NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS.

Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) has become a pressing clinical issue due to its unclear etiology and severe, persistent pelvic pain. Despite extensive research, the pathogenesis of IC/BPS remains unresolved, and current treatments primarily target symptom relief rather than addressing underlying disease mechanisms. This study aimed to investigate the effects of nuclear factor erythroid 2-related factor 2 (NRF2) on IC/BPS and the potential molecular mechanisms.

Construction of Fused-Bridged Tricycles by Molecular Reorganization Involving Prins Cyclization/Dicycloexpansion.

The development of efficient methods for constructing structurally complex and diverse polycyclic carbon frameworks remains in high demand for the synthesis of pharmaceuticals and bioactive natural products. One such method lies in engineered one-step molecular reorganization through the cascade cyclization/cycloexpansion of rationally designed precursors with interconnected small-ring systems. Here, we have strategically designed and developed a synthetically valuable method to construct fused-bridged tricyclic systems through cascade Prins cyclization/dicycloexpansion of substrates with a cycloalkylidene (CAD) tethered to a cycloketones.

Sodium zirconium cyclosilicate (Lokelma) to enable ACEIs/ARBs use in the treatment of patients with diabetic kidney disease.

Aims: In diabetic kidney disease (DKD), Angiotensin-converting enzyme inhibitors (ACEIs)/ angiotensin receptor blockers (ARBs) are key treatments but may cause hyperkalemia. This randomized controlled trial (RCT) firstly evaluates sodium zirconium cyclosilicate (SZC) to optimize renin-angiotensin-aldosterone system inhibitor (RAASi) use in DKD, addressing evidence gaps in this field.

Methods: This 24-weeks prospective multicenter study enrolled 86 DKD patients at hyperkalemia risk to SZC + ACEIs/ARBs or ACEIs/ARBs alone.

Preparation of hafnium nitride-coated titanium implants by magnetron sputtering technology and evaluation of their antibacterial properties and biocompatibility.

Hafnium nitride (HfN) coatings with different thicknesses and various composition ratios were successfully fabricated on the surface of titanium alloys by magnetron sputtering, and their antibacterial properties and biocompatibility were evaluated. The structures of the coatings were characterized by X-ray diffraction (XRD; DX-2700BH diffractometer) in symmetric -2 scanning mode. The surface morphologies of the coatings were characterized by scanning electron microscopy (SEM; Nova NanoSEM450).

Lupus nephritis association with idiopathic CD4 + T lymphocytopenia: a case report of a young man with recalcitrant warts.

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system is in a disordered state, with excessive production of autoantibodies and abnormal functions of immune cells. This imbalance in the immune system alters the body's defense capabilities against various pathogens. Patients with idiopathic CD4⁺ T lymphocytopenia (ICL) have a reduced number of lymphocytes, and the function of the immune system is also impaired.

The non-metabolic function of 6PGD coordinates CCNA2 and HMGA2 expression to drive colorectal cancer progression and drug response.

Emerging evidence demonstrates that the metabolic and non-metabolic functions of metabolic enzymes play a key role in tumorigenesis and progression. 6-phosphogluconate dehydrogenase (6PGD) is a key metabolic enzyme in the pentose phosphate pathway (PPP), which displays aberrant expressions and functions in cancer. However, whether 6PGD serves non-metabolic functions in regulating cancer progression and drug response has not been reported.

Honokiol rescues progranulin deficiency in pathogen-induced and genetically driven neurodegeneration: Bridging veterinary models with therapeutic development.

Progranulin (PGRN), a crucial regulator of lysosomal function, is deficient in several neurodegenerative disorders. Restoring PGRN levels with small molecules presents a promising therapeutic strategy for these conditions. Honokiol (HNK), a polyphenolic compound known for its neuroprotective effects, has demonstrated potential in various neurodegenerative diseases (ND), though its precise mechanisms remain unclear.

Optimizing nitrogen application frequency to enhance the post-flowering matter accumulation, yield and water/nitrogen use efficiency of densely planted and drip-irrigated maize.

