Associated factors in the development of rapidly progressive interstitial lung disease in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis.

Objectives: Interstitial lung disease (ILD), the main pulmonary manifestation of idiopathic inflammatory myopathy (IIM), frequently develops into rapidly progressive ILD (RP-ILD) with significantly worse prognosis. This meta-analysis identified risk and protective factors associated with developing RP-ILD in IIM patients.

Methods: PubMed, Embase, Web of Science, and Scopus (up to October 2024) were searched, analyzing 21 retrospective studies (2,099 patients).

Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study.

Background: Previous studies reported that patients with keloid, acne, or hypertrophic scar (HS) had lower serum vitamin D levels compared to healthy controls. Whereas, these works failed to verify their causal relationships. Hence, we performed a Mendelian randomization (MR) aimed to investigate the causal relationship between vitamin D and keloid, acne, or HS.

Risk factors for mortality in anti-MDA5 antibody-positive dermatomyositis with interstitial lung disease: a systematic review and meta-analysis.

Background: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis with interstitial lung disease (MDA5 DM-ILD) carries a high mortality risk. This meta-analysis aimed to identify mortality risk factors to guide early clinical intervention.

Methods: Following PRISMA guidelines, we systematically searched PubMed, Embase, Web of Science, and Scopus for studies published before November 18, 2024.

Gan-Mai-Da-Zao decoction ameliorates depressive-like behaviors in CUMS mice via the microbiota-metabolism-inflammation axis.

Background: Gan-Mai-Da-Zao decoction (GMDZ), a traditional Chinese formulation used as both food and medicines, exhibits antidepressant effects. However, its underlying mechanisms, particularly those involving the gut-brain axis, remain unclear.

Purpose: To integrate gut microbiota profiling, metabolomics, and neuroinflammation to systematically elucidate GMDZ's antidepressant mechanisms.

The GSK3β inhibitor attenuate APAP-induced liver injury by regulating PGC1α-mediated oxidative stress.

Acetaminophen (N-acetyl-p-aminophenol, APAP), is the most frequent cause of drug-induced liver injury. Reducing APAP-induced oxidative stress is an effective strategy to improve acute liver injury. Glycogen synthase kinase-3β (GSK3β), is sensitive to redox homeostasis and is involved in oxidative stress-related injuries.

A Multifunctional Electrochemical Biosensor Based on Near-Infrared Light-Responsive Hydrogel for In Vivo Recording and Modulation.

Monitoring and regulating neural signals are crucial for the management of neurological disorders. Herein, we constructed a near-infrared light (NIR)-responsive device for controllable recording and modulation of neural signals based on enzyme-loaded microgels/multiwalled carbon nanotubes (MWCNTs) composite-modified microelectrodes. The embedded MWCNTs within the composites can convert NIR light into heat via a photothermal effect.

Epimedii Folium and Curculiginis Rhizoma ameliorate age-related cognitive decline and neuroinflammation through modulation of the NLRP3 inflammasome.

Ethnopharmacological Relevance: Age-related cognitive decline and neuroinflammation are significant contributors to neurodegenerative diseases. In Traditional Chinese Medicine, aging is often associated with "kidney deficiency," a concept linked to impaired bone marrow production and brain function. Epimedii Folium and Curculiginis Rhizoma (XY), a classic herbal pair used to tonify the kidney, are traditionally employed to enhance vitality, bone health, and cognitive function.

Efficacy of pulmonary rehabilitation on health-related quality of life in patients with interstitial lung disease as assessed by SF-36: a systematic review and meta-analysis.

Introduction: The efficacy of pulmonary rehabilitation (PR) in improving health-related quality of life (HRQoL) in patients with interstitial lung disease (ILD) still have some unresolved issues. This study aimed to identify this gap by using the 36-Item Short Form Survey (SF-36) to assess the advantages and disadvantages of PR in improving the HRQoL of patients with ILD.

Evidence Acquisition: Self-controlled before-and-after interventional design research related to PR and ILD published in English were retrieved from PubMed, Embase, Web of Science, Scopus, Ovid, and Cochrane Library from inception to May 19, 2024.

A correlation study of serum tumor markers with systemic lupus erythematosus-associated interstitial lung disease.

Background: Systemic lupus erythematosus-associated interstitial lung disease (SLE-ILD) is a pulmonary manifestation of SLE. Currently, serum biomarkers for early identification of SLE-ILD are lacking. Our study aimed to investigate the correlation and clinical significance of serum tumor markers (TMs) in patients with SLE-ILD.

Computational mining and redesign of superoxide dismutase with activity-thermostability improvement.

Superoxide dismutase (SOD) is a redox metalloenzyme that serves as a critical defense against oxidative damage caused by reactive oxygen species, with applications across food, cosmetic, and pharmaceutical industries. However, the limited catalytic activity and poor thermostability restrict its effectiveness in industrial processes. Herein, we report a SOD from Deinococcus wulumuqiensis R12 (SOD(R12)) that demonstrates remarkable catalytic activity of 1356.

Prognostic factors in hospitalized patients with COVID-19 pneumonia and effectiveness of prophylactic anticoagulant therapy: a single-center retrospective study.

Background: COVID-19 pneumonia patients encounter the potential risk of venous thromboembolism (VTE) and mortality during hospitalization. This study aimed to analyzed risk factors of all-cause mortality in hospitalized patients with COVID-19 pneumonia, and investigated the effectiveness of prophylactic anticoagulation and hospital stays on the mortality in hospitalized patients with nonVTE.

