Nonlinear memory in cell-division dynamics across species.

Regulation of cell growth and division is essential to achieve cell-size homeostasis. Recent advances in imaging technologies, such as "mother machines" for bacteria or yeast, have allowed long-term tracking of cell-size dynamics across many generations, and thus have brought major insights into the mechanisms underlying cell-size control. However, understanding the governing rules of cell growth and division within a quantitative dynamical-systems framework remains a major challenge.

GDF15 Ameliorates Deoxynivalenol-Induced Anemia by Resolving Ribosomal Stress-Mediated Erythropoietic Arrest.

Deoxynivalenol (DON) is a prevalent trichothecene mycotoxin that contaminates global food supplies, posing significant health risks; however, targeted therapies against DON are scarce. Although DON-induced anemia is well-documented, the underlying mechanisms remain unclear. In this study, the effects of DON on erythropoiesis are examined in detail using complementary murine models and human primary erythroid cultures.

Metagenomic and molecular simulation insights into plastic degradation: Microenvironmental matching and the key role of residue Phe392.

Due to their chemical inertness, polyethylene (PE) and polystyrene (PS) persistently accumulate in the environment. This study integrates metagenomics, degradation profiling, and molecular simulations to elucidate their divergent microbial degradation pathways. PE degradation was dominated by Burkholderia (97 %), with selective C-C bond cleavage causing a 29.

3D-Printed Precision Porous Scaffolds Promote Healing In Vivo.

Precision porous scaffolds hold promise for tissue engineering and regenerative medicine due to their ability to support cell ingrowth and vascularization and mitigate the foreign body reaction (FBR). In previous work, we demonstrated that vat photopolymerization 3D printing enables the fabrication of porous scaffolds with 40 μm interconnected cubical pores. This study aims to do a preliminary evaluation of cellular responses and the FBR to 3D-printed scaffolds with 40 μm cubical pores, in comparison with template-fabricated spherical pores (optimized for healing) and non-porous slabs (negative control).

A Phase II Random, Double-Blind, Placebo-Controlled Study of the Safety and Immunogenicity of a Recombinant G Protein-Based Respiratory Syncytial Virus Vaccine in Healthy Older Adults.

: Respiratory syncytial virus (RSV) poses a significant global health threat, particularly to children and the elderly. While progress has been made in RSV vaccine development, gaps remain, especially in protecting the elderly population. BARS13, a recombinant non-glycosylated G protein-based RSV vaccine, has shown promise in preclinical and Phase 1 studies.

Associated factors in the development of rapidly progressive interstitial lung disease in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis.

Objectives: Interstitial lung disease (ILD), the main pulmonary manifestation of idiopathic inflammatory myopathy (IIM), frequently develops into rapidly progressive ILD (RP-ILD) with significantly worse prognosis. This meta-analysis identified risk and protective factors associated with developing RP-ILD in IIM patients.

Methods: PubMed, Embase, Web of Science, and Scopus (up to October 2024) were searched, analyzing 21 retrospective studies (2,099 patients).

Relationship between triglyceride and glucose related indexes and MAFLD in rural populations of northwest China.

Research has shown inconsistent links between triglyceride and glucose related indexes (TyG-related indexes) and metabolic dysfunction-associated fatty liver disease (MAFLD) across various groups and areas. Our research focuses on exploring these connections to improve early identification and prevention of MAFLD among rural residents in Xinjiang, China. A total of 10,703 rural residents were included in this cohort study.

Wuwei Ganlu and Myricetin alleviate rheumatoid arthritis by inhibiting M1 macrophage polarization through modulation of SHBG/SREBP1-mediated lipid metabolism.

Background: Rheumatoid arthritis (RA) is primarily characterized by imbalanced macrophage polarization. Wuwei Ganlu (WGL), a classical Tibetan topical formula, has been widely used in RA management.

Purpose: Nonetheless, the underlying mechanisms of WGL in protecting against RA and the bioactive components in WGL remain unclear.

Near-infrared light-activated -to- isomerization of azobenzene triplet sensitization from PbS quantum dots.

Azobenzene (Azo) photoswitches have attracted significant attention for developing smart photoresponsive materials owing to their reversible light-induced isomerization between and configurations. However, it is challenging to design an Azo capable of quantitative and efficient → photoisomerization under low-energy photon irradiation, particularly near-infrared (NIR) light above 800 nm. Here, we demonstrate that → photoswitching of Azo can be achieved under 808 nm light irradiation when PbS quantum dots (QDs) are combined with carboxylated Azo (Azo1).

