Successful endoscopic reduction of rare post-ESD colonic intussusception: A case report.

Colonic intussusception after endoscopic submucosal dissection (ESD) is an uncommon, yet clinically significant complication. Therapeutic approaches for postoperative intussusception encompass conservative management, endoscopic reduction, and surgical intervention. We present a case involving a woman in her early 40s who experienced acute abdominal pain and fever shortly after ESD for a large ascending colonic adenoma.

Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.

While the hyper- and hypo- reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, the lack of an overarching neurobiological characterization currently limits their early identification and neuromodulation. Here we combined microarray data from the Allen Human Brain Atlas with a multimodal fMRI approach to uncover the neurobiological signatures of RS and PS in a discovery-replication design (N=655 healthy participants, 442 Females). Both RS and PS were mapped separately in the brain, with the functional connectome in the fronto-striatal network encoding reward responsiveness, while the fronto-insular system was particularly engaged in punishment sensitivity.

Expressing Vitreoscilla hemoglobin in Escherichia coli Nissle 1917 enhances its probiotic potential for alleviating ulcerative colitis.

Ulcerative colitis causes chronic intestinal inflammation with a complex etiology and limited treatment options. Active probiotics are an effective way to treat gastrointestinal diseases, which often face challenges in surviving and colonizing the complex gastrointestinal environment. In this study, we investigated the potential of Escherichia coli Nissle 1917 with a cloned bacterial hemoglobin gene (EcN-VHb) in intestinal colonization and therapeutic efficacy for treating ulcerative colitis.

Risk of bias and low reproducibility in meta-analytic evidence from fast-tracked publications during the coronavirus disease 2019 pandemic.

The fast-tracked publication of coronavirus disease 2019 (COVID-19)-related meta-analytic evidence has undeniably facilitated rapid public health policymaking; however, concerns are mounting that this publication policy may compromise research quality and scientific integrity. To investigate this, we conducted a meta-research study systematically evaluating risk of bias (ROB), transparency, and reproducibility in pandemic-era meta-analyses synthesizing COVID-19-derived mental health problem epidemics. From 98 identified studies-including data from 18.

The association between urinary nitrate and prostate specific antigen without prostatic disease: a cohort study.

Purpose: The carcinogenic effects of nitrate reduction to nitrite are well established, and nitrate has been closely linked to various diseases. However, research on its effects on the urinary system remains limited, and its association with PSA remains unclear. This study aims to investigate the relationship between urinary nitrate and PSA.

Endometrial diseases: a summary of small experimental animal model†.

Endometrium plays a crucial role in embryonic growth and development. Endometrial-related diseases, such as endometritis, endometriosis, endometrial cancer, and intrauterine adhesions, hurt fertility and women's health. At present, these diseases often lack effective or permanent treatments, necessitating the construction of analogous animal models for research and solution development.

Barriers or helpers to health: A systematic review and three-level meta-analytic evidence to the associations between procrastination and health.

This study aims to clarify the overarching association between procrastination and health, as well as potential moderators, by conducting a systematic three-level meta-analysis. Following the PRISMA guidelines, a search across PubMed, Wiley, ScienceDirect, and Web of Science databases resulted in 66 studies with 32,131 participants. Results indicated a moderate positive correlation between procrastination and adverse health outcomes ( = 0.

Overlooked role of heterotrophic prokaryotes in sulfur oxidation makes the sediment of the Bohai Sea a sufficient sink of hydrogen sulfide.

Marine sediments are the active sites for the biogeochemical cycling of sulfur. Sulfate is used as a major terminal electron acceptor for the anaerobic oxidation of organic compounds in deep sediments, and the produced sulfide is normally oxidized back to sulfate in upper sediments. However, it is unclear which microorganisms, metabolic pathways, and enzymes are mainly involved in oxidation.

Developmental trajectories of depressive symptoms in left-behind children: A longitudinal cohort study of the early adolescents.

