The facile preparation of mixed-valence metal-organic frameworks through reduction.

A facile strategy was applied to prepare Cu(I)/Cu(II) MOFs, where the Cu(I) amount and porous structure can be adjusted by the degree of reduction and the size of HKUST-1, by partially reducing HKUST-1 with hydrazine hydrate at room temperature. The Cu(I)/Cu(II) MOFs exhibit excellent catalytic capability in the Cu(I)-catalyzed azide alkyne cycloaddition.

Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial.

Flexible fiberoptic bronchoscopy (FFB) for children is widely performed under sedation. Currently, the optimal sedation regimen remains unclear. Esketamine is an N-methyl-D-aspartic acid (NMDA) receptor antagonist, which has stronger sedative and analgesic effects and exerts less cardiorespiratory depression than other sedatives.

Degradation Mechanism Study and Safety Hazard Analysis of Overdischarge on Commercialized Lithium-ion Batteries.

With the continuous improvement of the energy density of traction batteries for electric vehicles, the safety of batteries over their entire lifecycle has become the most critical issue in the development of electric vehicles. Abuse of electricity encountered in the application of batteries has a great impact on the safety of traction batteries. In this study, focused on the overdischarge phenomenon that is most likely to be encountered in the practical use of electric vehicles and grid storage, the impact of overdischarge on battery performance degradation is analyzed by neutron imaging technology and its safety hazards is systematically explored, combined with multimethods including electrochemical analysis and structural characterization.

Control of SARS-CoV-2 transmission in orthodontic practice.

The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has attracted worldwide concerns because of its high person-to-person infectivity and lethality, and it was labeled as a pandemic as the rapid increase in the number of confirmed patients in most areas around the world became evident. The SARS-CoV-2 is mainly transmitted through respiratory droplets and close contact. There is also evidence of transmission through aerosols and digestive tracts.

Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processing.

Background: Dysfunction in the endolysosome, a late endosomal to lysosomal degradative intracellular compartment, is an early hallmark of some neurodegenerative diseases, in particular Alzheimer's disease. However, the subtle morphological changes in compartments of affected neurons are difficult to quantify quickly and reliably, making this phenotype inaccessible as either an early diagnostic marker, or as a read-out for drug screening.

Methods: We present a method for automatic detection of fluorescently labeled endolysosomes in degenerative neurons in situ.