Whole-Brain Analysis of Increased Brain Iron in Patients with β-Thalassemia.

Rationale And Objectives: β-thalassemia (β-TM) is an inherited hematological disorder characterized by impaired hemoglobin synthesis, leading to chronic anemia and systemic iron overload. While numerous studies have documented widespread iron deposition caused by repeated blood transfusions and disrupted iron metabolism, the impact of iron overload on the brain remains poorly understood. This study aimed to investigate whole-brain iron accumulation in patients with β-TM using quantitative susceptibility mapping (QSM).

Determination of the half-life of Sb using the reference source method.

Sb is a helpful radionuclide in nuclear forensics, yet discrepancies in previous measurements have led to a 1.8 % uncertainty in its recommended half-life value, compromising accurate activity determination. In this study, Sb samples were chemically separated from the fission products of U following thermal neutron irradiation at Xi'an Pulsed Reactor.

Bupi Yishen formula improves chronic kidney disease by restoring renal energy metabolism and mitochondrial oxidative phosphorylation.

Background: Bupi Yishen formula (BYF) is a traditional Chinese herbal mixture with proven efficacy in attenuating kidney function deterioration among patients with advanced chronic kidney disease (CKD), and improving renal fibrosis of CKD animal models. Previous studies have shown that BYF rehabilitates metabolic dysregulation under CKD condition, but its exact mechanism remains unclear.

Purpose: This study aimed to elucidate the therapeutic effect and its potential mechanism on regulating renal energy metabolism in CKD.

Copper immobilization and resource recovery from acidic copper mine water based on algae and bioelectrochemical system.

Acidic copper mine water, characterized by its organic matter scarcity, low pH, and high Cu pollution, presents major challenges due to limitations in traditional biological treatment and the high costs of physicochemical methods. There is an urgent need for an efficient treatment and resource recovery process. Algae could adsorb and immobilize Cu, and the secondary metabolic organics could be metabolized by bacteria, which compensates for the shortcomings of algae.

Advances in neoadjuvant therapy for pancreatic cancer: Current trends and future directions.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies, with poor survival rates due to late-stage diagnosis and limited treatment options. Neoadjuvant therapy (NAT), which involves chemotherapy or chemoradiation prior to surgical resection, has emerged as a promising approach to improve resectability and overall survival (OS). The integration of advanced imaging techniques and biomarkers for evaluating the response to NAT is crucial for optimizing therapeutic strategies and surgical outcomes.

Study on Large-Scale Brain Network Abnormalities in Patients With Beta-Thalassemia.

Background: Beta-thalassemia major (β-TM) is a hereditary blood disorder characterized by chronic anemia and hypoxia, which may have profound effects on brain function. This study systematically evaluates alterations in both intra-brain network functional connectivity (FC) and inter-network functional connectivity (FNC) in β-TM patients using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), aiming to uncover the potential mechanisms underlying their neurofunctional impairments.

Methods: This study included 72 β-TM patients and 50 age- and gender-matched healthy controls (HC).

Evaluation of glymphatic system function in patients with thalassemia: a study based on DTI-ALPS technology.

Background: Thalassemia is an inherited hematological disorder characterized by chronic anemia and multisystem involvement, including potential impacts on the central nervous system. Research has suggested a relationship between thalassemia and glymphatic system dysfunction, which may contribute to neurocognitive impairments. However, the exact mechanisms linking thalassemia to changes in glymphatic function remain unclear.

White matter microstructure abnormalities in thalassemia patients using TBSS analysis based on DTI.

Thalassemia is a hereditary hemoglobinopathy characterized by severe anemia and iron overload, which may affect brain microstructure. This study aims to investigate changes in the white matter (WM) microstructure of patients with β-thalassemia using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) analysis. The study included 40 patients with β-thalassemia (aged 18-45 years, mean age 30.

Development of a CT radiomics model for detection of bladder invasion by colorectal carcinoma.

To investigate the feasibility of a radiomics model for the detection of bladder invasion (BI) by colorectal cancer (CRC) on CT images. Ninety-six patients with CRC and a suspicion of BI who underwent tumor resection with partial or total cystectomy were reviewed. The 96 patients were randomly assigned to the training dataset (n = 68) or test dataset (n = 28) at a ratio of 7:3.

Reversing inhibition to promotion in phenol-ammonium metabolism via algal-microbial fuel cell: Mechanisms of phenol-ammonium interaction and synergistic removal.

Addressing the challenge of metabolic inhibition between phenol and ammonium in coal gasification wastewater (CGW), this study introduced a novel algal-microbial fuel cell (AMFC). It combined the advantages of electroactive bacteria and Synechocystis to achieve synergistic metabolism, establishing a cooperative mechanism for pollutant separation and enhanced transformation to achieve the mutual promotion of phenol and ammonium removal. Remarkably, raising phenol to 1500 mg COD/L boosted ammonium removal by 31.

