A multiset matrix product state approach to hierarchical equations of motion and its application to vibrational relaxation on metal surfaces.

We develop a multiset matrix product state (MPS) approach based on the time-dependent variational principle to solve the hierarchical equations of motion (HEOM) for the fermionic bath and apply it to inelastic vibrational scattering on metal surfaces. By using a Newns-Anderson model with two nuclear degrees of freedom, we investigate the vibrational energy relaxation of NO scattering on Au(111) and Ag(111) surfaces. Our results show that the extent of vibrational relaxation depends strongly on both incident energy and molecule-surface coupling strength.

Characteristics of corneal biomechanical parameters and corneal thickness measured by Corvis ST and AS-OCT in progressive keratoconus treated by accelerated corneal cross-linking.

Purpose: To explore the characteristics of corneal biomechanical parameters and corneal thickness in different corneal regions in progressive keratoconus treated by accelerated "epithelium off" cross-linking (A-CXL) surgery.

Methods: This is a retrospective study and is self-controlled before and after surgery. A total of 39 eyes of 25 patients with progressive keratoconus were recruited and treated by A-CXL.

Rational design of high visible light-harvesting photoelectrode for simultaneous detection of enrofloxacin residue markers with a dual-channel cathodic photoelectrochemical aptasensing approach.

It is imperative to develop convenient methodology to enable the simultaneous detection of enrofloxacin (ENR) residue markers coexisted in the aquatic environment. To this end, an efficient dual-channel photoelectrochemical (PEC) aptasensing approach is presented for the detection of trace ENR residue markers simultaneously through a single signal acquisition. Primarily, cathodic PEC aptasensing platform with superior anti-interference capability and high sensitivity was designed and constructed on the basis of the high visible light-harvesting CuInS photocathode and BiS/CN photoanode; and the simultaneous detection of ENR residue markers was then realized by the spatial resolution of aptasensing interfaces.

Toxicity of ubiquitous tire rubber antiozonant -(1,3-dimethylbutyl)-'-phenyl--phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids.

The tire rubber antioxidant -(1,3-dimethylbutyl)--phenyl--phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) were recently found in human bodies. Though 6PPD/6PPD-Q showed species-dependent toxicity in animals, human relevant data are scarce. Here, primary human hepatocytes (PHHs), the gold standard in vitro model for hepatotoxicity, were used for acute and subacute toxicity assessments, with test concentrations normalized to average human serum concentrations (C).

Effects of variety degeneration on yield formation, quality traits and 2-acetyl-1-pyrroline biosynthesis in high-quality Japonica rice.

The main purpose of the present study was to study the degeneration of the high-quality japonica rice varieties during long-term cultivation, with a focus on changes in yield, rice quality and indices related to 2-acetyl-1-pyrroline (2-AP) biosynthesis, to provide a scientific basis for the comprehensive purification and improvement of high-quality rice varieties. By selecting the lines from the populations of Nanjing 9108 and Nanjing 46 at Liyang, it was found that the mutant lines showed significant differences in the yield and yield components, processing and appearance quality, cooking and flavor quality, rapid viscosity analyser profile characteristics and 2-AP content. Molecular marker detection can be used as a primary method for seed purity identification.

3D-printed model combined with the Ilizarov technique in the treatment of genu varum in children with hypophosphatemic rickets.

Introduction: Genu varum in children with hypophosphatemic rickets are complex and always occur on multiple planes, which are difficult to correct. This present study is aimed to retrospectively explore the feasibility and efficacy of 3D-printed model combined with the Ilizarov technique in the treatment of genu varum in children with hypophosphatemic rickets.

Methods: From March 2010 to July 2020, 7 hypophosphatemic rickets patients with genu varum were retrospectively analyzed in our hospital.

Protein Recognition and Assembly by a Phosphocavitand.

Controlled protein assembly is an enabling technology, in particular, for biomaterials fabrication. Here, we report protein recognition and assembly by a phosphate-containing macrocycle (). We show that the -symmetric phosphocavitand is a versatile receptor for N-terminal residues or arginine but not lysine.

Nanocarrier mediated DOX/siRNA targeted co-delivery for synergistic treatment of cutaneous melanoma in outdoor athletes.

Athletes engaging in long-term and high-intensity outdoor exercise training are at high-risk for cutaneous melanoma (CM). Due to the limitations and side effects of traditional tumor treatment methods, it's difficult for athletes with CM to maintain athletic ability and prolong sport career. Targeted combination therapy based on nanocarriers is currently a promising method for achieving more satisfactory therapeutic effects.

The clinical features, muscle pathology, and role of autophagy in anti-Ku-positive patients.

Aims: This study aimed to examine the clinical and muscle histological characteristics of anti-Ku-positive patients. A preliminary investigation into the involvement of autophagy was conducted as well.

Methods: Clinical characteristics, laboratory findings, and muscle histological features were collected from patients with isolated anti-Ku antibodies at the Department of Neurology, First Medical Center of the PLA General Hospital, between February 2011 to June 2024.

Comparison of a progressive bone drilling system and a visualized reaming system in percutaneous transforaminal endoscopic discectomy: a comparative study.

Background: Percutaneous transforaminal endoscopic discectomy (PTED) is an alternative, minimally invasive procedure for the treatment of symptomatic lumbar disc herniation (LDH). Two foraminoplasty techniques exist, however, insufficient literature exists highlighting the differences between these procedures.

Methods: A multicentre retrospective study was conducted in consecutive patients diagnosed with symptomatic LDH who received PTED at spine centres from March 2015 to June 2019.

Evaluating the Effectiveness of Smart Glasses in Reducing Patient Care Time in Emergency Departments: Cohort Study From the Hangzhou Asian Games.