Methods: We retrospectively analyzed all COVID-19 pneumonia patients who were admitted to our medical center from December 2022 to January 2023.

Serum surfactant protein D as a significant biomarker for predicting occurrence, progression, acute exacerbation, and mortality in interstitial lung disease: a systematic review and meta-analysis.

Objective: Serum surfactant protein D (SP-D) is a potential biomarker for the non-invasive prediction of interstitial lung disease (ILD) status. However, previous studies lacked comprehensively qualitative and quantitative pooled analysis methods to summarize the relationship between SP-D and ILD.

Methods: We conducted a comprehensive literature search from PubMed, Embase, Web of Science, Scopus, Ovid, and Cochrane Library, up to 16 December 2023.

Risk factors for poor prognosis in ANCA-associated vasculitis with interstitial lung disease: a systematic review and meta-analysis.

Objective: Antineutrophil cytoplasm antibody-associated vasculitis (AAV) with interstitial lung disease (AAV-ILD) is the main manifestation of AAV involving the lung, further increasing the risk of poor prognosis in patients with AAV. This study aimed to investigate the risk factors associated with mortality in patients with AAV-ILD.

Methods: In Web of Science, PubMed, Embase and Scopus databases, a comprehensive search was performed for English studies on AAV and ILD published from inception date until May 17, 2024.

Genome-Wide Identification and Characterization of Ammonium Transporter (AMT) Genes in .

Ammonium transporters (AMTs) are vital plasma membrane proteins facilitating NH uptake and transport, crucial for plant growth. The identification of favorable AMT genes is the main goal of improving ammonium-tolerant algas. However, there have been no reports on the systematic identification and expression analysis of () AMT genes.

Imaging diagnosis of rudimentary horn pregnancy: a case report.

Background: Rudimentary horn pregnancy (RHP) is a special type of ectopic pregnancy and its pathophysiological basis is an abnormal fusion of the bilateral accessory mesonephric duct during the embryonic period. If sonographers lack experience to this disease, it is easily to be misdiagnosed in the early period, which often leads to rupture of the pregnant horn and life-threatening bleeding. Therefore, a high index of vigilance is required.

Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study.

Background: Anxiety and depression are common comorbidities in idiopathic pulmonary fibrosis (IPF) that impair health-related quality of life. However, there is a lack of studies focusing on the mental disorder of IPF after antifibrotic treatment and their related predictive factors.

Methods: Patients with an initial diagnosis of IPF were enrolled.

Association between SpO and the risk of death in elderly T2DM patients with cerebral infarction: a retrospective cohort study.

Objective: This study aimed to evaluate the SpO (transcutaneous oxygen saturation) -mortality link in elderly T2DM (diabetes mellitus type 2) patients with cerebral infarction and identify their optimal SpO range.

Methods: In this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific ICD-9 and ICD-10 codes.

Body mass index and weight loss as risk factors for poor outcomes in patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Objective: The association between nutritional status and prognosis of idiopathic pulmonary fibrosis (IPF) remains unclear. This systematic review and meta-analysis aimed to explore the effect of body mass index (BMI) and weight loss on the prognosis of IPF patients.

Methods: We accumulated studies on IPF, BMI, and weight loss from databases including PubMed, Embase, Web of science, Scopus, Ovid and Cochrane Library up to 4 August 2023.

Exosomes from ectopic endometrial stromal cells promote M2 macrophage polarization by delivering miR-146a-5p.

Background: Ectopic endometrial stromal cells (ESCs) and M2 macrophages co-exist in the lesions of endometriosis and participate in the occurrence and progression of endometriosis. However, the interaction between ectopic ESCs and M2-type macrophage polarization is poorly understood. This study aims to investigate the effect of exosomes released from ectopic ESCs on M2 macrophage polarization and the potential mechanism.

Serum ferritin as a significant biomarker for patients with idiopathic inflammatory myopathy-associated interstitial lung disease: A systematic review and meta-analysis.

Objective: The biomarkers for predicting the occurrence, progression, and death of idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) remain unclear. Serum ferritin (SF) is a potential candidate and this systematic review and meta-analysis aimed to reveal the clinical significance of SF in IIM-ILD.

Methods: Eligible English studies were selected from PubMed, Embase, Web of science and Scopus up to 9 June 2023.

Gene mutations as predictors of central lymph mode metastasis in cN0 PTC: A meta-analysis.

Gene mutations could predict the tumor progression and prognosis, which are us to predict CLNM in patients with cN0 PTC, however, these results are not consistent. This meta-analysis tried to identify gene mutations which could predict CLNM in patients with cN0 PTC. A systematic search was performed for identifying relevant literature published prior to July 2023 in three search engines: PubMed, EMBASE and Web of Science.

Evaluation of the diagnostic efficacy of liquid-based cytology obtained via percutaneous ultrasound-guided fine-needle aspiration for pancreatic masses: a large tertiary center's 8-year experience.

Purpose: There were limited data on the diagnostic efficacy of liquid-based cytology (LBC) for pancreatic tissues acquired by percutaneous ultrasound-guided fine-needle aspiration (US-FNA). This study aimed to evaluate the diagnostic value of LBC acquired via percutaneous US-FNA for pancreatic tumors compared with LBC combined with smear cytology (SC).

Methods: A retrospective database search (January 2014 and February 2022) was performed for patients who underwent percutaneous US-FNA with both LBC and SC.