Gut microbiota dysbiosis exacerbates polystyrene microplastics-induced liver inflammation via activating LPS/TLR4 signaling pathway in ducks.

Ubiquitous microplastics can bioaccumulate in organisms, resulting in detrimental health impacts, such as liver inflammation. Nonetheless, the exact mechanism by which polystyrene microplastics (PS-MPs) trigger liver inflammation via the gut-liver axis in ducks remains unclear. The purpose of this study was to clarify the impact of PS-MPs exposure to liver inflammation through the gut-liver axis in ducks.

Creating a delirium risk assessment model for geriatric patients with femoral neck fractures through artificial intelligence techniques: a theoretical exploration.

Background: Postoperative delirium (POD) is a common occurrence following orthopedic surgery, particularly in the older population. However, there is a relative scarcity of research on the use of intelligent algorithms to predict POD in older patients after orthopedic surgery. Therefore, the objective of this study was to evaluate the efficacy of ten distinct intelligent algorithms in predicting POD in older patients undergoing femoral neck fracture surgery.

How electronic health literacy influences physical activity behaviour among university students: A moderated mediation model.

Purpose: This study examines how eHealth literacy influences exercise behaviour among university students through a moderated mediation model. Specifically, peer relationships are positioned as mediators, while sleep quality moderates the effect of eHealth literacy on exercise behaviour among university students. The study explores the intricate interactions involved and elucidates how eHealth literacy affects exercise behaviour through multiple dimensions.

Magnetically actuated multimaterial fiberbot for precise minimally invasive knee laser surgery.

Conventional methods, such as open and arthroscopy-assisted surgery, still encounter challenges in terms of tool flexibility when addressing knee diseases in patients. Robotics has enhanced the precision and efficiency of numerous surgical procedures. However, there is still a lack of minimally invasive surgical tools capable of flexibly resecting knee lesions.

Tirofiban-induced acute profound thrombocytopenia in endovascular therapy for acute ischemic stroke: a rare case report.

Background: Studies have shown that tirofiban (a glycoprotein IIb/IIIa receptor antagonist) is effective in the endovascular treatment of cerebrovascular diseases. However, it has also been reported that tirofiban can cause thrombocytopenia. Here we report a rare case of tirofiban-induced acute profound thrombocytopenia in a patient undergoing endovascular therapy for acute ischemic stroke.

Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial.

Exaggerated orthostatic changes in systolic blood pressure (SBP) were associated with adverse cardiovascular events. We aim to assess the association between orthostatic SBP changes and incident atrial fibrillation (AF). We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial).

Catheter Ablation vs Drug Therapy in Patients With Atrial Fibrillation and Nonmodifiable Recurrence Risk Factors: A Secondary Analysis of the CABANA Randomized Clinical Trial.

Importance: Large-scale randomized studies evaluating the impact of catheter ablation on cardiovascular prognoses across different atrial fibrillation (AF) recurrence risk profiles are lacking.

Objective: To investigate the benefits of catheter ablation in patients with varying numbers of nonmodifiable recurrence risk factors (NMRRFs).

Design, Setting, And Participants: This study was a post hoc subanalysis of the multinational, multicenter, open-label Catheter Ablation vs Anti-Arrhythmic Drug Therapy for Atrial Fibrillation (CABANA) randomized clinical trial, for which enrollment occurred from November 2009 to April 2016, with follow-up until December 31, 2017.

The influence of physical activity on emotional management ability in college students: a chain mediating role of psychological resilience and health literacy.

Objective: This study aimed to investigate the impact of physical activity (PA) on emotional management ability (EMA) in college students and to analyze the chain mediating roles of psychological resilience (PR) and health literacy (HL) in the relationship between PA and EMA.

Methods: Demographic information was collected using a stratified, cluster, and multi-stage sampling method. Data on PA, PR, HL, and EMA among college students were collected using an online questionnaire.

Emerging contaminants in the lower Yangtze River basin: spatiotemporal distribution, ecological risks in surface water, and fate in wastewater treatment plants.

