Effects of GLP-1RA Treatment on Long-Term Post-PCI Prognosis in T2DM Patients: A Propensity Score Matching Study.

Purpose: Data on the effect of GLP-1RA treatment on the long-term prognosis of patients with diabetes after percutaneous coronary intervention (PCI) are scant. The purpose of this study was to evaluate the effect of GLP-1RA treatment on the long-term prognosis in T2DM patients after PCI.

Patients And Methods: Data on T2DM patients who underwent PCI from January 2019 to December 2020 were retrospectively analyzed.

Chairside-applicable MS/FGelMA hydrogel with enhanced osteogenesis and mechanical adaptability for alveolar ridge preservation.

Current alveolar ridge preservation (ARP) materials face unresolved trade-offs between mechanical stability, bioactivity, and clinical operability. To address this, we developed a fish-derived methacrylated gelatin (FGelMA) hydrogel composited with magnesium silicate (MS) microparticles combining the low immunogenicity of FGelMA with the dual osteo-angiogenic potential of MS. To characterize the physical properties of this material, the composite hydrogels (MS/FGelMA) were tested using a mechanical tester and a rheometer, and then its biocompatibility and osteogenic properties were analyzed using bone marrow mesenchymal stem cells (BMSCs) in a three-dimensional environment.

HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy.

Background: Invasive micropapillary carcinoma (IMPC) is a rare histopathological subtype of breast cancer (BC) that shows a high incidence of human epidermal growth factor receptor 2 (HER2)-positive expression. However, the therapeutic efficacy of current standard anti-HER2 therapies for this distinct BC subtype remains unclear.

Methods: We retrospectively analyzed patients with HER2-positive BC who underwent neoadjuvant therapy with trastuzumab (H) or trastuzumab plus pertuzumab (HP) between 2015 and 2023 at Sun Yat-sen University Cancer Center.

Clinical outcome and genomic biomarkers of immune checkpoint inhibitor-based therapies for cancer of unknown primary: a multicenter, real-world study.

Background: Given the limited treatment options recommended for cancer of unknown primary (CUP), especially the role of immune checkpoint inhibitors (ICIs), our study aimed to evaluate the efficacy of ICIs and identify associated genomic biomarkers in these patients.

Methods: This retrospective, multicenter, real-world analysis included individuals with oncologist-confirmed CUP cases treated with ICIs across four hospitals in China. Clinical outcomes, safety and biomarkers were analyzed.

STInt: An integrated dataset covering science, technology and industry information in the pharmaceutical field.

With the rapid development of the economy, the linkages among science, technology, and industry have become increasingly close, and more and more study focus on the binary or ternary interactions among the three. However, the different datasets and fields used in previous studies make it difficult to directly compare and synthesize research results. This further affects the comprehensive understanding of the binary and ternary interactions among science, technology, and industry.

Harnessing the power of Bacillus subtilis MR42: direct production of defined xylooligosaccharides (XOS) from corn stalks with enhanced prebiotic properties.

The production of value-added bioproducts from renewable carbon sources has gained increasing attention in recent years. The aim of this study was to develop economical approaches for the production of prebiotic XOS with defined degree of polymerization (DP) by Bacillus subtilis MR42 from corn stalks. The MR42 strain has been genetically modified to delete the xynC gene, which enables it to convert xylan into specific XOS without generating xylose as a byproduct.

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer.

Breast cancer is the most prevalent form of malignant tumor that frequently metastasizes to axillary lymph nodes (LNs). Nonetheless, the precise mechanisms underlying alterations in the tumor microenvironment (TME) in LN metastasis in breast cancer remain poorly understood. Single-cell RNA sequencing of 28 LN samples from 23 patients is performed, and a comprehensive landscape of the entire ecosystem is generated.

1-hydroxy-7-azabenzotriazole-cinnamic esters as anti- agents.

The emergence of pharmacological resistance mechanisms coupled with treatment-related toxicities inherent in conventional chemotherapeutic regimens necessitates the development of next-generation targeted therapeutics with enhanced therapeutic indices. It is anticipated that progress in research will aid in the development of more efficacious management and prevention strategies, thereby potentially reducing the global incidence of Toxoplasmosis. In this study, the viability of a one-step synthesis method for 1-hydroxy-7-azabenzotriazole-cinnamic esters was demonstrated.