Background: Maize yield stability is crucial for China's national food security. Conventional irrigation and nitrogen application methods have problems like low yield, inefficiency and environmental pollution. Optimizing water/fertilizer management is therefore imperative.

Maize Plant Morphology Affects Resistance to Stalk Breaking by Affecting Plant Stress.

The critical wind speed for stalk breaking is a direct and rapid method for evaluating stalk-breaking resistance. Maize lodging resistance is determined by the plant's wind-induced stress and the stalk's mechanical strength, yet the factors influencing plant stress remain unclear. This study analyzed the quantitative relationship between plant leaf area, weight, and stalk base torque by implementing different leaf-cutting and ear-removal treatments.

Hydrogen sulfide and its donors for the treatment of traumatic brain injury: A comprehensive review.

This article reviews the potential role of hydrogen sulfide (HS) and its donors in the treatment of traumatic brain injury (TBI), a common form of neurotrauma with a complex pathomechanism involving cerebral edema, cell death, inflammatory response, and oxidative stress. As an endogenous regulatory molecule, HS possesses various protective effects, such as anti-inflammatory, antioxidant, and anti-cellular death. The article discusses the endogenous pathways of HS production (via CSE, CBS, and 3-MST enzymes) and the application of exogenous donors (e.

Elevated Trimethylamine-N-oxide (TMAO) Is Associated with Vascular Access Dysfunction in Maintenance Hemodialysis Patients.

Introduction: Elevated levels of trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbiota, have been associated with cardiovascular diseases and complications in various populations. However, its role in vascular access dysfunction in hemodialysis patients remains underexplored. This study investigates the potential relationship between TMAO levels and vascular access dysfunction in maintenance hemodialysis patients.

Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma.

Lung cancer remains the leading cause of malignant tumors worldwide in terms of the incidence and mortality, posing a significant threat to human health. Given that distant metastases typically occur at the time of initial diagnosis, leading to a poor 5-year survival rate among patients, it is crucial to identify markers for diagnosis, prognosis, and therapeutic efficacy monitoring. Abnormal glycosylation is a hallmark of cancer cells, characterized by the disruption of core fucosylation, which is predominantly driven by the enzyme fucosyltransferase 8 (FUT8).

Cutaneous Pigment Cell Distributions and Skin Structure of Xenopus.

Pigment cells not only are intrinsic factors to determine animal patterns, but also play vital roles in numerous behavioral and physiological processes as well as health, such as melanomas originating from melanocytes. Model organisms are commonly used to study pigment cell development and the mechanisms underlying related diseases, with zebrafish and mice, and Xenopus being well-established examples. Xenopus tropicalis, a diploid amphibian model, offers advantages such as high fecundity and easily observable pigment cell development.

Doped-free structure is used to realize organic light-emitting devices with low blue harm, low color temperature, and high color rendering index.

With the development of light-emitting devices, researcher gradually shift their attention from the efficiency of the devices to the health of lighting sources. Herein, we first designed a low correlated color temperature (CCT) and high color rendering index (CRI) spectrum with minimal blue light accession, which is beneficial to reduce the inhibitory effect of melatonin secretion. Besides, the spectrum had suitable near-infrared light with a wavelength of 670-810 nm, which could promote cellular metabolism, migration, and value-added, achieving more comfortable and healthy lighting.

Clinical study of real-time three-dimensional echocardiography combined with radionuclide imaging to evaluate changes in cardiac function and synchronization before and after cardiac rehabilitation in patients with acute myocardial infarction.

Objective: This research aimed to unveil the effects of real-time three-dimensional echocardiography (RT-3DE) combined with radionuclide imaging to evaluate changes in cardiac function and synchronization before and after cardiac rehabilitation in patients with acute myocardial infarction (AMI).

Methods: RT-3DE and radionuclide imaging were performed after PCI (pre-rehabilitation) and the 8-week follow-up visit (post-rehabilitation). Relevant data were collected: heart rate (HR), left ventricular (LV) end-systolic volume (LVESV), LV end-diastolic volume (LVEDV), LV ejection fraction (LVEF), LV 16-segment maximum difference in time to minimum systolic volume (Tmsv-16-Dif), LV 16-segment standard deviation of time to minimum systolic volume (Tmsv-16-SD), Tmsv 16-Dif % and Tmsv 16-SD %, summed Stress Score (SSS), Summed Rest Score (SRS), and SDS (SRS-SSS).