Background: Challenges in emergency medicine include overcrowding, insufficient emergency care resources, and extended emergency department (ED) waiting times. These issues contribute to delays in treatment and unfavorable outcomes. This situation worsens in events with large crowds and particularly worsened during the COVID-19 pandemic.

Video-Assisted Thoracoscopic Left Lower Lobectomy and Bronchial Foreign Body Removal for Treating a Rare Occult Bronchial Foreign Body in an Adult.

Occult bronchial foreign bodies are extremely rare in adults. Affected patients typically lack a clear history of aspiration, exhibit no characteristic clinical signs and present with unremarkable chest imaging, often leading to misdiagnosis or missed diagnosis. This paper reports a case of an adult patient with occult bronchial foreign body aspiration that was initially misdiagnosed as pulmonary sequestration.

Application of artificial intelligence lesion labeling system-assisted endoscopic submucosal dissection for the treatment of esophageal lesions in a low-volume center: a prospective cohort study.

Background And Aims: Multiple artificial intelligence (AI) systems have been developed to assist with endoscopic diagnosis. We established the first real-time AI lesion-labeling system to assist in delineating lesion margin during endoscopic submucosal dissection (ESD). We aimed to further validate the efficacy of this system in improving histological complete resection rate especially for beginners in low-volume centers.

Evaluation of the Efficacy and Safety of DC-CIK Bioimmunotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer.

Non-small cell lung cancer (NSCLC) is a malignant tumor with a high incidence rate and mortality rate. This study aims to explore the efficacy and safety of dendritic cell cytokine-induced killer cell (DC-CIK) bioimmunotherapy in advanced NSCLC. Sixty-four NSCLC patients treated in our hospital from June 2019 to February 2021 were chosen as the DC-CIK group, all of whom received DC-CIK bioimmunotherapy based on synchronous radiotherapy and chemotherapy.

Cross-tissue multicellular coordination and its rewiring in cancer.

The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest. However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we systematically characterized cross-tissue coordinated cellular modules in healthy tissues, uncovering their spatiotemporal dynamics and phenotypic associations, and examined their rewiring in cancer.

Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations.

Pexidartinib is a regulatory agency approved small molecule kinase inhibitor (KI) with a boxed warning for hepatotoxicity, and FDA requires a Risk Evaluation and Mitigation Strategy (REMS) to mitigate such risk. The mechanism of pexidartinib hepatotoxicity is poorly understood. As mitochondrial injury and hepatocyte toxicity have been proposed to be a shared mechanism for the hepatotoxicity induced by many KIs, here we examined pexidartinib for such liabilities.

Direct Current Redox Imaging of Single Retinal Pigment Epithelial Cells Using Light-Addressable Electrochemistry at Semiconductor Electrodes.

Light-addressable electrochemistry (LAE) enables the activation and detection of localized faradaic electrochemical processes on a flat, unconstructed semiconductor electrode through targeted light illumination, making it a promising approach for single-cell electrochemistry. Herein, we report a direct current (DC) redox imaging technique for single retinal pigment epithelial cells utilizing LAE with an α-FeO electrode activated by a constant, focused laser beam. The proposed DC-LAE method showed micron-scale resolution and was successfully used to image single cells under physiological conditions.

Prediction of abnormal bone mass with a pericoronary adipose tissue Attenuation model.

Background: The aim is to explore the value of pericoronary adipose tissue (PCAT) attenuation in predicting abnormal bone mass by establishing a prediction model.

Materials And Methods: 361 patients with coronary computed tomography angiography (CCTA) and quantitative computed tomography (QCT) scans were retrospectively recruited. 311 patients from institution 1 from July 2021 to January 2023 were divided into a training cohort (n = 217) and an internal cohort (n = 94).

Considerations from the pharmaceutical industry (IQ MPS Affiliate) workshop on animal microphysiological systems and 3Rs in drug development.

Most complex in vitro models (CIVM) and microphysiological systems (MPS) are composed of human cells, with the goal of evaluating diseases, efficacy, safety, and pharmacokinetic ques­tions specifically for humans. The hope with CIVM/MPS is that they will eventually improve our predictivity of clinical responses and reduce or replace animal use in research, supporting the 3Rs concept of only using animals in research when necessary. Given the potential of animal-based models to advance this field by comparing existing in vivo animal data with new animal-based MPS responses, there are currently few CIVM and MPS utilizing animal tissues.

Microstructure and properties of TC4 titanium alloy micro-arc oxide composite coating based on laser surface texturing.

Micro-arc oxidation technology is one of the important means to improve the tribological properties of titanium alloys, but the bonding performance between the micro-arc oxidation film and the substrate material limits the further application of the micro-arc oxidation film. This study investigates TC4 titanium alloy as a model system, the microstructure and properties of the composite coating were obtained by laser surface texturing composite micro-arc oxidation process. The microstructure, phase composition, and worn morphology of the Micro-arc oxidation coating were characterized using X-ray diffraction, field emission scanning electron microscopy, and optical microscopy, respectively.

A Theoretical Model for Linear and Nonlinear Spectroscopy of Plexcitons.

We present a theoretical model to investigate the dynamics and spectroscopic properties of a plexciton system consisting of a molecular exciton coupled to a single short-lived plasmonic mode. The exciton is described as a two-level system (TLS), while the plasmonic mode is treated as a dissipative harmonic oscillator. The hierarchical equations of motion method is employed to simulate energy transfer dynamics, absorption spectra, and two-dimensional electronic spectra (2DES) of the system across a range of coupling strengths.

Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours.

Background: There are few clinicopathologic characteristics and clinical results for oesophageal gastrointestinal stromal tumours (GISTs). Thus, the objective of this study was to identify the clinicopathologic characteristics and clinical results of oesophageal GISTs.

Aim: To investigate endoscopic treatment effective of oesophageal GISTs.