Traditional wisdom meets modern science: The protective role of sanhuang shu'ai decoction in ulcerative colitis models.

Objective: Despite extensive research on ulcerative colitis (UC), the mechanisms behind its pathogenesis remain incompletely elucidated. Sanhuang Shu'ai decoction (SSD) has granted attention for its potential therapeutic influences in inflammatory conditions, yet the protective mechanisms of SSD in UC models are lacking.

Methods: We investigated the protective effects of SSD extract utilizing two experimental models: lipopolysaccharide (LPS)-induced human colonic organoids and dextran sulfate sodium (DSS)-provoked murine models.

Research on Displacement Tracking Device Inside Hybrid Materials Based on Electromagnetic Induction Principle.

Magnetic induction imaging technology, as a non-invasive detection method based on the principle of electromagnetic induction, has a wide range of applications in the field of materials science and engineering with the advantages of no radiation and fast imaging. However, it has not been improved to address the problems of high contact measurement interference and low spatial resolution of traditional strain detection methods in bulk materials engineering. For this reason, this study proposes a magnetic induction detection technique incorporating metal particle assistance and designs a hardware detection system based on an eight-coil sensor to improve the sensitivity and accuracy of strain detection.

Ultra-Photostable Fluorescent Boron-Bridged Near-Infrared Probes to Reveal New Mode of Lipid Droplet-Mitochondria Interaction at STED Super-Resolution.

Interactions between lipid droplets (LDs) and mitochondria are vital for maintaining the cellular metabolism and energy homeostasis. However, visualizing these interaction dynamics at a high resolution in live cells is still very challenging. Here, a boron-bridged near-infrared probe () was developed specifically for low-power stimulated emission depletion (STED) super-resolution imaging of LDs.

Synthesis of CuO/CuZnAl-LDHs heterojunction photocatalyst with enhanced antibacterial efficiency for personal protective equipment.

The growing prevalence of bacterial infections, along with the emergence of antibiotic-resistant bacteria, represents significant challenges to current anti-infective therapies. In order to address this critical issue, a series of CuO/CuZnAl-LDHs heterojunction photocatalysts were successfully synthesized via precise structural engineering. As a result, these photocatalysts demonstrated significantly enhanced antibacterial performance under simulated solar light irradiation, achieving over 99.

Correction: Effects of Yersinia pseudotuberculosis outer membrane vesicles on Pseudomonas aeruginosa antigens immune response.

[This corrects the article DOI: 10.1371/journal.pone.

Development of a 101.6K liquid-phased probe for GWAS and genomic selection in pine wilt disease-resistance breeding in Masson pine.

Masson pine (Pinus massoniana Lamb.), indigenous to southern China, faces serious threats from pine wilt disease (PWD). Several natural genotypes have survived PWD outbreaks.

Successful treatment with oxaliplatin and programmed cell death protein 1 inhibitor in recurrent advanced endometrial carcinoma with mismatch repair defects: a case report and literature review.

The incidence of endometrial cancer (EC), a widely prevalent gynecological malignancy, is witnessing a global surge. Although early-stage cancer demonstrates promising outcomes, advanced cancer is associated with an unfavorable prognosis. Nevertheless, for specific pathological types or molecular subtypes of advanced EC, an accurate treatment algorithm can lead to a favorable prognosis.

Target miRNA identification for the LPL gene in large yellow croaker (Larimichthys crocea).

MicroRNA (miRNA), a conservatively evolved single-stranded non-coding RNA, exerts pivotal control over the appearance of target genes and several biological processes. This study conducted a comprehensive screening of candidate microRNAs (miRNAs) associated with Lipoprotein Lipase (LPL) in the large yellow croaker (Larimichthys crocea), utilizing sophisticated bioinformatics techniques across the species' muscular and hepatic tissues. The bioinformatics analysis facilitated the compilation and examination of miRNA datasets specific to these tissues.

Effects of Yersinia pseudotuberculosis outer membrane vesicles on Pseudomonas aeruginosa antigens immune response.

Outer membrane vesicles (OMVs) are immunogenic self-adjuvanting vesicles produced by Gram-negative bacteria such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis. While the effects of OMVs on different antigens immune stimulation are not clear. In this study, we constructed recombinant Yersinia pseudotuberculosis ΔlpxL strain,with pBlue-PcrV and pBlue-OprF/I, and then purified ΔlpxL rOMVPcrV (rOMVyp2P)and ΔlpxL rOMVOprF/I (rOMVyp2F) and analyzed its effect on immune response and protection against Pseudomonas aeruginosa PAO1 infection.

Serum hsa_circ_0007534 as a diagnostic biomarker for ovarian cancer.

Objective: To investigate the implications of serum hsa_circ_0007534 levels in ovarian cancer (OC) patients.

Methods: A retrospective analysis was conducted on the clinical data of 102 OC patients, and 102 healthy controls (HCs) were included in this study. Serum levels of hsa_circ_0007534 were measured using qPCR.

ST-Phys: Unsupervised Spatio-Temporal Contrastive Remote Physiological Measurement.

