Interface Engineering and Optimization Strategies for High-Energy-Density Batteries Based on Polymer Composite Electrolytes.

Polymer composite electrolytes (PCEs) offer significant advantages in enhancing the safety, stability, and energy density of batteries, making them a crucial component for achieving high-energy-density energy storage systems. However, one of the primary bottlenecks in improving the performance of PCEs lies in the interface challenge, which can be exacerbated and manifested in interface instability, side reactions, and poor interface compatibility, ultimately leading to a significant decline in ion conduction efficiency and overall battery performance of high-voltage or high-energy-density systems. Therefore, systematically analyzing the critical technical narrowing and proposing targeted solutions under high-energy-density conditions is of great significance for advancing the development of next-generation energy storage systems.

Viscoelastic Hydrogel with Mechanomodulatory Tension Shielding and Time-Dependent Immunomodulatory Effects for Scarless Healing.

Wound healing is a complex process that, when disrupted, can result in hypertrophic scars or keloids, causing significant physical and psychological discomfort. Despite advances in understanding fibrotic scar formation, achieving scarless healing remains challenging. Inspired by fetal wound healing, this research aims to develop a viscoelastic hydrogel mimicking fetal extracellular matrix properties.

Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation.

In light of the escalating global prevalence of hair loss, there is an imperative to explore strategies for the prevention and promotion of hair growth. This article reviews the current situation, challenges, innovations, and prospects of cosmetics that promote anti-hair loss and hair growth. Firstly, the physiological and pathological mechanisms of hair loss, including androgenetic alopecia, telogen effluvium, and alopecia areata, as well as the influence of genetic, environmental, and lifestyle factors, are explored.

Decreased quantitative transport mapping velocity in the middle cerebral artery-supplied temporal lobe in Alzheimer's disease.

Introduction: Reduced blood perfusion has been observed in patients with Alzheimer's disease (AD), but the patterns of blood perfusion changes during AD progression remain insufficiently explored.

Methods: Quantitative transport mapping (QTM) is a novel biophysical modeling-based method for quantifying blood perfusion velocity. In this study, we examined regional changes in perfusion velocity throughout AD progression by combining QTM velocity measurements with Granger causality analysis using cross-sectional data, as a secondary and exploratory analysis following our previous QTM work, aiming to offer a comprehensive view of the QTM velocity patterns based on the arterial territories.

Local Cation-Ordered Superlattice Stabilizing Ni-Rich Single-Crystalline Cathodes.

Ni-rich single-crystalline cathodes are pivotal for advancing lithium-ion battery technology due to their high energy density and mechanical stability. However, Ni-rich single-crystalline particles face intrinsic structural heterogeneity due to excessively high sintering temperature required to shape micron-sized morphologies─typically over 150 °C above the polycrystalline optimum, leading to rapid electrochemical decay and unsatisfied rate performance that hinder their practical application. Here, we propose a lithium-deficient presintering strategy to synthesize cation-ordered single-crystalline LiNiCoMnO (S-NCM83), effectively minimizing lattice chemical heterogeneity and defect formation.

Unraveling the origin of air-stability in single-crystalline layered oxide positive electrode materials.

Single-crystalline Ni-rich layered oxides present compelling advantages over conventional polycrystalline counterparts toward large-scale applications, including enhanced mechanical stability and higher energy density. Nevertheless, the deleterious effects of air exposure, which is inevitable in industrial processing, on their structure and electrochemical performance remain poorly understood. Herein, we reveal that air exposure is more detrimental to the electrochemical performance of single-crystalline layered oxide positive electrodes than polycrystalline counterparts.

A Quasi-Ordered Mn-Rich Cathode with Highly Reversible Oxygen Anion Redox Chemistry.

Anionic oxygen redox chemistry in Li-rich Mn-based layer oxide cathodes represents a transformative approach for boosting the energy density of next-generation lithium-ion batteries. However, conventional oxygen redox reactions often induce oxygen dimerization at high voltages, leading to irreversible lattice oxygen loss and a rapid voltage fade. Herein, we achieve highly reversible oxygen redox chemistry through a new quasi-ordered structural design that incorporates both intra- and interlayer cation disorder configurations.

Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma.

