Early body temperature trajectories and short term prognosis in sepsis associated acute kidney injury.

To explore the associations between temperature trajectories and in-hospital mortality and renal replacement therapy in patients with sepsis-associated acute kidney injury (SA-AKI). By using data from the Medical Information Mart for Intensive Care (MIMIC)-IV, participants were divided into three groups (≤ 36 °C, 36-38 °C, ≥ 38 °C). We identified body temperature trajectories by a latent class mixed model and explored the associations of these trajectories with in-hospital mortality using Cox hazard proportional regression models, further exploring the associations with renal replacement therapy using logistic regression models.

Pharmacokinetic-pharmacodynamic and tissue distribution studies in physiological and cerebral ischemia-reperfusion injury rats after oral administration of anisodine hydrobromide tablets.

Aim: We aim to establish a rapid and sensitive UPLC-MS/MS method to analyze the pharmacokinetics of oral anisodine hydrobromide (AH) tablets.

Methods: Comparison of pharmacokinetic differences between AH (present in vivo as anisodine) and its metabolite NOAT3 in two groups of rats after administration of AH at doses of 5, 10, and 20 mg/kg. In addition, plasma concentrations of AH were used as a pharmacokinetic parameter, and interleukin-1β (IL-1β) and lactic dehydrogenase (LDH) were selected as pharmacodynamic indicators to establish a pharmacokinetics-pharmacodynamics (PK-PD) combined model in physiological and CIRI model rats, to analyze the protective effect of AH against CIRI.

Prognostic role and functional impact of cadherin genes in non-small cell lung cancer tumorigenesis: mechanistic insights from and analyses.

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide, with poor prognosis and limited treatment options for advanced stages. Dysregulation of cadherin expression has been implicated in various cancers, but their exact roles and diagnostic potential of these genes in NSCLC remain unclear. The aim of this study is to investigate the diagnostic and prognostic significance of cadherin family genes (CDH1, CDH2, and CDH3) in NSCLC.

Localized Hydrolysis-Based Proximity Reporting Platform for Protein Hierarchical Structure Profiling.

The substrate-specific bond cleavage capability of hydrolases provides a unique strategy for engineering off-on switches. This prompted our hypothesis that confining hydrolases and substrates to distinct biomolecular hierarchies (e.g.

Risk Factors for Pleural Reaction in CT-Guided Percutaneous Lung Nodule Localization: A Single-Center Retrospective Study.

Background: Pleural reaction (PR) frequently occurs during computed tomography (CT) -guided lung puncture procedures, and its development is influenced by various factors. This study aims to identify the risk factors associated with PR in CT-guided percutaneous lung nodule localization (CT-PLNL) procedures.

Methods: This retrospective study included 467 patients who underwent video-assisted thoracic surgery (VATS) at Nanjing Drum Tower Hospital between January 2022 and December 2023, all of whom had received CT-PLNL.

Using an Extension Catheter in Thrombus Aspiration for Coronary Subacute Myocardial Infarction.

We report a case of subacute myocardial infarction thrombus aspiration using extension catheters. The presence of refractory thrombus was observed in all patients during coronary angiography, and favorable outcomes were achieved through the use of an extended catheter for thrombus extraction. In cases involving subacute or refractory thrombus, the efficacy of traditional thrombus aspiration catheters may be limited, necessitating the use of an extension catheter for effective thrombus removal.

Risk factors for coronary artery disease progression: A retrospective cohort study of clinical and biochemical predictors.

This study aimed to identify clinical and biochemical predictors of coronary artery disease (CAD) progression in patients undergoing routine cardiovascular evaluation. A retrospective cohort study was conducted involving 183 patients with confirmed CAD (92 with progression and 91 without progression). Clinical data, echocardiographic parameters, and laboratory biomarkers were collected at baseline.

Evaluating the neuroprotective effects of the novel Kv2.1 blocker Zj7923 against ischemic stroke in vitro and in vivo.

The voltage-dependent potassium channel Kv2.1 correlates closely to the regulation of neuronal excitability and cellular apoptosis. Ischemia or oxidative treatment were known to stimulate the surge of Kv2.

