A lightweight small object detection model for UAV images based on deep semantic integration.

Most existing small object detection methods rely on residual blocks to process deep feature maps. However, these residual blocks, composed of multiple large-kernel convolution layers, incur high computational costs and contain redundant information, which makes it difficult to improve detection performance for small objects. To address this, we designed an improved feature pyramid network called L Feature Pyramid Network (L-FPN), which optimizes the allocation of computational resources for small object detection by reconstructing the original FPN structure.

Multi-omics insights into Chinese herbal medicine additives for mutton flavor enhancement: epigenetic and microbial mechanisms.

Chinese herbal medicine additives (CHMAs) have become increasingly popular as sustainable alternatives to synthetic compounds for improving the quality of mutton. However, the precise molecular mechanisms underlying their effects are not well understood. By integrating transcriptomic profiling, metabolomic pathways, and microbial community dynamics, this review deciphers the synergistic mechanisms of CHMAs in enhancing mutton flavor, supported by empirical evidence from 2014 to 2024.

LRDS-YOLO enhances small object detection in UAV aerial images with a lightweight and efficient design.

Small object detection in UAV aerial images is challenging due to low contrast, complex backgrounds, and limited computational resources. Traditional methods struggle with high miss detection rates and poor localization accuracy caused by information loss, weak cross-layer feature interaction, and rigid detection heads. To address these issues, we propose LRDS-YOLO, a lightweight and efficient model tailored for UAV applications.

Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis.

Introduction: Since their domestication, domestic sheep (Ovis aries) have been culturally and economically significant farming animals worldwide. Fat-tailed sheep serve as a unique genetic resource for understanding adipogenesis and adaptive evolution in livestock.

Objectives: Several genomic analyses have been conducted on various sheep breeds to elucidate the genome and regulation mechanism of the fat tail trait, prior genomic studies have failed to reconcile conflicting evidence about the genetic basis of tail morphology, particularly regarding the roles of PDGFD and BMP2.

Two-Generation Crossbreeding of White-Headed Suffolk and Small-Tailed Han Sheep: Heterosis, Sustainable Production Traits, and Morphological Features in Central China.

To address the bottleneck in meat production efficiency within China's mutton sheep industry, this study established a two-generation crossbreeding program between WHS rams and STH ewes. Hybrid offspring (F1 and BC1) were evaluated for growth performance, slaughter traits, meat quality, and reproductive performance. The F1 generation exhibited significant improvements over STH in 6-month body weight (52.

Genetic diversity, reproductive performance, and genetic enhancement strategies in Huang-Huai goats.

The Huang-huai goat, indigenous to China's Huang-Huai Plain, is celebrated for its exceptional reproductive capacity, succulent meat, and superior leather qualities. The Huang-huai goat's reproductive characteristics, genetic diversity, and the genetic underpinnings of intersexuality, aiming to inform conservation efforts and genetic resource management. Our study at monitored 600-800 female goats and 16-24 male goats from June 2020 to May 2022, adhering to NIH guidelines and with ethical approval from .

Caesarean Scar Endometrial Defects Contribute to Post-Caesarean Abnormal Uterine Bleeding and Chronic Endometritis: A Retrospective Case-Control Study.

Objective: To explore the role of endometrial defects in the pathogenesis of abnormal uterine bleeding (AUB).

Design: Retrospective case-control study.

Setting: Two tertiary centres.

The construction of a breast cancer prognostic model by combining genes related to hypoxia and endoplasmic reticulum stress.

Breast cancer (BC) is a malignant tumor that occurs in breast tissue. This project aims to predict the prognosis of BC patients using genes related to hypoxia and endoplasmic reticulum stress (ERS). RNA-seq and clinical data for BC were downloaded from TCGA and GEO databases.

The effects of optimized microstructured surfaces on bond strength and durability of NPJ-printed zirconia.

Objectives: This study was to investigate the effects of optimized microstructured surfaces on bond strength and bond durability of the latest nanoparticle jetting (NPJ)-printed zirconia.

Methods: Zirconia microstructured surfaces with different geometries and void volume were analyzed through three-dimensional finite element analysis for surface micromorphology optimization. Zirconia disks and cylinders were additively manufactured by an NPJ 3D printer (N = 128).

Whole-Genome Scanning for Selection Signatures Reveals Candidate Genes Associated with Growth and Tail Length in Sheep.

