Effect of microscope-assisted modified lateral lumbar interbody fusion and impact on lumbar lordosis and intervertebral height.

Purpose: This study aimed to evaluate the effectiveness of microscope-assisted modified lateral lumbar interbody fusion (micro-XOLIF) and to compare its impact on lumbar sagittal plane imaging parameters with extreme lateral interbody fusion (XLIF).

Methods: We retrospectively collected the data of patients who underwent XLIF and micro-XOLIF in our hospital. We compared general data, medical records, and imaging parameters of both groups, including lumbar sagittal balance and postoperative intervertebral height.

The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies.

Osteoarthritis (OA) is a degenerative joint disease associated with age, prominently marked by articular cartilage degradation. In OA cartilage, the pathological manifestations show elevated chondrocyte hypertrophy and apoptosis. The mitochondrion serves as key energy supporter in eukaryotic cells and is tightly linked to a myriad of diseases including OA.

DistilCLIP-EEG: Enhancing Epileptic Seizure Detection Through Multi-modal Learning and Knowledge Distillation.

Epilepsy is a prevalent neurological disorder marked by sudden, brief episodes of excessive neuronal activity caused by abnormal electrical discharges, which may lead to some mental disorders. Most existing deep learning methods for epilepsy detection rely solely on unimodal EEG signals, neglecting the potential benefits of multimodal information. To address this, we propose a novel multimodal model, DistilCLIP-EEG, based on the CLIP framework, which integrates both EEG signals and text descriptions to capture comprehensive features of epileptic seizures.

Luteolin Regulates Mitophagy to Alleviate Myocardial Ischemia-Reperfusion Injury via Sirt3/Foxo3a Pathway.

Luteolin (LUT) belongs to a kind of flavonoid, which has protective effects on myocardial ischemia/reperfusion (I/R) injury. Sirt3 is located in mitochondria and interacts with Foxo3a to protect mitochondrial function against stress. Mitophagy is an important form of mitochondrial quality control.

GDM-DTM: A Group Decision-Making-Enabled Dynamic Trust Management Method for Malicious Node Detection in Low-Altitude UAV Networks.

As a core enabler of the emerging low-altitude economy, UAV networks face significant security risks during operation, including malicious node infiltration and data tampering. Existing trust management schemes suffer from deficiencies such as strong reliance on infrastructure, insufficient capability for multi-dimensional trust evaluation, and vulnerability to collusion attacks. To address these issues, this paper proposes a group decision-making (GDM)-enabled dynamic trust management method, termed GDM-DTM, for low-altitude UAV networks.

Surface-Engineered Umbilical Cord Mesenchymal Stem Cell-Derived sEVs for Targeted Therapy of Osteoarthritis.

Small extracellular vesicles (sEVs) from human umbilical-cord-derived mesenchymal stem cells (UCMSCs) hold promise for cartilage regeneration in osteoarthritis (OA). However, their therapeutic effectiveness is significantly limited by rapid clearance through blood and lymphatic vessels in the synovial tissue after intra-articular injection. This study aimed to enhance the chondrocyte-targeting ability and improve the cartilage repair potential of UCMSC-derived sEVs by conjugating them with a chondrocyte-affinity peptide (CAP) using copper-free click chemistry.

Quzhuo tongbi formula for reducing gout flare related to uric acid lowering treatment: Study protocol for a multiple-center, randomized, double-blind, placebo, parallel-controlled clinical trial.

Introduction: Gout, a prevalent metabolic rheumatic disease, arises from the accumulation of monosodium urate (MSU) crystals in joints, directly associated with hyperuricemia. Long-term or lifelong urate-lowering therapy (ULT) stands as the primary management strategy. However, there is a significant risk of gout flares during ULT, and current methods have drawbacks, including side effects.

C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001-2010.

Background: Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP.

Methods: Participants from NHANES 2001-2010 were enrolled.

The Facile Construction of Defect-Engineered and Surface-Modified UiO-66 MOFs for Promising Oxidative Desulfurization Performance.

The effective and deep removal of unreactive sulfides to achieve ultra-low-sulfur or sulfur-free oils has recently attracted extensive attention. In this work, a series of UiO-66 based catalysts have been prepared facilely for the effective removal of unreactive sulfides. Here, the incorporation of nitro functional groups into UiO-66, along with the construction of defects, results in remarkable sulfur removal for dibenzothiophene (DBT), achieving oil with sulfur content of less than 1 ppm.

