Space-time crystals from particle-like topological solitons.

Time crystals are unexpected states of matter that spontaneously break time-translation symmetry either in a discrete or continuous manner. However, spatially mesoscale space-time crystals that break both space and time symmetries have not been reported. Here we report a continuous space-time crystal in a nematic liquid crystal driven by ambient-power, constant-intensity unstructured light.

OCT and OCTA Features of Optic Disc Melanocytoma: PHOMS, Perfusion Deficits, and Association with Vision Loss.

Purpose: To investigate the structural and vascular alternations of optic disc melanocytoma (ODM) using optical coherence tomography (OCT) and OCT angiography (OCTA) DESIGN: Retrospective case-series study.

Subjects: This study included 34 eyes diagnosed with ODM and 15 eyes with juxtapapillary choroidal melanoma (CM) who referred to Beijing Tongren Hospital from July 2019 to March 2025.

Methods: All subjects underwent OCT and OCTA cover the macula and optic nerve head (ONH) region.

On-DNA Synthesis of Privileged Dihydropteridinones via Diboron-Mediated Cyclizations.

DNA-encoded chemical library (DECL) technology has emerged as a pivotal platform for high-throughput screening in drug discovery. Expanding the chemical space of DECLs requires the development of novel, robust, and DNA-compatible transformations, with atom-economical cyclizations being particularly attractive for generating drug-like scaffolds. The 7,8-dihydropteridinone core represents a pharmacologically important heterocycle whose incorporation into DECLs has been hampered by harsh synthetic conditions.

A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistant .

Unlabelled: Carbapenem-resistant (CRKP) poses a major public health threat worldwide due to the limited treatment options available. There is an urgent need to explore new treatment strategies. Although phages are considered to be an effective treatment, most characterized phages demonstrate narrow host ranges restricted to specific capsular types (KL types), thereby limiting their clinical applicability.

Association of Breakfast Food Types with Dietary Knowledge, Attitudes, and Practices Among School-Aged Children.

Skipping breakfast, a prevalent issue among children and adolescents, has been reported to be associated with academic performance and long-term health. However, less attention has been given to the types of breakfast foods consumed. Therefore, our study aims to investigate the association between breakfast variety and dietary knowledge, attitude, and practice (KAP) among preadolescents.

Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries.

Discovery of cyclic peptide hits using DNA-encoded libraries (DELs) has recently been extensively researched, with significant efforts directed toward developing DEL-compatible macrocyclization methods. To investigate how different cyclic linkers influence DEL selection outcomes, we constructed eight distinct sublibraries and screened them against two protein targets, MDM2 and GIT1, resulting in two representative yet contrasting scenarios. Validation studies for MDM2 revealed that structural similarity patterns observed across multiple sublibraries could enhance confidence in the authenticity of identified hits.

antimicrobial susceptibility of isolates across different regions of China in 2023.

Objectives: To analyse the antimicrobial susceptibility of () isolates from 10 different provinces/municipalities across China during the 2023 epidemic.

Methods: We collected respiratory specimens from paediatric patients diagnosed with pneumonia from 10 different provinces/municipalities including Beijing, Shanghai, Liaoning, Gansu, Shanxi, Henan, Hunan, Jiangsu, Guangxi and Guangdong across China from October to December 2023. was isolated and cultured from these specimens.

Absolute Quantitative Detection of Hypervirulent Using a Novel Silicon-Doped Carbon Quantum Dot-Probe-Graphene Oxide.

() is a common opportunistic pathogen, with hypervirulent strains (hv) posing significant risks even to healthy individuals. Traditional clinical diagnostics often use real-time quantitative polymerase chain reaction (PCR) with TaqMan probes, which are costly and unstable due to their reliance on fluorophore and quencher molecules. This study introduces a novel probe using silicon-doped carbon quantum dots (Si-QDs) and single-layer graphene oxides (GOs), forming the Si-QD-probe-GO.

Using an Extension Catheter in Thrombus Aspiration for Coronary Subacute Myocardial Infarction.

