Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation.

Myocardial hypertrophy is one of the most prominent features of heart failure. SET domain-containing protein 7 (Setd7), a catalytic enzyme responsible for histone H3K4 methylation, has been implicated in various cardiac diseases. In this study we investigated whether Setd7 contributed to the development of cardiac hypertrophy.

Stable and accurate characterization of optical microcavity using linear frequency modulation and thermal locking.

Precise characterization of the quality factor () and coupling regimes in ultra-low-loss optical microcavities represents a critical research objective. Compact optical microcavities exhibit a smaller surface area, making thermal effects non-negligible. Consequently, the heat induced by the probe light can compromise the accuracy of characterization.

Joint association of cognitive reserve and frailty with incident Alzheimer's disease and related dementias.

Cognitive reserve and frailty are factors associated with Alzheimer's disease and related dementias (ADRD). However, whether cognitive reserve and frailty interact to influence ADRD has not been explored well. We included 908 participants from the ADNI study.

Electronic Modulation of a Polymerized Iron-Phthalocyanine Catalyst via Ligand Engineering toward the Oxygen Reduction Reaction for Aluminum-Air Batteries.

Aluminum-air batteries (AABs) are considered an advanced energy conversion system. However, the development of AABs is severely limited by slow kinetics of the oxygen reduction reaction (ORR) occurring at air cathodes. Although iron phthalocyanine (FePc) is considered a widely used ORR catalyst, rationally designing efficient and stable FePc-based electrocatalysts to replace commercial Pt/C is extremely challenging.

Synthesis and Biological Activity of Benzoselenazole and Benzo[b]Selenophene Analogues: A Review.

Selenium, an essential micronutrient in the human body, not only exhibits potent antioxidant properties but also plays a critical role in regulating thyroid hormone metabolism, maintaining normal immune function, and inhibiting tumour progression. Among selenium-containing compounds, ebselen is the most extensively studied drug candidate. Research has shown that various derivatives obtained through structural modifications of Ebselen exhibits significant biological activities; however, these compounds have yet to progress to clinical trials.

Gan-Mai-Da-Zao decoction ameliorates depressive-like behaviors in CUMS mice via the microbiota-metabolism-inflammation axis.

Background: Gan-Mai-Da-Zao decoction (GMDZ), a traditional Chinese formulation used as both food and medicines, exhibits antidepressant effects. However, its underlying mechanisms, particularly those involving the gut-brain axis, remain unclear.

Purpose: To integrate gut microbiota profiling, metabolomics, and neuroinflammation to systematically elucidate GMDZ's antidepressant mechanisms.

Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A-PKM2 Axis to Exacerbate Autoimmune and Autoinflammatory Diseases.

Hypobaric hypoxia, a defining feature of high-altitude environments, induces significant physiological and pathological changes in the human body. Under the disrupted homeostasis and altered disease microenvironment caused by high-altitude conditions, the immune system exhibits distinct responses compared to those observed in low-altitude settings. Our study investigates the impact of hypobaric hypoxia on autoimmune and autoinflammatory diseases and explores the underlying molecular mechanisms.

Hypobaric hypoxia-driven energy metabolism disturbance facilitates vascular endothelial dysfunction.

Hypobaric hypoxia in plateau environments inevitably disrupts metabolic homeostasis and contributes to high-altitude diseases. Vascular endothelial cells play a crucial role in maintaining vascular homeostasis. However, it remains unclear whether hypoxia-mediated changes in energy metabolism compromise vascular system stability and function.

Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11.

Background: The role of estrogen in liver cancer cells has attracted attention, but its specific actions and underlying mechanisms remain unclear.

Methods: Flow CytoMetry and Western blotting were used to investigate the mechanism of HOXA11-AS and estrogen in promoting apoptosis of hepatocellular carcinoma (HCC). In vivo subcutaneous tumorigenesis assays were uesd to confirm the regulatory role of HOXA11-AS in HCC progression.

Mutating the cysteine residues within the WCCH motif of tobacco curly shoot virus (TbCSV) V2 protein attenuates viral infection and confers cross-protection against infection by severe strain.

Background: Tobacco curly shoot virus (TbCSV, Begomovirus, Geminiviridae) is a viral agent that poses a serious threat to economically important crops like tomato and tobacco in Southwest China. The geminiviral V2 protein has been demonstrated to play multifunctional roles essential for viral infection and pathogenicity. This study comprehensively investigated the biological importance of five cysteines within the conserved 'WCCH' motif of the TbCSV V2 protein, and evaluated the effects of cysteine mutations on viral pathogenicity and the efficacy for cross-protection against wild-type severe TbCSV train.

Single and Combined Effects of Aged Polyethylene Microplastics and Cadmium on Nitrogen Species in Stormwater Filtration Systems: Perspectives from Treatment Efficiency, Key Microbial Communities, and Nitrogen Cycling Functional Genes.

Microplastics and heavy metal contamination frequently co-occur in stormwater filtration systems, where their interactions may potentially compromise nitrogen removal. Current research on microplastics and Cd contamination predominantly focuses on soils and constructed wetlands, with limited attention given to stormwater filtration systems. In this study, the single and synergistic effects of aged polyethylene microplastics (PE) and cadmium (Cd) contamination in stormwater infiltration systems were investigated from perspectives of nitrogen removal, microbial community structures, and predicted functional genes in nitrogen cycling.

Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis.

Background: Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This study aimed to investigate the role of SMYD5 in regulating synovial fibroblast homeostasis and the pathogenesis of rheumatoid arthritis (RA).

SARS-CoV-2 Infection Aggravates Physical and Mental Health in Cancer Patients Compared to Co-Living Individuals.

Introduction: Cancer patients are particularly vulnerable to the psychological sequels of COVID-19 due to their immunocompromised state and the disruptions to their regular oncological care. There is limited research comparing the effects of SARS-CoV-2 on cancer patients and their co-living individuals. This study aims to explore the similarities and differences in physical and psychological outcomes between these two groups, with a 1-year follow-up to assess long-term effects.

Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming.

Background: Histidine metabolism is crucial in role in tumor biology, contributing to tumor progression, immune regulation, and metabolic reprogramming. In hepatocellular carcinoma (HCC), dysregulated histidine metabolism may promote tumor growth and immune evasion, although the specific mechanisms remain poorly understood.

Methods: Using single-cell RNA sequencing, the expression patterns of histidine metabolism-related genes were evaluated across different cell types in HCC samples.

Hepcidin mediates the disorder of iron homeostasis and mitochondrial function in mice under hypobaric hypoxia exposure.

The human body to prolonged high-altitude environments exposure can cause the decreased hepcidin and the disorder of iron homeostasis. Few animal studies have examined the molecular basis of iron metabolism disorder and the impact of hepcidin on the complex phenotype of high-altitude environments. In this study, we display reduced hepcidin level and impaired iron homeostasis upon hypobaric hypoxia, accompanied by mitochondrial dysfunction, abnormal blood cells and metabolic disorder.

Frailty increases the risk of Alzheimer's disease in non-demented individuals: A longitudinal cohort study.

Background: Frailty, which is considered a potential modifiable risk factor for dementia, continues to generate debate when it comes to Alzheimer's disease (AD). Furthermore, the underlying pathological mechanisms linking frailty to AD remain uncertain.

Objective: We aimed to investigate the relationship between frailty and the risk of AD while elucidating the connections between frailty, AD biomarkers, and cognitive function.

Particle Size-Dependent Monthly Variation of Pollution Load, Ecological Risk, and Sources of Heavy Metals in Road Dust in Beijing, China.

Road dust carries various contaminants and causes urban non-point source pollution in waterbodies through runoff. Road dust samples were collected in each month in two years and then sieved into five particle size fractions. The concentrations of ten heavy metals (As, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Zn, Fe) in each fraction were measured.

The association of the triglyceride-glucose index with Alzheimer's disease and its potential mechanisms.

Background: The correlation between Alzheimer's disease (AD) and the glucose-triglyceride (TyG) index remains undetermined.

Objective: This study aimed to investigate the relationship between the TyG index and AD, as well as the relationship between the TyG index and cerebrospinal fluid (CSF) AD biomarkers and cognition.

Methods: Six hundred twenty-eight non-dementia participants were included.

Global research trends and hotspots on smoking and lung cancer from 1994-2023: A bibliometric analysis.

Introduction: Lung cancer is a significant cause of mortality, especially among smokers. Lung cancer and smoking are strongly associated, according to numerous studies.

Methods: Publications related to smoking and lung cancer were retrieved from the Science Citation Index Expanded (SCIE) database of the Web of Science Core Collection for the period 1994-2023.

Explore the Role of Frailty as a Contributor to the Association Between AT(N) Profiles and Cognition in Alzheimer's Disease.

Background: The relationship between Alzheimer's disease (AD)-related pathology and cognition was not exactly consistent.

Objective: To explore whether the association between AD pathology and cognition can be moderated by frailty.

Methods: We included 1711 participants from the Alzheimer's Disease Neuroimaging Initiative database.

Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb.: A network pharmacology analysis and transcriptomics integrated experimental verification.

Ethnopharmacological Relevance: Phytolacca acinosa Roxb. (PAR) is a Traditional Chinese Medicinal (TCM) plant with a broad global distribution encompassing 35 species, four of which are found in the People's Republic of China. It occupies a significant role in both Oriental and American traditional medicine, employed in treating a range of conditions such as edema, inflammation, dermatitis, and rheumatism.

An Evaluation of the Impact of Co Irradiation on Volatile Organic Compounds of Olibanum Using Gas Chromatography Ion Mobility Spectrometry.

Olibanum is a resinous traditional Chinese medicine that is directly used as a powder. It is widely used in China and is often combined with other traditional Chinese medicine powders to promote blood circulation and relieve pain, as well as to treat rheumatism, rheumatoid arthritis, and osteoarthritis. Powdered traditional Chinese medicine is often easily contaminated by microorganisms and Co irradiation is one of the good sterilization methods.

Associations of Frailty with Neuropsychiatric Symptoms of Alzheimer's Disease: A Longitudinal Study.

Background: Frailty is a vulnerability state increasing the risk of many adverse health outcomes, but little is known about the effects of frailty on neuropsychiatric health.

Objective: To explore the associations between frailty and the risk of neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD), especially in its different clinical stages.

Methods: We included 2,155 individuals assessed using modified frailty index-11 (mFI-11), Neuropsychiatric Inventory (NPI) and Neuropsychiatric Inventory Questionnaire (NPI-Q) in the Alzheimer's Disease Neuroimaging Initiative (ADNI).