Ultrahigh Efficiency LiAlGaO: Cr, Ni Near-Infrared Phosphor with an External Photoluminescence Quantum Yield Exceeding 70% via Cr-Ni Energy Transfer.

Ni-doped inorganic crystals are promising for generating broadband emissions from 1000 to 1700 nm, which are crucial for advancing NIR light sources. However, their commercial applications have been hindered due to their weak absorption. Herein, the LiAlO crystal is present as the host for Cr and Ni ions due to its high density of available doping sites (Al) per unit volume (0.

Single and Combined Effects of Aged Polyethylene Microplastics and Cadmium on Nitrogen Species in Stormwater Filtration Systems: Perspectives from Treatment Efficiency, Key Microbial Communities, and Nitrogen Cycling Functional Genes.

Microplastics and heavy metal contamination frequently co-occur in stormwater filtration systems, where their interactions may potentially compromise nitrogen removal. Current research on microplastics and Cd contamination predominantly focuses on soils and constructed wetlands, with limited attention given to stormwater filtration systems. In this study, the single and synergistic effects of aged polyethylene microplastics (PE) and cadmium (Cd) contamination in stormwater infiltration systems were investigated from perspectives of nitrogen removal, microbial community structures, and predicted functional genes in nitrogen cycling.

Ameliorating macrophage pyroptosis via ANXA1/NLRP3/Caspase-1/GSDMD pathway: Ac2-26/OGP-loaded intelligent hydrogel enhances bone healing in diabetic periodontitis.

Craniofacial bone defect healing in periodontitis patients with diabetes background has long been difficult due to increased blood glucose levels which cause overproduction of reactive oxygen species (ROS) and a low pH environment. These conditions negatively affect the function of macrophages, worsen inflammation and oxidative stress, and ultimately, hinder osteoblasts' bone repair potential. In this study, we for the first time found that annexin A1 (ANXA1) expression in macrophages was reduced in a diabetic periodontitis (DP) environment, with the activation of the NLRP3/Caspase-1/GSDMD signaling pathway, and, eventually, increased macrophage pyroptosis.

Unraveling the role of cancer-associated fibroblasts in colorectal cancer.

Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. This review endeavors to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, this review delineates insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, and neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors.

Anti-glioma effect of paclitaxel mediated by specific mode electroacupuncture stimulation and the related role of the Hedgehog pathway.

Introduction: Paclitaxel (PTX) cannot effectively treat glioma because it cannot cross the bloodbrain barrier (BBB). A specific mode electroacupuncture stimulation (SMES) can temporarily open the BBB, thereby improving drug delivery to the brain. This study aimed to observe SMES-mediated accumulation of PTX in the brain and its anti-glioma effect and explore the role of the Hedgehog pathway.

Association of Received Intergenerational Support with Subjective Well-Being among Elderly: The Mediating Role of Optimism and Sex Differences.

Even though an extensive body of previous research has examined the association between received intergenerational support and the well-being outcomes of older adults in a wide variety of contexts, few studies have been conducted to explore the impacts of intergenerational support on elders' subjective well-being, especially the intermediary mechanisms in this process. The purpose of this study is to fill this gap by exploring the mediating role of optimism in the association between received intergenerational support and subjective well-being among the elderly in China, as well as the sex differences that exist between males and females. The findings show that the intergenerational support received from adult children is positively related to subjective well-being and that this relationship is partly mediated by optimism.

Parental Beliefs and Actual Use of Corporal Punishment, School Violence and Bullying, and Depression in Early Adolescence.

Prior studies on adverse outcomes of parental corporal punishment on children have focused on examining one of two broad domains of parental corporal punishment: parental beliefs or actual use. Recently, researchers have argued that parental belief and actual use of corporal punishment should work jointly to contribute to children's depression and involvement in school violence. Yet, studies supporting this proposition are lacking.