Using high-frequency oscillation to detect acute brain injury in extracorporeal membrane oxygenation supported patients.

Objective: This study aims to utilize HFO analysis to enhance existing SSEP modality and develop it as a bedside diagnostic tool for acute brain injury (ABI) detection in Extracorporeal Membrane Oxygenation (ECMO) patients.

Significance: Timely diagnosis of ABI in ECMO patients is challenging due to logistical complexities with computed tomography (CT) and magnetic resonance imaging (MRI). Integrating time-frequency analysis into routine SSEP monitoring for early ABI detection can facilitate timely medical decisions.

Trifluoroethanol-assisted asymmetric propargylic hydrazination to α-tertiary ethynylhydrazines enabled by sterically confined pyridinebisoxazolines.

We report the highly enantioselective Cu-catalyzed asymmetric propargylic substitution (APS) of α-tertiary propargylic electrophiles using hydrazines and hydroxylamines as a fruitful strategy to access multifunctional α-tertiary hydrazines or hydroxylamines. Using trifluoroethanol (TFE) as the solvent play a key role to decrease the nucleophilicity of hydrazines to suppress side reactions such as elimination, thus improve the yield and the enantioselectivity. NMR analysis and theoretical calculations suggest the formation of an H-bond adduct of TFE with hydrazide, stabilized by multiple H-bonding interactions, including C-F···H-N interaction.

Temporal trends and risk factors associated with stroke mortality among cancer patients.

Background: This study aimed to explore the risk of stroke death (SD) in cancer patients, estimate rates, and identify risk factors associated with SD.

Methods: In this retrospective study, we used the 17 National Cancer Institute Surveillance, Epidemiology, and End Results registries (2000-2020). A total of 5,922,533 patients diagnosed with their first primary cancer were included.

Regulating the Electronegativity Difference and Piezoelectric Strain of the S-Mo-S Structure via Introducing Mo Vacancies for Boosting Piezo-Photoelectric Activity.

Recently, piezoelectric and photocatalytic processes have shown excellent synergistic effect addressing environmental remediation challenges. Herein, a nanoflower-like Mo vacancy-modulated MoS (V-MoS) piezo-photocatalyst with different V densities has been successfully synthesized using a one-step hydrothermal method. The high V density (12%) facilitates the enhancement of the photocatalytic activity but compromises its structural stability, resulting in unsatisfactory piezoelectric activity.

Construction of a Rh-doped SrTiO/g-CN p-n heterojunction for enhanced photoelectrochemical performance.

Semiconductor photoelectrochemical (PEC) technology, capable of generating hydrogen energy from water and solar energy, has emerged as a promising solution to address environmental and energy challenges. Rhodium-doped strontium titanate (Rh doped SrTiO, RST) is regarded as a highly promising photocathode material for PEC systems. Nevertheless, the PEC performance of RST is hindered by inefficient carrier separation and poor charge transfer properties.

Ultrafast, Targeting Fluorion-Capture Electrochemical Nanosystem Assembled with Polymeraldine Salt-Modulated TiCT MXene.

Fluoride-containing groundwater has become a major concern since it serves as a source of drinking water for over half the world's population. Here, we develop an ion-selective polymeraldine salt (PANI-Cl; PANI = polyaniline) modulated TiCT MXene electrode as a mediator for electrochemical capture of fluoride ion (F) from groundwater. The single-stage configuration equipped with PANI-Cl/TiCT electrode as anode and activated carbon as cathode exhibits an ultrafast removal rate of 4.

Synthesis of α-Chloroboronic Esters via Photoredox-Catalyzed Chloro-Alkoxycarbonylation of Vinyl Boronic Esters.

α-Chloroboronic esters are a class of stable multifunctional molecules that show unique applications in pharmaceutical science and organic chemistry. Despite their apparent utility, the synthetic methods of these compounds remain limited. Herein, a novel strategy for the efficient synthesis of α-chloroboronic esters is developed via photoredox-catalyzed chloro-alkoxycarbonylation of vinyl boronic esters.

Two-Level Spatially Localized Proximity Labeling for Cross-Biological-Hierarchy Measurement and Manipulation.