No robust biomarkers have been identified to predict the efficacy of programmed cell death protein 1 (PD-1) inhibitors in patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). We aimed to develop radiomic models using pre-immunotherapy MRI to predict the response to PD-1 inhibitors and the patient prognosis. This study included 246 LANPC patients (training cohort, = 117; external test cohort, = 129) from 10 centers.

Bilateral adrenal heterogeneity in contrast-enhanced CT for differentiating nodule-negative primary aldosteronism.

Objective: In nodule-negative primary aldosteronism (PA), quantitative CT findings in unilateral PA differed from those in bilateral PA. We attempted to identify PA by quantitative parameters of contrast-enhanced CT.

Methods: A retrospective search was performed for 81 patients with nodule-negative PA who underwent contrast-enhanced CT between January 2021 and November 2024 and adrenal vein sampling thereafter at XXXX.

Spin State Modulation via Magnetic Fields in Fe Single Atom Catalysts for High-Performance Aqueous Zinc-Sulfur Batteries.

Aqueous zinc-sulfur battery has garnered significant attention as a high-energy, low-cost, and safe energy storage system. However, the multielectron transfer kinetics of sulfur cathodes are relatively slow, presenting challenges such as limited sulfur utilization and lower discharge voltage, which significantly hinder their practical applications. In this study, we explored a comprehensive design approach for high-performance, long-cycle aqueous zinc-sulfur batteries.

White matter structure-function coupling alteration is associated with plasma biomarkers and cognition in Alzheimer's disease.

Objectives: There were white matter (WM) microstructural abnormalities in Alzheimer's disease (AD), and it may affect information transmission along WM tracts. We aim to investigate AD-related changes in the structure-function coupling of WM and their associations with AD plasma biomarkers and cognitive performance.

Methods: This retrospective study evaluated participants who provided blood samples, underwent MR brain scans, and completed neuropsychological assessments.

Minimizing Inter-Lattice Strain to Stabilize Li-Rich Cathode by Order-Disorder Control.

Li-rich Mn-based layered (LMR) cathodes with anionic redox chemistry show great potential for next-generation sustainable Li-ion battery (LIB) applications due to the low cost and high energy density. However, the asynchronous structural evolutions with cycling in the heterogeneous composite structure of LMR lead to serious lattice strain and thus fast electrochemical decay, which hinders the commercialization of LMR cathodes. Here, an order-disorder coherent LMR cathode is demonstrated that exhibits a higher average voltage (by 0.

High-Performance Al-S Batteries by Spin Polarization Modulation via Catalytic Ni-MoS Nanosheets.

Aluminum-sulfur (Al-S) batteries catalysts with adsorption and catalytic capabilities can effectively improve the slow redox kinetics, but the current research often ignores the effect of optimizing the electronic structure of the catalyst on improving charge transfer and adsorption. Here, Ni-doped monolayer MoS nanosheets are synthesized and used as a catalytic additive for the sulfur cathode. The addition of Ni promotes spin splitting of 4d orbital of Mo, thereby affecting polarization degree of the basal plane sulfur and making it change from a low spin state to a high spin one.

Disparity-amplified chiral SERS using a PSP-LSP-coupled substrate.

Chiral recognition plays a vital role in chemical, biological, and pharmaceutical studies. However, differentiating enantiomers is still challenging. This study presents a new approach to enhance the distinction between enantiomers in surface-enhanced Raman scattering (SERS) by leveraging the coupling effect of propagating surface plasmons (PSPs) and localized surface plasmons (LSPs).

Regulation mechanism of chemokine CXCL3 in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC), a malignancy arising from the nasopharyngeal mucosal epithelium, remains poorly understood at molecular level. This study identifies CXCL3, a chemokine, as a critical oncogenic driver in NPC through multi-dataset transcriptomic analysis (GSE12452, GSE53819 and GSE61218). CXCL3 was identified to be upregulated in NPC tissues and correlated with tumor progression (P = 0.

Ferromagnetic Atomic d-p Orbital Hybridization for Promoting Al-S Batteries.

Rechargeable aluminum-sulfur batteries (Al-S) are emerging as a promising alternative energy storage system beyond lithium-ion batteries due to their high energy density, abundant material resources, and economic efficiency. However, their practical application remains challenged by sluggish conversion kinetics, polysulfide shuttling, and low sulfur cathode utilization. While extensive studies have focused on enhancing polysulfide adsorption through catalytic strategies, the roles of electronic structure in dictating catalytic performance remain underexplored.

