A Small-Diameter Artificial Vascular Graft: Biocompatibility Evaluation and Regulatory Mechanisms of Vascular Remodeling at the Cellular and Molecular Levels.

The increasing prevalence of cardiovascular diseases highlights the urgent demand for small-diameter artificial vascular grafts (SD-AVGs). However, the clinical application of current SD-AVGs is limited by complications such as thrombosis and proliferative stenosis. We first designed and fabricated a triple-layered SD-AVG (TL-SD-AVG) composed of polycarbonate polyurethane and polyethylene terephthalate using electrospinning and mixed weaving techniques.

Whole-Brain Analysis of Increased Brain Iron in Patients with β-Thalassemia.

Rationale And Objectives: β-thalassemia (β-TM) is an inherited hematological disorder characterized by impaired hemoglobin synthesis, leading to chronic anemia and systemic iron overload. While numerous studies have documented widespread iron deposition caused by repeated blood transfusions and disrupted iron metabolism, the impact of iron overload on the brain remains poorly understood. This study aimed to investigate whole-brain iron accumulation in patients with β-TM using quantitative susceptibility mapping (QSM).

Sagittal Classification of Calcified Lumbar Disc Herniation and Therapeutic Analysis of Percutaneous Endoscopic Interlaminar Discectomy.

Background: Calcified lumbar disc herniation (CLDH) is one specific type of lumbar disc herniation (LDH). Currently, there are no uniform classification standards for different calcification degrees of herniated lumbar disc tissue. Percutaneous endoscopic interlaminar discectomy (PEID) has been proved to exhibit great efficacy in treating LDH, but whether it can achieve satisfactory results in treating CLDH with different calcification remains unclear.

More severe microdamage and micromechanical alterations: altered subchondral bone remodeling in varus knee osteoarthritis with osteoporosis.

Unlabelled: Previous studies show osteoporosis causes tibial varus in knee osteoarthritis patients. Our analysis of tibial plateau specimens from osteoarthritic patients reveals that osteoporosis accelerates the deterioration of the subchondral microstructure of the tibial plateau, exacerbating tibial varus.

Introduction: The relationship between osteoporosis (OP) and knee osteoarthritis (OA) has garnered significant clinical interest, particularly regarding the prevalence of tibial varus in patients suffering from both conditions.

Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques.

Objective: To investigate the difference of black blood (DB) and bright blood (BB) T2* techniques at 1.5 T and 3 T in the assessment of myocardial iron load in patients with thalassemia (TM).

Methods: As a retrospective study.

Analysis of Strain Transfer Characteristics of Fiber Bragg Gratings for Asphalt Pavement Health Monitoring.

Fiber Bragg grating (FBG) exhibits strong resistance to electromagnetic interference and excellent linear strain response, making it highly promising for structural health monitoring (SHM) in pavement. This research investigates the strain transfer characteristics of embedded FBG in pavement structure and materials by using the relevant theoretical models. Results indicate adhesive layer thickness and sheath modulus are the primary factors influencing the strain transfer coefficient.

Copper-Mediated Oxidative Coupling of Difluoromethyl Bromides/Chlorides with Primary Amines: Direct Synthesis of α-Ketoamides.

A practical and efficient protocol for one-pot synthesis of α-ketoamides has been developed through ligand-free copper-mediated using commercially available 2-bromo/chloro-2,2-difluorophenylethanones and primary amines as starting materials. The reaction exhibits moderate to good yields, broad functional group tolerance, and mild reaction conditions. Mechanistic studies indicate a plausible pathway involving copper-mediated oxidative elimination in DMSO to generate a key acyl fluoride intermediate, which subsequently reacts with aniline to afford the corresponding ketoamide.

A study on the spatial distribution and driving factors of traditional villages-a case study of the Beijing-Tianjin-Hebei region in China.

Traditional villages encompass abundant cultural resources, possessing significant humanistic and socio-economic value. This study used ArcGIS 10.8 and GeoDa software, took "Chinese Traditional Villages" as the research object, and analyzed their spatial autocorrelation and spatial heterogeneity through methods such as nearest neighbor analysis, Moran's Index, and kernel density estimation.

A Comparison Between the Oddball Paradigm and the Multi-Feature Paradigm: Evidence From an Event-Related Potential Study on Processing Mandarin Vowels and Tones.

The multi-feature paradigm, despite its growing use in studies on MMN (mismatch negativity), faces challenges in broader adoption due to doubts about its efficacy compared to the oddball paradigm. More studies are needed to determine whether the multi-feature paradigm is sensitive to capture the MMN under complex auditory conditions, particularly in tonal languages like Mandarin. In the present study, Mandarin syllables were used as stimuli to examine differences in event-related potentials (ERPs) between the two paradigms.

