Corrigendum to: real-time and noninvasive tracking of injectable hydrogel degradation using functionalized AIE nanoparticles.

[This corrects the article DOI: 10.1515/nanoph-2020-0087.].

Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning.

Seawater drowning-induced acute lung injury (ALI) presents a significant challenge due to the lack of effective prevention and treatment strategies. Hesperidin (Hep) possesses diverse biological activities, including potent antioxidant and anti-inflammatory effects. However, its clinical utility is hindered by poor solubility and limited bioavailability.

Feeding on Beauveria bassiana-treated Frankliniella occidentalis causes negative effects on the predatory mite Stratiolaelaps scimitus.

The soil-inhabiting predatory mite Stratiolaelaps scimitus (Womersley) (Acari: Laelapidae) and the entomopathogenic fungus Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Cordycipitaceae) can both serve as effective biocontrol agents against the pest Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae). Assuming the fungus B. bassiana does not adversely affect S.

Hyperspectral Imaging for Distinguishing Granulomatous Mastitis From Normal Breast Tissue in Core Needle Biopsies.

This study explores the use of hyperspectral imaging (HSI) to distinguish granulomatous mastitis (GM) from normal breast tissue in core-needle biopsy specimens. High-resolution spectral data were captured from paraffin-embedded sections across the 400-1000 nm range. Following preprocessing, normalization, and principal component analysis, one-way analysis of variance revealed ten wavelengths with the greatest diagnostic power.

Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study.

Background: Knee osteoarthritis (KOA) worsens both structurally and symptomatically, yet no model predicts KOA progression using Magnetic Resonance Image (MRI) radiomics and biomarkers. This study aimed to develop and test the longitudinal Load-Bearing Tissue Radiomic plus Biochemical biomarker and Clinical variable Model (LBTRBC-M) to predict KOA progression.

Methods And Findings: Data from the Foundation of the National Institutes of Health Osteoarthritis Biomarkers Consortium were used.

Virtual screening, synthesis, optimization and anti-inflammatory activity of novel chromones as specific COX-2 inhibitors.

In this study, we pioneered the use of SMARTS screening to construct a chromone database, and the Discovery Studio was used to achieve precise molecular docking of COX-2 through LibDock and CDOCKER, and successfully locked 7 hit compounds from the massive chromone library. In cell experiments, Q7 had a significant inhibitory effect on LPS-induced PGE (IC = 68.23 ± 8.

Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3.

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and a potent environmental pollutant, has been implicated in the dysregulation of lipid metabolism and metabolic diseases, warranting investigation into its effects on liver functions, particularly regarding fibroblast growth factor 21 (FGF21) mediated pathways. This study aimed to elucidate the effects of BaP on liver lipid metabolism and FGF21 expression via the aryl hydrocarbon receptor (AhR), with a focus on the regulatory interactions between BaP and xenobiotic response elements (XRE) within the promoter region of FGF21. Utilizing HepG2 cells, lipid accumulation was assessed through Oil Red O and Nile Red staining, while the expression of FGF21 protein was quantified by Western blotting and immunofluorescence techniques.

Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis.

Elevated glucocorticoid (GC) levels are common in conditions such as aging, chronic stress, Cushing syndrome, and GC therapy. While GCs suppress inflammation through the glucocorticoid receptor (GR), they also cause metabolic side effects. Investigating alternative pathways beyond GR activation is crucial for reducing these side effects.

The transcription factor AHL21 links phyB and PIF4 to promote photomorphogenesis in Arabidopsis.

Phytochrome B (phyB), the predominant red-light photoreceptor, interacts with various proteins, initiating a set of molecular events in plant cells that promote light responses. In this study, we identified AHL21, a member of the AT-hook motif nuclear-localized (AHL) family, as a phyB-interacting protein in Arabidopsis. AHL21 positively regulates photomorphogenesis by directly binding to PHYTOCHROME INTERACTING FACTOR 4 (PIF) promoter and downregulating its expression.

Association between weight-adjusted waist circumference index and risk of cognitive decline in Chinese hypertensive patients: a case-control study.

Background: As a new obesity-related index, the weight-adjusted waist circumference index (WWI) seems to be a good predictor of cognitive decline in hypertensive patients. This study aimed to verify the relationship between WWI and cognitive decline in Chinese hypertensive patients.

Methods: Data were obtained from the Hypertension Follow-up System of Shandong Province.

Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication.

Unlabelled: Porcine epidemic diarrhea, caused by porcine epidemic diarrhea virus (PEDV), is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets. The host factors required for PEDV replication, including receptors, remain poorly understood. Here, we developed a porcine membrane-protein-scale CRISPR/Cas9 knockout (PigMpCKO) library and performed two rounds of PEDV infection.

Molecular epidemiology and immunopathogenesis of bovine viral diarrhea virus: a growing threat to regional cattle industry of Xinjiang, China.

Bovine viral diarrheal virus (BVDV), identified as a serious global pathogen, presents a significant and formidable challenge for the global cattle sector. This presents not only serious economic consequences but also serious immunopathological consequences causing lasting impacts. In the Chinese province of Xinjiang, where the ruminants are high and the topographical features unique and contribute towards complex epidemiology, multiple genotypes of the BVDV are continuously interacting and adapting.

Alterations in Signaling Pathways and Therapeutic Strategies of Traditional Chinese Medicine in Granulomatous Lobular Mastitis.

