The FN1-targeted delivery of low-molecular-weight heparin to venous clots revolutionizes thrombosis treatment in CVT.

The systemic administration of low-molecular-weight heparin (LMWH) as the standard initial treatment for venous thromboembolism is intended to prevent thrombus growth during the acute phase and prevent thrombus recurrence during the chronic phase. However, precisely controlling the specificity and localization of LMWH presents significant challenges, which has necessitated research into targeted delivery methods. Furthermore, due to different thrombosis mechanisms, tailored pharmacologic interventions are needed, particularly for arterial and venous thrombosis.

Electroacupuncture Pretreatment Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Engulfment by Microglia in the Lateral Hypothalamus.

Aim: The occurrence of myocardial ischemia-reperfusion injury (MIRI) is accompanied by neuroinflammatory reactions and is closely related to the overactivation of microglia. Currently, effective clinical strategies to prevent MIRI are unclear. This study investigated potential therapeutic targets and the mechanisms of electroacupuncture pretreatment (EA-pre) for MIRI.

Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses.

Negative-stranded segmented RNA viruses (NSVs) employ a cap-snatching mechanism for transcription, which makes cap-dependent endonuclease (CEN) an attractive target for drug development. Pathogenic arenaviruses pose a serious threat to humans, yet no approved treatments exist, underscoring the importance of discovering novel compounds targeting arenaviral CENs. Therefore, this study aimed to identify novel CEN inhibitors for arenaviruses and investigate their antiviral mechanisms.

Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning.

Seawater drowning-induced acute lung injury (ALI) presents a significant challenge due to the lack of effective prevention and treatment strategies. Hesperidin (Hep) possesses diverse biological activities, including potent antioxidant and anti-inflammatory effects. However, its clinical utility is hindered by poor solubility and limited bioavailability.

Effects of Oral Nutritional Supplements in Gastric Cancer Patients with Malnutrition-Sarcopenia Syndrome.

Malnutrition and sarcopenia may occur concurrently (Malnutrition-sarcopenia syndrome, MSS) in gastric cancer patients, affecting the prognosis and clinical outcomes. This study aimed to evaluate MSS prevalence and oral nutritional supplements (ONS) efficacy. This study included a retrospective analysis of 761 gastric cancer patients post-resection to assess MSS prevalence/prognosis, and a prospective non-randomized trial enrolled 81 MSS patients comparing ONS (500 kcal/day ×4 wk) versus standard care.

Chromatin dynamics and regulatory drivers of hypoplastic hepatic progenitor cells in partial hepatectomy model.

The remarkable plasticity of hepatocytes underlies diverse roles in distinct patterns of liver injury. Specifically, hepatocyte-derived progenitor cells play dominant roles in driving the regenerative response during chronic liver injury. However, the potential for hepatocytes to transdifferentiate into progenitor-like cells following partial hepatectomy (PHx) remains debated.

Plasma non-targeted metabolomics unravels the metabolic features of normal trans-right heart.

Introduction: Right heart (RH), as a junction between the venous system and pulmonary circulation, gains great emphasis on exploring the relevant pathological mechanism of many cardiopulmonary diseases. Although these pathogensis researches centering on RH-related diseases advance, the physiological mechanism research of the RH is scarce.

Objectives: This study aimed to accurately unravel the metabolic features of normal trans-RH through non-targeted metabolomics.

Recombinant live attenuated measles virus-based vaccines inducing comprehensive protection against Ebola and Marburg viruses.

Filoviruses, including Ebola and Marburg viruses, present significant global health challenges due to their high mortality rates. Despite the availability of several Ebola virus vaccines, none provide cross-protection against multiple filovirus species. In this study, we developed recombinant live attenuated measles virus-based vaccine candidates designed to express Ebola or Marburg virus glycoproteins and generate virus-like particles for pan-filovirus immunization.

Hypoxia-Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis.

Metastasis contributes to around 90% of cancer mortality, but effective strategies to disrupt metastatic cascades remain elusive. Hypoxia-driven epithelial-mesenchymal transition (EMT) promotes cancer cell spread, yet the post-translational mechanisms governing cytoskeletal reprogramming here remain incompletely defined. This study reports a hypoxia-inducible post-translational modification cascade: under hypoxia, protein arginine methyltransferase 1 (PRMT1) is lactylated at evolutionarily conserved residues K134/K145, enhancing its methyltransferase activity to catalyze the asymmetric dimethylation (aDMA) of vimentin at R64.

The impact of completely shrunken blastocysts on clinical outcomes in vitrified-warmed single blastocyst transfer cycles.

The aim of this study was to evaluate whether blastocysts that do not re-expand 2–4 h after thawing were of value for utilization and to analyze the relevant factors affecting clinical pregnancy in completely shrunken blastocyst transfer (CSBT) cycles. The retrospective cohort study included 104 single embryo transfer cycles with CSBT and 2172 cycles with re-expanded blastocyst transfer (REBT). Confounders between groups were adjusted using propensity scoring matching.

Rapid Detection of Pesticide Residues in Leaf Vegetables by SERS Technology.

Organophosphate pesticides, fungicides, and neonicotinoid insecticides are frequently employed in the cultivation and production of leafy vegetables. The conventional detection methods for these pesticides rely on chromatographic techniques, which are characterized by good precision and sensitivity. Nevertheless, these methods suffer from drawbacks such as complex sample pretreatment, prolonged detection times, and high costs, hindering the realization of on-site detection.

Lipid-Based Nanoparticles in Cancer Therapy: Advances in Targeted Drug Delivery and Therapeutic Potential for Renal Cell Carcinoma.

Renal cell carcinoma (RCC) remains a significant clinical challenge due to delayed diagnosis and multidrug resistance, necessitating innovative strategies to enhance early detection and therapeutic efficacy. This review evaluates the role of lipid-based nanoparticles (LNPs), including liposomes, micelles, nanoemulsions, solid lipid nanoparticles, and nanostructured lipid carriers, as advanced drug delivery systems in providing innovative solutions for RCC diagnosis and treatment. These LNPs exhibit unique advantages of great biocompatibility, biodegradability, extended circulation, and tumor-targeting capabilities, which enable precise drug delivery, controlled release, and circumvention of drug resistance mechanisms.

Association of 6:2 Fluorotelomer Ethoxylate Exposure with Serum Lipids in General Adults.

A series of 6:2 fluorotelomer ethoxylates (FTEOs) has been recently detected in human serum. Whether it has the potential to disrupt lipid metabolism in human populations remains largely unexplored. This study quantified serum concentrations of 6:2 FTEOs in 237 healthy Chinese adults, examined the gender- and age-specific differences in serum levels of 6:2 FTEOs, and investigated the associations between serum levels of 6:2 FTEOs and lipid profiles for the first time.

Biocompatible Mesoporous Materials for Bone Therapy.

As global population aging intensifies, bone-related diseases have become a significant public health challenge, necessitating the development of efficient and precise bone repair strategies. Biocompatible mesoporous materials (BMMs), characterized by their high specific surface area, tunable pore size, multidimensional functionalization potential, and excellent biocompatibility, have demonstrated revolutionary application prospects in treating bone-related diseases. This review systematically summarizes the latest research progress and application mechanisms of BMMs (e.

Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma.

IL-1α is a potent inflammatory cytokine that is released by cell necrosis and activates IL-1R. More recently, IL-1α has been shown to have intracellular functions. In the current study, we investigated the expression and distinctive role of IL-1α in tumor progression.

Systemic immune-inflammation index as a versatile biomarker in autoimmune disorders: insights from rheumatoid arthritis, lupus, and spondyloarthritis.

Autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic vasculitis, spondyloarthritis (SpA), including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), are characterized by chronic immune activation and systemic inflammation. The systemic immune-inflammation index (SII), computed as platelet count × neutrophil count/lymphocyte count, is a promising biomarker that reflects both inflammatory burden and immune dysregulation. In RA, elevation of SII is correlated with disease activity score, response to TNF-α inhibitors, and reduced serum Klotho levels.

Synergy of nanoclusters/single atoms regulates sustainable oxidation pathways for self-motivated Fenton-like processes.

Synergy mechanism of nanoclusters/single atoms as coexisting electron-rich centers for sustainable Fenton-like catalysis without oxidant addition remains unclear. In this study, a composite catalyst consisting of FeP nanoclusters coexisting with Fe single atoms (FeP/FeNP/C) was synthesized and utilized in two catalytic systems: one with zero-peroxymonosulfate (PMS) addition and the other with low-PMS addition. Results indicated that FeP/FeNP/C catalyst with electron-deficient region could adsorb pollutants via π-π bond and extract electrons from pollutants to the atomic FeNP/C as electron acceptor, and this self-motivated process in PMS-free system could be modulated by the FeP nanoclusters via dynamic synergistic effects.

Exploring SERS methods for rapid determination of ofloxacin residues in egg white.

In this investigation, surface-enhanced Raman spectroscopy (SERS) combined with multivariate analysis was investigated for detection and characterization of ofloxacin residues in egg white. Gold nanoparticles (AuNPs) were meticulously synthesized to serve as the substrate for enhancing Raman signals, its average particle size was approximates 50 nm, and a significant absorption peak appears at 536 nm. The SERS characteristic peaks of ofloxacin were conducted using the density functional theory (DFT) calculations.

Unlocking Efficient Direct Charge Transfer of Ni-N Bridge 2D N-ZnInS/Ni Single-Atom Photocatalysts for Hydrogen Evolution.

This study reports a strategy for constructing highly efficient single-atom photocatalysts through the formation of Ni-N chemical bonds. By anchoring Ni single atoms on nitrogen-doped ZnInS (N-ZIS), we created a localized charge region that enables directed interfacial charge transfer. The newly formed Ni-N bond plays dual roles of significantly enhancing charge carrier separation and prolonging their lifetime, and serving as an efficient electron transfer pathway from N trap states to Ni active sites.

Temporal Adaptivity Enabled High-Efficiency In-Sensor Reservoir Computing Based on MoS Phototransistors.

Reservoir computing (RC) excels in temporal signal processing, driving advances in efficient reservoir hardware. However, dynamic target recognition faces challenges due to mismatches between event time scales and temporal properties of the optoelectronic RC system. In this work, a bridge is built between the event chronological information and the temporal dynamic of optoelectronic physical nodes in RC.

prevents NRF2 nuclear translocation to drive hypoperfusion-related cognitive deficits by targeting .

-based therapeutics represent a promising approach for treating multiple diseases, yet the key regulatory in chronic cerebral hypoperfusion (CCH)-related cognitive impairment remains unclear. Here, we identify as consistently upregulated in both male and female mild cognitive impairment (MCI) and late-stage of Alzheimer's disease (AD) patients, as well as in the basal forebrain of both male and female postmortem AD specimens and male CCH rats. Knockdown of in the basal forebrain alleviated CCH-induced cognitive deficits.

A Culturally Integrative Occupational Therapy Practice Model Based on Traditional Chinese Health Culture in Mainland China.

A core philosophy of occupational therapy is adopting a holistic approach, considering individuals' cultural and societal values. While occupational therapy is rooted in modern Western cultures, which contrasts with traditional Chinese medicine (TCM) health beliefs, TCM conceptualizes health as multidimensional-a notion akin to occupational therapy's philosophy. This article attempts to explore the relationships between TCM health culture and occupational therapy perspectives by integrating culturally relevant activities and traditional Chinese Wellness practices into clinical occupational therapy.

Integrin factor (FAM27E3), as a metastatic marker of papillary thyroid carcinoma, through the p53 signaling pathway promoting lymph node metastasis.

Background: Papillary thyroid carcinoma (PTC) has a lymph node metastasis rate of 20%-90%. This study aims to explore the role and regulatory mechanism of the FAM27E3 in PTC lymph node metastasis.

Method: The seven thyroid cancer (THCA) datasets from the Gene Expression Omnibus (GEO) were combined as the training group, while the PTC dataset served as the testing group.

Transcriptome Analysis of Potato ( L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance.

Early blight, caused by the pathogen , is a major fungal disease impacting potato production globally, with reported yield losses of up to 40% in susceptible varieties. As one of the most common diseases affecting potatoes, its incidence has been steadily increasing year after year. This study aimed to elucidate the molecular mechanisms underlying resistance to early blight by comparing gene expression profiles in resistant (B1) and susceptible (D30) potato seedlings.