Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP.
Methods: Participants from NHANES 2001-2010 were enrolled. CMI was computed based on anthropometric and biochemical indexes, covering height, waist circumference, triglyceride, and high-density lipoprotein cholesterol. OA diagnosis data were derived from the Medical Conditions questionnaires. Multivariate logistic regressions, restricted cubic spline (RCS) analysis, subgroup analyses, and interaction tests were implemented to investigate the association. A mediation analysis was employed to verify the mediating role of CRP.
Results: After controlling for all covariates, CMI was significantly linked with OA (OR: 1.07, 95% CI (1.01, 1.13), P = 0.038). RCS analyses elicited a non-linear link between CMI and OA (P - non - linear = 0.0012). The inflection point was 0.54. Threshold effect analysis was conducted through two-segment linear regression, including the left side ( < = 0.54) (OR: 2.06, 95% CI: 1.03, 6.58) and the right side of the inflection point (> 0.54) (OR: 0.40, 95% CI: 0.15, 1.03). CRP partially mediated the link between CMI and OA, around 7.59% of the total effect.
Conclusion: CMI is positively linked with OA, with CRP mediating the link. This paper unveils novel perspectives on the mechanism that links CMI to OA. Managing CMI and monitoring CRP levels may alleviate OA.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232760 | PMC |
| http://dx.doi.org/10.1186/s12944-025-02603-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hyperhomocysteinemia in chronic schizophrenia: prevalence, clinical correlates, and paradoxical associations with symptom severity.
Eur Arch Psychiatry Clin Neurosci
September 2025
Tianjin Anding Hospital, Institute of Mental Health, Psychiatric Medical Center of Tianjin University, Mental Health Center of Tianjin Medical University, 13 Liulin Road, Tianjin, 300222, China.
Background: Elevated homocysteine levels, known as hyperhomocysteinemia (HHcy), have been implicated in the pathophysiology of schizophrenia. Most prior studies focused on first-episode or acute-phase schizophrenia patients, leaving the prevalence, determinants, and clinical correlates of HHcy in chronic schizophrenia understudied. This study aims to investigate the prevalence and determinants of HHcy in patients with chronic schizophrenia, as well as its clinical correlates.
View Article and Find Full Text PDF[Interleukin-6 as a biochemical marker of intestinal anastomotic leakage].
Khirurgiia (Mosk)
September 2025
Saint Petersburg State University, Saint Petersburg, Russia.
Objective: To evaluate diagnostic significance of IL-6 compared to CRP for early detection of anastomotic leakage after colon resection for colorectal cancer.
Material And Methods: The study included 277 patients who underwent total resection for colorectal cancer. Patients were retrospectively divided into three groups: without complications (=227), with anastomotic leakage (=30), and other postoperative complications (=20).
[Clinical and laboratory aspects of ultrasound treatment for chronic wounds].
Khirurgiia (Mosk)
September 2025
Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
Objective: To evaluate clinical and laboratory effectiveness of ultrasound treatment for purulent wounds.
Material And Methods: The study enrolled 46 patients with purulent wounds divided into the main group (23 patients, ultrasonic treatment) and the control group (23 patients, traditional treatment). We assessed treatment effectiveness considering visual data, quality of granulation tissue, wound defect area and marginal epithelialization, complete blood count and C-reactive protein.
Robotic arm-assisted total knee arthroplasty reduces postoperative inflammatory response and blood loss compared to manual total knee arthroplasty: A matched-pairs analysis of 688 patients.
Knee Surg Sports Traumatol Arthrosc
September 2025
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Purpose: Robotic arm-assisted total knee arthroplasty (raTKA) has demonstrated several advantages over manual TKA (mTKA), including enhanced early recovery. Reduced soft tissue trauma and avoidance of femoral intramedullary canal opening have been hypothesised to lower the systemic inflammatory response. However, findings from previous small-cohort studies have been inconsistent.
View Article and Find Full Text PDFStudy of Clinical Profile of Patients of Acute Kidney Injury in Critically Ill Patients.
Ann Afr Med
September 2025
Department of General Medicine, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.
Background: Acute kidney injury (AKI) represents one of the most challenging and common complications encountered in critically ill patients admitted to intensive care units (ICUs) worldwide. This sudden deterioration in kidney function substantially contributes to morbidity and mortality in the intensive care setting, prolongs hospital stays, and increases healthcare costs.
Objective: The objective of this study is to study the clinical profile, etiology, complications, and outcomes of AKI in critically ill patients admitted to the medicine ICU.