Ag/TA@CNC Reinforced Hydrogel Dressing with Enhanced Adhesion and Antibacterial Activity.

Developing multifunctional wound dressings with excellent mechanical properties, strong tissue adhesion, and efficient antibacterial activity is crucial for promoting wound healing. This study prepared a novel nanocomposite hydrogel dressing based on sodium alginate-polyacrylic acid dual crosslinking networks, incorporating tannic acid-coated cellulose nanocrystals (TA@CNC) and in-situ reduced silver nanoparticles for multifunctional enhancement. The rigid CNC framework significantly improved mechanical properties (elastic modulus of 146 kPa at 1 wt%), while TA catechol groups provided excellent adhesion (36.

Naringenin-loaded Flammulina velutipes chitin-glucan complexes gel system: structural modulation and dual lipid-lowering mechanisms.

This study developed a synergistic lipid-lowering system using chitin-glucan complex (CGC) from Flammulina velutipes through green preparation and structural optimization. Enzyme-alkali treated CGC3 exhibited superior acetylation (47.85 %), crystallinity (42.

X-Aggregation Enhanced Room Temperature Phosphorescence from Terphenylamine.

Organic room temperature phosphorescence (RTP) materials have drawn wide attention because of their unique photoluminescence performances. As is known, their molecular aggregation shows determined influences on their RTP performances. However, the regulation mechanism of the molecular aggregation is still unclear.

The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.

Osteoarthritis (OA) is a highly prevalent chronic joint disease with complicated pathogenesis, causing pain and dysfunction. The mechanosensitive ion channel Piezo1 is an important mechanoreceptor on chondrocytes and may be involved in the process of OA. However, its role and mechanism remain elusive.

Decoding the Interactive Effects of Litchi Pectin and EGCG on Immune Microenvironment Remodeling: A Microbiota-Metabolic-Immune Perspective.

Plant-derived pectic polysaccharides and epigallocatechin gallate (EGCG) extensively interact during processing and consumption. Both compounds are known to regulate host immunity, yet their respective roles and combined effects in the microbiota-metabolic-immune axis remain unclear. This study investigated the effects of litchi-derived pectic polysaccharides (SCLP) and EGCG in cyclophosphamide-induced immunocompromised and intestinal barrier-damaged mice.

Enhanced Positron Emission Tomography Imaging of β-Amyloid through Focused Ultrasound-Mediated Gallium-68 Radiotracer Delivery across the Blood-Brain Barrier.

Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is an innovative approach for enhancing the delivery of central nervous system drugs. Ga radiotracers are advantageous for imaging due to their ideal half-life and imaging properties; however, their limited ability to traverse the BBB constrains their application in brain imaging. This study investigates the application of FUS to selectively deliver the Ga radiotracer, [Ga]STZL4110, into the hippocampus for β-amyloid positron emission tomography (PET) imaging in an Alzheimer's disease (AD) mouse model.

In Situ Generation of Ni Nanoparticles on Al Powder Surface via F-Ion-Mediated Oxide Layer Disruption: Enhanced the Energy Release of Oxidizer/Al Composite Energetic Microunits.

Designing stable and efficient catalysts is always an immeasurable challenge. It is difficult to achieve efficient dispersion and effective catalysis of catalysts by traditional mixing method. In this study, fuel-catalyst composites with high performance are prepared and aluminum fluoride (AlF) encapsulation of nickel (Ni) nanoparticles is also achieved, and it leads to a significant increase in the peak heat flow and heat release during the thermal oxidation process.

Limonene-loaded nanostructured lipid carriers incorporated in hydrogels: Enhanced acid stability and controlled release properties.

Improving the acid stability of nanostructured lipid carriers (NLCs) is critical for broadening their engineering applications. The integration of NLCs with hydrogels results in a more stable, multifunctional system that facilitates the effective and sustained release of bioactive ingredients. In this study, The chitosan/alginate hydrogel (CAH) exhibited minimal limonene release under combined high-temperature and acidic conditions when the degree of carboxyl substitution (DS) of chitosan reached 17.

A novel water-soluble antibacterial films of gelatin/carboxymethyl cellulose sodium incorporated with Grifola frondosa polysaccharides and pearl powder for fruit preservation.

Grifola frondosa polysaccharides (GFG) is a polysaccharide-protein complex, rich in hydrophilic groups, and has antioxidant and antibacterial biological activities. Nano-pearl powder (PP) with a large amount of calcium carbonate can be used as a chelating agent, antioxidant, and antibacterial agent. The incorporation of PP and GFG into gelatin/carboxymethyl cellulose sodium (G/C) is a novel approach for the development of bioactive edible films, in line with the concept of sustainability and environmental protection.

Self-polymerized metal-phenolic ionogel with multifunctional properties towards theranostic wearable electronics.

With the rapid development of wearable technology toward integrated diagnostics and therapy, wearable electronic materials are required to possess a range of properties, such as stretchable, compressible, conductive, anti-freezing, biocompatible, and antimicrobial properties. Metal-phenolic dual-network ionogel (MP-DN ionogel) was thus prepared by using Fe-tannic acid and HO as dual self-catalysis system to trigger the polymerization of hydrophilic ionic liquid monomer and hydrophobic acrylamide glycidyl ester monomer. The prepared ionogel showed well-rounded properties including high conductivity, good self-healing, anti-freezing (remains ice-free at -20 °C), anti-swelling, effective antibacterial property (anti-bacterial ratio > 99.

Efficiently Constructed Core-Shelled Structured AP-Based Composites with Excellent Balance of High Energy Release and Low Sensitivity.

Ammonium perchlorate (AP) plays an important role in solid propellants because of its high specific impulse, high energy density and low cost. However, the excellent performance cannot conceal the many shortcomings of AP, and the problems of non-concentrated exothermic, high sensitivity and hygroscopicity still seriously impede its application in solid propellants. In this study, the solvent evaporation method is used to directionally modify the order of the cupric oxide (CuO) and fluororubber (F) shell layers so as to obtain AP-based composites with different core-shell structures.

Molecular dynamics insights into pulsed electric field-induced structural and functional changes in polygalacturonase.

Pulsed electric field (PEF) is one of the emerging non-thermal sterilization technologies which can be applied to fruit juice preservation. The PEF process can also affect the activity and structure of enzymes and other natural macromolecules in fruit juice, including polygalacturonase (PG), an undesired enzyme which can dissolve the turbidity state of juice. However, the precise molecular mechanisms driving this phenomenon remain elusive.

evidence on the chirality-enhanced oxygen evolution reaction in intrinsically chiral electrocatalysts.

Electrolytic hydrogen is identified as a crucial component in the desired decarbonisation of the chemical industry, utilizing renewable energy to split water into hydrogen and oxygen. Water electrolysis still requires important scientific advances to improve its performance and lower its costs. One of the bottlenecks in this direction is related to the sluggish anodic oxygen evolution reaction (OER).

Tiliroside from Ameliorates Myocardial Ischemia Injury in Zebrafish by Activating the -Mediated PI3K-Akt and MAPK Signaling Pathways.

(Steph. ex. Willd.

Extraction, characterization, and biological activity in vitro of polysaccharides from discarded young fig fruits based on various extraction methods.

Discarded young fig fruits (DYFFs) are rich in polyphenols, polysaccharides, and other active substances, and fig polysaccharides (FPs) extracted from DYFFs using different methods vary in structure, processing characteristics, and biological activities, which are of great research value. The polysaccharides extracted from DYFFs using different extraction methods were used to compare the structures, processing characteristics, and biological activities of FPs, and to research the conformational relationships. The yield of MDP (6.

Effects of n-3 Polyunsaturated Fatty Acid Supplementation on Cardiovascular Indices in Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials.

Background: Individuals with type 2 diabetes (T2DM) face a significantly increased risk of cardiovascular disease. This study aims to explore the impact of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular indices in this population. Although the benefits of n-3 PUFAs on cardiovascular health and glycemic outcomes are highly regarded, previous research reports have shown inconsistent results.

The high efficiency protective effectiveness of a newly isolated myoviruses bacteriophage vB_AceP_PAc in protecting mice from Aeromonas caviae infection in mice.