We report a case of subacute myocardial infarction thrombus aspiration using extension catheters. The presence of refractory thrombus was observed in all patients during coronary angiography, and favorable outcomes were achieved through the use of an extended catheter for thrombus extraction. In cases involving subacute or refractory thrombus, the efficacy of traditional thrombus aspiration catheters may be limited, necessitating the use of an extension catheter for effective thrombus removal.

Study on the role and mechanism of intermittent theta burst stimulation (iTBS) induced N-acetylaspartylglutamate (NAAG) in suppressing ferroptosis in ischemic stroke.

This study investigates the mechanism through which intermittent theta burst stimulation (iTBS) inhibits ferroptosis in ischemic stroke by inducing N-acetylaspartylglutamate (NAAG). In SD rats subjected to middle cerebral artery occlusion (MCAO), iTBS treatment significantly decreased ischemia-reperfusion (I/R) injury, improving motor, coordination, spatial memory abilities and Cognitive Impairment by enhancing synaptic function and neuronal repair. Western blot analysis showed that in MCAO rats treated with iTBS, GPX4 protein expression increased, while ACSL4, TFRC, and DMT1 protein levels decreased.

Association of mold exposure and solid household fuel use with depression and anxiety among older adults in China.

Background: Exposure to mold and solid cooking fuels represents a significant environmental health concern, contributing substantially to indoor air pollution among elderly populations. However, the association between mold exposure, household fuel use, and mental health remains poorly understood. Here we examine individual and joint associations of these exposures on depression, anxiety, and their co-occurrence in older adults.

Life's Crucial 9, Genetic Susceptibility, and the Risk of Atrial Fibrillation: A Prospective Study in the UK Biobank Cohort.

Background: To date, the association between Life's Crucial 9 (LC9) and incidence of atrial fibrillation (AF) has not been explored. This study aimed to investigate the association between LC9 and the incidence of AF and evaluate the potential role of genetic risk.

Methods: LC9 consists of 9 elements categorized as low, medium, and high cardiovascular health (CVH).

Tick-Borne Infectious Diseases in China, 2003-2023.

Tick-borne diseases (TBDs) pose a substantial threat to global public health, including China. This article systematically reviews the epidemiology of TBDs in Chinese mainland between 2003 and 2023. We retrieved and analyzed the incidence and distribution of notable bacterial, viral, and parasitic TBDs in China, and discussed their clinical characteristics, diagnostic approaches, and vectors.

Enhanced electrocatalytic oxidation of high-salinity quaternary ammonium compound wastewater using CNTs-(RuIrO)/Ti Anode.

The organic pollutants, such as quaternary ammonium compounds, in high salinity flowback water from shale gas extraction may pose a severe risk to public health. Conventional biological technologies have limited effectiveness in the treatment of high-salt wastewaters, whereas electrocatalytic oxidation has shown potential for treating organic pollutants in high-salt flowback water. This study developed a carbon nanotubes (CNTs) doped Ru/Ir oxide coated Ti electrode CNTs-(RuIrO)/Ti, which exhibited enhanced electrocatalytic performance for the treatment of quaternary ammonium compound in high-salt wastewater compared to the control metal oxide coated Ti anode (RuIrO)/Ti, with pseudofirst-order reaction rate constant improved from 7.

Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia.

Background: The emergence of hypervirulent and antibiotic-resistant Klebsiella pneumoniae isolates poses a significant global public health threat, necessitating stringent prevention and control strategies on an international scale. However, current research efforts are often geographically restricted and lack integration of large-scale data analyses, limiting the understanding of the global prevalence and molecular epidemiology of K. pneumoniae.

Comparison of AI-Automated and Manual Subfoveal Choroidal Thickness Measurements in an Elderly Population Using Optical Coherence Tomography.

Purpose: To evaluate the agreement and correlation between manual and automated measurements of subfoveal choroidal thickness (SFCT) using enhanced depth imaging spectral-domain optical coherence tomography in an elderly population and to investigate the factors influencing measurement discrepancies.

