Identification and validation of , , and as potential diagnostic markers of postmenopausal osteoporosis.

Postmenopausal osteoporosis (PMOP) is recognized as the most prevalent bone disease worldwide. N6-methyladenosine (m6A) is one of the most common RNA modifications influencing the progression of various disorders; however, its specific role in PMOP remains unexplored. This study aims to investigate the expression profiles of m6A-related genes and their impact on the prognosis of PMOP patients.

Thermal proteome profiling of itaconate interactome in macrophages.

Itaconate (ITA) is an upregulated immunometabolite in macrophages during pathogen infection. It is known to influence oxidation stress, cellular metabolism, programmed cell death and many other biological processes to regulate the immune response interaction with proteins. Previous studies capture covalently ITA-modified proteins by activity-based proteome profiling with bioorthogonal chemical probes; however, how itaconate interacts non-covalently with other proteins at the proteome level remains unexplored.

PDMS Membrane Using Phenyl as Rigid Molecular Spacer for Phenol Recovery.

Polydimethylsiloxane (PDMS) is extensively utilized for the recovery of bio-alcohols, but it encounters significant obstacles in volatile organic compounds (VOCs) removal, because of the narrow size for molecules diffusion. In this work, we designed a high-efficiency diffusion channel by introducing phenyl as a spacer into PDMS chains. The monomer divinylbenzene and vinyl-terminated PDMS (vinyl-PDMS) can be chemically crosslinked with thiol-grafted PDMS (thiol-PDMS) based on thiol-ene click reaction.

Meta-analysis of the effects of multimodal physical therapy on improving depression.

Background: Depression is a widespread psychological disorder that has substantial effects on public health and society. Conventional therapies include medication and psychotherapy, recent investigations have highlighted the possible advantages of multimodal treatments, such as physical therapy, for improving depression.

Aim: To perform a meta-analysis of how multimodal physical therapy can help treat depression.

Reduction recovery of Sb(III) and Sb(V) from wastewater by UV/thiourea dioxide system: Efficiency, radical generation and mechanism.

For antimony-containing wastewater, conventional methods, such as chemical precipitation, adsorption and membrane separation inevitably generate substantial quantities of hazardous waste. This paper introduces a UV/thiourea dioxide(TDO) reduction method, which efficiently recovers Sb(III)/Sb(V) from wastewater as the metalloid Sb(0) within 30 min, achieving a purity greater than 99.8 wt%.

Reductive Removal of Antimony from Wastewater by a UV/Sulfite Process: Targeted Recovery of Strategic Metalloid Antimony.

The removal of antimony from wastewater using traditional methods such as adsorption and membrane filtration generates large amounts of antimony-containing hazardous wastes, posing significant environmental threats. This study proposed a new treatment strategy to reductively remove and recover antimony from wastewater using an advanced UV/sulfite reduction process in the form of valuable strategic metalloid antimony (Sb(0)), thus preventing hazardous waste generation. The results indicated that more than 99.

Semantic information guided diffusion posterior sampling for remote sensing image fusion.

The task of image fusion for optical images and SAR images is to integrate valuable information from source images. Recently, owing to powerful generation, diffusion models, e.g.

Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer.

Background: Accurate evaluation of the response to preoperative treatment enables the provision of a more appropriate personalized therapeutic schedule for locally advanced rectal cancer (LARC), which remains an enormous challenge, especially neoadjuvant immunotherapy plus chemoradiotherapy (nICRT).

Methods: This prospective, multicenter cohort study enrolled patients with LARC from 6 centers who received nICRT. The dynamic variation in the gut microbiome during nICRT was evaluated.

An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies of Acupuncture for Cancer Pain.

Background: Systematic reviews (SRs) and meta-analyses (MAs) for the use of acupuncture for cancer pain have been increasing, but the evidence has not been systematically and comprehensively assessed. We aimed to perform an overview of the evidence quality of SRs/MAs of acupuncture for improving cancer pain.

Methods: 8 databases were systematically searched to identify SRs/MAs of acupuncture for improving cancer pain.

Toxoplasma gondii Causes Adverse Pregnancy Outcomes by Damaging Uterine Tissue-Resident NK Cells That Secrete Growth-Promoting Factors.

Vertical transmission of the intracellular parasite, Toxoplasma gondii can lead to adverse pregnancy outcomes especially when infection occurs in early pregnancy. Decidual natural killer (dNK) cells accumulate at the maternal-fetal interface in large numbers during early pregnancy. Their nutritional roles during infection with T.

Salvage of Supervision in Weakly Supervised Object Detection and Segmentation.

Weakly supervised vision tasks, including detection and segmentation, have attracted much attention in the vision community recently. However, the lack of detailed and precise annotations in the weakly supervised case leads to a large accuracy gap between weakly- and fully-supervised methods. In this article, we propose a new framework, Salvage of Supervision (SoS), with the key idea being to effectively harness every potentially useful supervisory signal in weakly supervised vision tasks.

Identification of the Hub Genes Involved in Stem Cell Treatment for Intervertebral Disc Degeneration: A Conjoint Analysis of Single-Cell and Machine Learning.

Intervertebral disc degeneration (IDD), which is distinguished by a variety of pathologic alterations, is the major cause of low back pain (LBP). Nonetheless, preventative measures or therapies that may delay IDD are scarcely available. In this study, we sought to identify new diagnostic biological markers for IDD.

Fuzzy Logic System Assisted Sensing Resource Allocation for Optical Fiber Sensing and Communication Integrated Network.