Phage therapy is an effective strategy to combat multidrug resistance in bacteria and has been increasingly utilized to protect animals from bacterial infections. This study involved the isolation and purification of a novel myoviruses phage, vB_AceP_PAc, from a drug-resistant bacterial strain Aeromonas caviae. Genome sequence analysis based on nucleotide sequences revealed that vB_AceP_PAc shared significant similarity with the genomes of 10 other Aeromonas phages, with the highest coverage rate of 52% with phiA047.

Water Oxidation Electrocatalysis in Acidic Media with Fe-Containing POMs/Carbon Composites.

Iron-based catalysts are very appealing in terms of applications due to the low cost of Fe and to its abundance in the Earth's crust. In the field of water oxidation, unfortunately, iron oxides cannot match the activity of Co or Ni oxides, much less than the activity of noble metal oxides (IrO). The activity of transition metals to promote the oxygen evolution reaction (OER) can be tuned and enhanced by their incorporation into polyoxometalate frameworks (POMs).

Theoretical design of 2D 2 SiNOX (X = H, F, and Cl) phases: a new family of flexible wide bandgap semiconductors.

By first-principles calculations, a new family of two-dimensional (2D) 2 SiNOX (X = H, F, and Cl) phases were rationally designed by theoretical exfoliation of bulk layered α-LiSiON compounds, taking advantage of the in- and out-of-plane bonding anisotropy of the bulk parental compound. It is found that 2D 2 SiNOX phases have wide direct and quasi-direct bandgaps of 4.99-6.

Efficient construction of core/double-shelled structured AP@nano-graphite@F energetic microcapsules with low sensitivity and hygroscopicity.

Ammonium perchlorate (AP) is widely utilized in aerospace, defense and other fields due to its high energy density, exceptional stability, easy availability and adaptability. However, the high sensitivity and hygroscopicity of AP severely constrain its application in numerous fields. In this study, a two-step continuous coating method was employed to construct AP-based energetic microcapsules with low sensitivity and hygroscopicity.

Rheological Properties and Modification Mechanism of Emulsified Asphalt Modified with Waterborne Epoxy/Polyurethan Composite.

In research aimed at improving the brittleness of WER (waterborne epoxy)-modified emulsified asphalt, commonly encountered issues are that the low-temperature performance of this type of asphalt becomes insufficient and the long curing time leads to low early strength. Matrix-emulsified asphalt was modified with WPU (waterborne polyurethane), WER, and DMP-30 (accelerator). Firstly, the performance changes of modified emulsified asphalt at different single-factor dosages were explored through conventional performance tests and assessments of its adhesion, tensile properties, and curing time.

Stepwise-targeting and hypoxia-responsive liposome AMVY@NPs carrying siYAP and verteporfin for glioblastoma therapy.

Background: The Hippo pathway is a conserved tumour suppressor signalling pathway, and its dysregulation is often associated with abnormal cell growth and tumorigenesis. We previously revealed that the transcriptional coactivator Yes-associated protein (YAP), the key effector of the Hippo pathway, is a molecular target for glioblastoma (GBM), the most common malignant brain tumour. Inhibiting YAP with small interfering RNA (siYAP) or the specific inhibitor verteporfin (VP) can diminish GBM growth to a certain degree.

Clinical outcome after open-wedge high tibial osteotomy: comparison of double-triangle locking compression plate (DT-LCP) and T-shaped locking compression plate (T-LCP).

Background: The objective of this study was to compare the clinical outcomes of two internal fixation methods for high tibial osteotomy (HTO): double-triangle locking compression plate (DT-LCP) and T-shaped locking compression plate (T-LCP).

Methods: 202 adult patients in our hospital between January 2018 and December 2021 were included and followed up for at least one year: group 1(DT-LCP, 98 patients) and group 2 (T-LCP, 104 patients). Detailed information on demographics, preoperative and postoperative follow-up, surgical procedures, and complications were collected.

Construction of Fe Nanoparticles Interfacial Layer on Micron Al Surface: Boosting the Efficient Energy Release of High-Energy DAP-4 as a Gradient Catalyst.

The high-energy (Hdabco)[NH(ClO)] (DAP-4) with excellent energetic performance attracts wide attention from researchers. The investigation of its interaction with the Aluminum (Al) is of great importance. However, the higher ignition threshold of DAP-4 and the dense oxide layer (AlO) of Al severely limit the energy release efficiency of Al/DAP-4.