Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial.

Exaggerated orthostatic changes in systolic blood pressure (SBP) were associated with adverse cardiovascular events. We aim to assess the association between orthostatic SBP changes and incident atrial fibrillation (AF). We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial).

Mapping the Metastatic Landscape: A Population-Based Cohort Study for Prognostic Insights Into Newly Diagnosed Stage IV Breast Cancer Cases.

Background: Breast cancer is the most common malignancy and a leading cause of cancer-related deaths among women worldwide. Although treatment advances have improved outcomes, the 5-year survival rate for metastatic breast cancer remains low. Understanding the anatomical distribution, associated risks, and prognostic features of metastases in patients with newly diagnosed stage IV breast cancer is essential for improving clinical management.

[Spatial Prediction of Selenium in Soils by Using INLA-SPDE Approach and the Delimitation of Selenium-enriched Land with Low Heavy Metal Pollution Risk].

Soil is the main medium for plants， animals， and humans to obtain the selenium element required for growth and development. Rapid economic development has caused serious soil heavy metal pollution， threatening soil environment and human health. Therefore， predicting the spatial distribution of soil selenium elements and delineating "clean and selenium-rich land" with low heavy metal pollution risk can provide a reference for the healthy development of agriculture and industry.

Discovery of a potential anti-ischemic stroke agent by suppressing ferroptosis through the ATF3/SLC7A11/GPX4 pathway.

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Despite its widespread impact, effective treatments remain limited. Idebenone (IDE) has shown promise in promoting recovery following stroke; however, its efficacy during the acute phase of ischemic stroke remains suboptimal.

Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing.

Background: Angiosarcoma, a rare and highly aggressive malignancy originating from vascular endothelial cells, is characterized by its rapid progression, high invasiveness, and poor prognosis. Due to the limited understanding of its tumor microenvironment (TME) and the absence of effective treatments, further research is essential to elucidate its pathogenic mechanisms and improve therapeutic strategies.

Objective: This study aims to characterize the cellular heterogeneity and unique TME of primary breast angiosarcoma using single-cell RNA sequencing (scRNA-seq), to identify potential therapeutic targets and improve clinical outcomes.

Field-Based Evaluation of Insecticide Effectiveness on in Guangdong, China: Implications for Pest Control Strategies.

In southern China, cowpea production is severely threatened by due to its fast-evolving resistance to insecticides. The toxicity monitoring of commonly used insecticides against field populations provides key information for the resistance management of pests. In this study, field populations of were collected from three locations (QY, YF, MM) in Guangdong, and the sensitivity of these populations against insecticides was determined by using a thrips insecticides bioassay system (TIBS) method.

Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis.

Background: The occurrence of comorbid metabolic syndrome and psoriasis (MS-P) is owing to the complex interplay between metabolic dysregulation and inflammatory responses. However, current treatments have shown limited efficacy in improving the symptoms of both conditions simultaneously.

Objective: This study aimed to investigate the therapeutic efficacy of Fufang Longdan Mixture (FLM) in treating MS-P comorbidity, elucidate its mechanism through the miR-29a-5p/IGF-1R axis and evaluate treatment responses between APOE and C57BL/6 mice.

Tall Cell Carcinoma with Reversed Polarity of the breast: Clinicopathological insights, molecular profile, and future therapeutic directions.

Tall Cell Carcinoma with Reversed Polarity (TCCRP) is a rare and distinct subtype of invasive breast carcinoma, first described in 2003. It is histologically characterized by tall columnar epithelial cells with reversed nuclear polarity and shares morphological features with papillary thyroid carcinoma (PTC). However, its unique molecular signature, including IDH2 and PIK3CA mutations, differentiates it from other breast cancer subtypes.

Recent Advances in Green Hydrogen Production by Electrolyzing Water with Anion-Exchange Membrane.