Granulomatous lobular mastitis (GLM), a clinically challenging inflammatory breast disease, is characterized by a high recurrence rate, strong invasiveness, and a trend of affecting younger individuals, posing significant challenges to patients and clinical practitioners. Its pathological processes involve the abnormal activation of multiple signaling pathways, including NF-κB, NLRP3, JAK/STAT, TLR, MAPK, PI3K/AKT/mTOR, and Nrf2/HO-1. These pathways contribute to the disease's onset and progression by regulating inflammatory responses, immune reactions, and oxidative stress.

Analysis of regional characteristics in mortality trends of three chronic infectious diseases among the elderly in China, 2004-2021.

Background: HIV/AIDS, hepatitis B, and tuberculosis (TB) are chronic infectious diseases prioritized by the United Nations Sustainable Development Goals (SDGs) and China's "Healthy China Initiative (2019-2030)," posing persistent challenges to global and Chinese public health systems. This study analyzed mortality trends and regional/urban-rural disparities of these three diseases among Chinese elderly individuals aged 60 years and older from 2004 to 2021 to identify priority areas for targeted prevention strategies.

Methods: Data were sourced from the "China Cause-of-Death Surveillance Dataset (2004-2021)" published by the Chinese Center for Disease Control and Prevention.

Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway.

Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are linked to numerous chronic conditions, including cardiovascular disease, atherosclerosis, chronic kidney disease, and type II diabetes. Previous research identified the natural flavonoid diosmin, derived from Chrysanthemum morifolium, as a regulator of glucose metabolism. However, its effects on lipid metabolism and underlying mechanisms remained unexplored.

Dietary Nutrition, Gut Microbiota, and Health Status Across Geographically Diverse Populations in Mongolia: A Cross-Sectional Study.

Until recently, nomadic nomadism has been the dominant culture in Mongolia. Dietary patterns have evolved to fit this culture and ensure the health of people. This cross-sectional study was conducted to investigate the key role of dietary nutrition in maintaining the health of the Mongolian population and its impact on gut microbiota.

mRNA-based induction of ETV2 to restore blood flow in a preclinical mouse hindlimb ischemia model.

Regenerative medicine aims to repair tissue defects and functional abnormalities by enhancing endogenous cellular processes. Additional to cell-based therapy, viral and nonviral gene therapies have raised substantial interest as promising approaches that allow the direct modulation of key signaling pathways for tissue regeneration in the body. E26 transformation-specific (ETS) variant transcription factor 2 (ETV2) is a well-validated transcription factor which enables vascular regeneration.

Associations between serum lipid levels and cognitive impairment in hypertensive patients: a case-control study.

Objective: Previous studies have shown that lower serum lipid levels are associated with the development of cognitive impairment (CI), dementia, and Alzheimer's disease. However, the relationship between serum lipid levels and CI in hypertensive patients has not been determined. This case-control study aimed to investigate the relationship between serum lipid levels and CI in hypertensive patients.

Accelerated discovery of stable, extra-large-pore nano zeolites with micro-electron diffraction.

Stable zeolites with extra-large pores and nano dimensions that are capable of processing large molecules are in high demand but have been difficult to produce. Their complex structures and nanoscale crystal sizes present challenges for analysis using conventional x-ray diffraction techniques, leading to inefficiencies in material development. We report NJU120-1 and NJU120-2, two robust and fully connected aluminosilicate nano zeolites featuring interconnected channel systems with extra-large 22-ring pores.

Global research trend of graphene application in breast cancer: a bibliometric analysis.

Breast cancer (BC) is the most common malignancy among women, and its incidence has steadily increased annually. Traditional diagnostic and therapeutic approaches have limitations, prompting an urgent need to explore innovative strategies. Graphene possesses notable advantages, including strong biocompatibility, excellent biosafety, and effective active targeting, providing promising new avenues for BC treatment.

Recent progress in the pharmacotherapy for obesity.

Obesity has become a global epidemic and is one of the most significant public health challenges. Traditional interventions, including diet and exercise, often fail to deliver sustained weight loss due to the intricate neuroendocrine systems regulating energy balance. In this review, we explore current anti-obesity medications (AOMs) such as gastrointestinal lipase inhibitors, nutrient-stimulated hormone-based therapies, and emerging multi-receptor agonists, emphasizing their mechanisms, efficiency, and limitations.

Minimum Data Set and Metadata for Active Vaccine Safety Surveillance: Systematic Review.

Background: Active vaccine safety surveillance (AVSS) stands as a top priority for the World Health Organization (WHO), serving as a critical indicator of the fourth maturity level for national regulatory agencies.

Objective: This review aims to define the minimal data scope for association studies in vaccine safety, providing a reference framework for implementing AVSS systems worldwide, especially in low- and middle-income countries.

Methods: The study systematically searched PubMed, Embase, and Web of Science for cohort and case-control studies related to AVSS published between January 1, 2018, and September 7, 2022.

Case Report: Minimally invasive management of suspected active bleeding from intercostal vessel after axillary thoracotomy ventricular septal defect repair: an application of Foley catheter.

The right axillary thoracotomy, an alternative approach for selected open-heart procedures, offers aesthetic advantages. However, intercostal vessel injury is a potential postoperative complication that can lead to major bleeding. Herein, we report a case of postoperative active bleeding from intercostal vessel injury after right axillary thoracotomy for ventricular septal defect repair.

Bioinformatics meets machine learning: identifying circulating biomarkers for vitiligo across blood and tissues.

Background: Vitiligo is a skin disorder characterized by the progressive loss of pigmentation in the skin and mucous membranes. The exact aetiology and pathogenesis of vitiligo remain incompletely understood.

Methods: First, a microarray dataset of blood samples from multiple patients with vitiligo was collected from GEO database.