Developing a predictive nomogram model for incidence of adverse outcomes in oral and maxillofacial tumor patients undergoing free flap reconstruction.

Background: Surgical treatment of oral and maxillofacial tumors is complex, and the factors contributing to adverse outcomes remain incompletely understood. This study aimed to identify independent risk factors and develop an efficient nomogram for predicting such outcomes.

Methods: Potential risk factors were identified using univariate logistic regression, followed by multivariate logistic regression to determine independent predictors.

Mapping evolutionary paradigm of bovine viral diarrhea virus associated with different organizations of nucleotide.

The non-structural protein (Npro) of bovine viral diarrhea virus (BVDV) is a crucial virulence factor that impairs the host's antiviral immune response and facilitates virus production. This study establishes a foundation for understanding how different selective pressures influence the formation of nucleotide pairs, synonymous codon, and context-dependent codon bias (CDCB) in BVDV . BVDV genotype 1 exhibits a greater number of subgenotypes compared to other genotypes, yet its overall nucleotide usage bias in is stronger.

High-Efficiency Strategy for Reducing Decomposition Potential of Lithium Formate as Cathode Prelithiation Additive for Lithium-Ion Batteries.

Lithium-ion batteries (LIBs) have attracted extensive attention as a distinguished electrochemical energy storage system due to their high energy density and long cycle life. However, the initial irreversible lithium loss during the first cycle caused by the formation of the solid electrolyte interphase (SEI) leads to the prominent reduction in the energy density of LIBs. Notably, lithium formate (HCOOLi, LFM) is regarded as a promising cathode prelithiation reagent for effective lithium supplementation due to its high theoretical capacity of 515 mAh·g.

Connecting generations: an integrative review of intergenerational technology programs and older adults' technology use.

Older adults have adopted new information technologies at lower rates than their younger counterparts. This is a concern as the integration of information technologies into society continues to advance, while older adults are among those who can potentially reap the greatest benefits from these technologies. Intergenerational Programs (IGPs), which pair older and younger adults for learning and socializing, are strong vehicles for countering the age usage gap.

Size-segregated emission characteristics and associated toxicity of polycyclic aromatic compounds from agricultural machinery.

Non-road agricultural machinery (AM) emissions now exceed road vehicles as major atmospheric particulate contributors in China. Though recent changes to fuels and emission standards have been implemented, their effects on particle size-resolved chemical compositions and public health impacts remain poorly understood. This study systematically analyzed the particle size-resolved polycyclic aromatic compounds (PACs) chemical composition from 5 AM, evaluating the impacts of fuel type (diesel B0, biodiesel B5/B20), emission standards (stage II/III), and working status (idling, moving, working) on emission characteristics and health risks.

Injectable Antimicrobial Quaternary Chitosan Salt/Tannic Acid as a Delivery Platform for Enhanced Cranial Bone Regeneration via the Synergy of BMP-2 and VEGF.

Treating large, irregularly shaped bone defects continues to be a major challenge in clinical practice. In this work, an innovative injectable antimicrobial delivery platform is introduced. The therapeutic system leverages the combination of quaternary chitosan salt (QCS) and tannic acid (TA), synergistically supplemented with BMP-2 and VEGF, to enhance the regenerative efficacy.

DreamStory: Open-Domain Story Visualization by LLM-Guided Multi-Subject Consistent Diffusion.

Story visualization aims to create visually compelling images or videos corresponding to textual narratives. Despite recent advances in diffusion models yielding promising results, existing methods still struggle to create a coherent sequence of subject-consistent frames based solely on a story. To this end, we propose DreamStory, an automatic open-domain story visualization framework by leveraging the LLMs and a novel multi-subject consistent diffusion model.

Service delivery costs of vaccination at health facilities in Guangzhou, China.

Regular, comprehensive, and effective cost analyses of immunization services are essential for evaluating whether current policy subsidies are suitable for these services. However, such studies are relatively limited in China. This study is the first comprehensive investigation of the costs of immunization services in Guangzhou City.

Dual VEGF-Targeting Strategy Via AAV2-Delivered sFLT-1 and shVEGF for Retinal Neovascularization Therapy.