This longitudinal study aimed to identify developmental trajectories of depressive symptoms among left-behind children during early adolescence (ages 9-14) in China and to examine baseline predictors differentiating stable-low from escalating symptom pathways. Data were drawn from the Psychological Health Guard for Children and Adolescents Project of China, including 72,887 left-behind children from Nanchong, Sichuan, a region characterized by high labor out-migration, whose parents had migrated and left them behind. They were assessed three times over 18 months using the Center for Epidemiological Studies-Depression Scale.

Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters.

(1) Background: The early diagnosis of keratoconus is critical for prognosis. Traditional methods like ORA and Corvis ST measure overall corneal biomechanics but lack regional specificity and are affected by intraocular pressure. In contrast, Brillouin microscopy assesses regional corneal biomechanics without such limitations; (2) Methods: In total, 25 keratoconus patients and 28 healthy controls were included in this study.

NIR-II Fluorescence Imaging-Guided Combinatorial Therapy of Breast Cancer Using ICG/Chelerythrine-Loaded Aptamer-Targeted Liposomes.

Breast cancer remains a major global health challenge. Great efforts have been made to develop advanced theranostic platforms for breast cancer. A critical limitation of the current approaches is insufficient tumor accumulation.

Development and validation of the adolescents' perceptions of parental involvement scale in China.

Introduction: Given the increasing academic pressures associated with intensified social competition, the role of parental involvement in education has emerged as a pivotal research area, especially within the context of Chinese culture. However, there remains a need to further delineate the characteristic dimensions of parental involvement and to develop appropriate measurement tools to quantify such involvements. By the perspective from adolescents' reports, this study proposed a psychometric and theoretical framework for understanding Chinese adolescents' perceptions to their parental involvement.

Dual retrieving and ranking medical large language model with retrieval augmented generation.

Recent advancements in large language models (LLMs) have significantly enhanced text generation across various sectors; however, their medical application faces critical challenges regarding both accuracy and real-time responsiveness. To address these dual challenges, we propose a novel two-step retrieval and ranking retrieval-augmented generation (RAG) framework that synergistically combines embedding search with Elasticsearch technology. Built upon a dynamically updated medical knowledge base incorporating expert-reviewed documents from leading healthcare institutions, our hybrid architecture employs ColBERTv2 for context-aware result ranking while maintaining computational efficiency.

The impact of primary mental healthcare on core symptoms of depression among underrepresented adolescents: a network analysis perspective.

Background: Depression has emerged as a leading contribution of the global mental health burden, particularly among underrepresented adolescents. Despite the World Health Organization's promotion of primary mental healthcare as a critical solution, its real-world effectiveness in low- and middle-income countries remains debated due to high costs and insufficient follow-up. This study aimed to explore the impact of primary mental healthcare on the core symptoms of adolescent depression using network analysis, while examining the influence of demographic factors such as gender, age, and family support, to identify more precise and targeted healthcare strategies, improving its effectiveness.

Microfluidic-engineering Prussian blue hydrogel microspheres for enhanced osteoarthritis antioxidant therapy.

Osteoarthritis (OA), a degenerative joint disorder and leading cause of global disabilty, imposes substantial societal and familial burdens. Current antioxidant therapies for OA are hindered by poor targeting and transient efficacy, failing to address the excessive reactive oxygen species (ROS)-driven pathogenesis. Herein, we innovatively integrate Prussian blue (PB) nanozymes with alginate-hyaluronic acid (HA) hydrogel microspheres through microfluidic engineering, creating the injectable AlgHA@PB platform that synergizes dual therapeutic mechanisms: ROS scavenging and oxygen generation via PB nanozymes, and sustained intra-articular retention and mechanical compatibility enabled by the hydrogel microsphere architecture.

The application of ultrasound artificial intelligence in the diagnosis of endometrial diseases: Current practice and future development.

