Event-driven architecture and intelligent decision tree facilitated sustainable trade activity monitoring model design.

This paper introduces a groundbreaking monitoring model tailored for sustainable trade activity surveillance, which synergistically integrates event-driven architecture with an intelligent decision tree. Confronting the constraints of conventional trade monitoring approaches that falter in adapting to the intricate and ever-changing market landscape, our model innovatively establishes an efficient, adaptable, and sustainable monitoring framework. By embedding an intelligent decision tree, it enables dynamic resource allocation, thereby optimizing operational efficacy.

The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data.

The Genome Sequence Archive family (GSA family) provides a comprehensive suite of database resources for archiving, retrieving, and sharing multi-omics data for the global academic and industrial communities. It currently comprises four distinct database members: the Genome Sequence Archive (GSA, https://ngdc.cncb.

Utilizing Octanoic Acid to Quantitatively Assess the Oxidation Status of PS80.

Purpose: The study aims to address the gap in research concerning the stability of polysorbate (PS) in placebo samples, as opposed to drug products. While PS is a critical excipient in protein drug formulations, its stability in placebo samples has been less explored. Notably, PS in placebo samples is more susceptible to oxidation rather than hydrolysis, even at low temperatures like 5℃.

Rapid and actionable nasal-swab screening supports antimicrobial stewardship in patients with pneumonia: a prospective study.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) nasal screening by polymerase chain reaction (PCR) is a rapid diagnostic tool with a high negative predictive value for pneumonia caused by MRSA. MRSA remains an important emerging pathogen in China and at present, there is little published data on the effect of rapid MRSA test results on antibiotic utilization for pneumonia.

Methods: A total of 300 inpatients who met the criteria of pneumonia in a tertiary general hospital were randomly assigned to a notification group (NG, n = 150) or a control group (CG, n = 150).

Compound Salt-Based Coagulants for Tofu Gel Production: Balancing Quality and Protein Digestibility.

Tofu quality is critically influenced by coagulants, though their impact on protein digestibility remains underexplored. This study aimed to investigate the effects of calcium sulfate (CaSO), magnesium chloride (MgCl), and their combination (CaSO + MgCl) on the physicochemical properties and protein digestibility of tofu. Water-holding capacity, cooking loss, texture, protein composition, and protein digestibility were analyzed.

Identifying pivotal sites affecting thermostability of GH11 xylanase via conventional and deep learning-based energy calculation.

The GH11 xylanase XynCDBFV, derived from Neocallimastix patriciarum, is widely used in various industries. However, its relatively low thermostability limits its potential. In this study, two computational approaches-Rosetta Cartesian_ddG and the deep learning-based tool Pythia-were employed to identify key residues affecting XynCDBFV thermostability.

Lineage-associated Human Divergently-paired Genes Exhibit Structural and Regulatory Characteristics.

Divergently-paired genes (DPGs) are minimal co-transcriptional units of clustered genes, representing over 10% of human genes. Our previous studies have shown that vertebrate DPGs are highly conserved compared to those from invertebrates. Three critical questions remain: (1) which DPGs are conserved across vertebrates, especially among mammals and primates? (2) to what extent and precision do these paired promotors share their sequences mechanistically and stringently? and (3) how are human DPGs distributed over selected primate lineages, and what are their possible biological functional consequences? There are 1399 human DPGs (approximately 12% of all human protein-coding genes), of which 1136, 1118, 925, and 830 human DPGs show conservation when compared to selected primates, mammals, avians, and fishs, respectively.

Dyadic coping experience of persons with young-onset dementia and their spousal caregivers: A review of qualitative studies and meta-synthesis.

BackgroundPersons with young-onset dementia (PwYOD) often face issues with social role conflicts, financial crises, and family relationship breakdowns. Spousal caregivers (SCGs) balance numerous family responsibilities while facing a significant burden of care and emotional strain. Currently, an increasing number of qualitative studies focus on the experience of illness from the perspective of the YOD couple's dyadic experience.

Myometrial extracellular vesicles promoted endometrial mesenchymal stem/stromal cells to self-renewal via jag1-mediated notch signaling.

Background: In the human endometrium, studies show the importance of extracellular vesicles in mediating various physiological as well as pathological processes. We have demonstrated that the myometrial cells are candidate niche cells of the endometrial mesenchymal stem/stromal cells (eMSC) modulating their biological function. The Notch signaling pathway regulates the endometrial stem cell functions.

Metacommunity theory and its application in community ecology of nematodes.

The mechanism underlying community assembly is a core content in the fields of biogeography and community ecology. Understanding community assembly is of great significance for biodiversity conservation. The theory of metacommunity incorporates spatial dynamics into community ecology, elucidating how ecological processes drive community construction at local and regional scales.

Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.

Ethnopharmacological Relevance: Epimedii Folium is a famous traditional Chinese medicine that has been utilized to treat depression, impotency and rheumatism for centuries in China. Icariin (ICA) is the primary flavonoid and quality control ingredient of Epimedii Folium.

Aims Of The Study: The objective of this investigation was to clarify the mechanisms through which ICA improved depressive-like behavior in prenatal stress (PS) offspring rats.

Translation of Nickel-Catalyzed C(sp)-C(sp) Cross-Electrophile Coupling to Non-Amide Solvents.

The cross-electrophile coupling of organobromides is widely utilized in organic synthesis but generally requires undesirable amide solvents (e.g., DMF, DMA, and NMP).

Analysis of the characteristics of community-acquired pneumonia in children and the high-risk factors leading to severe disease in China.