Emerging contaminants (ECs) have drawn significant attention due to their adverse effects on aquatic ecosystems. This study investigated the spatiotemporal distribution and ecological risks of 43 ECs in surface water and examined their fate in wastewater treatment plants (WWTPs) in the lower Yangtze River basin. In surface water, 34 ECs were detected, including 13 antibiotics, 4 endocrine-disrupting compounds, 9 pharmaceutical and personal care products, 4 perfluoroalkyl and polyfluoroalkyl substances and 4 organophosphate esters.

Chairside-applicable MS/FGelMA hydrogel with enhanced osteogenesis and mechanical adaptability for alveolar ridge preservation.

Current alveolar ridge preservation (ARP) materials face unresolved trade-offs between mechanical stability, bioactivity, and clinical operability. To address this, we developed a fish-derived methacrylated gelatin (FGelMA) hydrogel composited with magnesium silicate (MS) microparticles combining the low immunogenicity of FGelMA with the dual osteo-angiogenic potential of MS. To characterize the physical properties of this material, the composite hydrogels (MS/FGelMA) were tested using a mechanical tester and a rheometer, and then its biocompatibility and osteogenic properties were analyzed using bone marrow mesenchymal stem cells (BMSCs) in a three-dimensional environment.

Engineering of a multi-modular CRISPR biomachine for ultrasensitive monitoring of β-glucosyltransferase activity.

β: [note: ":" is changed to "-"] Glucosyltransferase (β-GT) is a pivotal enzymatic tool for 5-hydroxymethylcytosine (5-hmC) detection, and it can specifically catalyze the glycosylation of 5-hmC. This enzymatic reaction plays a crucial role in modulating bacteriophage-specific gene expression and facilitating the survival of bacteriophages and parasites within host cells. Herein, we engineer a multi-modular and structurally ordered CRISPR/Cas-based biomachine by integrating 5-hmC glycosylation-triggered palindrome-primed hyperbranched rolling circle amplification (PP-HRCA) for ultrasensitive analysis of exogenous β-GT activity.

Study on sedentary behavior and its influencing factors in elderly ovarian cancer patients during home confinement.

Sedentary behavior is prevalent among the elderly and has become an increasingly serious public health issue. Although extensive research has been conducted on the status and risk factors of sedentary behavior in the general elderly population, the current situation and related influencing factors of sedentary behavior in elderly patients with ovarian cancer, a disease-specific group, have not been fully explored. In this study, a total of 206 elderly ovarian cancer (EOC) patients who received treatment at the First Affiliated Hospital of Zhejiang University School of Medicine from September 1, 2022, to February 28, 2025, were selected as the research subjects by convenience sampling.

LR-COBRAS: A logic reasoning-driven interactive medical image data annotation algorithm.

The volume of image data generated in the medical field is continuously increasing. Manual annotation is both costly and prone to human error. Additionally, deep learning-based medical image algorithms rely on large, accurately annotated training datasets, which are expensive to produce and often result in instability.

Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice.

Background: Cholestasis, including primary sclerosing cholangitis (PSC), remains a challenging condition with limited treatment options. The gut-liver axis and FXR signaling pathways play critical roles in maintaining bile acid homeostasis and preventing liver injury. Capsaicin, a natural compound with anti-inflammatory properties, has the potential to modulate these pathways and offer therapeutic benefits for cholestasis.

CD36 attenuates pressure overload-induced myocardial insulin resistance via HSF1-dependent HSP90α suppression and competitive disruption of the HSP90α-InsR complex.

Background: Insulin resistance (IR) is an early hallmark of pressure overload-induced myocardial injury and heart failure. Although CD36, a fatty acid transporter, regulates systemic insulin sensitivity, its role in myocardial insulin resistance under pressure overload remains unclear. This study aimed to elucidate CD36's cardioprotective mechanisms in this context.

Catheter Ablation for Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy: Electrophysiological Characteristics and Long-Term Outcomes.

