Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This study explores the use of hyperspectral imaging (HSI) to distinguish granulomatous mastitis (GM) from normal breast tissue in core-needle biopsy specimens. High-resolution spectral data were captured from paraffin-embedded sections across the 400-1000 nm range. Following preprocessing, normalization, and principal component analysis, one-way analysis of variance revealed ten wavelengths with the greatest diagnostic power. Notably, hemoglobin absorption peaks and lipid-collagen signatures provided the strongest spectral discrimination between GM and healthy tissue. These results underscore HSI's promise as a rapid, real-time adjunct for preoperative and intraoperative evaluation of breast lesions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jbio.202500240 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fast-hyperspectral imaging remote sensing: Emission quantification of NO and SO from marine vessels.
Light Sci Appl
September 2025
Key Lab of Environmental Optics & Technology, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, China.
Marine vessels play a vital role in the global economy; however, their negative impact on the marine atmospheric environment is a growing concern. Quantifying marine vessel emissions is an essential prerequisite for controlling these emissions and improving the marine atmospheric environment. Optical imaging remote sensing is a vital technique for quantifying marine vessel emissions.
View Article and Find Full Text PDFMapping PFAS behavior via meta-analysis of soil dynamics, predictive modeling and policy integration.
Sci Total Environ
September 2025
University Hohenheim, Department of Process Analytics and Cereal Science, Stuttgart, 70599, Germany.
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants with increasing prevalence in agricultural soils, primarily introduced through biosolid application, wastewater irrigation, and atmospheric deposition. This review provides a meta-analysis of terminologies across 145 peer-reviewed studies, identifying inconsistency in the classification of PFAS subgroups-such as "long-chain vs. short-chain," "precursors," and "emerging PFAS"-which hinders regulatory harmonization and model calibration.
View Article and Find Full Text PDFRecent Advances in Traceability, Authentication, and Bioactive Profiling of Fruit and Fruit-Based Products Using Analytical Techniques Combined With Chemometrics.
Compr Rev Food Sci Food Saf
September 2025
Agricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Fruit and fruit-based products are a valuable source of essential nutrients, critical for food security, and drive economic productivity with minimal inputs. The significant rise in global demand for high-quality imported fruit and fruit-based products reflects a shift in consumer awareness and interest in the products origin and potential health-promoting bioactive compounds. Analytical techniques such as liquid chromatography, gas chromatography, inductively coupled plasma techniques, isotope-ratio mass spectrometry (IRMS), near infrared (NIR) spectroscopy, visible near infrared (VIS-NIR) spectroscopy, hyperspectral imaging (HSI), mid-infrared (MIR) spectroscopy, Raman spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy, terahertz spectroscopy, dielectric spectroscopy, electronic nose (e-nose), and electronic tongue (e-tongue) coupled with supervised and unsupervised chemometrics can be employed for traceability, authentication, and bioactive profiling of fruit and fruit-based products.
View Article and Find Full Text PDFNovel development of lipid-based formulations: Improved wettability and homogeneous API solid dispersion visualised via near-infrared hyperspectral imaging.
Eur J Pharm Biopharm
September 2025
Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria; University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical, Technology and Biopharmacy, Graz, Austria. Electronic address:
Lipid-based formulations have been successfully applied to improve the aqueous solubility of active pharmaceutical ingredients (APIs), however, with the bottleneck of limited wettability of the system. In this study, a lipid-based system was developed using polyglycerol ester of fatty acids (PGFA) as the main component and hexaglycerol (PG6) as a wetting agent. Felodipine, a BCS class II compound was selected as a model API.
View Article and Find Full Text PDFA Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells.
J Vis Exp
August 2025
Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology.
We present multimodal confocal Raman micro-spectroscopy (RS) and tomographic phase microscopy (TPM) for quick morpho-chemical phenotyping of human breast cancer cells (MDA-MB-231). Leveraging the non-perturbative nature of these advanced microscopy techniques, we captured detailed morpho-molecular data from living, label-free cells in their native physiological environment. Human bias-free data processing pipelines were developed to analyze hyperspectral Raman images (spanning Raman modes from 600 cm to 1800 cm, which uniquely characterize a wide range of molecular bonds and subcellular structures), as well as morphological data from three-dimensional refractive index tomograms (providing measurements of cell volume, surface area, footprint, and sphericity at nanometer resolution, alongside dry mass and density).
View Article and Find Full Text PDF