Analysis of regional characteristics in mortality trends of three chronic infectious diseases among the elderly in China, 2004-2021.

Background: HIV/AIDS, hepatitis B, and tuberculosis (TB) are chronic infectious diseases prioritized by the United Nations Sustainable Development Goals (SDGs) and China's "Healthy China Initiative (2019-2030)," posing persistent challenges to global and Chinese public health systems. This study analyzed mortality trends and regional/urban-rural disparities of these three diseases among Chinese elderly individuals aged 60 years and older from 2004 to 2021 to identify priority areas for targeted prevention strategies.

Methods: Data were sourced from the "China Cause-of-Death Surveillance Dataset (2004-2021)" published by the Chinese Center for Disease Control and Prevention.

Tissue zinc restoration alleviates the levodopa-induced dyskinesia via impeding ERK phosphorylation.

Purpose: Levodopa administration has been the standard therapy for Parkinson's disease (PD) and prolonged treatment is associated with levodopa-induced dyskinesia (LID). This study aimed to identify the effects of zinc (Zn) supplements on LID and to explore the underlying mechanisms.

Methods: Male C57BL/6J mice were injected with 6-OHDA at medial forebrain bundle, followed by daily levodopa injection to induce LID.

Deep learning in nuclear medicine: from imaging to therapy.

Background: Deep learning, a leading technology in artificial intelligence (AI), has shown remarkable potential in revolutionizing nuclear medicine.

Objective: This review presents recent advancements in deep learning applications, particularly in nuclear medicine imaging, lesion detection, and radiopharmaceutical therapy.

Results: Leveraging various neural network architectures, deep learning has significantly enhanced the accuracy of image reconstruction, lesion segmentation, and diagnosis, improving the efficiency of disease detection and treatment planning.

Advances in understanding the role and mechanism of the cGAS-STING signaling pathway in ocular diseases.

The cGAS-STING signaling pathway plays a critical role in the immune defense against DNA viruses and in autoimmunity, coordinating a cascade of events that enhance cytokine production, particularly type I interferons. This review summarizes recent advancements in understanding the pathway's impact on various ocular diseases, including age-related macular degeneration (AMD), diabetic retinopathy, and uveitis. Activation of this pathway by cytoplasmic DNA from either damaged retinal cells or external pathogens induces inflammatory responses that may accelerate disease progression.

Continuous Electrosynthesis of Pure HO Solution with Medical-Grade Concentration by a Conductive Ni-Phthalocyanine-Based Covalent Organic Framework.

Electrosynthesis of HO provides an environmentally friendly alternative to the traditional anthraquinone method employed in industry, but suffers from impurities and restricted yield rate and concentration of HO. Herein, we demonstrated a Ni-phthalocyanine-based covalent-organic framework (COF, denoted as ) with a higher inherent conductivity of 1.14 × 10 S m, which exhibited an ultrahigh current density of 530 mA cm with a Faradaic efficiency (HO) of ∼100% at a low cell voltage of 3.

Explosion of research on psychopathology and social media use after COVID-19: A scientometric study.

Background: Despite advances in research on psychopathology and social media use, no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019 (COVID-19) outbreak.

Aim: To explore the status of research on psychopathology and social media use before and after the COVID-19 outbreak.

Methods: We used Bibliometrix (an R software package) to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection, PubMed, and Scopus databases.

Identification of disease-specific genes related to immune infiltration in nonalcoholic steatohepatitis using machine learning algorithms.

To identify disease signature genes associated with immune infiltration in nonalcoholic steatohepatitis (NASH), we downloaded 2 publicly available gene expression profiles, GSE164760 and GSE37031, from the gene expression omnibus database. These profiles represent human NASH and control samples and were used for differential genes (DEGs) expression screening. Two machine learning methods, the Least Absolute Shrinkage and Selection Operator regression model and Support Vector Machine Recursive Feature Elimination, were used to identify candidate disease signature genes.

Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction.

Objective: To study the effect of Shexiang Tongxin Dropping Pill (STDP) on angiogenesis in diabetic cardiomyopathy mice with coronary microcirculation dysfunction (CMD).

Methods: According to a random number table, 6 of 36 SPF male C57BL/6 mice were randomly selected as the control group, and the remaining 30 mice were injected with streptozotocin intraperitoneally to replicate the type 1 diabetes model. Mice successfully copied the diabetes model were randomly divided into the model group, STDP low-dose group [15 mg/(kg·d)], medium-dose group [30 mg/(kg·d)], high-dose group [60 mg/(kg·d)], and nicorandil group [15 mg/(kg·d)], 6 in each group.

The 'whole landscape' of research on systemic sclerosis over the past 73 years.

Objective: This study aimed to analyse existing research on systemic sclerosis (SSc) conducted over the past 73 years to develop an essential reference for a comprehensive and objective understanding of this field of inquiry.

Methods: Using the Web of Science Core Collection, PubMed, and Scopus databases as data sources for the bibliometric analysis, we searched for published literature related to SSc over the past 73 years. The Bibliometrix package was used to analyse key bibliometric indicators, such as annual publication volume, countries, journals, author contributions, and research hotspots.

[Nutrients and Ecological Stoichiometry Characteristics of Typical Wetland Soils in the Lower Yellow River].

Carbon, nitrogen, phosphorus, and potassium in the soil are the necessary nutrient elements for plant growth, and their contents and ecological stoichiometry can reflect the status of soil quality and nutrient limitation. The Huayuankou Yellow River Floating Bridge Wetland in the lower Yellow River was selected as the research object. The methods of ANOVA, redundancy analysis, and linear regression fitting were used to study the contents of organic carbon (SOC), total nitrogen (TN), total phosphorus (TP), total potassium (TK), alkaline nitrogen (AN), available phosphorus (AP), available potassium (AK), and their ecological stoichiometric ratios as well as the limiting elements of soil nutrients, and the key physicochemical properties that affect soil nutrients and their ecological stoichiometry in the wetland were revealed.

Utilisation of carbon dioxide and nitrate for urea electrosynthesis with a Cu-based metal-organic framework.

It is important and challenging to utilise CO and NO as a feedstock for electrosynthesis of urea. Herein, we reported a stable 2D metal-organic framework (MOF) Cu-HATNA, possessing planar CuO active sites, as an efficient electrocatalyst for coupling CO and NO into urea, achieving a high yield rate of 1.46 g h g with a current density of 44.

Continuously Producing Highly Concentrated and Pure Acetic Acid Aqueous Solution via Direct Electroreduction of CO.

It is crucial to achieve continuous production of highly concentrated and pure C chemicals through the electrochemical CO reduction reaction (eCORR) for artificial carbon cycling, yet it has remained unattainable until now. Despite one-pot tandem catalysis (dividing the eCORR to C into two catalytical reactions of CO to CO and CO to C) offering the potential for significantly enhancing reaction efficiency, its mechanism remains unclear and its performance is unsatisfactory. Herein, we selected different CO-to-CO catalysts and CO-to-acetate catalysts to construct several tandem catalytic systems for the eCORR to acetic acid.

gen. nov., sp. nov., isolated from marine sediment, and genomic comparison with multiple genera.

A Gram-stain-negative, rod-shaped, non-gliding, non-flagellated, yellow, facultatively aerobic bacterial strain, designated as W260, was isolated from marine sediment of Xiaoshi Island, Weihai, PR China. The cells of W260 were 0.3-0.

Acute acquired concomitant esotropia with congenital paralytic strabismus: A case report.

Background: An unusual case of acute acquired concomitant esotropia (AACE) with congenital paralytic strabismus in the right eye is reported.

Case Summary: A 23-year-old woman presented with complaints of binocular diplopia and esotropia of the right eye lasting 4 years and head tilt to the left since 1 year after birth. The Bielschowsky head tilt test showed right hypertropia on a right head tilt.

Brumimicrobium oceani sp. nov., isolated from coastal sediment saline lake and environmental adaptability analysis.