Remote photoplethysmography (rPPG) is a non-contact method that employs facial videos for measuring physiological parameters. Existing rPPG methods have achieved remarkable performance. However, the success mainly profits from supervised learning over massive labeled data.

Jeotgalibacillus haloalkalitolerans sp. nov., a novel alkalitolerant and halotolerant bacterium, isolated from the confluence of the Fenhe River and the Yellow River.

A Gram-stain positive, aerobic, alkalitolerant and halotolerant bacterium, designated HH7-29, was isolated from the confluence of the Fenhe River and the Yellow River in Shanxi Province, PR China. Growth occurred at pH 6.0-12.

Wip1 contributes to the adaptation of HepG2 human liver cancer cells to stress hormone-induced DNA damage.

Numerous studies have shown that the release of stress hormones resulting from repeated exposure to chronic psychological stress increases DNA damage and promotes tumorigenesis. However, the mechanisms that enable cancerous cells adapt to stress hormone-induced DNA damage and survive remain unclear. The present study aimed to investigate the impact of stress hormones on the survival of liver cancer cells and the underlying mechanism.

Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits.

Background: Insights into the genetic basis of complex traits and disease in both human and livestock species have been achieved over the past decade through detection of genetic variants in genome-wide association studies (GWAS). A majority of such variants were found located in noncoding genomic regions, and though the involvement of numerous regulatory elements (REs) has been predicted across multiple tissues in domesticated animals, their evolutionary conservation and effects on complex traits have not been fully elucidated, particularly in ruminants. Here, we systematically analyzed 137 epigenomic and transcriptomic datasets of six mammals, including cattle, sheep, goats, pigs, mice, and humans, and then integrated them with large-scale GWAS of complex traits.

Structure Rigidification Promoted Ultrabright Solvatochromic Fluorescent Probes for Super-Resolution Imaging of Cytosolic and Nuclear Lipid Droplets.

Lipid droplets (LDs) containing cytosolic and nuclear LDs have recently received increasing attention because of their diverse biological roles in living systems. However, developing fluorescent probes for super-resolution visualization of these subcellular LDs still remains challenging due to insufficient fluorescence brightness and poor nuclear membrane permeability. Herein, we rationally synthesized a series of ultrabright solvatochromic fluorescent probes based on benzoboranils (BBAs) for LD-specific super-resolution imaging using structured illumination microscopy (SIM).

Near-Infrared Light-Triggered Lysosome-Targetable Carbon Dots for Photothermal Therapy of Cancer.

Photothermal therapy (PTT) has inherent advantages in the treatment of hypoxic tumors due to its optically controlled selectivity on tumor ablation and oxygen-independent nature. The subcellular organelle-targeting capability and photothermal conversion efficiency (PCE) at near-infrared (NIR) wavelength are the key parameters in the assessment of the photothermal agent (PTA). Here, we report that carbon dots (CDs) prepared by the hydrothermal treatment of coronene derivatives show a high PCE of 54.

Determination of genetic effects and functional SNPs of bovine HTR1B gene on milk fatty acid traits.

Background: Our previous genome-wide association study (GWAS) on milk fatty acid traits in Chinese Holstein cows revealed, the SNP, BTB-01556197, was significantly associated with C10:0 at genome-wide level (P = 0.0239). It was located in the down-stream of 5-hydroxytryptamine receptor 1B (HTR1B) gene that has been shown to play an important role in the regulation of fatty acid oxidation.

Differential Membrane Protein Profile in Bovine X- and Y-Sperm.

The aim of this study was to understand the molecular mechanisms behind the biological differences of X- and Y-sperm and to screen the sex-specific candidate antigen proteins for sexed semen production. To this end, we investigated differential expression of total membrane proteins of the two sperm types by using high-purity X- and Y-sperm from 20 Holstein bulls and applying the label-free proteomic technique; 1521 proteins were identified. In the X-sperm group, 8 and 23 proteins were significantly up- and down-regulated, respectively.

Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades.

Myeloid-derived suppressor cells (MDSCs) play an important role in tumor immune escape. Recent studies have shown that MDSCs contribute to tumor progression under psychological stress, but the underlying mechanism of MDSCs mobilization and recruitment remains largely unknown. In the present study, a chronic restraint stress paradigm was applied to the H22 hepatocellular carcinoma (HCC) bearing mice to mimic the psychological stress.

A mature cystic teratoma adherent to the vaginal wall: a case report.

We present the case of a woman diagnosed with a teratoma adherent to the vaginal wall. The patient had been misdiagnosed with an ovarian teratoma 8 years previously at her local hospital, but no mass was found in the pelvic cavity during cesarean section. She therefore attended our institution for further examination.

Pan-RNA editing analysis of the bovine genome.

RNA editing is an essential process for modifying nucleotides at specific RNA sites during post-transcription in many species. However, its genomic landscape and characters have not been systematically explored in the bovine genome. In the present study, we characterized global RNA editing profiles from 50 samples of cattle and revealed a range of RNA editing profiles in different tissues.