Fe(OTf)-Catalyzed Diastereoselective Synthesis of α-Aminophosphonates via Phosphorylation of -Acetals.

An efficient approach to αaminophosphonates has been developed through an Fe(OTf)-catalyzed α phosphonylation of -acetals with triethyl phosphite. As a result, a series of 2,6- and 2,5- αaminophosphonates were obtained in moderate to excellent yields and with excellent diastereoselectivities ( up to 19:1).

Construction of Charge Transfer Complexes for Highly Selective Detection and Ultraefficient Separation of Uranium.

Selective detection and efficient separation of uranium from lanthanides (Ln) is very important but currently remains a great challenge considering the chemical similarities between uranium and Ln. Herein, a charge transfer complex (CTC) (TPP-TCNQ CTC) was constructed by introducing triphenylphosphine (TPP) as the donor and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as the receptor. The optical properties of TPP-TCNQ CTC, including absorption, fluorescence, and light scattering (LS), simultaneously exhibit distinct evolution upon the specific interaction with UO, facilitating its sensitive and selective detection with the limit of detection (LOD) down to 6.

Effects of Intelligence Levels and Autistic Severity on Adaptive Functioning and Cognitive-Adaptive Functioning Gaps in School-Aged Children with Autism Spectrum Disorder.

Purpose: The aim of our study was to explore the underlying influencing factors of adaptive functioning and cognitive-adaptive functioning gaps in school-aged children with autism spectrum disorder (ASD).

Patients And Methods: Adaptive functioning of our subjects (n=107) were evaluated via Adaptive Behavior Assessment System (ABAS). Wechsler Intelligence Scale for Children (WISC) and Autism Diagnostic Observation Schedule (ADOS) were applied to assess the intelligence levels and autistic severity of them, respectively.

Comparison of the application value of contrast-enhanced ultrasound and contrast-enhanced CT in puncture biopsy of peripheral pulmonary lesions.

Objective: This study assesses the clinical utility of contrast - enhanced ultrasound (CEUS) in comparison to contrast - enhanced computed tomography (CECT) in the context of peripheral lung mass biopsy. The overarching objective is to establish robust clinical benchmarks that can guide evidence - based decision - making in the field of pulmonary interventional procedures.

Methods: A comparison of 420 patients admitted to our hospital from January 2019 to December 2022 who underwent biopsy using two different guidance methods, including 196 cases in the CEUS-guided biopsy group and 224 cases in the CECT-guided biopsy group.

Chinese Guideline for the Diagnosis and Management of Drug-Induced Liver Injury in Primary Care (2024).

Drug-induced liver injury (DILI) is a drug-induced disease that not only complicates the treatment of the primary disease but may also lead to acute liver failure or even death in severe cases. Drugs commonly used in primary care, such as anti-infective agents and nonsteroidal anti-inflammatory drugs, are major causes of DILI. In addition, a large elderly population, comorbidities, and combination therapy with multiple drugs increase the risk of DILI in primary care.

Cuprous-Sulfide-Nanoplate-Catalyzed Click Chemistry for In Situ Construction of Covalent Organic Polymer Heterostructures for Efficient Photocatalytic Reduction and Removal of U(VI).

In this study, a core-shell heterostructure of cuprous sulfide (CuS) nanoplates and covalent organic polymers (COPs) (CuS@COP) was constructed in situ by a CuS-catalyzed azide-alkyne reaction for efficient reduction and rapid removal of U(VI) from uranium mine wastewater. The simple in situ synthesis of heterojunctions through click chemistry reactions can create a tight bond at the interface and evade the laborious process of conventional composites. The different Fermi energy levels of CuS and COP induce the formation of a built-in electric field within the core-shell heterojunction, and the photogenerated charge transfer from the COP to CuS nanoplate results in a substantial boost in the efficiency of the photocatalytic reduction of U(VI).

A rare metachronous primary clear cell renal cell carcinoma and pancreatic ductal adenocarcinoma: case report and literature review.

Metastatic spread to the pancreas from renal cell carcinoma is a relatively rare event. Even rarer is the metachronous occurrence of clear cell renal cell carcinoma (ccRCC) and pancreatic ductal adenocarcinoma (PDAC). Our case report contributes to the existing literature by documenting the unusual occurrence of metachronous ccRCC and PDAC in a 69-year-old patient, and we review the literature.

Untargeted metabolomics combined with pseudotargeted lipidomics revealed the metabolite profiles of blood-stasis syndrome in type 2 diabetes mellitus.

Objective: Blood-stasis syndrome (BSS), an important syndrome in Type 2 diabetes mellitus(T2DM), is associated with the pathophysiological mechanisms underlying diabetic vascular complications. However, BSS has not been fully characterized as of yet. Due to the strong correlation between BSS and vasculopathy, we hypothesized that the metabolic characteristics of BSS in T2DM (T2DM BSS) are highly specific.

Chain-Like Pentanuclear Complexes: Syntheses, Crystal Structures and Long-Range Electronic Interactions of Cyanido-Bridged MRu (M=Fe, Ru).

