Running exercise alleviates depressive-like behaviors through the activation of PINK1-Parkin mediated mitophagy in mice exposed to chronic social defeat stress.

Aims: Running exercise has demonstrated efficacy in the prevention and treatment of depression, yet the underlying mechanisms remain incompletely elucidated. Mitochondrial dysfunction and impaired mitophagy have been implicated in depression pathogenesis, while SIRT1 has been shown to play a critical role in both depression and mitochondrial regulation. Building on these established associations, this study aimed to investigate the antidepressant mechanisms of running exercise, with particular fucus on mitophagy regulated by SIRT1.

SRT1720 ameliorates LPS-induced depressive-like behaviors in mice and activates Parkin-mediated mitophagy.

Background: Emerging evidence suggests a connection between mitophagy-a key mitochondrial quality control mechanism-and depression. Furthermore, sirtuin 1 (SIRT1), a NAD⁺-dependent deacetylase, has been implicated in the pathophysiology of depression, though its precise role remains elusive. This study aimed to investigate how SIRT1 modulates depressive-like behaviors in mice and to determine whether mitophagy mediates this process.

Association between Endothelial Activation and Stress Index and mortality in diabetic nephropathy ICU patients: A retrospective cohort study.

Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, often leading to poor outcomes in critically ill patients. Endothelial Activation and Stress Index (EASIX), a marker of endothelial dysfunction and systemic stress, has been associated with adverse outcomes in various diseases, but its role in predicting mortality in DN patients remains unclear.

Methods: A retrospective cohort study was conducted using the MIMIC-IV database.

Association between mean corpuscular volume and mortality in chronic kidney disease ICU patients: A retrospective multicenter cohort study.

Background: Chronic kidney disease (CKD) affects over 10% of the global population and is closely linked to increased cardiovascular morbidity and mortality. Mean corpuscular volume (MCV), a key hematological parameter, has been associated with various clinical outcomes. However, the relationship between MCV and mortality in CKD patients admitted to the intensive care unit (ICU) has not been thoroughly investigated, with previous studies primarily limited to single-center designs.

Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens.

Background: Aging is a major risk factor for chronic diseases and cancer. Cellular aging, particularly in adult stem cells, offers a high-throughput framework for dissecting the molecular mechanisms of aging.

Results: We perform multiple genome-wide CRISPR interference (CRISPRi) screenings in human primary mesenchymal stem cells derived from adipose tissue during either replicative senescence or inflammation-induced senescence.

3D-Printed Bioinspired Meta-Structural Perovskite Catalysts for Dry Reforming of CH and CO.

Conventional packed-bed catalysts suffer from single-scale porosity, insufficient mechanical strength, and suboptimal mass transfer efficiency. Inspired by the fractal structure of the lung bronchi, a design and 3D printing method for gradient meta-structural catalysts is proposed by integrating synthesized LaFeNiO (LFN) perovskite with pseudo-boehmite, achieving ultralow pressure drop and high catalytic efficiency. Computational fluid dynamics and reaction simulations guide the design of uniform and gradient-structured catalysts with hierarchical woodpile channels (0.

Fluid Nanoforest Interfaces for Efficient Capture and MicroRNA and Protein Profiling of Tumor-Derived Extracellular Vesicles.

Co-profiling of microRNAs (miRNAs) and membrane proteins of tumor-derived extracellular vesicles (tEVs) is crucial for accurate tumor diagnosis. However, it is hindered by the low abundance of tEVs and the challenge of simultaneous signal transformation from internal and surface markers due to the membrane barrier. Here, we engineered a fluid nanoforest interface (FluidforestFace) within a microfluidic chip by coating supported lipid bilayers (SLBs) on nanoforest substrates, enabling the efficient capture of tEVs and profiling of tEV miRNAs and surface proteins.

Subcellular redistribution of Rhein from whole cellular to single mitochondria for enhancing anti-hepatoma efficacy.

Background: RECQL4 is a critical factor in DNA repair and serves as a significant biomarker for liver cancer. Inhibiting RECQL4 induces apoptosis in liver cancer cells. Given the role of mitochondria in regulating apoptosis and the dual localization of RECQL4 in both the mitochondria and nucleus, targeting mitochondrial RECQL4 may induce mitochondrial dysfunction, thereby enhancing the therapeutic efficacy of liver cancer treatments.

Effects of Intelligence Levels and Autistic Severity on Adaptive Functioning and Cognitive-Adaptive Functioning Gaps in School-Aged Children with Autism Spectrum Disorder.

Purpose: The aim of our study was to explore the underlying influencing factors of adaptive functioning and cognitive-adaptive functioning gaps in school-aged children with autism spectrum disorder (ASD).

Patients And Methods: Adaptive functioning of our subjects (n=107) were evaluated via Adaptive Behavior Assessment System (ABAS). Wechsler Intelligence Scale for Children (WISC) and Autism Diagnostic Observation Schedule (ADOS) were applied to assess the intelligence levels and autistic severity of them, respectively.

Comprehensive evaluation of regional variations in phytochemical composition and bioactive properties of Artemisia argyi.

Ethnopharmacological Relevance: Artemisia argyi (A. argyi) from distinct cultivation ecoregions exhibit significant phytochemical and bioactivity variations. However, no systematic study has yet elucidated their intrinsic correlations, hindering reproducible quality marker development.

The triglyceride-glucose index positively associates with the prevalence and severity of coronary heart disease in patients among hypertension.