Methods: Based on the Beijing Eye Study, SFCT was measured manually using Heidelberg Eye Explorer software and automatically via a TransUNet-based deep learning model. Agreement between manual and automated SFCT measurements was assessed using Bland-Altman plots, intraclass correlation coefficients (ICC), and Pearson correlation coefficients.

Synthesis of CuO/CuZnAl-LDHs heterojunction photocatalyst with enhanced antibacterial efficiency for personal protective equipment.

The growing prevalence of bacterial infections, along with the emergence of antibiotic-resistant bacteria, represents significant challenges to current anti-infective therapies. In order to address this critical issue, a series of CuO/CuZnAl-LDHs heterojunction photocatalysts were successfully synthesized via precise structural engineering. As a result, these photocatalysts demonstrated significantly enhanced antibacterial performance under simulated solar light irradiation, achieving over 99.

Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.

Importance: Nontraumatic subarachnoid hemorrhage (SAH) represents the third most common stroke type with unique etiologies, risk factors, diagnostics, and treatments. Nevertheless, epidemiological studies often cluster SAH with other stroke types leaving its distinct burden estimates obscure.

Objective: To estimate the worldwide burden of SAH.

Prognostic prediction model for Chinese uveal melanoma patients based on matrix metalloproteinase-2 and -28 expression levels in the tumor.

Aim: To explore the relationship between matrix metalloproteinases (MMPs) expression levels in the tumor and the prognosis of uveal melanoma (UM) and to construct prognostic prediction models.

Methods: Transcriptome sequencing data from 17 normal choroid tissues and 53 UM tumor tissues were collected. Based on the differential gene expression levels and their function, MMPs family was selected for establishing risk-score system and prognostic prediction model with machine learning.

Synergistic effects of air pollution and artificial light at night on diabetes risk: A prospective cohort study.

Previous studies have indicated associations between air pollutants, outdoor artificial light at night (ALAN) exposure, and diabetes risk, but their interactive effects remain insufficiently validated. Based on data from two large Chinese cohorts (CHARLS and CFPS) with 28,903 participants followed for 3 years (2013-2018), we employed Cox proportional hazards regression models to evaluate the associations of pollutants and outdoor ALAN with diabetes incidence risk and their interactions, along with stratified analyses. Results demonstrated significant linear relationships between PM and PM concentrations and diabetes risk.

PocketSCP: A Method for Spatiotemporal Topological Visualization and Analysis of Protein Pocket Dynamics.

The identification and analysis of pockets are crucial for understanding the functional mechanisms and therapeutic potential of proteins. However, it is challenging to track the dynamic characteristics of the pockets. In this paper, we present a method for the visualization and analysis of protein pocket dynamics called PocketSCP.

LILRB1 enhances the progression of diffuse large B-cell lymphoma through the CREB-SORBS3 pathway.

Purpose: Although 60-70% of diffuse large B-cell lymphoma (DLBCL) patients can be cured with the current standard of chemotherapy and immunotherapy, the remaining patients experience treatment resistance and have poor clinical outcomes. More effective strategies are needed for the DLBCL treatment.

Methods: Databases of clinical patients were analyzed to investigate potential functions of leukocyte immunoglobulin-like receptor B1 (LILRB1) in DLBCL.

Epidermal growth factor receptor antibody and axial elongation in experimental myopia.

Purpose: To evaluate the effect of intraocularly applied epidermal growth factor receptor (EGFR) antibody panitumumab on axial elongation.

Methods: This is a preclinical, safety, and efficacy experimental study. Guinea pigs aged 2-3 weeks were fitted with bilateral plano lenses (Group I; n = 10) or underwent bilateral lens-induced myopization (LIM) (Group II; n = 10) with no intravitreal injections.

Baicalin Inhibits Lung Cancer Cell Proliferation and Migration via ALOX12-Mediated Ferroptosis.

Background: Lung cancer remains a leading cause of cancer-related mortality worldwide, primarily due to late-stage diagnosis and resistance to conventional therapies. Recent studies have highlighted the potential of natural compounds in enhancing the efficacy and reducing the side effects of conventional cancer treatments. Baicalin, a bioactive compound from Scutellaria baicalensis, exhibits significant anticancer properties.