This was a research study, analysed the characteristics of community-acquired pneumonia (CAP) in children and the high-risk factors causing severe disease. Three hundred and ninety CAP children accepted therapy to First Hospital of Qinhuangdao from February 2019 to January 2020 were divided into spring onset group, summer onset group, autumn onset group and winter onset group. The detection rates of streptococcus pneumonia, haemophilus influenzae and mycoplasma pneumoniae in the winter onset group were higher than the other groups, while the detection rate of moraxella mucositis in the spring onset group was higher as than the other groups.

Collaborative regulation of eco-environment pressure and sci-technology innovation ability in Beijing-Tianjin-Hebei urban agglomeration with environmental footprint integrated inversion.

The previous studies have separately assessed regional eco-environment pressure (EEP) and sci-technology innovation ability (STIA), ignoring their dynamic relationship. This study assesses EEP in the Beijing-Tianjin-Hebei urban agglomeration (BTHUA) based on water-carbon-nitrogen footprints and an integrated inversion model. The dynamic relationship between EEP and STIA is illustrated by integrating spatial-temporal matching degree with various development scenarios, and their collaborative control schemes are selected through the Cloud-VIKOR decision-making approach.

Synthesis, Biological Evaluation, and Mechanistic Insights of Rubrolide Analogues as Antitumor Agents.

Marine natural products and their analogues have as of now been acknowledged as an important source of bioactive molecules for the treatment of cancer. Rubrolides, a unique group of -butenolides derived from marine microorganisms, have shown strong cytotoxic activity against various tumor cells. In this study, we synthesized and characterized 21 rubrolide analogues (including 16 new compounds) and investigated their antitumor activities in order to screen more active molecules and elucidate their mechanism of action.

Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy.

Tumor-initiating cells (TICs) possess the ability to evade anti-tumor immunity, potentially explaining many failures of cancer immunotherapy. Here, we identify CD49f as a prominent marker for discerning TICs in hepatocellular carcinoma (HCC), outperforming other commonly used TIC markers. CD49f-high TICs specifically recruit tumor-promoting neutrophils via the CXCL2-CXCR2 axis and create an immunosuppressive milieu in the tumor microenvironment (TME).

Deciphering the Multifaceted Immune Landscape of Unresectable Primary Liver Cancer to Predict Immunotherapy Response.

Immunotherapies employing PD-1/PD-L1 immune checkpoint inhibitors (ICIs) are vital for primary liver cancer (PLC), but response rates remain unsatisfying. Accurate differentiation of responders from non-responders to immunotherapy is imperative. Here, single-cell-scaled mass cytometry analysis on sequential peripheral blood mononuclear cells (PBMCs) from ICI-treated PLC patients is conducted, and tissue residence of immune subpopulations is assessed via multiplex immunohistochemistry.

Zeolitic imidazolate framework functionalized magnetic multiwalled carbon nanotubes as efficient adsorbents for rapid extraction of fluoroquinolones.

Herein, a new, environmentally friendly, and economical magnetic solid-phase extraction method for fluoroquinolones (FQs) from milk samples was developed using novel recyclable zeolitic imidazolate framework functionalized magnetic multiwalled carbon nanotubes (FeO@MWCNTs@SiO@ZIF-8) as adsorbents. Various characterization techniques, including scanning electron microscopy, N adsorption-desorption analysis, and vibrating sample magnetometry, demonstrated that the adsorbent possessed a remarkable specific surface area, pore volume, and superparamagnetic properties, rendering it an excellent adsorbent. Combined with high-performance liquid chromatography, this method exhibited excellent linearity (R ≥ 0.

Bibliometrics analysis and knowledge mapping of pertussis vaccine research: trends from 1994 to 2023.

Purpose: This study aims to use bibliometric methods to explore the evolving landscape, hotspots, and emerging frontiers of pertussis vaccine research, providing deeper insights into the current research landscape and guiding future vaccine development efforts.

Methods: We conducted a comprehensive search of the Web of Science Core Collection database (WoSCC) from January 1, 1994, to December 31, 2023, employing search terms related to vaccination (vacc* or immun*) and pertussis (pertussis, Whooping Cough, Bordetella pertussis, B. pertussis, Bordetella pertussis infection, or B.

Rapid screening of xanthine oxidase inhibitors from Ligusticum wallichii by using xanthine oxidase functionalized magnetic metal-organic framework.

In this study, xanthine oxidase was immobilized for the first time using a novel magnetic metal-organic framework material (FeO-SiO-NH@MnO@ZIF-8-NH). A ligand fishing method was established to rapidly screen XOD inhibitors from Ligusticum wallichii based on the immobilized XOD. Characterization and properties of the immobilized enzyme revealed its excellent stability and reusability.

Advancing microvascular invasion diagnosis: a multi-center investigation of novel MRI-based models for precise detection and classification in early-stage small hepatocellular carcinoma (≤ 3 cm).

Purpose: This study aimed to develop two preoperative magnetic resonance imaging (MRI) based models for detecting and classifying microvascular invasion (MVI) in early-stage small hepatocellular carcinoma (sHCC) patients.

Methods: MVI is graded as M0 (no invasion), M1 (invasion of five or fewer vessels located within 1 cm of the tumor's peritumoral region), and M2 (invasion of more than five vessels or those located more than 1 cm from the tumor's surface). This study enrolled 395 early-stage sHCC (≤ 3 cm) patients from three centers who underwent preoperative gadopentetate-enhanced MRI.

The effects of optimized microstructured surfaces on bond strength and durability of NPJ-printed zirconia.

Objectives: This study was to investigate the effects of optimized microstructured surfaces on bond strength and bond durability of the latest nanoparticle jetting (NPJ)-printed zirconia.

Methods: Zirconia microstructured surfaces with different geometries and void volume were analyzed through three-dimensional finite element analysis for surface micromorphology optimization. Zirconia disks and cylinders were additively manufactured by an NPJ 3D printer (N = 128).