Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Aging is a major risk factor for chronic diseases and cancer. Cellular aging, particularly in adult stem cells, offers a high-throughput framework for dissecting the molecular mechanisms of aging.
Results: We perform multiple genome-wide CRISPR interference (CRISPRi) screenings in human primary mesenchymal stem cells derived from adipose tissue during either replicative senescence or inflammation-induced senescence. These screens reveal distinct sets of potential novel regulators specific to each senescence pathway. Combining our perturbation-based functional genomic data with 405 genome-wide association study datasets, including 50 aging-related studies, we find that the inflammatory aging signatures identified from CRISPRi screenings are significantly associated with diverse aging processes, suggesting novel molecular signatures for analyzing and predicting aging status and aging-related disease.
Conclusions: The signatures verified through comprehensive functional genomics and genetic analyses may provide new targets for modulating the aging process and enhancing the quality of cell therapy products.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326738 | PMC |
| http://dx.doi.org/10.1186/s13059-025-03683-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Work-related stress and burnout: Is epigenetic aging the missing link?
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFCorrection: Therapeutic potential of NGF-enriched extracellular vesicles in modulating neuroinflammation and enhancing peripheral nerve remyelination.
Acta Neuropathol Commun
September 2025
Department of Stem Cell and Regenerative Biotechnology, School of Advanced Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, and Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Older adults' perspectives on physical activity during hospitalization: a qualitative interview study.
BMC Geriatr
September 2025
Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Stockholm, Sweden.
Background: The benefits of physical activity for frail older acutely hospitalized adults are becoming increasingly clear. To enhance opportunities for physical activity on geriatric wards, it is essential to understand the older adult's perspective.
Aim: The aim of the study was to explore the experiences and perceptions of physical activity among older adults during hospital stays on a geriatric ward.
Physical activity, physical mobility, and mental health among persons 70 years or older: results from a large population-based study in Sweden.
Arch Public Health
September 2025
Centre for Clinical Research, Region Värmland, Karlstad, 651 85, Sweden.
Background: Physical inactivity, impaired physical mobility and poor mental health are common in the older population and increasing as the population ages. We examined the relationships between physical activity, physical mobility, and mental health in the general population of older adults.
Methods: The study is based on 12 959 men and women aged 70 years or older answering a survey questionnaire sent to a random population sample in Mid-Sweden in 2022 (response rate 66%).
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.
Immun Ageing
September 2025
Department of Biomedical Data Sciences, Molecular Epidemiology, LUMC, Leiden, The Netherlands.
The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay and liquid chromatography-mass spectrometry-based proteomics we explored the plasma proteins associating with the difference in 100 extreme scoring individuals selected from two large population cohorts, the Leiden Longevity Study (LLS) and the Rotterdam Study (RS), and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR).
View Article and Find Full Text PDF