Multiregional Radiomics to Predict Microvascular Invasion in Hepatocellular Carcinoma Using Multisequence MRI.

Objectives: This study aimed to develop a multiregional radiomics-based model using multisequence MRI to predict microvascular invasion in hepatocellular carcinoma.

Methods: We enrolled 141 patients with hepatocellular carcinoma, including 61 with microvascular invasion, who were diagnosed between March 2017 and July 2022. Clinical data were compared using the Wilcoxon rank-sum test or χ2 test.

A rare case of chondroblastoma of the jugular foramen: Imaging and pathological features.

Chondroblastoma is a rare benign tumor that typically arises in the epiphyses or apophyses of long bones in patients with immature skeletal structures. Occasionally, it presents in atypical sites such as the bones of the foot and craniofacial region. This report details the case of an 18-year-old female who experienced neck pain and was found to have a lesion in the left jugular foramen.

Comparative efficacy and safety of PD-1 versus PD-L1 inhibitors in breast cancer treatment: A systematic review and meta analysis.

The comparative efficacy and safety of programmed death-ligand 1 (PD-L1) inhibitors versus programmed death protein 1 (PD-1) inhibitors in breast cancer treatment remain inconclusive, as no head-to-head randomized controlled trials (RCTs) conducted. This study aims to evaluate the efficacy and safety of PD-1/PD-L1 inhibitors as monotherapy or in combination with chemotherapy for breast cancer. A systematic review and meta-analysis were performed using major databases and oncology conference proceedings.

The Influence of Exemestane on the Lipid Profile in Breast Cancer Patients: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.

Controversial results exist regarding the influence of exemestane on serum lipids in women affected with breast cancer. Since CVD remains the predominate cause of demise in women with breast cancer and considering the long-term use of exemestane in women with breast cancer, this meta-analysis holds significant value. Hence, we carried out the current meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of exemestane treatment on lipid parameters in women with breast cancer.

Decreased brain interstitial fluid dynamics is associated with risk of Alzheimer's disease-related cognitive decline.

Background: Diffusion-tensor image analysis along the perivascular space (ALPS) index that has the potential to reflect brain interstitial fluid (ISF) dynamics may predict the development of Alzheimer's Disease (AD). We aimed to study whether brain ISF dynamics indicated by the ALPS index relate to AD dementia diagnosis and AD-related changes.

Methods: This study included a discovery cohort (n = 180) and a validation cohort (n = 127), which were composed of cognitively normal, subjective memory concern, mild cognitive impairment, and AD dementia subjects.

Improving the fast-charging capability of NbWO-based Li-ion batteries.

The discovery of Nb-W-O materials years ago marks the milestone of charging a lithium-ion battery in minutes. Nevertheless, for many applications, charging lithium-ion battery within one minute is urgently demanded, the bottleneck of which largely lies in the lack of fundamental understanding of Li storage mechanisms in these materials. Herein, by visualizing Li intercalated into representative NbWO, we find that the fast-charging nature of such material originates from an interesting rate-dependent lattice relaxation process associated with the Jahn-Teller effect.

GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles.

Pronounced elevation of glycoprotein non-metastatic melanoma B (GPNMB) is a common phenomenon in a variety of brain diseases, but the expression patterns, functions, and molecular signaling of GPNMB have not been well studied. Here, we showed that pathological factors, including neuronal degeneration caused by seizures, caspase-3-induced neuronal apoptosis, neuronal debris, and β-amyloid, induced "on-demand" GPNMB expression in hippocampal microglia. Genetic ablation of GPNMB did not affect acute seizures but worsened chronic epileptogenesis.

Predicting progression-free survival using dynamic contrast-enhanced imaging-based radiomics in advanced nasopharyngeal carcinoma patients treated with nimotuzumab.

Purpose: The purpose of this study was to explore the potential value of the radiomics model based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), compared with the clinical model mostly based on the epidermal growth factor receptor (EGFR) expression, in predicting progression-free survival (PFS) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) treated with nimotuzumab (NTZ).

Methods: A total of 136 patients with LA-NPC who received NTZ treatment between January 2018 and June 2022 were included in this study. Patients were randomly divided into training (n = 95) and validation (n = 41) groups in a 7:3 ratio.