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Background: Mercury ions, a toxic heavy metal, pose a significant threat to environmental health, leading to pollution and accumulation in living organisms.
Results: In this study, we have developed a novel ratiometric near-infrared fluorescent probe for the detection of Hg. The probe TM-ND-Hg demonstrated a remarkable Stokes shift (358 nm), a rapid response time (within 1 min), excellent selectivity, stability, and ratiometric fluorescence changes from green to red. Moreover, the probe enabled the portable detection of Hg through color recognition software, which can discern color alterations.
Significance: The probe has been successfully applied to monitor Hg in living A549 cells, zebrafish, and real water samples, showcasing its potential for environmental and biological monitoring.
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http://dx.doi.org/10.1016/j.aca.2025.344176 | DOI Listing |
Spectrochim Acta A Mol Biomol Spectrosc
September 2025
College of Chemistry, Chemical Engineering and Material Science, Soochow University, No. 199 Ren'Ai Road, Suzhou 215123, China; Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China. Electronic address: g
The dynamic monitoring of cell death processes remains a significant challenge due to the scarcity of highly sensitive molecular tools. In this study, two hemicyanine-based probes (5a-5b) with D-π-A structures were developed for organelle-specific viscosity monitoring. Both probes exhibited correlation with the Förster-Hoffmann viscosity-dependent relationship (R > 0.
View Article and Find Full Text PDFJ Fluoresc
September 2025
School of Intelligent Manufacturing, Huzhou College, Huzhou, 313000, P.R. China.
The antibiotic contamination in aquatic environments, particularly in aquaculture systems, poses substantial risks to ecological balance and human health. To address this issue, we engineered a novel ratiometric fluorescent probe utilizing dual-emission carbon dots (D-CDs) synthesized from sustainable biomass carrot and nitrogen-rich precursors (melamine and o-phenylenediamine) through an efficient one-pot hydrothermal approach. The D-CDs exhibited dual emission peaks at 425nm and 540 nm under 370nm excitation.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
Hebei Key Laboratory of Public Health Safety, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Public Health, College of Chemistry and Materials Science, Hebei University, Baoding, 071002, China.
This work presents the development of a highly sensitive, selective, and efficient aptamer-based fluorescent sensor for detecting cortisol in human urine. Carbon quantum dots-nucleic acid aptamer (CQDs-Apt) synthesized with excellent photoluminescent properties and stability, were selected as the fluorescent probe. In the presence of MoS-NSs, CQDs-Apt adsorbed onto the surface of MoS-NSs via electrostatic and π-π interactions, leading to strong and rapid fluorescence quenching due to static quenching mechanism between them.
View Article and Find Full Text PDFChem Asian J
September 2025
School of Chemistry and Chemical Engineering, Hainan University, Haikou, 570228, China.
Molecules that exhibit excited-state intramolecular proton transfer (ESIPT) have demonstrated great promise in fluorescent probes. The electronic effect of substituents has an important influence on the ESIPT process. In this study, we investigated the effects of substituents on the ESIPT mechanism and the photophysical behavior of single-benzene fluorophore (SBF) derivatives with computational chemistry methods.
View Article and Find Full Text PDFChemistry
September 2025
International School for Optoelectronic Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by β-amyloid (Aβ) deposition, imposing significant social and economic burdens globally. Despite extensive efforts have been devoted to developing fluorescent probes for Aβ imaging, further improving the luminescent efficiency of prevailing probes still remains a significant challenge. Herein, we investigated the inner mechanism of constructing high-efficient Aβ probes via a structural cyclization strategy.
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