In this work, we report the design and synthesis of two chain-like pentanuclear cyanido-bridged complexes trans-[Ru(bpy)(μ-CN)][cis-Ru(bpy)(μ-NC)M(dppe)Cp*][PF] (M=Fe, 1; M=Ru, 2) and the electronic communication properties of their oxidized products 1 (m=6, 7, 8) and 2 (n=5, 6, 7, 8). The single-crystal X-ray diffraction analysis of 1 (m=4, 6, 7) and 2 show that 1 and 2 possess a Z-type array structure, 1 is a U-type one, and 1 exhibits both the types. The investigations indicate that both 1 and 2 show an extraordinarily strong electronic interaction between the two side Ru across the central NC-Ru-CN, leading to the formation of a fully delocalized cyanidometal Ru-Ru-Ru bridge for both three-electron oxidized states 1 and 2.

SARS-CoV-2 reinfection broadens the antibody responses and promotes the phenotypic differentiation of virus-specific memory T cells in adolescents.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants raises concerns regarding the effectiveness of immunity acquired from previous Omicron subvariants breakthrough infections (BTIs) or reinfections (RIs) against the current circulating Omicron subvariants. In this study, we prospectively investigate the dynamic changes of virus-specific antibody and T cell responses among 77 adolescents following Omicron BA.2.

Dapagliflozin alleviates right heart failure by promoting collagen degradation by reducing ROS levels.

Background: Right ventricular (RV) fibrosis is an important pathological change that occurs during the development of right heart failure (RHF) induced by pulmonary hypertension (PH). Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has been shown to play a major role in left heart failure, but it is unclear whether it has a positive effect on RHF. This study aimed to clarify the effect of DAPA on PH-induced RHF and investigate the underlying mechanisms.

Epidemiological characteristics and antibody kinetics of elderly population with booster vaccination following both Omicron BA.5 and XBB waves in China.

After the termination of zero-COVID-19 policy, the populace in China has experienced both Omicron BA.5 and XBB waves. Considering the poor antibody responses and severe outcomes observed among the elderly following infection, we conducted a longitudinal investigation to examine the epidemiological characteristics and antibody kinetics among 107 boosted elderly participants following the Omicron BA.

The Effect of Topical Vancomycin Powder Application on the Rate of Intervertebral Fusion Following Lumbar Fusion: A Retrospective Study.

Purpose: The occurrence of surgical site infection (SSI) after lumbar spinal fusion is a serious complication. Therefore, an increasing number of clinicians are applying vancomycin powder topically in the surgical field to reduce the incidence of SSI. However, there is concern that topical vancomycin powder application may affect intervertebral fusion.

Fine-tuning of thermally induced SCO behaviors of trinuclear cyanido-bridged complexes by regulating the electron donating ability of C-terminal fragments.

To achieve fine regulation of Fe SCO behavior, a series of trinuclear cyanido-bridged complexes (1-4) (1, M = Fe2 and = 1; 2, M = Fe2 and = 4; 3, M = Fe2 and = 5; 4, M = Ru and = 5; CpMe = alkyl cyclopentadienyl with = 1, 4, 5; dppe = 1,2-bis-(diphenylphosphino)ethane; abpt = 4-amino-3,5-bis-(pyridin-2-yl)-1,2,4-triazole and OTf = CFSO) were synthesized and fully characterized by using elemental analysis, X-ray crystallography, magnetic measurements, variable-temperature IR spectroscopy and Mössbauer spectroscopy. It is worth mentioning that different from many mononuclear Fe(abpt)X (X = NCS, NCSe, N(CN), C(CN), (NC)CC(OCH)C(CN), (NC)CC(OCH)C(CN), CSO and Cl) complexes with more than one polymorph, only one polycrystalline form was found in complexes 1-4. Moreover, the thermally induced SCO behaviors of these four complexes are independent of intermolecular π-π interactions.

Efficient capture of iodine in steam and water media by hydrogen bond-driven charge transfer complexes.

Untreated radioactive iodine (I and I) released from nuclear power plants poses a significant threat to humans and the environment, so the development of materials to capture iodine from water media and steam is critical. Here, we report a charge transfer complex (TCNQ-MA CTC) with abundant nitrogen atoms and π-conjugated system for adsorption of I vapor and I from aqueous solutions. Due to the synergistic binding mechanism of benzene/triazine rings and N-containing groups with iodine, special I-π and charge transfer interaction can be formed between the guest and the host, and thus efficient removal of I and I can be realized by TCNQ-MA CTC with the adsorption capacity up to 2.

A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease.

Gap junction (GJ) is a special cell membrane structure composed of connexin. Connexin is widely distributed and expressed in all tissues except differentiated skeletal muscle, red blood cells, and mature sperm cells, which is related to the occurrence of many genetic diseases due to its mutation. Its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis makes it a therapeutic target for a variety of diseases.

Different delocalized ranges in mixed valence cyanido-metal-bridged Fe-Ru-Fe complexes controlled by terminal ligand substitution modification.