Purpose: Retinal neovascular diseases, often associated with elevated vascular endothelial growth factor (VEGF) levels, are major causes of blindness. Current therapies lack sustained efficacy and safety. This study aimed to evaluate the effectiveness of an adeno-associated virus 2 (AAV2)-based gene therapy vector carrying soluble fms-like tyrosine kinase-1 (sFLT-1) and short hairpin RNA targeting VEGF (shVEGF) in treating retinal neovascularization.

Association of hematological malignancies with clinical and financial outcomes following transcatheter aortic valve replacement.

Background: While Transcatheter Aortic Valve Replacement (TAVR) is increasingly performed in patients with severe aortic stenosis, the impact of Hematologic Malignancies (HM) on associated outcomes, remains unclear. The authors The authors used a contemporary national database to investigate whether HM is associated with adverse clinical and financial outcomes following elective TAVR.

Materials And Methods: The authors The authors identified all adult (≥ 18-years) hospitalizations for elective TAVR in the 2016-2021 Nationwide Readmissions Database.

Midterm Outcomes of Pediatric Mitral Valvuloplasty for Moderate to Severe Mitral Valve Regurgitation and Associated Risk Factors for Postoperative Deterioration.

Background: Mitral valvuloplasty is considered the best treatment for pediatric mitral valve regurgitation. The objective of this analysis was to identify risk factors for postoperative mitral valve regurgitation progression and evaluate valvuloplasty effectiveness.

Methods: This retrospective, single-center study investigated the clinical efficacy of mitral valvuloplasty and identified factors that affect prognosis.

Uncovering the molecular mechanisms of Qingdu Zengye Decoction in the treatment of nasopharyngeal carcinoma: an integrative investigation.

Background: Nasopharyngeal carcinoma (NPC) remains a therapeutic challenge due to its aggressive nature and limited treatment efficacy. Traditional Chinese Medicine, particularly Qingdu Zengye Decoction (QZD), has shown clinical potential, but its mechanistic basis in NPC treatment requires elucidation.

Purpose: This study aims to elucidate the mechanisms of action of QZD in the treatment of NPC, focusing on its multi-target regulatory effects on cell apoptosis, oncogenic signaling pathways, and tumor immune microenvironment.

Investigation on the Carrier Dynamics in P-I-N Type Photovoltaic Devices with Different Step-Gradient Distribution of Indium Content in the Intrinsic Region.

InGaN-based photovoltaic devices have attracted great attention due to their remarkable theoretical potential for high efficiency. In this paper, the influence of different distributions of step-gradient indium content within the intrinsic region on the photovoltaic performance of P-I-N type InGaN/GaN solar cells is numerically investigated. Through the comprehensive analysis of carrier dynamics, it is found that for the device with the indium content decreasing stepwise from 50% at the top to 10% at the bottom in intrinsic region, the photovoltaic conversion efficiency is increased to 10.

Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.

Hepatic fibrosis progression involves complex multicellular crosstalk, highlighting the critical need to identify key therapeutic targets. In this study, we identify insulin-like growth factor binding protein 6 (IGFBP6) as a marker specifically enriched in hepatic stellate cells (HSCs) and upregulated in viral hepatitis-associated fibrosis. Using thioacetamide (TAA)-induced mouse models and transforming growth factor-β (TGF-β)-stimulated cell models, we demonstrate the pro-fibrotic role of IGFBP6.

NLRP3 Inflammasome: A New Perspective on Revealing Hotspots and Trends in Uric Acid Metabolism Disorders through Bibliometric Analysis.

Uric acid metabolism disorders have become major health concerns, primarily causing conditions such as hyperuricemia, uric acid nephropathy, and gout. Recent research has focused on these disorders' underlying pathological mechanisms and pharmacological treatments, emphasizing the role of the NLRP3 inflammasome. This study aims to analyze and summarize the current research status, hotspots, and trends in this field from a new perspective of the NLRP3 inflammasome, providing insights for future research and disease treatment.

Outcomes and costs in splenectomy after failed splenic arterial embolization for blunt splenic injury.

Background: Splenic injury (BSI) is present in nearly 45 % of abdominal blunt trauma cases in the US and splenic artery embolization (SAE) has been increasingly utilized to manage BSI in recent years. However, SAE failure necessitating delayed splenectomy remains a critical concern with significant implications for patient outcomes and healthcare resource utilization.

Methods: We conducted a retrospective cohort study utilizing the 2016-2021 Nationwide Readmissions Database.

Persistent racial disparities in the use of high-volume esophagectomy centers in the United States.

Background: Although the volume-outcome relationship in esophagectomy has been established, disparities in the use of high-volume esophagectomy centers persist. The present study examined the representation of various racial groups undergoing esophagectomy at high-volume hospitals and explored the associated clinical and financial outcomes.

Methods: All elective adult (≥18 years) hospitalizations entailing esophagectomy were identified in the 2012-2021 National Inpatient Sample.

Kagome electronic states in gradient-strained untwisted graphene bilayers.

Moiré superlattices in twisted homo-bilayers have revealed exotic electronic states, including unconventional superconductivity and correlated insulating phases. However, their fabrication process often introduces moiré disorders, hindering reproducibility and experimental control. Here, we propose an alternative approach using gradient strain to construct moiré superlattices in untwisted bilayer graphene (gs-BLG).

Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories.

Human brain charts provide unprecedented opportunities for decoding neurodevelopmental milestones and establishing clinical benchmarks for precision brain medicine . However, current lifespan brain charts are primarily derived from European and North American cohorts, with Asian populations severely underrepresented. Here, we present the first population-specific brain charts for China, developed through the Chinese Lifespan Brain Mapping Consortium (Phase I) using neuroimaging data from 43,037 participants (aged 0-100 years) across 384 sites nationwide.

Eradicating fungal biofilm-based infections by ultrasound-assisted semiconductor sensitized upconversion photodynamic therapy.

Fungal biofilms, as self-produced extracellular polymeric substances that resist antifungal agents and immune defense, represent a major cause of treatment failure and recurrent infections. Therefore, it is of great importance to eradicate fungal biofilms to achieve efficient therapy. This study develops a synergistic reactive oxygen species (ROS)-enhanced strategy to eradicate Candida albicans biofilms by designing ultrasound-light dual-responsive nanohybrids (UCNP@CR).

Diversity of endophytic bacteria in mulberry ( spp.) scions with different genetic resources.

Endophytic bacteria in plants play crucial roles in promoting plant growth, facilitating nutrient acquisition, and enhancing stress tolerance. Although many studies have recently investigated endophytic bacteria in plants, the characteristics of endophytic bacterial communities in germplasm resource populations have rarely been reported. In this study, we investigated the endophytic bacterial communities of 21 mulberry scions, representing both wild and cultivated resources, all grafted onto a common rootstock and grown under identical cultivation conditions.

C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001-2010.

Background: Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP.

Methods: Participants from NHANES 2001-2010 were enrolled.

Palmitoylation Dynamics in Systemic Lupus Erythematosus: Multi-Omics Insights and Potential Therapeutic Implications.

Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by immune dysregulation. The role of palmitoylation in regulating immune responses and its contribution to SLE pathogenesis remains insufficiently understood.

Methods: We conducted a multi-omics analysis using the GSE61635 dataset to identify differentially expressed genes (DEGs) in SLE.

Improved noninvasive diagnostic evaluations in treatment-naïve adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome.

Background: Bilateral inferior petrosal sinus sampling (BIPSS) is important in the differential diagnosis of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome, but BIPSS is invasive and is not reliable on tumor lateralization. Thus, we evaluated the noninvasive diagnostic evaluations, high-dose dexamethasone suppression test (HDDST) combined with different pituitary MRI scans (conventional contrast-enhanced MRI [cMRI], dynamic contrast-enhanced MRI [dMRI], and high-resolution contrast-enhanced MRI [hrMRI]), by comparison with BIPSS.

Methods: We retrospectively analyzed 95 patients with ACTH-dependent Cushing's syndrome who underwent HDDST, preoperative MRI scans (cMRI, dMRI and hrMRI) and BIPSS in our hospital between January 2016 and December 2021.