Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial.

Exaggerated orthostatic changes in systolic blood pressure (SBP) were associated with adverse cardiovascular events. We aim to assess the association between orthostatic SBP changes and incident atrial fibrillation (AF). We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial).

Effects of Tai Chi and resistance exercise on sleep quality in Japanese community-dwelling older adults with chronic pain.

This study examined the effects of a combined Tai Chi and resistance exercise program on sleep quality in community-dwelling older adults with chronic pain. Participants were divided into an intervention group (n = 38) and a control group (n = 33). After 12 weeks, significant improvements were observed in the intervention group, including reduced pain intensity (p < 0.

PDMS Membrane Using Phenyl as Rigid Molecular Spacer for Phenol Recovery.

Polydimethylsiloxane (PDMS) is extensively utilized for the recovery of bio-alcohols, but it encounters significant obstacles in volatile organic compounds (VOCs) removal, because of the narrow size for molecules diffusion. In this work, we designed a high-efficiency diffusion channel by introducing phenyl as a spacer into PDMS chains. The monomer divinylbenzene and vinyl-terminated PDMS (vinyl-PDMS) can be chemically crosslinked with thiol-grafted PDMS (thiol-PDMS) based on thiol-ene click reaction.

Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs.

Background: Patients with atrial fibrillation (AF) have a higher risk of cognitive impairment (CI). However, complexity of CI diagnosis and lack of simple screening approaches limited early screening and intervention of CI in AF patients.

Objective: Our study aimed to develop deep learning models based on fundus photographs for easy screening of CI in AF patients.

Patterns of Postablation Recurrence and Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation.

Background: Atrial arrhythmia recurrence after atrial fibrillation (AF) catheter ablation is conventionally assessed as a binary end point. However, the prognostic value of recurrence patterns is less studied.

Methods And Results: This study included patients undergoing catheter ablation from the multicenter China Atrial Fibrillation Registry study (2011-2022).

The relationship between transformational leadership and work engagement among intensive care unit nurses: the mediating function of organizational climate.

Background: The high attrition rate and nursing shortage have a negative impact on the stability and advancement of the nursing business. For this reason, it is imperative to delve into the factors influencing nurses' professional stability. Work engagement and transformational leadership are positively correlated with a decrease in nursing staff burnout.

Polypyrrole-modified gelatin-based hydrogel: A dressing for intestinal perforation treatment with enhanced wound healing and anti-adhesion properties.

Intestinal perforation is a serious medical emergency, and traditional surgery often causes adhesion and other complications. Innovative hydrogels improve postoperative care and rehabilitation with their anti-adhesion, antibacterial, and hemostatic properties. We have developed an advanced anti-adhesion hydrogel, AA-A30, composed of polypyrrole-modified gelatin (PPy-GelMA), carboxymethyl chitosan (CMCS), and NHS-functionalized polyethylene glycol (PEG-NHS).

Antiarrhythmic Drug Use in the Blanking Period After Re-Ablation and Recurrence in Paroxysmal Atrial Fibrillation.

Background: The effectiveness of continuous anti-arrhythmic drugs (AAD) therapy during the 3-month blanking period following repeat catheter ablation to prevent atrial fibrillation (AF) recurrence remains unclear. To evaluate the impact of continuous AAD therapy during the blanking period on AF recurrence in patients with paroxysmal atrial fibrillation (PAF) undergoing repeat ablation.

Methods: Patients with PAF who underwent repeat ablation from the China-AF Registry (2011-2022) were included in this study and categorized into two groups based on AAD use during the 3-month blanking period.

Machine learning-based risk prediction model for neuropathic foot ulcers in patients with diabetic peripheral neuropathy.

Background: Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes, marked by symptoms like hyperalgesia, numbness, and swelling that impair quality of life. Nerve conduction abnormalities in DPN significantly increase the risk of neuropathic foot ulcers (NFU), which can progress rapidly and lead to severe outcomes, including infection, gangrene, and amputation. Early prediction of NFU in DPN patients is crucial for timely intervention.

Burden of Atrial Fibrillation and Atrial Flutter From 1990 to 2021 in China: Global Burden of Disease Study 2021 Update.

Background: Atrial fibrillation (AF) and atrial flutter (AFL) represent increasingly significant health burden globally. We aimed to systematically evaluate the status and trends of AF/AFL burden and attributable risk factors in China.

Methods: We assessed the burden of AF/AFL measured as prevalence, incidence, mortality, and disability-adjusted life years (DALYs), by sex and age groups in China based on the Global Burden of Diseases Study (GBD) 2021 project.

Physiological, ionomic, transcriptomic and metabolomic analyses reveal molecular mechanisms of root adaption to salt stress in water spinach.

Water spinach (Ipomoea aquatica Forsk.) is an important leaf vegetable affected by salt stress, however, little is known about its salt adaption mechanism. Here, we integrated physiomics, ionomics, transcriptomics, and metabolomics to analyze the root adaptation response of two water spinach varieties, BG (salt-tolerant) and MF (salt-sensitive), at 150 mM NaCl.

Light-intersecting Photoclick Reactions for Bioorthogonal Labeling on Single Cells: Dibenzo[b,f][1,4,5]thiadiazepine-11,11-dioxide as a Photoswitchable Reporter.

The advancement of ring-strain preloaded dipolaro-/dienophiles plays a crucial role in bioorthogonal chemistry, enabling multiple high-precision conjugations toward biomolecules simultaneously. However, durability of these ring-strain preloaded reagents in vivo is a concern, as the ring-strain is not reloadable once released during delivery process. In situ conversion of light-energy into ring-strain is a promising approach to ensure both biostability and spatiotemporal control endowed by light.