Diagnosis and treatment of endometrial diseases are crucial for women's health. Over the past decade, ultrasound has emerged as a non-invasive, safe, and cost-effective imaging tool, significantly contributing to endometrial disease diagnosis and generating extensive datasets. The introduction of artificial intelligence has enabled the application of machine learning and deep learning to extract valuable information from these datasets, enhancing ultrasound diagnostic capabilities.

Synergy of dissolving microneedles and ultrasound to enhance transdermal delivery for rheumatoid arthritis.

Dissolving microneedles (DMNs) are an emerging transdermal drug delivery system that has gained increasing attention as an alternative to traditional oral and injectable methods for treating rheumatoid arthritis (RA). However, these DMNs encounter challenges related to insufficient drug diffusion through passive mechanisms. To address this issue, we developed biocompatible DMNs fabricated from hyaluronic acid (HA) loaded with ultrasound-responsive nanoparticles, aiming at enhancing drug permeation and diffusion through ultrasound (US) assistance.

Screening of antioxidant peptides from soy protein isolate: In vitro activity validation and structure-activity relationships investigation through quantum chemical calculations.

Soy protein isolate (SPI) holds significant potential for providing antioxidant peptides. In this study, we optimized the hydrolysis conditions to obtain SPI hydrolysates with high antioxidant activity. Subsequently, we isolated, identified and screened three antioxidant peptides through ultrafiltration, liquid chromatography-tandem mass spectrometry, and bioinformatics methods, respectively.

Application of bacteria-mediated gene therapy in tumor treatment.

Introduction: Gene therapy refers to the use of vectors to introduce target genes into target cells to exert a therapeutic effect on tumors. As a new type of tumor therapy, gene therapy has the advantage of precision and specificity. Excellent delivery vehicles have a major impact on the efficiency, precision and safety of gene therapy.

Ultrasound Molecular Imaging With VEGFR2-Targeted Microbubbles to Evaluate Intrauterine Adhesion After Endometrial Injury and Monitor the Therapeutic Effects.

Objectives: To assess the severity of intrauterine adhesion (IUA) after endometrial injury via ultrasound molecular imaging (USMI) of vascular endothelial growth factor receptor 2 (VEGFR2) expression on the uterine endothelium.

Methods: MB was constructed via "biotin-avidin-biotin" bridging technology. A rat IUA animal model was constructed via chemical injury.

Subclinical Psychiatric Symptomatology and a Proposed Diagnostic Criterion Separating Psychopathological Procrastinators From Trait Procrastinators.

Procrastination trait describes irrational delays of scheduled tasks despite clear awareness of the adverse consequences of doing so. Although procrastination is well-known to be linked to psychiatric or pathological processes, the criterion for "psychopathological procrastination" distinguishing from the procrastination trait is understudied. This is a 5-year longitudinal observational study.

Research progress on ultrasound in bacteria-mediated tumor treatment.

Bacteria-mediated tumor treatment (BMTT) has recently garnered significant attention as a promising avenue in tumor treatment. Despite the application of various strains in animal models and clinical trials, the effectiveness of BMTT has been hindered by its toxicity and inefficiency. In recent years, it has been explored that applying the biological effects of ultrasound could further improve the precision and effectiveness of BMTT.

Thermal-responsive ultrasound activatable production of therapeutics for real-time imaging and targeted tumor therapy.

Engineered bacteria with tumor-targeting capabilities and genetic modification potential have emerged as promising vectors for targeted tumor therapy through the effective production and release of therapeutic molecules. Controlled gene expression and real-time monitoring of therapeutic protein expression in tumors are of great significance for optimizing the therapeutic effective of engineered bacteria production as well as anti-tumor effects. We constructed engineered MG1655 cells using recombinant thermal plasmid pBV220 carrying the optical imaging reporter gene miRFP720 and the therapeutic gene Cytolysin A, which could be controlled expressed synchronously by thermal effect produced by focused ultrasound.