Assess the Oxidation Status of PS80.

Purpose: The study aims to address the gap in research concerning the stability of polysorbate (PS) in placebo samples, as opposed to drug products. While PS is a critical excipient in protein drug formulations, its stability in placebo samples has been less explored. Notably, PS in placebo samples is more susceptible to oxidation rather than hydrolysis, even at low temperatures like 5℃.

Mechanism of nodulation and nitrogen fixation in Caucasian clover ( Bieb.) based on transcriptomics and proteomics analyses.

Introduction: Caucasian clover ( Bieb.), a perennial legume forage grass, exhibits strong adaptability and resistance to adverse conditions. Owing to its rhizome specificity, it cannot nodulate or fix nitrogen outside of its original location, which limits its promotion and cultivation.

Hospitalization risk and burden for cause-specific cardiovascular diseases following tropical cyclones: A multicountry study.

The indirect health risks of tropical cyclones (TCs), the costliest climate extremes, remain unclear, with cardiovascular diseases (CVDs) being a major contributor. We applied two-stage time-series analysis to 6.54 million CVD hospitalizations across six countries/territories (Canada, New Zealand, South Korea, Taiwan, Thailand, and Vietnam) between 2000 and 2019 to quantify the long-term risks and burden of CVD hospitalizations following TCs.

Population Cohort-Validated PM-Induced Gene Signatures: A Machine Learning Approach to Individual Exposure Prediction.

Transcriptomic profiling has shown that exposure to PM, a common air pollutant, can modulate gene expression, which has been linked to negative health effects and diseases. However, there are few population-based cohort studies on the association between PM exposure and specific gene set expression. In this study, we used an unbiased transcriptomic profiling approach to examine gene expression in a mouse model exposed to PM and to identify PM-responsive genes.

Transcriptome Analysis Reveals the Role of Trehalose in Response to Polyethylene Terephthalate Nanoplastics Treatment in Foxtail Millet () Seedlings.

Foxtail millet (), a drought-tolerant C4 model plant, faces increasing threats from polyethylene terephthalate (PET) nanoplastics in agricultural ecosystems. While prior studies indicate that PET nanoplastics induce reactive oxygen species (ROS) accumulation and impair crop productivity, the physiological mechanisms underlying plant responses remain unclear. This study investigates the role of trehalose metabolism in mitigating PET nanoplastic stress in foxtail millet.

Air pollution exposure associated with decline rates in skeletal muscle mass and grip strength and increase rate in body fat in elderly: a 5-year follow-up study.

Background: The effect of air pollution on annual change rates in grip strength and body composition in the elderly is unknown.

Objectives: This study evaluated the effects of long-term exposure to ambient air pollution on change rates of grip strength and body composition in the elderly.

Methods: In the period 2016-2020, grip strength and body composition were assessed and measured 1-2 times per year in 395 elderly participants living in the Taipei basin.

Measurement Invariance of the Manchester Orofacial Pain Disability Scale (MOPDS) for Biopsychosocial Factor Among Orofacial Patients and Nonclinical Populations: An Evidence for Clinical Investigations.

Background: Orofacial pain (OFP) harms mental health and functionality. The Manchester Orofacial Pain Disability Scale (MOPDS) is a questionnaire for assessing OFP.

Objectives: The purpose of this study was to examine the validity of the Chinese version of MOPDS in clinical populations, measurement invariance across different clinical statuses and sex cohorts.

Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.

Ubiquitin-specific protease 14 (USP14) is a crucial modulator of proteasomal function and cellular proteostasis, which plays an important role in the development and progression of various cancers including colorectal cancer (CRC). In this study we screened 670 covalent compounds using the in vitro Ub-AMC hydrolysis assay, and identified AKOS, initially a Chikungunya virus inhibitor, as a novel small-molecule inhibitor of USP14. We showed that AKOS inhibiting USP14 deubiquitinase activity with an IC value of 0.

Thermal ocular injury associated with retinal necrosis and vitreous inflammation: a case report.

Background: A case of thermal ocular injury associated with retinal necrosis and vitreous inflammation is reported.

Case Presentation: A 53-year-old man's right eye was hit by a heated screw, which embedded directly into the nasal orbit. Two weeks after the foreign body was removed, serious vitreous inflammation and a large yellow-white lesion on the nasal peripheral retina, which resembled a subretinal abscess, were observed.