Olanzapine combined with standard antiemetics for the prevention of nausea and vomiting in patients with germ cell tumor undergoing a 5-day cisplatin-based chemotherapy (NAVIGATE study)： A phase III crossover trial.

Purpose Prophylactic use of olanzapine significantly improves chemotherapy-induced nausea and vomiting (CINV) in patients receiving single-day highly emetogenic chemotherapy and 3-day cisplatin-based chemotherapy. This phase III, double-blind, placebo-controlled crossover trial aimed to evaluate the efficacy and safety of olanzapine combined with triple antiemetic therapy for CINV in germ cell tumor (GCT) patients receiving 5-day cisplatin-based chemotherapy.Methods Eligible patients receiving at least two consecutive identical courses of 5-day cisplatin-based chemotherapy were randomly assigned to either olanzapine (5 mg) or its matching placebo during days 1-7 of the first chemotherapy cycle, then crossed over to the alternate group during the second cycle.

RC48-ADC monotherapy or in combination with immunotherapy for locally advanced or metastatic urothelial carcinoma with HER2 low and null expression: a multicenter, real-world, retrospective study.

Background: Approximately half of urothelial carcinoma (UC) patients exhibit low or null HER2 expression. Limited data are available on the efficacy of anti-HER2 RC48-ADC (Disitamab Vedotin) in HER2 low and null advanced UC.

Methods: Patients with locally advanced or metastatic UC (la/mUC) with HER2 low (IHC 1+) and null (IHC 0) expression who received RC48-ADC monotherapy or in combination with programmed cell death protein 1 (PD-1) inhibitors were enrolled in this multi-center, retrospective study.

The Effect of EEG Neurofeedback Training on Sport Performance: A Systematic Review and Meta-Analysis.

Neurofeedback training (NFT) has emerged as a promising technique for enhancing sports performance by enabling individuals to self-regulate their neural activity. However, only 53% of the 13 included studies, all of which published before 2021, in the latest meta-analyses of NFT and motor performance focused on motor performance outcomes. Due to the rapid development of neurofeedback, 8 high-quality articles were published in 2023-2024 alone.

Efficacy and safety of modified bleomycin administration with EP chemotherapy in adult male patients with germ cell tumors: a retrospective study.

Background: Given the substantial inconvenience caused by weekly bleomycin administration, we initiated a study to evaluate the efficacy and toxicity of the modified bleomycin combined with EP (modified-BEP) regimen in Chinese adult male patients with germ cell tumors (GCTs).

Methods: We conducted a retrospective analysis of 274 adult male GCT patients treated with modified-BEP at the Sun Yat-sen University Cancer Center between 2005 and 2022. The regimen involved a tri-weekly 5-day schedule with 30 IU modified bleomycin (administered on days 1, 3, and 5), 20 mg/m2 cisplatin (days 1-5), and 100 mg/m2 etoposide (days 1-5).

Neoadjuvant toripalimab plus nimotuzumab combined with taxol-based chemotherapy in locally advanced penile squamous cell carcinoma.

The conventional neoadjuvant chemotherapy regimen for locally advanced penile squamous cell carcinoma (La-PSCC) has shown moderate response rates and survival benefits. This single-arm, phase II trial (NCT04475016) evaluated a neoadjuvant regimen of four cycles of toripalimab (anti-PD-1 antibody), nimotuzumab (anti-EGFR antibody), and taxol-based chemotherapy (TNT), followed by consolidative surgery. The primary endpoint was the pathological complete response (pCR) rate.

Bevacizumab, tislelizumab and nab-paclitaxel for previously untreated metastatic triple-negative breast cancer: a phase II trial.

Background: Optimal first-line therapy for metastatic triple-negative breast cancer (mTNBC) varied in different situations. This phase II trial explores the efficacy and safety of combination regimens with vacizumab, slelizumab and b-paclitaxel (BETINA) in first-line setting for mTNBC.

Methods: Patients with previously untreated advanced TNBC received tislelizumab 200 mg and bevacizumab on day 1 and nab-paclitaxel 125 mg/m on day 1, day 8 in 3-week cycles.

Nearly 100% CO Selectivity for CO Reduction via Synergistic Engineering of Heteronuclear CuCo Dual Atoms.