Background: Studies on catheter ablation of hypertrophic cardiomyopathy (HCM)- ventricular tachycardia (VT) are relatively limited and mainly focused on feasibility and safety, whereas the VT distribution and electrophysiological properties remain insufficiently characterized.

Objectives: The aim of this study was to detail the site-specific electrophysiological properties and ablation outcomes in HCM-VT.

Methods: A total of 32 patients with HCM-VT who underwent catheter ablation were included.

Light-Controlled Oscillation of Microplates Leveraging Contact Adhesion.

Miniaturized mechanical oscillation is mostly realized in microelectromechanical systems (MEMS). Its routine implementation involves carefully configuring a driving force, such as electrostatic force, while concurrently mitigating contact adhesion that tends to anchor moving parts. Though often undesirable, contact adhesion plays a significant role at micronano scales and may be harnessed as a driving force for miniaturized oscillators.

Risk Factors for Pleural Reaction in CT-Guided Percutaneous Lung Nodule Localization: A Single-Center Retrospective Study.

Background: Pleural reaction (PR) frequently occurs during computed tomography (CT) -guided lung puncture procedures, and its development is influenced by various factors. This study aims to identify the risk factors associated with PR in CT-guided percutaneous lung nodule localization (CT-PLNL) procedures.

Methods: This retrospective study included 467 patients who underwent video-assisted thoracic surgery (VATS) at Nanjing Drum Tower Hospital between January 2022 and December 2023, all of whom had received CT-PLNL.

Transcriptomic Insights into the Protective Effects of Apigenin and Sodium Butyrate on Jejunal Oxidative Stress in Ducks.

Apigenin and sodium butyrate have been reported to help alleviate oxidative stress. This study evaluated the jejunal transcriptomic responses in ducks receiving apigenin and sodium butyrate supplementation under oxidative stress. In total, 200 healthy 300-day-old female Jinyun Ma ducks (1.

Influencing factors and mechanisms promoting proactive health behavior intention: an integration of the health belief model and the theory of planned behavior.

Background: Promoting proactive health behaviors is an effective strategy for addressing public health challenges and advancing the "Healthy China" initiative. This study aims to explore the driving factors and mechanisms influencing proactive health behavior intention by integrating the theory of planned behavior (TPB) and the health belief model (HBM).

Methods: A cross-sectional survey design was employed.

Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex.

The Mitochondrial Pyruvate Carrier (MPC) bridges cytosolic and mitochondrial metabolism by transporting pyruvate into mitochondria for ATP production and biosynthesis of various essential molecules. MPC functions as a heterodimer composed of MPC1 and MPC2 in most mammalian cells. Here, we present the cryogenic electron microscopy (cryo-EM) structures of the human MPC1-2 complex in the mitochondrial intermembrane space (IMS)-open state and the inhibitor-bound in the mitochondrial matrix-open state.

Outcomes of radiotherapy combined with immune checkpoint inhibitors in locally advanced unresectable esophageal squamous cell carcinoma: a retrospective analysis.

Background: The benefit of immune checkpoint inhibitors (ICIs) for esophageal cancer has been investigated and integrated into the treatment strategy. The integration of ICIs with radiotherapy offers significant potential for future applications in patients with locally advanced unresectable esophageal squamous cell carcinoma (ESCC). This study aimed to investigate the outcomes of ICIs combined with radiotherapy.

Intensive Blood Pressure Control in Patients With Diabetes and Previous Stroke: A Post-Hoc Analysis of ACCORD-BP Trial.

Intensive systolic blood pressure (SBP) control reduces cardiovascular outcomes in hypertensive patients, but its effects in those with diabetes and prior stroke need further evidence. Among 4733 patients with elevated SBP enrolled in the ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood Pressure) trial, this post-hoc analysis focused on 307 patients with type 2 diabetes and prior stroke to evaluate intensive versus standard SBP control. The primary outcome was major adverse cardiovascular events (MACE), a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke.