Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning.

Seawater drowning-induced acute lung injury (ALI) presents a significant challenge due to the lack of effective prevention and treatment strategies. Hesperidin (Hep) possesses diverse biological activities, including potent antioxidant and anti-inflammatory effects. However, its clinical utility is hindered by poor solubility and limited bioavailability.

Full color visible imaging with crystalline silicon meta-optics.

Silicon is a common material of choice for semiconductor optics in the infrared spectral range, due to its low cost, well-developed high-volume manufacturing methods, high refractive index, and transparency. It is, however, typically ill-suited for applications in the visible range, due to its large absorption coefficient, especially for green and blue light. Counterintuitively, we demonstrate how ultra-thin crystalline meta-optics enable full-color imaging in the visible range.

[The causal relationship between serum bile acids and gastric cancer: evidence based on regression discontinuity design].

Objective To investigate the causal relationship between serum total bile acid (TBA) levels and gastric cancer (GC) using regression discontinuity design (RDD). Methods A total of 1244 GC patients and 1333 healthy controls were included in the study. Demographic characteristics, gallbladder disease history, tumor markers, and serum TBA levels were collected from both groups.

Natural surgical risks and age distribution in Chinese patients with Peutz-Jeghers syndrome: Real-world research based on a web survey.

Background: Complications arising from the polyps in Peutz-Jeghers syndrome (PJS) have historically been addressed through surgical treatment. Enteroscopic polypectomy is hypothesized to reduce the risk of surgery in PJS. However, the optimal timing for polyp screening and preventive intervention using enteroscopic polypectomy remains uncertain.

Combined influence of healthy lifestyles, nutritional and inflammatory status on mortality among US adults with depression.

Objective: Healthy lifestyles, nutritional and inflammatory status are interrelated and influence mortality. This study aimed to evaluate their separate and combined effects on all-cause and cause-specific mortality in individuals exhibiting depression.

Methods: 6143 individuals with depression (median age 47) were recruited from the US National Health and Nutrition Examination Survey (NHANES 2005-2018), with mortality followed up through December 31, 2019.

Association of past obesity and BMI trajectories with cancer mortality: a prospective cohort study.

Objective: This study aimed to assess the association of past obesity and past BMI trajectories with cancer mortality in National Health and Nutrition Examination Survey.

Methods: Past obesity was identified based on past maximum body weight, and trajectories of past BMI change were determined by latent class trajectory modeling (LCTM). Cox regression was used to assess the association of past obesity and past BMI trajectories with cancer mortality.

Successful management of bleeding ectopic small bowel varices secondary to portal hypertension: A retrospective study.

Background: Bleeding ectopic varices located in the small bowel (BEV-SB) caused by portal hypertension (PH) are rare and life-threatening clinical scenarios. The current management of BEV-SB is unsatisfactory. This retrospective study analyzed four cases of BEV-SB caused by PH and detailed the management of these cases using enteroscopic injection sclerotherapy (EIS) and subsequent interventional radiology (IR).

Beating spectral bandwidth limits for large aperture broadband nano-optics.

Flat optics have been proposed as an attractive approach for the implementation of new imaging and sensing modalities to replace and augment refractive optics. However, chromatic aberrations impose fundamental limitations on diffractive flat optics. As such, true broadband high-quality imaging has thus far been out of reach for fast f-numbers, large aperture, flat optics.

Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies.

Percutaneous neoadjuvant therapy has proven effective in diminishing tumor size and the surgical intervention area, which couldeffectively mitigate the risk of tumor recurrence and enhance immunotherapy efficacy. Lenalidomide, an approved medication orally used to treat myeloma, was loaded into nanosuspensions-based hydrogels (Len-NBHs) for transdermal administration as a percutaneous neoadjuvant therapy. This study was designed to investigate the inhibitory effect and mechanism of Len-NBHs on melanoma.

Effects of BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats.

Background: Simulated microgravity environment can lead to gastrointestinal motility disturbance. The pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor (SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal cells. Moreover, intestinal flora can also affect the regulation of SCF/c-kit signaling pathway, thus affecting the expression of Cajal stromal cells.

The intake of solid fat and cheese may be associated with a reduced risk of Helicobacter pylori infection status: a cross-sectional study based on NHANES 1999-2000.

Background: Diet plays an important role in Helicobacter pylori (HP) infection, and our objective was to investigate potential connections between dietary patterns, specific food groups, and HP infection status in U.S. adults.

Innate lymphoid cell subsets in the pathogenesis of primary biliary cholangitis.

Background And Aim: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by destructive lymphocytic cholangitis and specific anti-mitochondrial antibodies. Innate lymphoid cells (ILCs) have been reported to play a role in liver homeostasis and autoimmunity.

Methods: We evaluated the features of peripheral ILC1s and ILC3 in patients with PBC and hepatic ILC1 and ILC3 in two different PBC mouse models (dominant-negative transforming growth factor-beta receptor II [dnTGFβRII] and 2-octynoic acid-bovine serum albumin [2OA-BSA]).

Broadband thermal imaging using meta-optics.