Construction and application of a NIR benzothianone-based ratiometric fluorescent probe for visual detection of Hg in biological systems and water samples.

Background: Mercury ions, a toxic heavy metal, pose a significant threat to environmental health, leading to pollution and accumulation in living organisms.

Results: In this study, we have developed a novel ratiometric near-infrared fluorescent probe for the detection of Hg. The probe TM-ND-Hg demonstrated a remarkable Stokes shift (358 nm), a rapid response time (within 1 min), excellent selectivity, stability, and ratiometric fluorescence changes from green to red.

METTL3 inhibits primed-to-naïve transition of pluripotent stem cells through mA-YTHDF2-pluripotency/Gstp1 mRNA degradation axis.

N6-methyladenosine (mA) plays crucial roles in development and cellular reprogramming. During embryonic development, pluripotency transitions from a naïve to a primed state, and modeling the reverse primed-to-naïve transition (PNT) provides a valuable framework for investigating pluripotency regulation. Here, we show that inhibiting METTL3 significantly promotes PNT in an mA-dependent manner.

ECAE: An Efficient Certificateless Aggregate Signature Scheme Based on Elliptic Curves for NDN-IoT Environments.

As a data-centric next-generation network architecture, Named Data Networking (NDN) exhibits inherent compatibility with the distributed nature of the Internet of Things (IoT) through its name-based routing mechanism. However, existing signature schemes for NDN-IoT face dual challenges: resource-constrained IoT terminals struggle with certificate management and computationally intensive bilinear pairings under traditional Public Key Infrastructure (PKI), while NDN routers require low-latency batch verification for high-speed data forwarding. To address these issues, this study proposes ECAE, an efficient certificateless aggregate signature scheme based on elliptic curve cryptography (ECC).

Advanced droplet microfluidic platform for high-throughput screening of industrial fungi.

Industrial fungi are pivotal candidates for the production of a diverse array of bioproducts. To enhance their productivity, these strains are frequently subjected to genetic modifications. Following transformation, the selection of optimal production strains is critical; however, traditional screening methods often suffer from limitations in throughput and sensitivity.

Exploring the spatiotemporal impact and pathways of temperature and CO2 concentration based on network approach.

Mitigating carbon dioxide (CO2) emissions and curbing temperature rise hold profound significance for global climate protection and economic advancement, particularly in China. From a climatic systems perspective, the interplay between temperature fluctuations and CO2 emissions remains underexplored. Based on the surface-level 1000 hPa atmospheric temperature (T) and CO2 concentration data for China from 2004 to 2020, with a spatial resolution of 3°×2°, this study introduces a multi-layer network framework with time-lag effects to investigate the interaction patterns between temperature and carbon concentration across regions in China.

Development and Validation of a Nomogram for Predicting Adjacent Vertebral Fracture After Osteoporotic Vertebral Compression Fracture Surgery: A Multicenter Retrospective Cohort Study.

Objective: Osteoporotic vertebral compression fractures (OVCFs) are a major public health concern. While percutaneous vertebral augmentation (PVA) is an effective treatment for OVCF, adjacent vertebral fractures (AVF) often occur post-PVA, adversely affecting treatment outcomes. This study aims to develop a nomogram for predicting AVF risk using multicenter data to aid clinical decision-making for OVCF patients.

Nucleus pulposus clamping procedures based on optimized material point method for surgical simulation systems.

Clamping and removal of the nucleus pulposus (NP) are critical operations during transforaminal endoscopic lumbar discectomy. To meet the challenge of simulating the NP in real-time for better training output, an improved material point method is proposed to represent the physical properties of the NP and compute its deformation in real time. Corresponding volume rendering of the NP and its hosting bones are also presented.

Knockdown of TSP-4 alleviates MI/RI-induced myocardial injury and improves brain inflammation by enhancing blood-brain barrier stability.

Myocardial ischemia-reperfusion injury (MI/RI) not only affects cardiac function but also has significant implications for neurological health, potentially leading to cognitive and behavioral impairments. At present, the regulatory role of thrombospondin-4 (TSP-4) in MI/RI has not been reported. A MI/RI mouse model was constructed, and primary cardiomyocytes were isolated.