Development and validation of machine learning models for predicting no. 253 lymph node metastasis in left-sided colorectal cancer using clinical and CT-based radiomic features.

Background: The appropriate ligation level of the inferior mesenteric artery (IMA) in left-sided colorectal cancer (CRC) surgery is debated, with metastasis in No. 253 lymph node (No. 253 LN) being a key determining factor.

Noninvasive Intracranial Source Signal Localization and Decoding with High Spatiotemporal Resolution.

High spatiotemporal resolution of noninvasive electroencephalography (EEG) signals is an important prerequisite for fine brain-computer manipulation. However, conventional scalp EEG has a low spatial resolution due to the volume conductor effect, making it difficult to accurately identify the intent of brain-computer manipulation. In recent years, transcranial focused ultrasound modulated EEG technology has increasingly become a research hotspot, which is expected to acquire noninvasive acoustoelectric coupling signals with a high spatial and temporal resolution.

Molecular-Level Understanding of Water Transport Mechanisms in Functionalized TiCT MXene Membrane-Combined Experimental Approaches.

The hydrophilicity of two-dimensional (2D) transition-metal carbides, carbonitrides, and nitrides (MXene) nanochannels plays a critical role in water transport during filtration, yet its specific effects on MXene membranes remain inadequately understood. Herein, we systematically investigated water transport through TiCT MXene nanochannels using molecular dynamics simulations coupled with experimental validation, addressing a significant knowledge gap in MXene-based separation membranes. Our simulations demonstrated that strong interactions between water molecules and hydrophilic nanochannel MXene surfaces (TiC(OH) MXene or TiC(NH) MXene) facilitated the formation of ordered molecular arrangements, substantially improving water permeability.

Random survival forest model in patients with epithelial ovarian cancer: a study based on SEER database and single center data.

Clinical data of 1,780 patients with epithelial ovarian carcinoma (EOC) in the Surveillance, Epidemiology and End Results (SEER) database were retrospectively analyzed. A random survival forest model and a nomogram model were built based on the prognostic factors. The clinical data of 140 patients with EOC treated in Liuzhou Worker's Hospital were collected for the validation of the prognostic model.

Position Optimization of Bulky Tetraphenylsilane in Multiple Resonance Molecules for Highly Efficient Narrowband OLEDs.

Multiple resonance (MR)-type thermally activated delayed fluorescence (TADF) emitters have garnered significant interest due to their narrow full width at half maximum (FWHM) and high electroluminescence efficiency. However, the planar structures and large singlet-triplet energy gaps (ΔEs) characteristic of MR-TADF molecules pose challenges to achieving high-performance devices. Herein, two isomeric compounds, p-TPS-BN and m-TPS-BN, are synthesized differing in the connection modes between a bulky tetraphenylsilane (TPS) group and an MR core.

Fluorescence enhancement of cyanine/hemicyanine dyes with adamantane as an auxochrome through host-guest inclusion with methylated cyclodextrin in water.

Fluorescence of cyanine dyes is often quenched in aqueous solution, limiting their application in water or biological system. In this work, a novel strategy of host-guest interaction based on cyanine derivatives containing auxochromes was proposed to enhance fluorescence in aqueous solution and cell imaging. By using the host (methylated β-cyclodextrin, M-β-CD) to inclusion and suppress the TICT effect of the dye, the fluorescence was significantly enhanced at lower host concentration.

Characteristics and treatment of pediatric nasal foreign bodies with button batteries-A retrospective analysis of 176 cases.

Purpose: Button battery nasal impactions pose serious risks due to complications and the need for prompt removal, yet research on interventions remains limited due to its rare occurrence. To delineate the clinical manifestations of nasal foreign bodies associated with button batteries and to explore treatment approaches focused on minimizing the reliance on general anesthesia and surgical interventions.

Methods: This study focuses on 176 cases of children who received treatment for nasal cavity button battery impactions.

Abdominal multi-organ iron content and the risk of Parkinson's disease: a Mendelian randomization study.

Background: To evaluate the causal relationship between abdominal multi-organ iron content and PD risk using publicly available genome-wide association study (GWAS) data.

Methods: We conducted MR analysis to assess the effects of iron content in various abdominal organs on PD risk, followed by reverse analysis. Additionally, MVMR analysis evaluated the independent effects of organ-specific iron content on PD.

Characterization of RNA Processing Genes in Colon Cancer for Predicting Clinical Outcomes.

Objective: Colon cancer is associated with multiple levels of molecular heterogeneity. RNA processing converts primary transcriptional RNA to mature RNA, which drives tumourigenesis and its maintenance. The characterisation of RNA processing genes in colon cancer urgently needs to be elucidated.