Subwavelength diffractive optics known as meta-optics have demonstrated the potential to significantly miniaturize imaging systems. However, despite impressive demonstrations, most meta-optical imaging systems suffer from strong chromatic aberrations, limiting their utilities. Here, we employ inverse-design to create broadband meta-optics operating in the long-wave infrared (LWIR) regime (8-12 μm).

Large field-of-view thermal imaging via all-silicon meta-optics.

A broad range of imaging and sensing technologies in the infrared require large field-of-view (FoV) operation. To achieve this, traditional refractive systems often employ multiple elements to compensate for aberrations, which leads to excess size, weight, and cost. For many applications, including night vision eye-wear, air-borne surveillance, and autonomous navigation for unmanned aerial vehicles, size and weight are highly constrained.

Ocean current redistributed the currently using Organoamine Pesticides in Arctic summer water.

In a comprehensive study on the presence and distribution of Currently Using Organoamine Pesticides (CUOAPs) in the Arctic Ocean, this study collected and analyzed 36 surface seawater samples during the summer of 2021. The study detected 36 CUOAPs, 17 of these compounds at levels exceeding the Method Detection Limits (MDLs). Concentrations of CUOAPs ranged from 0.

Network analysis of the relationships between problematic smartphone use and anxiety, and depression in a sample of Chinese college students.

Background: Problematic smartphone use (PSU) is associated with both anxiety and depression. However, the relationships between components of PSU and symptoms of anxiety or depression have not been investigated. Hence, the aim of this study was to closely examine the relationships between PSU and anxiety and depression to identify the pathological mechanisms underpinning those relationships.

Spatiotemporal variations, surface inventory, and cross regional impact of current-use organoamine pesticides in Chinese Marginal Seas.

Current-use Organoamine Pesticides (CUOAPs) are a growing concern as emerging pesticide pollutants that were initially discovered on a large scale in Chinese Marginal Seas (CMSs). The highest level was detected in the East China Sea in the late spring and decreased in the following order: East China Sea (early spring) > the South China Sea > the Bohai Sea. The crucial role played by the Yangtze and Yellow rivers as significant terrestrial sources were established.

Spatial distribution and risk assessment of conazole fungicides in surface seawater of the East China Sea.

Conazole fungicides (CFs), the common-used pesticide in agriculture distributed widely in the environment. This research analyzed the occurrence, potential sources, and risks of eight CFs in the East China Sea surface seawater in the early summer of 2020. The total CF concentration ranged from 0.

The military occupational stress response scale: Development, reliability, and validity.

Soldiers in the military are exposed to numerous stressors, including some that are of an extreme nature. The main objective of this military psychology research study was to evaluate soldiers' occupational stress. Even though several tools have been developed to measure stress in this population, to date, none have focused on occupational stress.

Endogenous Follistatin-like 1 guarantees the immunomodulatory properties of mesenchymal stem cells during liver fibrotic therapy.

Background: Mesenchymal stem cell (MSC) therapy has been shown to be a promising option for liver fibrosis treatment. However, critical factors affecting the efficacy of MSC therapy for liver fibrosis remain unknown. Follistatin-like 1 (FSTL1), a TGF-β-induced matricellular protein, is documented as an intrinsic regulator of proliferation and differentiation in MSCs.

Millimeter-scale focal length tuning with MEMS-integrated meta-optics employing high-throughput fabrication.

Miniature varifocal lenses are crucial for many applications requiring compact optical systems. Here, utilizing electro-mechanically actuated 0.5-mm aperture infrared Alvarez meta-optics, we demonstrate 3.

Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases.

Oxidative stress plays a dominant role in inflammatory skin diseases. Emerging evidence has shown that the close interaction occurred between oxidative stress and the gut microbiome. Overall, in this review, we have summarized the impact of oxidative stress and gut microbiome during the progression and treatment for inflammatory skin diseases, the interactions between gut dysbiosis and redox imbalance, and discussed the potential possible role of oxidative stress in the gut-skin axis.

Wireless Rehabilitation Training Sensor Arrays Made with Hot Screen-Imprinted Conductive Hydrogels with a Low Percolation Threshold.

Herein, we propose a highly sensitive wireless rehabilitation training ball with a piezoresistive sensor array for patients with Parkinson's disease (PD). The piezoresistive material is a low percolation threshold conductive hydrogel which is formed with polypyrrole (PPy) nanofibers (NFs) as a conductive filler derived from a polydopamine (PDA) template. The proton acid doping effect and molecular template of PDA are essential for endowing PPy NFs with a high aspect ratio, leading to a low percolation threshold (∼0.

Symptoms Burden and Health-related Quality of Life in Chinese Patients with Primary Biliary Cholangitis.

Background And Aims: Primary biliary cholangitis (PBC) is a chronic liver disease that negatively affects the health-related quality of life (HRQoL) of patients. Furthermore, the HRQoL of Chinese patients has been neglected for a long time. The present study aimed to assess the HRQoL of Chinese patients with PBC and explore the clinical variables correlating to the improvement of itch and fatigue.