Compared to Chinese indigenous sheep, Western sheep have rapid growth rate, larger physique, and higher meat yield. These excellent Western sheep were introduced into China for crossbreeding to expedite the enhancement of production performance and mutton quality in local breeds. Here, we investigated population genetic structure and genome-wide selection signatures among the Chinese indigenous sheep and the introduced sheep based on whole-genome resequencing data.

Construction and Validation of a Nomogram Model to Predict the Severity of Pneumonia in Children.

Background: This study aimed to develop a nomogram model for early prediction of the severe pneumonia (MPP) in children.

Methods: A retrospective analysis was conducted on children with MPP, classifying them into severe and general MPP groups. The risk factors for severe MPP were identified using Logistic Stepwise Regression Analysis, followed by Multivariate Regression Analysis to construct the nomogram model.

Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels.

Phthalates (PAEs), a group of environmental endocrine disruptors, are associated with oxidative stress and have adverse effects on female ovarian reserves. However, this association has been poorly investigated, particularly with respect to clinical evidence. In this study, we provided clinical evidence of a relationship between exposure levels of PAEs, oxidative stress and decreased ovarian reserve (DOR).

Exosomes from ectopic endometrial stromal cells promote M2 macrophage polarization by delivering miR-146a-5p.

Background: Ectopic endometrial stromal cells (ESCs) and M2 macrophages co-exist in the lesions of endometriosis and participate in the occurrence and progression of endometriosis. However, the interaction between ectopic ESCs and M2-type macrophage polarization is poorly understood. This study aims to investigate the effect of exosomes released from ectopic ESCs on M2 macrophage polarization and the potential mechanism.

Pan-genome analysis highlights the role of structural variation in the evolution and environmental adaptation of Asian honeybees.

The Asian honeybee, Apis cerana, is an ecologically and economically important pollinator. Mapping its genetic variation is key to understanding population-level health, histories and potential capacities to respond to environmental changes. However, most efforts to date were focused on single nucleotide polymorphisms (SNPs) based on a single reference genome, thereby ignoring larger scale genomic variation.

Efficacy of Multi-slice Spiral CT and Rapid On-site Evaluation in Diagnosis of Pulmonary Nodules.

Objective: This study aims to explore the efficacy of multi-slice spiral computed tomography (MSCT) and rapid on-site evaluation (ROSE) in diagnosing pulmonary nodules, thereby providing more diagnostic information for clinical diagnosis, and improving the diagnostic efficiency of pulmonary nodules.

Methods: With the means of a retrospective study, 103 patients with pulmonary nodules in our hospital from January 2019 to December 2021 were analyzed. The included patients had no history of lung surgery, and had no cognitive, audio-visual, language communication and physical activity disorders, with visual lesions in bronchoscopy.

Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep.

Wool color is controlled by a variety of genes. Although the gene regulation of some wool colors has been studied in relative depth, there may still be unknown genetic variants and control genes for some colors or different breeds of wool that need to be identified and recognized by whole genome resequencing. Therefore, we used whole genome resequencing data to compare and analyze sheep populations of different breeds by population differentiation index and nucleotide diversity ratios (Fst and θπ ratio) as well as extended haplotype purity between populations (XP-EHH) to reveal selection signals related to wool coloration in sheep.

Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness.

Wool fineness affects the quality of wool, and some studies have identified about forty candidate genes that affect sheep wool fineness, but these genes often reveal only a certain proportion of the variation in wool thickness. We further explore additional genes associated with the fineness of sheep wool. Whole-genome resequencing of eight sheep breeds was performed to reveal selection signals associated with wool fineness, including four coarse wool and four fine/semi-fine wool sheep breeds.

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway.

Context: di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has much lower cytotoxicity than BSTJF1.

The Effects of on Inducing Differentiation in Ovine Preadipocytes via Oar-miR-432.

Reducing fat deposition in sheep () tails is one of the most important ways to combat rising costs and control consumer preference. Our previous studies have shown that oar-miR-432 is differentially expressed in the tail adipose tissue of Hu (a fat-tailed sheep breed) and Tibetan (a thin-tailed sheep breed) sheep and is a key factor in the negative regulation of fat deposition through in ovine preadipocytes. This study investigated the effect of oar-miR-432 and its target genes in ovine preadipocytes.

MiRNA-Seq reveals key MicroRNAs involved in fat metabolism of sheep liver.

There is a genetic difference between Hu sheep (short/fat-tailed sheep) and Tibetan sheep (short/thin-tailed sheep) in tail type, because of fat metabolism. Previous studies have mainly focused directly on sheep tail fat, which is not the main organ of fat metabolism. The function of miRNAs in sheep liver fat metabolism has not been thoroughly elucidated.