Mismatch Repair Status and Lymph Node Ratio in Survival Prediction of Stage II/III Rectal Cancer Patients: A Comprehensive Analysis of a Multi-Center Retrospective Study.

Background: The microsatellite status (dMMR vs. pMMR) in colorectal cancer can serve as a guiding factor for patient prognosis and treatment, where dMMR status indicates a better prognosis and often obviates the need for adjuvant chemotherapy (ACT). Conversely, a higher lymph node ratio (LNR) is associated with a poorer prognosis.

FGF19 is a biomarker associated with prognosis and immunity in colorectal cancer.

Objective: This study aimed to investigate the relationship between fibroblast growth factor 19 (FGF19) and the prognosis and immune infiltration of colorectal cancer (CRC) and identify the related genes and pathways influencing the onset and progression of CRC.

Introduction: The potential of FGF19 to guide the prognosis of CRC and inform immunotherapeutic strategies warrants further investigation.

Methods: We performed Quantitative Real-Time PCR to assess the expression of FGF19 and conducted a bioinformatics analysis to evaluate the impact of FGF19 expression on the clinical prognosis of CRC.

Patient selection and operative strategies for laparoscopic intersphincteric resection without diverting stoma.

Background: Diverting stoma (DS) is routinely proposed in intersphincteric resection for ultralow rectal cancer, but it is associated with increased stoma-related complications and economic burden. Appropriate patient selection and operative strategies to avoid stoma formation need further elucidation.

Aim: To select patients who may not require DS.

Research Advances in the Construction and Application of Intestinal Organoids.

The structure of intestinal tissue is complex. simulation of intestinal structure and function is important for studying intestinal development and diseases. Recently, organoids have been successfully constructed and they have come to play an important role in biomedical research.

Quantitative simulation of near-infrared light treatment for Alzheimer's disease using patient-individualized optical-parametric phantoms.

Significance: Alzheimer's disease (AD) is a brain disorder characterized by its multifactorial nature and complex pathogenesis, highlighting the necessity for multimodal and individualized interventions. Among emerging therapies, near-infrared (NIR) light treatment shows promise as a therapeutic modality for AD. However, existing clinical studies lack sufficient data on light dosimetry, parameter optimization, and dose-response.

Multi-resource constrained elective surgical scheduling with Nash equilibrium toward smart hospitals.

This paper focuses on the elective surgical scheduling problem with multi-resource constraints, including material resources, such as operating rooms (ORs) and non-operating room (NOR) beds, and human resources (i.e., surgeons, anesthesiologists, and nurses).

A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation.

Colorectal cancer (CRC), one of the diseases posing a threat to global health, according to the latest data, is the third most common cancer globally and the second leading cause of cancer-related deaths. The development and refinement of novel structures of small molecular compounds play a crucial role in tumor treatment and overcoming drug resistance. In this study, our objective was to screen and characterize novel compounds for overcoming drug resistance via the B Lymphoma Mo-MLV insertion region 1 (Bmi-1) reporter screen assay.

Meta-Analysis of Pulsed-Field Ablation Versus- High-Power Short-Duration Ablation for Atrial Fibrillation.

Purpose: To optimize the effectiveness and safety of pulmonary vein isolation, pulsed-field ablation (PFA) and high-power short-duration ablation (HPSD) have recently been incorporated into clinical practice. The objective of this study is to conduct a comparative analysis, focusing on the efficacy, safety, and procedural efficiency of PFA and HPSD in the treatment of atrial fibrillation (AF).

Methods: A thorough search was performed across multiple databases to identify trials that compared PFA with HPSD for AF from their inception until July 2024.

Effect of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer: a prospective observation study.

Background: Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes in the third-line and subsequent treatments of patients with microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance the antitumor effect of immunotherapy. However, the effect of RT exposure on patients receiving ICIs and targeted therapy remains unclear.