The development of clean and efficient renewable energy is of great strategic importance to realize green energy conversion and low-carbon growth. Hydrogen energy, as a renewable energy with "zero carbon emission", can be efficiently converted into hydrogen energy and electric energy by electrolysis of water to hydrogen technology. Anion-exchange membrane water electrolysis (AEMWE), substantially advanced by nonprecious metal electrocatalysts, is among the most cost-effective and promising water electrolysis technologies, combining the advantages of proton exchange membranes with the proven technology of traditional alkaline water electrolysis and potentially eliminating the disadvantages of both.

Nanomaterials-driven in situ vaccination: a novel frontier in tumor immunotherapy.

In situ vaccination (ISV) has emerged as a promising strategy in cancer immunotherapy, offering a targeted approach that uses the tumor microenvironment (TME) to stimulate an immune response directly at the tumor site. This method minimizes systemic exposure while maintaining therapeutic efficacy and enhancing safety. Recent advances in nanotechnology have enabled new approaches to ISV by utilizing nanomaterials with unique properties, including enhanced permeability, retention, and controlled drug release.

Combating cancer immunotherapy resistance: a nano-medicine perspective.

Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti-cancer immunity and leading to resistance. Various functionalized nanoparticles (NPs), modified with cationic lipids, pH-sensitive compounds, or photosensitizers, exhibit unique physicochemical properties that facilitate the targeted delivery of therapeutic agents to cancer cells or the tumor microenvironment (TME).

Comparative efficacy and safety of PD-1 versus PD-L1 inhibitors in breast cancer treatment: A systematic review and meta analysis.

The comparative efficacy and safety of programmed death-ligand 1 (PD-L1) inhibitors versus programmed death protein 1 (PD-1) inhibitors in breast cancer treatment remain inconclusive, as no head-to-head randomized controlled trials (RCTs) conducted. This study aims to evaluate the efficacy and safety of PD-1/PD-L1 inhibitors as monotherapy or in combination with chemotherapy for breast cancer. A systematic review and meta-analysis were performed using major databases and oncology conference proceedings.

Nomogram construction for overall survival in breast angiosarcoma based on clinicopathological features: a population-based cohort study.

Background: Breast angiosarcoma (BAS) is a rare, aggressive malignancy with a poor prognosis, often challenging to assess due to its unique biology. This study aimed to develop a nomogram to predict 3- and 5-year overall survival (OS) for BAS patients using key clinicopathological factors.

Methods: Data from 450 BAS patients diagnosed between 2000 and 2021 were extracted from SEER database.

Burden of Atrial Fibrillation and Atrial Flutter From 1990 to 2021 in China: Global Burden of Disease Study 2021 Update.

Background: Atrial fibrillation (AF) and atrial flutter (AFL) represent increasingly significant health burden globally. We aimed to systematically evaluate the status and trends of AF/AFL burden and attributable risk factors in China.

Methods: We assessed the burden of AF/AFL measured as prevalence, incidence, mortality, and disability-adjusted life years (DALYs), by sex and age groups in China based on the Global Burden of Diseases Study (GBD) 2021 project.

Sex-specific trends in the global burden and risk factors of atrial fibrillation and flutter from 1990 to 2021.

Significant sex disparities exist in the burden of atrial fibrillation and flutter. However, comprehensive and systematic analysis of its global trend by sex is scarce. The Global Burden of Disease Study 2021 was used as data source for analysis.

Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive.

Male breast cancer is a rare neoplasm, accounting for approximately 1% of all breast cancer cases. It typically presents as a painless, retroareolar mass. An exceedingly rare variant is male occult breast cancer, which is primarily characterized by axillary lymph node enlargement without an identifiable primary breast tumor.

Application of chest wall perforator flaps in oncoplastic breast-conserving surgery.

Objective: This study aims to explore the application value of chest wall perforator flaps (CWPF) in oncoplastic breast-conserving surgery.

Methods: A retrospective review was conducted on 22 early-stage breast cancer patients who underwent oncoplastic breast-conserving surgery using CWPF between January 2021 and December 2022. This included 4 cases (18.