In order to investigate the properties of metal to metal charge transfer (MMCT) influenced by the relative energy level between the bridging unit and the terminal unit, two groups of heterotrimetallic cyanido-metal-bridged complexes, -[Cp(dppe)Fe-CN-Ru(MeOpy)-NC-Fe(dppe)Cp][X] (1[X]n; = 2, 3, or 4; X = PF or BF) (Cp = cyclopentadiene, dppe = 1,2-bis(diphenylphosphino)ethane, MeOpy = 4-methoxypyridine) and [Cp*(dppe)Fe-CN-Ru(MeOpy)-NC-Fe(dppe)Cp*] [X] (2[X]n; Cp* = 1,2,3,4,5-pentamethylcyclopentadiene; = 2, 3, or 4; X = PF or BF) were synthesized and fully characterized. The crystallography data suggest different oxidation sites in the ground state for one-electron oxidation products 13+ and 23+, and the electrochemical and Mössbauer spectra suggest that in the one-electron oxidation compounds 13+, the charge is delocalized all along the trimetal backbone Fe-Ru-Fe, while in 23+, the charge is rather delocalized between the two metal parts Fe-Ru. Further oxidation of N3+ gives N4+ ( = 1 or 2), during which a spin transfer towards the terminal units is observed in both series.

Heterogeneity and synaptic plasticity analysis of hippocampus based on db mice induced diabetic encephalopathy.

Chronic hyperglycemia can cause changes in synaptic plasticity of hippocampal cells, which has accelerated the pathological process of cognitive dysfunction. However, the heterogeneity of the hippocampal cell populations under long term high glucose statement remains largely unknown. To mimic chronic hyperglycemia induced cognitive function deficit in vivo, db diabetic mice was selected and Novel Object Recognition(NOR) behavior tests were performed.

Metal-Metal Charge Transfer Properties of a Series of Trinuclear Fe Ru and Corresponding Pentanuclear Fe Ru Ag Cyanido-Bridged Complexes.

A series of trimetallic cyanidometal-bridged compounds [Me Cp(dppe)Fe -(μ-NC)-Ru (MeOpy) -(μ-CN)-Fe (dppe)CpMe ] - [PF ] (N[PF ] , n=0, N =1; n=1, N=2; n=3, N=3; Cp=cyclopentadiene, dppe=1,2-bis(diphenylphosphino)ethane, MeOpy=4-methoxypyridine) and their one- and two-electron oxidized compounds N and N were synthesized and characterized. Meanwhile, a series of corresponding linear cyanido-bridged pentanuclear compounds [Me Cp(dppe)Fe -(μ-NC)-Ru (MeOpy) -(μ-NC)-Ag -(μ-CN)-Ru (MeOpy) -(μ-CN)-Fe (dppe)CpMe ][BF ] (M[BF ] , n=0, M=4; n=1, M=5; n=3, M=6) were also obtained and well characterized. The investigations suggest that in the trinuclear system there exists remote interaction between the two Fe centers, but no significant interactions exist across the central silver unit between the metals on the two sides of the silver center in the pentanuclear system.

Electric double layer contribution to sum frequency generation signal from Au electrode.

Understanding the electric double layer (EDL) of the metal electrode-electrolyte interface is essential to electrochemistry and relevant disciplines. In this study, potential-dependent electrode Sum Frequency Generation (SFG) intensities of polycrystalline gold electrodes in HClO4 and H2SO4 electrolytes were thoroughly analyzed. The potential of zero charges (PZC) of the electrodes was -0.

[Evaluation of the effect of repairing unilateral cleft lip nose deformity with autogenous concha cartilage].

Purpose: To explore the effect of nasal deformity correction after unilateral cleft lip repair with autogenous concha cartilage transplantation.

Methods: Thirteen patients with nasal deformity after unilateral cleft lip surgery were collected, who were treated with autogenous concha cartilage and nasal septum deviation correction at the same time. Their chin-lifting photos were taken before operation, five days, one month and six months after operation.

as a model to study the ecotoxicity of 1-alkyl-3-methylimidazolium bromide.

The purple non-sulfur bacterium was selected as a biological model to investigate its response to the toxicity of 1-alkyl-3-methylimidazolium bromide ([Cmim]Br), a type of ionic liquid (IL), with different alkyl chain lengths ( describes the number of carbon atoms in the alkyl chain). The inhibition of bacterial growth by [Cmim]Br was positively correlated with . Morphological characterization revealed that [Cmim]Br caused cell membrane perforation.

Intelligence profiles and adaptive behaviors of high-functioning autism spectrum disorder and developmental speech and language disorders.

Objective: The present study was aimed at investigating the intelligence profiles and adaptive behaviors of children with high-functioning autism spectrum disorder (HFASD) and developmental speech and language disorders (DSLDs). We compared the similarities and differences of cognitive capabilities and adaptive functions and explored their correlations in the HFASD and DSLDs groups.

Methods: 128 patients with HFASD, 111 patients with DSLDs and 114 typically developing (TD) children were enrolled into our study.