Monatomic catalysts demonstrate exceptional activity in CO hydrogenation for mitigating the greenhouse effect and achieving carbon neutrality goals. However, single-atom catalysts are limited by having only one type of active site, resulting in unsatisfactory activity and selectivity. In this work, a heteronuclear dual-atom catalyst (CuCo) is successfully synthesized using a dual-anchoring method and applied to CO hydrogenation.

PD-1/PD-L1 Inhibitors Plus Chemotherapy Versus Chemotherapy Alone as First-Line Therapy for Patients With Unfavorable Cancer of Unknown Primary: A Multicenter, Retrospective Cohort Study.

This multicenter study aimed to investigate the efficacy and safety of PD-1/PD-L1 inhibitors plus chemotherapy (ICI-Chemo group) versus chemotherapy alone (Chemo group) for patients with cancer of unknown primary (CUP) in the first-line setting. We included patients with unfavorable CUP across four medical centers in China. Between January 2014 and December 2023, 117 patients were enrolled: 46 patients in the ICI-Chemo group and 71 patients in the Chemo group.

Catalase-induced changes in rheological properties and structure of wheat gluten proteins.

This study investigates the impact of catalase (CAT) on the rheological properties of wheat gluten by analyzing CAT-induced structural changes in gluten proteins to uncover the mechanisms behind these modifications. The results showed that CAT significantly enhanced the storage modulus (G') and loss modulus (G″) of gluten while reducing creep strain and recovery strain. The most pronounced effects were observed with the addition of 250 U/g CAT for 30 min.

CYP2D6 polymorphisms and endoxifen concentration in Chinese patients with breast cancer.

Background: The plasma concentration of endoxifen, the active metabolite of tamoxifen, might be affected by different CYP2D6 genotypes in patients with breast cancer, but solid evidence is still lacking in Asian patients. This prospective study aimed to investigate the relationship between CYP2D6 genetic polymorphisms and endoxifen plasma concentrations among Chinese patients with breast cancer treated with tamoxifen.

Methods: From August 2015 to June 2018, 110 patients with breast cancer were enrolled.

Long-term high altitude exposure reduces positive bias of facial recognition: Evidence from event-related potential.

High-altitude environments influence emotional biases. Nonetheless, the neural mechanisms underlying emotional facial processing, which could help explain depression due to high altitudes, remain unexplored. An emotional face recognition task was used to explore the impact of high-altitude hypoxia on emotional face recognition and event-related potentials were recorded in relation to a high-altitude group (n = 22) and a low-altitude group (n = 24).

dsRNAEngineer: a web-based tool of comprehensive dsRNA design for pest control.

Over the past two decades, many double-stranded (ds)-RNAs have been synthesized to silence target genes for exploration of gene functions in pests. Some of these dsRNAs are lethal to pests, leading to a new category of pesticides. The generation of these environmentally friendly pesticides requires precise in silico design of dsRNA molecules that target pests but not non-pest organisms.

Non-Linear Effects of Acute Sleep Deprivation on Spatial Working Memory: Cognitive Depletion and Neural Compensation.

Background: Spatial working memory is crucial for processing visual and spatial information, serving as a foundation for complex cognitive tasks. However, the effects of prolonged sleep deprivation on its dynamics and underlying neural mechanisms remain unclear. This study aims to investigate the specific trends and neural mechanisms underlying spatial working memory alterations during 36 h of acute sleep deprivation.

Impacts of genomic alterations on the efficacy of HER2-targeted antibody-drug conjugates in patients with metastatic breast cancer.

Background: HER2-targeted antibody-drug conjugates (ADCs) have revolutionized the treatment landscape of metastatic breast cancer. However, the efficacy of these therapies may be compromised by genomic alterations. Hence, this study aims to identify factors predicting sensitivity to HER2 ADC in metastatic breast cancer.

Protein aggregation behavior and structural characteristics in a lipoxygenase-linoleic acid-wheat gluten model system.

This study explores the synergistic effects of linoleic acid (LA) oxidation on the aggregation behavior and structural properties of wheat gluten (WG). Using lipoxygenase to induce LA oxidation, it was observed that this process significantly influenced WG's viscoelasticity and structural characteristics. Specifically, LA oxidation enhanced WG's viscoelastic properties while reducing its instantaneous elastic and recovery deformations.