Long-term exposure to ambient air pollution and the incidence of nonalcoholic fatty liver disease: a cohort study.

Background: Nonalcoholic fatty liver disease (NAFLD) affects approximately one-third of adults and may progress to advanced fibrosis and hepatocellular carcinoma. Epidemiologic studies linking air pollution to NAFLD incidence remain limited. This study examined associations between long-term exposure to ambient air pollution and NAFLD incidence.

Construction and Preclinical Evaluation of a Recombinant Attenuated Measles Vaccine Candidate of the H1a Genotype.

: Measles, an acute respiratory infectious disease caused by the measles virus, continues to pose a significant threat to children under five years old worldwide. Despite the availability of effective vaccines, challenges such as insufficient vaccination coverage and antigenic drift contribute to its persistence. Based on a newly isolated wild-type measles virus strain (genotype H1a), designated MVs/Jiangsu.

Associations between children's upper respiratory tract mycobiome, school air mycobiome, and surrounding greenness.

Fungal spores are ubiquitous in the air, shaped by landscape and climate, and are known contributors to respiratory allergy in children. However, the contribution of airborne fungi to the upper respiratory tract (URT) mycobiome in children remains poorly understood, as does the influence of natural landscape on this exposure. This study investigated associations between children's URT mycobiome, the school air mycobiome, and surrounding greenness.

[Surgical strategies for osteotomy correction of severe lower limb deformities in hypophosphatemic rickets].

Objective: To explore the corrective strategies and effectiveness of osteotomy surgery for severe lower limb deformities in hypophosphatemic rickets.

Methods: A retrospective analysis was conducted on 29 patients with severe lower limb deformities of hypophosphatemic rickets who underwent surgical treatment between February 2012 and August 2024. There were 9 males and 20 females.

"On-Off" electrochemical sensing toward mercury pollution in tea exonuclease III triggered target recycling amplification.

Mercury ion (Hg) pollution in tea poses significant risks to human health due to its high toxicity, bioaccumulation, and potential to cause neurological and kidney damage. Sensitive monitoring of Hg in tea is therefore critical for food safety and public health. Here, we developed an electrochemical biosensor for ultrasensitive Hg assay by integrating thymine-Hg-thymine (T-Hg-T) mismatch recognition with exonuclease III (EXO III)-assisted dual signal amplification.

Operating Room Nurses: A Deep Dive Into the Quality of Care and Job Stressors.

Background: The relationship between occupational stress and the quality of nursing care in the operating room (OR) is an area that has not been thoroughly explored in the literature. The present study was designed to examine the correlation between job-related stress and the quality of care delivered by nurses in the OR setting.

Methods: A cross-sectional survey was administered to OR nurses at our institution from 1 April to 30 April 2023.

Predicting carbapenem-resistant Pseudomonas aeruginosa infection risk using XGBoost model and explainability.

The prevalence and spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global public health problem. This study aims to identify the risk factors of CRPA infection and construct a machine learning model to provide a prediction tool for clinical prevention and control. A total of 1949 patients with P.

Daphnane Diterpenoids from with Antiadipogenic Activity: Concurrent Suppression of Lipid Biosynthesis and Enhancement of Metabolic Pathways.

Phytochemical investigation of the rarely studied employing molecular networking and bioactivity-guided strategies led to the identification of 12 daphnane diterpenoids (-), including seven previously undescribed compounds, daphretusins A-G (-). Structural elucidation was achieved through comprehensive spectroscopic analysis (HRESIMS, 1D/2D NMR), combined with experimental and calculated electronic circular dichroism (ECD), NMR calculations, and DP4+ analysis. All isolates demonstrated potent dose-dependent antiadipogenic effects, inhibiting lipid accumulation in 3T3-L1 cells with EC values ranging from 0.

Exploring the Association Between Patient-Nurse Ratio and Nurses' Occupational Stressors: A Cross-Sectional Study.

The patient-nurse ratio significantly influences nursing workloads, but its specific relationship with nurses' occupational stressors is poorly understood. This study aimed to examine the association between patient-nurse ratio and occupational stressors among nurses, highlighting understaffing as a potential driver of stress in clinical environments. A self-administered questionnaire was distributed to full-time nurses in the medical and surgical wards of accredited hospitals.