The enhanced osteogenesis of calcium phosphate oligomers modified collagen membrane to guide bone regeneration.

Guided bone regeneration (GBR) is a promising technology for enhancing osteogenesis while preventing the invasion of fibrous tissue in implantation. Although collagen membranes have been widely utilized in GBR applications, their ability to support sufficient bone formation remains limited. Herein, we developed collagen-sodium alginate membranes (CSaM) with ultrasmall calcium phosphate oligomers (CPOs) incorporation by either physical adsorption (CSaM-em) or coprecipitation (CSaM-im).