Gosha-Jinki-Gan Reduces Inflammation in Chronic Ischemic Stroke Mouse Models by Suppressing the Infiltration of Macrophages.

Ischemic stroke is a primary cause of cerebrovascular diseases and continues to be one of the leading causes of death and disability among patients worldwide. Pathological processes caused by vascular damage due to stroke occur in a time-dependent manner and are classified into three categories: acute, subacute, and chronic. Current treatments for ischemic stroke are limited to effectiveness in the early stages.

Graph-based multi-modality network for axillary lymph node metastasis prediction in early-stage breast cancer.

Background And Objective: Accurate evaluation of the axillary lymph node (ALN) status in early-stage breast cancer is crucial for prognosis and guiding treatment decisions, while also preventing unnecessary surgeries and postoperative complications. Numerous methods have been proposed for ALN status classification using radiomic images which face the challenge of low diagnostic accuracy. This study aims to explore the potential of multi-modality that integrates clinical parameters and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to provide complementary information for image features, thereby enhancing the model's ability to predict ALN metastasis.

Construction of a Multimodal Machine Learning Model for Papillary Thyroid Carcinoma Based on Pathomics and Ultrasound Radiomics Dataset.

The use of machine learning to integrate and analyse multimodal information has broad prospects for enhancing the precision of tumour diagnosis. Our study constructed a multimodal diagnostic model for papillary thyroid carcinoma (PTC) by integrating pathomics and ultrasound radiomics characteristics using artificial intelligence machine learning methods, aiming to improve the efficiency of pathologists. A retrospective analysis was conducted on 222 cases with postoperative diagnoses of PTC and 163 cases with postoperative diagnoses of benign thyroid nodules.

Semiconductor MOF Metamaterials Enable Thin Structures with Robust Electromagnetic Wave Absorption.

Developing thin electromagnetic wave (EMW) absorbers with ultra-broadband absorption is challenging, as current designs often struggle to achieve high causality efficiency (R), which measures effective absorption bandwidth (EAB) relative to thickness (ideal R is 1). Herein, a broadband semiconductor metal-organic framework (SC-MOF) metamaterial is proposed that approaches the R limit. The design synergizes both the micro and macro properties of the materials.

Construction and application of a NIR benzothianone-based ratiometric fluorescent probe for visual detection of Hg in biological systems and water samples.

Background: Mercury ions, a toxic heavy metal, pose a significant threat to environmental health, leading to pollution and accumulation in living organisms.

Results: In this study, we have developed a novel ratiometric near-infrared fluorescent probe for the detection of Hg. The probe TM-ND-Hg demonstrated a remarkable Stokes shift (358 nm), a rapid response time (within 1 min), excellent selectivity, stability, and ratiometric fluorescence changes from green to red.

Pharmacological Effects and Immune Mechanisms of Oriental Medicines in Restoring Male Infertility.

Male infertility can be the result of many factors, including pathologies in the motility and formation of sperm and obstructions in the genitourinary system. Oriental medicine, using multiple components to address various targets and enhance therapeutic effectiveness, has been used to treat male infertility for thousands of years. Given the complex pathological mechanisms of aspermatogenesis, this multi-target approach in oriental medicine is believed to positively impact the prevention of male infertility.

Multi-pathway fusion network for early-stage breast tumor segmentation from MRI.

Background: Breast cancer is one of the most common cancers in women, with a notably high mortality rate. Early diagnosis can improve survival rates. However, early-stage breast tumors suffer challenges for accurate detection and are hard to detect due to their tiny sizes and blurry edges, thereby obtaining degraded performance.

Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats.

Introduction: This study assesses the effects of chronic high-altitude hypoxia on blood pressure regulation in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats, focusing on cardiovascular remodelling, hemodynamic alterations, and renin-angiotensin system (RAS) modulation.

Methods: Eight-week-old male SHR and WKY rats were divided into four groups: the SHR high-altitude hypoxia group (SHR-H), WKY high-altitude hypoxia group (WKY-H), SHR control group (SHR-C), and WKY control group (WKY-C). The hypoxia groups were exposed to 4,300 m (PaO: 12.

Barriers and Facilitators of Cardiac Rehabilitation in a Middle-Income Country: A Qualitative Study from China.