Mask-Free Direct Printing of Highly Customizable, Conformable, Robust, and Recyclable Microelectrodes for Advanced Curvy Electronics.

Highly conformal and mechanically robust curvy electronics that seamlessly adapt to sophisticated and unpredictable 3D geometries provide breakthrough solutions in advanced fields such as health monitoring, wireless energy transmission, and human-computer interface. Nevertheless, existing material choices along with manufacturing techniques substantially impede these electronics from achieving their full potential. This study presents a mask-free and straightforward direct writing and transfer (DW&T) technique that employs a polytetrafluoroethylene film as a temporary substrate, utilizing the phase transition of printed electrodes between hydrogel and dry states to enable cost-effective fabrication of conformally adhering conductive microelectrode patterns on nearly all 3D surfaces.

How to estimate the probability of a live birth after one or more complete IVF cycles? the development of a novel model in a single-center.

Objective: To develop a predictive tool in the form of a Nomogram based on the Cox regression model, which incorporates the impact of the length of treatment cycles on the outcome of live birth, to evaluate the probability of infertile couples having a live birth after one or more complete cycles of In Vitro Fertilization (IVF), and to provide patients with a risk assessment that is easy to understand and visualize.

Methods: A retrospective study for establishing a prediction model was conducted in the reproductive center of Shenzhen Zhongshan Obstetrics & Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital). A total of 4413 patients who completed ovarian stimulation treatment and reached the trigger were involved.

Exploring fatty acid metabolism in Alzheimer's disease: the key role of CPT1A.

Alzheimer's disease (AD) is a severe neurodegenerative disease, and the most common type of dementia, with symptoms of progressive cognitive dysfunction and behavioral impairment. Studying the pathogenesis of AD and exploring new targets for the prevention and treatment of AD is a very worthwhile challenge. Accumulating evidence has highlighted the effects of fatty acid metabolism on AD.

Effects of Diverse Crop Rotation Sequences on Rice Growth, Yield, and Soil Properties: A Field Study in Gewu Station.

This long-term field study conducted in Yancheng, China, evaluated the effects of diverse crop rotation sequences on rice growth, yield, and soil properties. Six rotation treatments were implemented from 2016 to 2023 as follows: rice-wheat (control), rice-rape, rice-hairy vetch, rice-barley, rice-faba bean, and rice-winter fallow. Rice growth parameters, yield components, biomass accumulation, and soil properties were measured.

Investigation on the Changes of Perioperative Psychological State of Young Patients With Early Breast Cancer.

Objective: This study aims to explore the variations and dynamics in the mental states of young patients with early breast cancer across different perioperative periods and to analyse how different surgical methods impact these patients' psychological well-being.

Methods: A prospective observational study was conducted on young patients with early breast cancer who underwent surgery from March 2021 to March 2022. Mental status questionnaires were administered at four key time points: preoperatively, 1 month, 6 months and 1 year postoperatively.

Bilateral transcranial direct-current stimulation confers neuroprotection through suppression of PKM2 after mouse cerebral ischemia injury.

Background: In its tetrameric form, pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays a key role in the metabolic reprogramming via regulating the signaling of pentose phosphate pathway (PPP). But the role of PKM2 in cerebral ischemia-reperfusion (I/R) injury remains unknown.

Methods: Mice model of middle cerebral artery occlusion (MCAO) and model of oxygen-glucose deprivation (OGD) injury in cultured neurons were established.

Single-cell sequencing unveils mitophagy-related prognostic model for triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking hormone receptors and HER2 expression, leading to limited treatment options and poor prognosis. Mitophagy, a selective autophagy process targeting damaged mitochondria, plays a complex role in cancer progression, yet its prognostic significance in TNBC is not well understood.

Methods: This study utilized single-cell RNA sequencing data from the TCGA and GEO databases to identify mitophagy-related genes (MRGs) associated with TNBC.