Fibroblast growth factor 23 and outcomes of atrial fibrillation: from clinical association to genetic evidence.

Aims: Fibroblast growth factor 23 (FGF23) has been implicated in the occurrence of atrial fibrillation (AF), but its prognostic value in AF patients remains unclear.

Methods And Results: A total of 35 197 AF patients with available follow-up data (3.56, 0.

Manipulating Dynamic Light-Driven Solid-Liquid Transition and Static Reversible Photochromism by an Organic Cocrystal Strategy.

Developing of molecular crystalline materials with light-induced multiple dynamic deformation in space dimension and photochromism on time scales has attracted much attention for its potential applications in actuators, sensoring and information storage. Nevertheless, organic crystals capable of both photoinduced dynamic effects and static color change are rare, particularly for multi-component cocrystal system. In this study, we first report the construction of charge transfer cocrystal allows their light-induced solid-to-liquid transition and photochromic behaviors to be controlled by trans-stilbene (TSB) as an electron donor and 3,4,5,6-tetrafluorophthalonitrile (TFP) as an electron acceptor.

Interpretable adenylation domain specificity prediction using protein language models.

Natural products have long been a rich source of diverse and clinically effective drug candidates. Non-ribosomal peptides (NRPs), polyketides (PKs), and NRP-PK hybrids are three classes of natural products that display a broad range of bioactivities, including antibiotic, antifungal, anticancer, and immunosuppressant activities. However, discovering these compounds through traditional bioactivity-guided techniques is costly and time-consuming, often resulting in the rediscovery of known molecules.

Design, synthesis, and anti-liver fibrosis activity of novel non-steroidal vitamin D receptor agonists based on open-ring steroid scaffold.

Vitamin D receptor (VDR) has emerged as a crucial target for the treatment of hepatic fibrosis, a condition characterized by excessive deposition of extracellular matrix (ECM) components leading to impaired liver function. Activation of VDR has been shown to inhibit the transformation of hepatic stellate cells (HSCs), which play a key role in the development of liver fibrosis, thus reducing ECM production. In this study, a series of 37 non-steroidal VDR agonists with novel scaffold were designed and synthesized utilizing the scaffold hopping strategy.

Visible-Light-Induced ArC(sp)-F Bond Activation in Aqueous Media: From DFT Study to Molecular Design.

Trifluoromethylarenes (ArCF) are crucial bioisosteres in medicinal chemistry, but catalyst-free and controlled photo-activation of the ArC(sp)-F bond remains a significant challenge. The photo-induced defluorination acyl fluoride exchange (photo-DAFEx) of m-trifluoromethylaniline, induced by ultraviolet light, emerges as a promising novel photo-click reaction for photoaffinity drug discovery. However, the photophysical properties of NMePhFC(sp)-F derivatives and factors affecting ArC(sp)-F bond activation in photo-DAFEx are not yet fully understood, hindering the development of new photo-defluorination reagents with longer absorption wavelength for the photo-DAFEx.

Apocrine Gland Damage and the Release of Specific Keratins in Early Stage Indicate the Crucial Involvement of Apocrine Glands in Hidradenitis Suppurativa.

The apocrine glands (AGs) are not considered to be primarily involved in hidradenitis suppurativa (HS). This study investigated the potential role of AGs in HS pathogenesis using immunohistochemistry and single-cell sequencing of nonlesional skin and early lesional skin (LS) from patients with HS (n = 12) and healthy controls (n = 8). AG cell destruction was more frequent, and AG size was significantly reduced in the nonlesional skin and LS.

Engineered manganese-BODIPY coordinated nanoadjuvants for enhanced NIR-II photo-metalloimmunotherapy.

Immunotherapy, a pivotal and promising approach for tumor treatment, has demonstrated prominent clinical efficacy. However, its effectiveness is often impeded by insufficient antitumor immune responses attributed to the immunosuppressive tumor microenvironment (TME). The combination of immune activation through the stimulator of interferon genes (STING) pathway and phototherapy holds great potential for surmounting this challenge in advanced tumor immunotherapy.

Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3-Diaryl-1H-benzo[f]indazole-4,9-dione.

Bioorthogonal click-release chemistry is a cutting-edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it is challenging to achieve the precise regulation or therapy of individual cells via click-release strategies driven by proximity and thermodynamics. Herein, we propose a novel photoclick-release approach based on a photo-induced cycloaddition between 4,4'-bis(N-arylsydnone) or C-bithienyl-diarylsydnone and 2-arylamino-naphthoquinone via irradiation with 405 or 485 nm light.

[Accuracy of tooth segmentation algorithm based on deep learning].

Purpose: The established automatic AI tooth segmentation algorithm was used to achieve rapid and automatic tooth segmentation from CBCT images. The three-dimensional data obtained by oral scanning of real isolated teeth were used as the gold standard to verify the accuracy of the algorithm.

Methods: Thirty sets of CBCT data and corresponding 59 isolated teeth were collected from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.

Life-Cycle Environmental Impacts of Additive-Related Chemicals in Polyvinyl Chloride Plastics and the Mitigation Potential.

Plastic additive-related chemicals, particularly in polyvinyl chloride (PVC) plastics, have become a key issue in plastic pollution. Although addressing plastic pollution through the life-cycle approach is crucial, the environmental impacts of typical plastic additive-related chemicals in PVC plastics during the cradle-to-gate stage remain unexplored. Consequently, managing the life-cycle environmental impacts of these additives remains challenging.