Ultrawide-Field Optical Coherence Tomography Angiography-Guided Navigated Laser Therapy of Non-Perfused Areas in Branch Retinal Vein Occlusion.

: This study evaluates whether ultrawide-field optical coherence tomography angiography (UWF-OCTA) can guide navigated laser therapy for non-perfused areas (NPAs) in branch retinal vein occlusion (BRVO). It further explores whether the laser spots can be accurately placed according to plan, considering that the retina is three-dimensional (3D), while UWF-OCTA provides two-dimensional (2D) images. : UWF-OCTA images from three devices-VG200, Xephilio OCT-S1, and Bmizar-guided the treatments.

Fluoride-Effect-Directed Catalyst-Controlled Regioselective Acylation of Carbohydrate Diols and Triols.

Herein, we report that acyl fluorides enable the switchable selective acylation of vicinal 1,2--diol motifs in carbohydrates. While DMAP as a catalyst directs equatorial acylation, DBU highly promotes the thermodynamically unfavorable axial O-acylation, reversing conventional preferences. NMR studies and DFT calculations indicate that triple hydrogen bonding governs this unusual regioselectivity.

Metastatic Cervical Cancer in the Asia-Pacific Region: Current Treatment Landscape and Barriers.

Unlabelled: Despite treatment advances for metastatic cervical cancer (mCC), the Asia-Pacific region faces significant barriers in treatment accessibility, availability, and healthcare infrastructure. This study explored the treatment landscape and barriers for mCC in the Asia-Pacific. A descriptive, cross-sectional, web-based study evaluating cervical cancer treatment patterns was conducted among medical, radiation, and gynecologic oncologists and gynecologists in the Chinese mainland (n = 80), Australia, the Philippines, South Korea, and Taiwan (n = 20 each).

Atomically Precise Silver Nanocluster Riveted by Uneven Charged Traps toward Enhancing Electrocatalytic Activity for the Oxygen Reduction Reaction.

Metal nanoclusters (MNCs) possessed promising potentials for catalytic applications but were hindered by the intrinsic charge-carrier mobility and the exposure of active sites. To this point, our work developed the uneven charged traps strategy to realize the homogeneous dispersion and immobilization of atomically precise silver nanoclusters (Ag) and obtained an Ag cluster-based oxygen reduction reaction (ORR) electrocatalyst with enhanced performance. As expected, the uneven charged traps derived by graphitized nitrogen-doped carbon (NDC) extended the effective catalytic active area, tuned the electrical environment, and facilitated the binding between ORR intermediates and the active sites.

Tissue-Selective Separation Mechanism of Multi-type Soft Tissues Under Waterjet Impact for Low-Trauma Cutting Surgery.

Purpose: Waterjet is increasingly used in medicine for cutting and ablation of soft tissues due to its non-thermal damage and tissue-selective separation. However, the tissue-selective separation mechanism for cutting target tissues while protecting blood vessels under waterjet impact remains little known. In this study, the mechanical properties, dynamic responses and tissue-selective separation mechanisms of four typical soft tissues including liver, muscle, and arterial-venous blood vessels under waterjet impact were investigated.

Integrating transcriptomic and metabolomic profiles of primiparous Holstein cows across multiple lactation periods reveals the regulatory mechanism underlying milk component traits.

To investigate the regulatory mechanisms underlying milk production traits, transcriptional sequencing (RNA-seq) and metabolomic analysis with liquid chromatography-MS were implemented in blood and serum samples from 25 lactating Holstein cows across multiple lactation stages. We identified 16,147, 15,859, and 16,010 expressed genes (fragments per kilobase million >1) and 160, 332, and 142 differentially expressed genes (DEG) during early, peak, and late lactation, respectively; the DEG were significantly enriched in adipocytokine, PPAR, and cAMP signaling and influenced cholesterol, vitamin B, and fat metabolism; 9 candidate genes were identified by comparing QTLs related to milk production, reproduction, and disease resistance traits. Additionally, 303 metabolites in 22 categories were detected, in which 19, 22, and 32 metabolites displayed differential abundance in the early versus peak, early versus late, and peak versus late comparison groups, respectively.

Ultra-depleted mantle source of basalts from the South Pole-Aitken basin.

