Preliminary safety risk assessment of parabens in children's cosmetics sold in China.

Since adverse health outcomes of parabens added in children's cosmetics have been reported, it is important to investigate preliminary risk characteristic assessment of parabens preservatives in children's cosmetics. This study aimed to calculate exposure parameters using a combination experimental data and an exposure assessment tool to make safety assessment for parabens in children's cosmetics. The paraben concentration of different formulation types of 63 products of children's cosmetic products were measured by High Performance Liquid Chromatography.

Effects of Tai Chi and resistance exercise on sleep quality in Japanese community-dwelling older adults with chronic pain.

This study examined the effects of a combined Tai Chi and resistance exercise program on sleep quality in community-dwelling older adults with chronic pain. Participants were divided into an intervention group (n = 38) and a control group (n = 33). After 12 weeks, significant improvements were observed in the intervention group, including reduced pain intensity (p < 0.

Pre-treatment Circulating Tumor Cell Associated White Blood Cell Clusters Independently Predict Poor Survival in Patients with Extensive-disease Small Cell Lung Cancer.

Background: Patients with extensive disease (ED)-small cell lung cancer (SCLC) commonly suffer a more inferior prognosis than those with limited disease (LD)-SCLC.

Objectives: This study aims to investigate the heterogeneity and prognostic significance of various aneuploid circulating tumor cells (CTCs) subtypes and CTC-associated white blood cell (CTC-WBC) clusters in patients with LD-and ED-SCLC respectively.

Design: This prospective, non-interventional, single-center study included 48 patients with LD-SCLC and 47 patients with ED-SCLC.

The enhanced osteogenesis of calcium phosphate oligomers modified collagen membrane to guide bone regeneration.

Guided bone regeneration (GBR) is a promising technology for enhancing osteogenesis while preventing the invasion of fibrous tissue in implantation. Although collagen membranes have been widely utilized in GBR applications, their ability to support sufficient bone formation remains limited. Herein, we developed collagen-sodium alginate membranes (CSaM) with ultrasmall calcium phosphate oligomers (CPOs) incorporation by either physical adsorption (CSaM-em) or coprecipitation (CSaM-im).

Relationship Between the Change in Post-Cardiovascular Surgery Patients' 6-min Walking Distance and Physical Activity During Hospitalization.

Background: The 6-min walking distance (6MWD) is an indicator of exercise tolerance in post-cardiovascular surgery patients and is associated with life expectancy. The association between the physical activity levels of these patients during hospitalization and changes in their 6MWD and the association by activity types are unknown. We investigated the association between 6MWD changes and physical activity by activity types in post-cardiovascular surgery patients.

Gastric cancer in children infected with .

Background: This retrospective study aimed to define associations between () in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.

Aim: To define associations between in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.

Methods: Details of 600 children who were subjected to upper gastrointestinal endoscopies at our institution are analyzed.

Multi-omics analysis and experiments uncover the link between cancer intrinsic drivers, stemness, and immunotherapy in ovarian cancer with validation in a pan-cancer census.

Background: Although immune checkpoint inhibitors (ICIs) represent a substantial breakthrough in cancer treatment, it is crucial to acknowledge that their efficacy is limited to a subset of patients. The heterogeneity and stemness of cancer render its response to immunotherapy variable, warranting the identification of robust biomarkers for evaluation.

Methods: Publicly available Ovarian Cancer (OV) single-cell RNA (scRNA) sequence dataset was collected and analyzed to elucidate the intrinsic driver gene of OV cancer cells.

Review on research methods of the surface urban heat island effect based on CNKI bibliometrics.

The urban heat island (UHI) effect is an increasingly prominent local climate issue in the process of global urbanization, significantly impacting human settlement health and energy consumption. Based on the China National Knowledge Infrastructure (CNKI) database, we searched and analyzed Chinese journal articles on the surface urban heat island (SUHI) effect published during 1980 and 2024. Using CiteSpace software, we conducted a visual analysis of publication trends and keywords to systematically summarize the research advances.

The facile preparation of mixed-valence metal-organic frameworks through reduction.

A facile strategy was applied to prepare Cu(I)/Cu(II) MOFs, where the Cu(I) amount and porous structure can be adjusted by the degree of reduction and the size of HKUST-1, by partially reducing HKUST-1 with hydrazine hydrate at room temperature. The Cu(I)/Cu(II) MOFs exhibit excellent catalytic capability in the Cu(I)-catalyzed azide alkyne cycloaddition.

Associations between sleep duration and quality and physical frailty in community-dwelling older adults: a cross-sectional study.

The effects of sleep duration and quality on physical frailty may differ. We examined the association between sleep duration/quality and frailty phenotype according to frailty components. This cross-sectional study analyzed 848 community-dwelling Japanese adults aged 65-75 years (mean age 70.

Pyogenic liver abscess and sepsis caused by mixed anaerobic bacteria in an immunocompetent adult: a case report.

Background: Anaerobic bacterial communities in the digestive tract play an important role in digestive tract infections and aspiration pneumonia. However, ectopic infections originating from these communities are uncommon.