Neutrophil extracellular trap-derived double-stranded RNA aggravates PANoptosis in renal ischemia reperfusion injury.

A dysregulated inflammatory response and inflammation-associated cell death are central features of renal ischemia-reperfusion injury (IRI). PANoptosis, is a recently recognized form of inflammatory programmed cell death characterized by key features of pyroptosis, apoptosis and necroptosis; however, the specific involvement of PANoptosis in renal IRI remains unknown. By using neutrophil extracellular trap (NETs)-depleted Pad4 mice, we found that NETs are essential for exacerbating tissue injury in renal IRI.

LKB1 activated by NaB inhibits the IL-4/STAT6 axis and ameliorates renal fibrosis through the suppression of M2 macrophage polarization.

Background: Renal fibrosis is a critical pathological characteristic of chronic kidney disease, and current antifibrotic therapies has limited efficacy. Sodium butyrate (NaB) has been shown to be highly effective in mitigating bleomycin-induced pulmonary fibrosis; however, its specific impact on renal fibrosis and the underlying mechanisms remain unclear. This study aims to elucidate the role and mechanism of NaB in renal fibrosis by using a mouse model of renal fibrosis induced through Unilateral Ureteral Obstruction (UUO) and folic acid (FA) administration.

Ecdysterone Alleviates Atherosclerosis by Inhibiting NCF2 and Inhibiting Ferroptosis Mediated by the PI3K/Akt/Nrf2 Pathway.

Ecdysterone (Ecd), an active ingredient in trianthema, has a strong anti-inflammatory effect. This study aimed to explore the potential mechanism by which Ecd improves atherosclerosis (AS). Here, we systematically investigated the mechanism of Ecd in human umbilical vein endothelial cells (HUVECs) treated with oxidised low-density lipoprotein (ox-LDL).

Global trends and disparities in gallbladder and biliary tract cancers: insights from the global burden of disease study 2021.

Background: Gallbladder and biliary tract cancers (GBC and BTC) are highly malignant, with poor prognoses and substantial regional variability in the disease burden. Although advances in medical science have improved outcomes in high-income regions, low- and middle-income regions continue to face rising incidence and mortality rates owing to delayed detection and treatment. Understanding the global trends and risk factors of GBC and BTC is essential for targeted interventions to reduce disease burden.

Improvement of the Wear and Corrosion Resistance of CrSiN Films on ZE52 Magnesium Alloy Through the DC Magnetron Sputtering Process.

The utilization of magnesium alloys as lightweight structural materials is becoming increasingly prevalent, particularly within the fields of electronics, automotive engineering, and defense. These alloys display high specific strength and excellent heat dissipation properties. The magnesium-zinc-rare earth alloy ZE52 displays superior formability and strength-ductility when compared to conventional magnesium alloys.

Intravascular imaging-guided versus angiography-guided percutaneous coronary intervention in patients with diabetes mellitus: Rationale and design of an international, multicenter, randomized IVI-DIABETES trial.

Background: Intravascular imaging (IVI)- guided percutaneous coronary intervention (PCI) can improve clinical outcomes compared with angiography guidance in patients with complex lesions or acute coronary syndrome. However, the impact of this approach among diabetic patients remains unknown.

Trial Design: IVI-DIABETES trial is an investigator-initiated, prospective, international, multicenter, randomized trial, involving at least 30 sites, aiming to enroll 1,332 diabetic patients with obstructive coronary artery disease undergoing PCI.

Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes.

Hepatic organoid cultures are a powerful model to study liver development and diseases in vitro. However, hepatocyte-like cells differentiated from these organoids remain immature compared to primary human hepatocytes (PHHs), which are the benchmark in the field. Here, we applied integrative single-cell transcriptome and chromatin accessibility analysis to reveal gene regulatory mechanisms underlying these differences.

LncRNA-AC006129.1 Aggravates kidney hypoxia-ischemia injury by promoting CXCL2-dependent inflammatory response.

Purpose: Hypoxia ischemia (HI) injury is an inevitable risk factor in kidney transplantation. The inflammatory response is crucial in HI. Long non-coding RNAs (lncRNAs) are known to regulate inflammation and immunity, but their role in HI remains unclear.