Lunar mare basalts illuminate the nature of the Moon's mantle, the lunar compositional asymmetry and the early lunar magma ocean (LMO). However, the characteristics of the mantle beneath the vast South Pole-Aitken (SPA) basin on the lunar farside remain a mystery. Here we present the petrology and geochemistry of basalt fragments from Chang'e-6 (CE6), the first returned lunar farside samples from the SPA basin.

Exploring the rarity: insights into primary diffuse large B-cell lymphoma of the prostate from a global retrospective analysis.

Background: The purpose of this study is to comprehensively analyze cases of primary diffuse large B-cell lymphoma of the prostate (P-DLBCL-P) from a global perspective, aiming to understand the disease's characteristics, treatment responses, and outcomes. By doing so, we seek to establish a valuable reference for the clinical management of this rare malignancy.

Materials And Methods: This study conducted a retrospective review of P-DLBCL-P cases reported worldwide, using various online databases, including PubMed, Scopus, and other English databases, as well as WanFang Data and China National Knowledge Infrastructure in Chinese, collecting clinical pathology information, treatment modalities, and prognosis of patients, and conducted survival analysis using the Kaplan-Meier method.

Tectorigenin Ameliorates Glucocorticoid-Induced Osteoporosis by Inhibiting the NF-κB Signal Pathway and Modulating Treg-Th17 Cell Balance.

Glucocorticoid-induced osteoporosis is a common clinical orthopaedic disease, primarily due to excessive use of hormones. Tectorigenin has shown a certain efficacy in treating osteoporosis, but its underlying mechanisms are not yet fully understood. This study aimed to evaluate tectorigenin (TEC)'s potential in treating glucocorticoid-induced osteoporosis (GIOP) by restoring the osteoclast-osteoblast balance.

[Expression Levels of EZH2 and KMT2D in Patients with Diffuse Large B-Cell Lymphoma and Their Relationship with Pathological Features].

Objective: To investigate the expression levels of EZH2 and KMT2D in patients with diffuse large B-cell lymphoma (DLBCL) and their relationship with pathological features.

Methods: 84 patients with DLBCL treated in our hospital from January 2021 to June 2022 were selected as the study subjects, and clinical characteristics such as sex, age and pathological classification of the patients were collected. Immunohistochemistry was used to detecet the expression of KMT2D and EZH2 proteins in tumor tissue cells of the DLBCL patients.

Construction of a novel prognostic model for pancreatic adenocarcinoma to predict prognosis and guide immunotherapy.

Pancreatic adenocarcinoma (PAAD) remains one of the most lethal malignant tumors, with poor prognosis and limited treatment options. This study aims to explore the role of butyrate metabolism-related genes (BMRGs) in PAAD to improve diagnostic and prognostic strategies. The study analyzed PAAD based on transcriptomic and clinical data obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases.

Preoperative chlorhexidine mouthwash can reduce the risk of postoperative pulmonary complications in elderly patients undergoing general anesthesia with endotracheal intubation.

To investigate whether preoperative chlorhexidine mouthwash can reduce the risk of postoperative pulmonary complications(PPCs) in elderly patients with tracheal intubation under general anesthesia. 78 elderly patients undergoing elective surgery under general anesthesia and endotracheal intubation were randomly divided into the chlorhexidine group (CH group, n = 39) and the normal saline group (NS group, n = 39). Nurses instructed patients to gargle with 15 ml saline or compound chlorhexidine mouthwash the night before surgery, on the morning of surgery, and upon entering the operating room.

Inetetamab triggers cardiotoxicity through its interaction with apoptosis, oxidative stress and autophagy pathways.

Inetetamab, a trastuzumab biosimilar, has obtained approval for the treatment of HER2-positive advanced metastatic breast cancer. Despite studies indicating its cardiotoxic properties, the intricate mechanisms underlying its toxicity remain elusive. In the present study, we demonstrated in vitro that exogenous administration of Inetetamab triggered injury in H9c2 myocardial cells, characterized by a significant decrease in cell viability and noticeable morphological changes.

Understanding the relations between cognition and academic skills in the context of instruction.

Research underscores a link between cognition and academic abilities. This article reviews some of the work from my research team to shed light on this evolving viewpoint. I first present studies on the mutual relationship between cognitive and academic skills, illustrating their interactive and supportive development.

Exploring supply and demand imbalance of community-based older adult care: an observational study in Chongqing, China.

Objective: Using an urban area in southwest China as a case study, this research investigates and analyzes the supply and demand of community-based older adult care services to provide a basis for optimizing the older adult care service system.

Methods: A two-stage sampling method was employed to select older participants. Questionnaires, designed based on the Kano model, were administered to participants, and semi-structured interviews were conducted with community senior center managers and services users.