A novel Gram-stain-negative, aerobic, non-motile, rod-shaped and orange-colored bacterium, designated as strain C305, was isolated from marine sediment of the coast area of Weihai, China. Strain C305 growth occurs at 4-40 °C (optimally at 30-33 °C), pH 6.0-9.

Halocynthiibacter halioticoli sp. nov., isolated from the viscera of abalone Haliotis discus hannai.

A Gram-stain-negative, rod-shaped, glide, non-flagellated, and facultatively anaerobic bacterial strain, designated as Z654, was isolated from the gut of abalone Haliotis discus hannai from Rongcheng, Shandong province, China. Cells are 0.2-0.

sp. nov. and sp. nov., two novel bacteria isolated from intertidal sediment.

Two novel Gram-stain-negative, facultative anaerobic, chemoheterotrophic, non-motile and rod-shaped strains were isolated from intertidal sediment sampled at Xiaoshi Island, Weihai, PR China. Full sequence analysis of the 16S rRNA genes showed that the two strains were closely related to members of the genus and the phylogenetic similarities to their closest relative, , were 96.7 and 95.

Self-Accelerating Effect in a Covalent-Organic Framework with Imidazole Groups Boosts Electroreduction of CO to CO.

Solvent effect plays an important role in catalytic reaction, but there is little research and attention on it in electrochemical CO reduction reaction (eCO RR). Herein, we report a stable covalent-organic framework (denoted as PcNi-im) with imidazole groups as a new electrocatalyst for eCO RR to CO. Interestingly, compared with neutral conditions, PcNi-im not only showed high Faraday efficiency of CO product (≈100 %) under acidic conditions (pH ≈ 1), but also the partial current density was increased from 258 to 320 mA cm .

Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model.

Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well controlled by current therapeutics. How epileptic seizure affects cognitive performance remains largely unclear. In this study we investigated the role of subicular seizure-activated neurons in cognitive impairment in TLE.

Cd(II)/Mn(II)/Co(II)/Ni(II)/Zn(II) Coordination Polymers Built from Dicarboxylic Acid/Tetracarboxylic Acid Ligands: Their Structural Diversity and Fluorescence Properties.

Six Cd(II)/Mn(II)/Co(II)/Ni(II)/Zn(II) coordination complexes are formulated as [Cd(X)(-O)] (), [Mn(X)(-O)] (), {[Co(Y)(4,4'-bpy)(OH)]·2HO} (), {[Ni(X)(4,4'-bpy)(HO)]·4HO} (), [Zn(-bdc)(bebiyh)] (), and [Cd(5-tbia)(bebiyh)] () (HX = 3,3'-(2,3,5,6-tetramethyl-1,4-phenylene) dipropionic acid. HY = 2,2'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene) dimalonic acid, bebiyh = 1,6-bis(2-ethyl-1H-benzo[d]imidazol-1-yl)hexane, -Hbdc = 1,3-benzenedicarboxylic acid, and 5-Htbia = 5-(tert-butyl)isophthalic acid) were obtained by hydrothermal reactions and structurally characterized. Complexes and have a 6-connected 3D architecture and with several point symbols of (3·4·5).

Zinc Deficiency Exacerbates Behavioral Impediments and Dopaminergic Neuron Degeneration in a Mouse Model of Parkinson Disease.

Background: Circulating zinc (Zn) concentrations are lower than normal in patients with Parkinson disease (PD). It is unknown whether Zn deficiency increases the susceptibility to PD.

Objectives: The study aimed to investigate the effect of dietary Zn deficiency on behaviors and dopaminergic neurons in a mouse model of PD and to explore potential mechanisms.

Synergistic Effect in a Metal-Organic Framework Boosting the Electrochemical CO Overall Splitting.

It is a very important but still challenging task to develop bifunctional electrocatalysts for highly efficient CO overall splitting. Herein, we report a stable metal-organic framework (denoted as -), composed of (2,3,9,10,16,17,23,24-octahydroxyphthalocyaninato)nickel(II) (PcNi-(O)) ligands and the planar CoO nodes, for CO overall splitting. When working as both cathode and anode catalysts (i.