Case Report: We present a rare case of a 64-year-old immunocompetent female was admitted with no significant medical history who developed a pyogenic liver abscess and sepsis caused by multiple anaerobic bacteria of digestive tract origin.

Wettability modification of a nano-silica/fluoro surfactant composite system for reducing the damage of water blocking in tight sandstone reservoirs.

In the process of drilling and development of tight sandstone reservoirs, a large number of external fluids can invade the pore structure of the reservoir due to its strong hydrophilicity, resulting in blockage of the pore structure and a decrease in oil and gas production capacity. To reduce the aqueous phase trapping damage of tight sandstone reservoirs, the SiO@KH550/FC-A nano-composite system was prepared to construct hydrophobic surfaces in core samples. First, the surface of nano-SiO was modified by KH550 to prepare nanoparticles with good dispersion.

Addressing unexpected bacterial RNA safety concerns of E. coli produced influenza NP through CpG loaded mutant.

Influenza virus nucleoprotein (NP) is a promising target for universal influenza vaccines due to its conservation and high immunogenicity. Here, we uncovered a previously unknown factor that E. coli-produced NP carries bacterial RNA, which is crucial for its high immunogenicity but may pose safety and consistency concerns due to batch variability.

Harnessing Non-standard Nucleic Acids for Highly Sensitive Icosaplex (20-Plex) Detection of Microbial Threats for Environmental Surveillance.

Environmental surveillance and clinical diagnostics heavily rely on the polymerase chain reaction (PCR) for target detection. A growing list of microbial threats warrants new PCR-based detection methods that are highly sensitive, specific, and multiplexable. Here, we introduce a PCR-based icosaplex (20-plex) assay for detecting 18 enteropathogen and two antimicrobial resistance genes.

Cross-sectional study of proteomic differences between moderate and severe psoriasis.

Although an ongoing understanding of psoriasis vulgaris (PV) pathogenesis, little is known about the proteomic differences between moderate and severe psoriasis. In this cross-sectional study, we evaluated the proteomic differences between moderate and severe psoriasis using data-independent acquisition mass spectrometry (DIA-MS). 173 differentially expressed proteins (DEPs) were significantly differentially expressed between the two groups.

Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention.

Heart rate (HR) has been proved to be associated with major adverse cardiovascular events (MACE) in Acute coronary syndrome patients. However, the threshold value and clinical significance of time in target of resting heart rate (TTR-HR) remain insufficiently elucidated. Our study aimed to evaluate the independent association between TTR-HR and cardiovascular outcomes in the follow-up study of ACS.

Joining Natural and Synthetic DNA Using Biversal Nucleotides: Efficient Sequencing of Six-Nucleotide DNA.

By rearranging hydrogen bond donor and acceptor groups within a standard Watson-Crick geometry, DNA can add eight independently replicable nucleotides forming four additional not found in standard Terran DNA. For many applications, the orthogonal pairing of standard and nonstandard pairs offers a key advantage. However, other applications require standard and nonstandard nucleotides to communicate with each other.

Predictive value of qSOFA and hypothermia combined with PT for prognosis in patients with severe trauma: a single-center retrospective cohort study.

Background: Trauma represents a significant global health challenge.The development of an effective scoring tool capable of predicting mortality risk in trauma cases is essential. This study aimed to investigate the combined effects of quick sequential organ failure assessment (qSOFA) and hypothermia (H) along with prothrombin time (PT) in predicting the prognosis of patients with severe trauma.

Preclinical pharmacology characterization of HX009, a novel PD1 x CD47 Bi-specific antibody.

Certain immune-checkpoint inhibitors have a narrow therapeutic window (TW) as cancer therapeutics, and engineered dual-/multi-targeting agents could potentially widen the TW to bring true clinical benefits. We report a new rationally-designed bispecific-antibody (BsAb), HX009, simultaneously targeting PD1 and CD47 to improve both the efficacy and safety over the respective single-targeting agents by grafting the extracellular domain of SIRPα onto the parental anti-PD1-monoclonal antibody, HX008. This resulted in an IgG4-based "2 × 2" symmetric structure but with an intentionally-reduced CD47-binding affinity, suggesting a novel candidate cancer immunotherapy.

Angular Trajectory of the Vestibular Aqueduct in a Cohort of Chinese Patients with Unilateral Ménière's Disease: Association with Other Imaging Indices and Clinical Profiles.

Objective: We aimed to investigate the association between the angular trajectory of the vestibular aqueduct (ATVA) with other radiological parameters of temporal bone and clinical characteristics in patients with Ménière's disease (MD).

Methods: A total of 125 unilateral MD patients and 118 controls were enrolled. Computer tomography (CT)-based radiological parameters included ATVA, vestibular aqueduct (VA) visibility, VA morphology, the vertical part of the posterior semicircular canal-the posterior fossa distance (PPD), and peri-VA pneumatization.

Multi-rater Prism: Learning self-calibrated medical image segmentation from multiple raters.

In medical image segmentation, it is often necessary to collect opinions from multiple experts to make the final decision. This clinical routine helps to mitigate individual bias. However, when data is annotated by multiple experts, standard deep learning models are often not applicable.