Proximity labeling (PL) has emerged as a powerful technique for the in situ elucidation of biomolecular interaction networks. However, PL methods generally rely on single-biological-hierarchy control of spatial localization at the labeling site, which limits their application in multi-tiered biological systems. Here, we introduced another enzymatic reaction upstream of an enzyme-based PL reaction and targeted the two enzymes to markers indicating different biological hierarchies, establishing a two-level spatially localized proximity labeling (PL) platform for in situ molecular measurement and manipulation.

MALDI-TOF mass spectrometric immunoassay of multiple tumor biomarkers for non-small cell lung cancer screening.

Cancer biomarkers have been facing some issues such as poor accuracy and low sensitivity in the early diagnosis of tumors. Utilizing biotin-labelled peptide as a mass tag (MT), this work proposes a high-throughput biosensing strategy for matrix-assisted laser desorption/ionization-time of flight mass spectrometric (MALDI-TOF-MS) immunoassay of multiple lung cancer biomarkers. Due to little required dosage, satisfied stability, high sensitivity and accuracy, this method can achieve off-site centralized signal detection after on-site sample incubation.

Electrochemical Dicarboxylation of Vinyl Epoxide with CO for the Facile and Selective Synthesis of Diacids.

We present a novel electrochemical dicarboxylation of epoxides with CO, characterized by the cleavage of two C-O single bonds. Not only are vinyl epoxides viable, but cyclic carbonates also serve as effective substrates, facilitating the synthesis of E-configured adipic and octanedioic acids with high chemo-, regio-, and stereoselectivity. The synthetic practicality is further highlighted by the diverse functionalizations of the resulting multifunctional diacids.

Selective Inhibition of P2Y and P2Y Receptor Signal Pathways in Platelet Aggregation in Transgenic Cell Lines and Rats by Potassium 2-(1-Hydroxypentyl)-Benzoate, Puerarin and Salvianolic Acid B.

Aim: Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB), puerarin and salvianolic acid B are three natural products or derivatives that can inhibit platelet aggregation. However, the mechanisms of dl-PHPB, puerarin and salvianolic acid B to inhibit platelet aggregation are still not clear.

Method: Here, 2-methylthioadenosine diphosphate (2-MeSADP) was used as an inducer to confirm the effects of three drugs on platelet aggregation and illustrate the corresponding mechanisms.

Enhanced Capability of Hydrogen Evolution Photocathode by Laminated Interface Engineering of Co/MoS QDs/pyramid-black Si.

We present a novel and stable laminated structure to enhance the performance and stability of silicon (Si) photocathode devices for photoelectrochemical (PEC) water splitting. First, by utilizing Cu nanoparticle catalysts to work on a np-black Si substrate via the metal-assisted chemical etching, we can achieve the black silicon with a porous pyramid structure. The low depth holes on the surface of the pyramid caused by Cu etching not only help enhance the light capture capability with quite low surface reflectivity (<5%) but also efficiently protect the p-n junction from damage.

Evaluation of the FPMC respiratory panel for detection of respiratory tract pathogens in nasopharyngeal swab and sputum specimens.

Objectives: The performance of the new Respiratory Pathogen panel (fluorescent probe melting curve, FPMC) for the qualitative detection of 12 organisms (chlamydia pneumoniae, mycoplasma pneumoniae, adenovirus, influenza A virus, influenza B virus, parainfluenza virus, rhinovirus, etc.) was assessed.

Methods: Prospectively collected nasopharyngeal swab (NPS) and sputum specimens (n = 635) were detected by using the FPMC panel, with the Sanger sequencing method as the comparative method.

A fault isolation strategy for industrial processes using outlier-degree-based variable contributions.

In industrial process monitoring, it is always a challenging and practical problem to analyze the causes of the system fault by isolating true fault variables from vast amounts of process data. However, the phenomenon of smearing effect occurs by using the traditional contribution analysis-based isolation methods since the defined isolation indices of different variables affect each other. In this paper, a new fault isolation method is proposed based on local outlier factor and improved k-nearest neighbor rule aiming to improve the isolation accuracy.