High-quality real-time 3D holographic display for real-world scenes based on the optimized layered angular spectrum method.

Holographic display is ideal for true 3D technology because it provides essential depth cues and motion parallax for the human eye. Real-time computation using deep learning was explored for intensity and depth images, whereas real-time generating holograms from real scenes remains challenging due to the trade-off between the speed and the accuracy of obtaining depth information. Here, we propose a real-time 3D color hologram computation model based on deep learning, realizing stable focusing from monocular image capture to display.

Enhancing art creation through AI-based generative adversarial networks in educational auxiliary system.

Creative art education increasingly demands interactive, personalized tools that support students in developing aesthetic expression and technical skill. Traditional digital art tools often lack adaptive feedback and require manual intervention, which limits their pedagogical potential in self-guided or remote learning environments. This study introduces an AI-enhanced educational auxiliary system powered by Generative Adversarial Networks (GANs) to support art creation, creativity development, and learning engagement.

Greenspace and intestinal diseases: a systematic review and meta-analysis.

Greenspace has been reported potential therapeutically beneficial for intestinal diseases, yet the findings remain controversial Current researches demonstrate diversity in the assessment of greenspace and involve broad population groups, with the publication bias remaining a concern. This study offers convincing and reliable evidence supporting the beneficial effects of greenspace exposure on intestinal health, through a systematic review and meta-analysis examining the association between greenspace and intestinal disorders. The Greenspace exposure was primarily assessed using the Normalized Difference Vegetation Index (NDVI) and residential proximity to greenspaces.

Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries.

Discovery of cyclic peptide hits using DNA-encoded libraries (DELs) has recently been extensively researched, with significant efforts directed toward developing DEL-compatible macrocyclization methods. To investigate how different cyclic linkers influence DEL selection outcomes, we constructed eight distinct sublibraries and screened them against two protein targets, MDM2 and GIT1, resulting in two representative yet contrasting scenarios. Validation studies for MDM2 revealed that structural similarity patterns observed across multiple sublibraries could enhance confidence in the authenticity of identified hits.

Risk factors for mortality in anti-MDA5 antibody-positive dermatomyositis with interstitial lung disease: a systematic review and meta-analysis.

Background: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis with interstitial lung disease (MDA5 DM-ILD) carries a high mortality risk. This meta-analysis aimed to identify mortality risk factors to guide early clinical intervention.

Methods: Following PRISMA guidelines, we systematically searched PubMed, Embase, Web of Science, and Scopus for studies published before November 18, 2024.

Effectiveness of Scalp Acupuncture Combined With Speech Therapy on Language Function in Individuals With Poststroke Motor Aphasia.

Objective: To examine the rehabilitative effects of a combined scalp acupuncture and speech therapy (ST) protocol on language function and quality of life in individuals with motor aphasia following stroke (MAAS).

Methods: A randomized controlled trial was conducted involving 68 individuals with MAAS who satisfied the inclusion criteria. Participants were randomly assigned to either the observation group (n=34; scalp acupuncture+ST) or the control group (n=34; sham acupuncture+ST) through a computer-generated random number table.

Aqueous extract of root alleviates rheumatoid arthritis by acting on TNF-α and RAGE signaling pathways.

Saposhnikovia divaricata (Turcz.) Schisch (SADS) is classified as a special-grade traditional Chinese medicine in Shennong's Materia Medical due to its immune-protective effects, including dispelling cold, relieving edema and pain, and its potential in treating rheumatoid arthritis (RA). Over 130 traditional Chinese medicine formulations containing SADS are used for RA treatment.

The Synergy Between In Situ Gradient Polymerization and Phase Separation Enables Practical Solid-State Ni-Rich Lithium-Ion Batteries.

Solid polymer electrolytes (SPEs) have garnered significant attention due to their exceptional safety property. However, most of the previously reported SPEs cannot well match with high-loading and high-voltage cathodes due to their low ionic conductivity and limited anodic stability. Herein, a SPE with superior compatibility with high-loading Ni-rich cathodes is generated by in situ gradient polymerization of a deep eutectic electrolyte.

Identification of FADS2 as a Contributor of Ferroptosis Escape in Bladder Cancer.