Background: Although effective and recommended by guidelines worldwide, Cardiac Rehabilitation (CR) remains scarce and underutilized. CR implementation has taken place in middle-income countries, but the progress is influenced by both positive and negative factors that remain underexplored. This study identified the barriers and facilitators of CR in a middle-income country, specifically China.

Enhanced optical encryption via polarization-dependent multi-channel metasurfaces.

Optical encryption offers a powerful platform for secure information transfer, combining low power consumption, high-speed transmission, and intuitive visualization. Metasurfaces, with their unprecedented ability to manipulate light across multiple degrees of freedom within quasi-two-dimensional nanostructures, are emerging as promising devices for advanced encryption. However, encryption capacity remains constrained by limited information channels.

Morphology of the Calcaneofibular Ligament Reflects Degeneration of the Talonavicular Articular Surface: A Cadaver Study.

Osteoarthritis is caused by damage to the articular cartilage due to bone-on-bone collisions and friction. The length, width, and thickness of the ligaments are expected to change in order to regulate excessive bone-to-bone movement. We aimed to clarify the relationship between ligament morphology and joint surface degeneration in the ankle joints using macroscopic observations and measurements.

Temperature-Robust Broadband Metamaterial Absorber via Semiconductor MOFs/Paraffin Hybridization.

The demand for temperature-robust electromagnetic wave (EMW) absorption materials is escalating due to the varying operational temperatures of electronic devices, which can easily soar up to 100 °C, significantly affecting EMW interference management. Traditional absorbers face performance degradation across broad temperature ranges due to alterations in electronic mobility and material impedance. This study presented a novel approach by integrating semiconductor metal-organic frameworks (SC-MOFs) with paraffin wax (PW), leveraging the precise control of interlayer spacing in SC-MOFs for electron mobility regulation and the introduction of paraffin wax for temperature-inert electromagnetic properties.

Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.

Anaplastic thyroid cancer (ATC) is the most lethal tumor arising from thyroid follicular epithelium. Lenvatinib is an off-label use option for ATC patients in many countries but an approved prescription in Japan. However, lenvatinib resistance is a substantial clinical challenge.

Hyperbolic response and low-frequency ultra-flat plasmons in inhomogeneous charge-distributed transition-metal monohalides.

Plasmon, the collective oscillations of free electron gas in materials, determines the long-wavelength excitation spectrum and optical response, are pivotal in the realm of nanophotonics and optoelectronics. In this study, using the first-principles calculations, we systematically investigated the dielectric response and plasmon properties of bulk transition-metal monohalides MXs (M = Zr, Mo; X = Cl, F). Due to the strong electronic anisotropy, MXs exhibit a broadband type-II hyperbolic response and direction-dependent plasmon modes.

An Artificial Intelligence-Driven Preoperative Radiomic Subtype for Predicting the Prognosis and Treatment Response of Patients with Papillary Thyroid Carcinoma.

Purpose: From 8% to 28% of patients with papillary thyroid carcinoma (PTC) experience recurrence, complicating risk stratification and treatment. We previously identified an inflammatory molecular subtype of PTC associated with poor prognosis. Based on this subtype, we aimed to develop and validate a noninvasive radiomic signature to predict prognosis and treatment response in patients with PTC.

Association between breastfeeding, mammographic density, and breast cancer risk: a review.

Background: Mammographic density has been associated with breast cancer risk, and is modulated by established breast cancer risk factors, such as reproductive and hormonal history, as well as lifestyle. Recent epidemiological and biological findings underscore the recognized benefits of breastfeeding in reducing breast cancer risk, especially for aggressive subtypes. Current research exploring the association among mammographic density, breastfeeding, and breast cancer is sparse.

Bibliometric study of the application of the chicken embryo chorioallantoic membrane model in cancer research: the top 100 most cited articles.

The chicken embryo chorioallantoic membrane (CAM) model has played a crucial role in various aspects of cancer research. The purpose of this study is to help researchers clarify the research direction and prospects of the CAM model. A bibliometric analysis was conducted on the top 100 most cited articles on use of the CAM model in tumour research, retrieved from the Web of Science Core Collection database.