With the development of information transmission, there is an increasing demand for state monitoring of fiber-optic communication networks to improve the security and self-healing ability of the network. Distributed optical fiber sensing is one of the most attractive methods because it can achieve real-time detection of the whole network without additional sensing heads. However, when the sensing network is introduced into the communication network, the failure probability should be efficiently suppressed with limited sensing resources.

Functional data analysis with covariate-dependent mean and covariance structures.

Functional data analysis has emerged as a powerful tool in response to the ever-increasing resources and efforts devoted to collecting information about response curves or anything that varies over a continuum. However, limited progress has been made with regard to linking the covariance structures of response curves to external covariates, as most functional models assume a common covariance structure. We propose a new functional regression model with covariate-dependent mean and covariance structures.

Knowledge-Aware Multispace Embedding Learning for Personalized Recommendation.

Recommender systems help users filter items they may be interested in from massive multimedia content to alleviate information overload. Collaborative filtering-based models perform recommendation relying on users' historical interactions, which meets great difficulty in modeling users' interests with extremely sparse interactions. Fortunately, the rich semantics hidden in items may be promising in helping to describing users' interests.

A novel circRNA-miRNA-mRNA network reveals hsa-circ-0040039 as a biomarker for intervertebral disc degeneration.

Objective: Alterations in the structure and function of intervertebral discs by multifaceted chronic processes can result in intervertebral disc degeneration (IDD). The mechanisms involved in IDD are still unknown.

Methods: We investigated the possible mechanisms underlying IDD using a bioinformatics analysis of publicly available microarray expression datasets and built a circular RNA-microRNA-mRNA (circRNA-miRNA-mRNA) network based on the results.

Metal- and halide-free, solid-state polymeric water vapor sorbents for efficient water-sorption-driven cooling and atmospheric water harvesting.

Metal- and halide-free, solid-state water vapor sorbents are highly desirable for water-sorption-based applications, because most of the solid sorbents suffer from low water sorption capacity caused by their rigid porosity, while the liquid sorbents are limited by their fluidity and strong corrosivity, which is caused by the halide ions. Herein, we report a novel type of highly efficient and benign polymeric sorbent, which contains no metal or halide, and has an expandable solid state when wet. A group of sorbents are synthesized by polymerizing and crosslinking the metal-free quaternary ammonium monomers followed by an ion-exchange process to replace chloride anions with benign-anions, including acetate, oxalate, and citrate.

Solar Seawater Distillation by Flexible and Fully Passive Multistage Membrane Distillation.

Solar-assisted distillation is considered promising to solve the freshwater supply for off-grid communities. In this work, a passive and flexible multistage membrane distillation (F-MSMD) device is devised to produce freshwater via solar distillation with the latent heat of vapor condensation being recycled to enhance its energy efficiency. By designing a siphon effect, source water is continuously wicked into the evaporation layer and the concentrated brine flows out of the device before reaching saturation, which successfully solves the otherwise challenge of salt accumulation inside the device.

The low expression of NUP62CL indicates good prognosis and high level of immune infiltration in lung adenocarcinoma.

A primary factor in tumor morbidity and mortality, lung adenocarcinoma (LUAD) is known to be a major subtype of lung cancer, having the lowest survival rate among all other cancers. Using The Cancer Genome Atlas (TCGA) database the relationship between the immune infiltrate and the NUP62CL was explored and the value of the NUP62CL expression in the prognosis and diagnosis LUAD was examined. Using the logistic regression and the Wilcoxon signed-rank test the relationship between the NUP62CL and the clinico-pathological features was analyzed.

Designing a next generation solar crystallizer for real seawater brine treatment with zero liquid discharge.

Proper disposal of industrial brine has been a critical environmental challenge. Zero liquid discharge (ZLD) brine treatment holds great promise to the brine disposal, but its application is limited by the intensive energy consumption of its crystallization process. Here we propose a new strategy that employs an advanced solar crystallizer coupled with a salt crystallization inhibitor to eliminate highly concentrated waste brine.

High-speed Gaussian-modulated continuous-variable quantum key distribution with a local local oscillator based on pilot-tone-assisted phase compensation.

A high-speed Gaussian-modulated continuous-variable quantum key distribution (CVQKD) with a local local oscillator (LLO) is experimentally demonstrated based on pilot-tone-assisted phase compensation. In the proposed scheme, the frequency-multiplexing and polarization-multiplexing techniques are used for the separate transmission and heterodyne detection between quantum signal and pilot tone, guaranteeing no crosstalk from strong pilot tone to weak quantum signal and different detection requirements of low-noise for quantum signal and high-saturation limitation for pilot tone. Moreover, compared with the conventional CVQKD based on homodyne detection, the proposed LLO-CVQKD scheme can measure X and P quadrature simultaneously using heterodyne detection without need of extra random basis selection.

Development and Validation of a Clinical Prognostic Model Based on Immune-Related Genes Expressed in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) is the most frequent and terminal subtype of RCC. Reliable markers associated with the immune response are not available to predict the prognosis of patients with ccRCC. We exploited the extensive number of ccRCC samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) repository to perform a comprehensive analysis of immune-related genes (IRGs).

SYT16 is a prognostic biomarker and correlated with immune infiltrates in glioma: A study based on TCGA data.

Background: Glioma is the most lethal primary brain tumor. Lower-grade glioma (LGG) is the crucial pathological type of Glioma. Immune-infiltration of the tumor microenvironment positively associated with overall survival in LGG.