Targeting PBK in the fibroblast-to-myofibroblast transition: A novel therapeutic strategy for IPF.

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology with poor prognosis and limited therapies. OTS514, a PBK inhibitor, has been implicated in suppressing tumor progression by modulating various cellular biological processes. Nonetheless, the potential impact of PBK and OTS514 on IPF have yet to be elucidated.

Review on research methods of the surface urban heat island effect based on CNKI bibliometrics.

The urban heat island (UHI) effect is an increasingly prominent local climate issue in the process of global urbanization, significantly impacting human settlement health and energy consumption. Based on the China National Knowledge Infrastructure (CNKI) database, we searched and analyzed Chinese journal articles on the surface urban heat island (SUHI) effect published during 1980 and 2024. Using CiteSpace software, we conducted a visual analysis of publication trends and keywords to systematically summarize the research advances.

Research progress in parameterizing irrigation and fertilization in land surface model.

Under the context of global climate change and growing population, irrigation and fertilization have become important ways to ensure food production, with consequences on water cycling, energy flow, and materials cycling in terrestrial ecosystems. In the land surface model (LSM), coupling irrigation and fertilization schemes are of great importance for clearly understanding the land-atmosphere interactions to ensure food security. We reviewed the expression methods of three key parameters, namely, the applied method, usage, and time in the parameterization process of irrigation and fertilization (nitrogen fertilizer) in LSM.

[Health Risk Assessment of Heavy Metals in Soil and Wheat Grain in the Typical Sewage Irrigated Area of Shandong Province].

Sewage irrigation is a common alternative to make up for the shortage of agricultural irrigation in intensive agricultural areas. Abundant organic matter and nutrients in sewage can improve soil fertility and crop yield, but hazardous materials, such as heavy metals, will damage the soil environmental quality and threaten human health. To better understand the characteristics of heavy metal enrichment and potential health risk in a sewage irrigated soil-wheat system, a total of sixty-three pairs of topsoil and wheat grain samples were collected from the sewage irrigated area of Longkou City in Shandong Province.