Ferroptosis is an iron-dependent form of regulated cell death. Previous research indicates that inducing ferroptosis holds significant promise in cancer therapy, particularly for patients who have failed traditional treatments. However, the presence of a ferroptosis escape mechanism in bladder cancer remains unclear, and the therapeutic potential of ferroptosis induction in this context requires further exploration.

[A multi-feature fusion-based model for fetal orientation classification from intrapartum ultrasound videos].

Objectives: To construct an intelligent analysis model for classifying fetal orientation during intrapartum ultrasound videos based on multi-feature fusion.

Methods: The proposed model consists of the Input, Backbone Network and Classification Head modules. The Input module carries out data augmentation to improve the sample quality and generalization ability of the model.

Synergistic Effect of MWCNT and CB on the Piezoresistive Properties of Laser Ablation Composites Strain Sensors.

A flexible and highly sensitive piezoresistive strain sensor was fabricated through the application of CO laser ablation on a composite film composed of multi-walled carbon nanotubes, carbon black, and polydimethylsiloxane (MWCNT/CB/PDMS). The results of scanning electron microscopy (SEM) surface analysis shows that the "bush-like" conductive structure on the PDMS-based composite material membrane post-laser ablation is formed. Transmission electron microscopy (TEM) images and X-ray diffraction (XRD) spectra of the ablation products indicated the formation of an amorphous carbon layer on the surface of carbon nanomaterials due to laser ablation.

Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema.

p53, encoded by the TP53 gene, is a critical tumor suppressor, and its pharmacological activation has been clinically validated as an effective strategy for the treatment of human malignancies. In recent years, numerous novel approaches have emerged to activate both wild-type and mutant p53, including MDM2 degraders, p53 stabilizers, gene therapies targeting TP53, and inhibitors of the MDM2-p53 protein-protein interaction. Since 2020, drug discovery efforts in these areas have advanced rapidly, leading to several notable breakthroughs.

Knee injury prevention via personalized exercise using EDAS method and Sugeno Weber operator under complex q rung orthopair fuzzy data.

Knee injuries are common in several people, frequently controlling for significant injuries and health care costs. This article explains the role of personalized exercise prescriptions in preventing knee injuries. For this purpose, we used the multicriteria decision-making (MCDM) technique to select the best alternative, including criteria such as level of muscle strength improvement, cardiovascular endurance, recovery time, and improvement in flexibility and range of motion.

Enhanced production of syngas from supercritical water gasification of lignin in a CO atmosphere: ReaxFF molecular dynamic simulation and DFT calculation study.

Supercritical water gasification (SCWG) emerged as a promising route to tackle solid pollution induced by lignin to obtain syngas. Combined with the characteristics of SCWG technology for hydrogen-rich generation and CO gasification technology for CO-rich generation, the use of CO atmosphere in the SCWG of biomass could effectively regulate the H/CO molar ratio in syngas. The study of the SCWG mechanism of lignin in CO atmosphere was conducive to the understanding and optimization of the lignin conversion process and reaction pathways.

Expert Consensus on Subxiphoid and Subcostal Arch Thoracoscopic Resection for the Treatment of Thymoma.

Surgery is the primary treatment for thymoma. Although subxiphoid and subcostal arch thoracoscopic thymoma surgery is widely used, there is currently a lack of consensus regarding its use, nor have standards been established. Based on the surgical experience of many domestic thoracic surgery centers, the Department of Thoracic Surgery of Tangdu Hospital of Air Force Medical University has formulated this expert consensus regarding key clinical issues related to thoracoscopic thymoma surgery, including preoperative evaluation, surgical indications, preoperative preparation, surgical details, perioperative management, postoperative treatment, and follow-up.

Mitigating gaseous nitrogen emissions in cotton fields through green manure and reduced nitrogen fertilization.

Integrating green manure with reduced nitrogen (N) fertilization is a promising strategy to mitigate N emissions in intensive cotton cultivation, however, the underlying mechanisms remain poorly understood. This study investigated the effects of three green manure incorporation patterns-no green manure (NG), (OVG), and (VVG)-combined with four N reduction levels (100, 50, 25%, and conventional) on gaseous N emissions (NH and NO), soil physicochemical properties, and bacterial community characteristics using a cotton field experiment in the Yellow River Basin. Results showed that OVG incorporation with 25% N reduction (N2 treatment) significantly reduced total gaseous N emissions by 36.