Insulin resistance (IR) links hypertension (HTN) and coronary heart disease (CHD). This study investigated the link between the triglyceride-glucose (TyG) index, a marker for detecting IR, and the prevalence and severity of CHD in patients with HTN. Limited evidence exists on this relationship.

Monocytes/Macrophages Promote Regional Immune Injury in Mesangial Proliferative Glomerulonephritis through Crosstalk with Activated Mesangial Cells.

Mesangial proliferative glomerulonephritis (MsPGN) is the most common glomerulonephritis pathological type, including IgA nephropathy (IgAN), in which regional immune injury leads to disease progression without targeted treatment approaches. The mechanism of regional immune injury in MsPGN is unclear. We previously performed single-cell RNA sequencing (scRNA-seq) of IgAN and identified that the gene increased in kidney.

A constant pH molecular dynamics and experimental study on the effect of different pH on the structure of urease from Sporosarcina pasteurii.

Context: Urease is pivotal in microbial-induced calcium carbonate precipitation (MICP), where its catalytic efficiency directly governs calcium carbonate formation. However, practical MICP applications in extreme environments (e.g.

Transcriptomic analysis of AhAHL23-mediated root development and space-induced mutations in peanut (Arachis hypogaea L.).

Peanut seedling development encompasses four distinct tissues (leaf, stem, hypocotyl, root) with largely uncharacterized transcriptional regulatory networks, so we conducted RNA-seq on the space mutant line ZHM112. Transcriptome analysis showed that differentially expressed genes (DEGs) in peanut seedlings were enriched in basic biosynthesis and physiological metabolism pathways, with photosynthetic metabolism prominent in leaves and hormone metabolism in roots. The weighted gene co-expression network analysis (WGCNA) identified eight modules related to the four tissues.

IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy.

Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis globally and a major cause of renal failure. Immune dysregulation drives its pathogenesis. This study identifies novel genes as potential diagnostic and therapeutic targets, elucidating immune mechanisms in IgAN.

Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer.

The disruption of mitochondrial homeostasis in acute kidney injury (AKI) is an important factor that drives persistent renal dysfunction. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown great therapeutic potential in AKI, but insufficient specificity of targeting the impaired mitochondrial function. Herein, we developed an engineered nitric oxide (NO)-primed MSC-EVs (pEVs) to restore mitochondrial homeostasis for AKI therapy.

Association between social determinants of health with the all-cause and cause-specific (cancer and cardio-cerebrovascular) mortality among the population with metabolic syndrome: NHANES 2005-2018.

Background: Social determinants of health (SDOH) and metabolic syndrome (MetS) are related, but their combined effect on mortality risk remains unclear.

Methods: We analyzed data from NHANES (National Health and Nutrition Examination Survey) cycles between 2005 and 2018. The composite SDOH score was calculated by summing the weighted scores for each SDOH, categorizing participants into four groups: Q1 (0-1), Q2 (2-3), Q3 (4) and Q4 (≥ 5).

Enhanced cortical activity of swallowing under acid stimulation in normal individuals: an fNIRS study.

Introduction: The aims of this study are to investigate the activation patterns of the cerebral cortex in healthy individuals during liquid swallowing, as well as the differences in cerebral cortex activation between swallowing distilled water and swallowing acidic solutions, using functional near-infrared spectroscopy (fNIRS).

Methods: Eighteen healthy right-handed volunteers participated in this study. Each volunteer randomly completed two swallowing tasks: swallowing distilled water and swallowing an acidic solution, which differed in taste.

The global, regional, and national burden of pediatric stone disease: 1990-2021 and projections for the next two decades.

Background: Pediatric stone disease, once considered rare, has gained significant attention over the past decade owing to its rapidly increasing incidence. Despite this surge, a comprehensive evaluation of this burden is lacking.

Objectives: This study aimed to estimate the burden of pediatric stone disease, stratified by age and sex, at the global, regional, and national levels from 1990 to 2021.

Intraocular pressure-lowering effects of selective laser trabeculoplasty for normal tension glaucoma patients in Chinese.

To evaluate the efficacy of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) for the normal tension glaucoma (NTG) in Chinese. Consecutive patients with NTG treated with monocular SLT for eye with higher IOP were enrolled. IOP was evaluated for each patient before SLT, 1 h, 1 week, 1, 3, 6 months, 1 and 2 years after treatment.

Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management.

In spite of significant progress made in the management in recent decades, atrial fibrillation (AF) continues to cause increased mortality and significant morbidities, including heart failure and stroke. Diabetes mellitus (DM) is an independent risk factor for AF, and adds risks to increased mortality and hospitalizations when present along with AF. The pathophysiology of AF related to DM is complex with many inter-related factors.

IS26 carrying bla mediates carbapenem resistance heterogeneity in extensively drug-resistant Klebsiella pneumoniae isolated from clinical sites.

Background: Due to the widespread and irrational use of antibiotics, the emergence and prevalence of carbapenem-resistant Klebsiella pneumoniae (K. pneumoniae) have become a major challenge in controlling bacterial infections in hospitals. The bla gene located on mobile genetic elements has further complicated the control of resistant bacteria transmission.

ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.

Abnormal lipid metabolism in microglia leads to the formation of pathological lipid droplets (LDs), a phenomenon also observed in neurodegenerative diseases such as Alzheimer's disease (AD). The abnormal accumulation of LDs disrupts normal cellular function and exacerbates the pathological process of AD. ATP11B is a P4-ATPase and the expression of changes in the brain of patients with AD and diseases of lipid metabolism.